The invention provides a multi-component high-entropy alloy prepared from the components of early transition metal elements such as titanium, zirconium, tantalum and molybdenum. The multi-component high-entropy alloy is characterized in that the alloy comprises the components of the early transition metal elements of Ti, Zr, Nb and Ta, the component chemical formula of the alloy is TiaZrbNbcTad, wherein a, b, c and d show the atom content percentage, a is 20-30, b is 20-30, c is 20-30, d is 20-30, and the sum of a, b, c and d is 100; and the appropriate quantity of elements of Mo, Si, Cu and Ag can be further added in the alloy. The high-entropy alloy has the characteristics of body-centered cubic crystal structure, high strength, high hardness, corrosion resistance, good biocompatibility and the like, and is suitable for being used as a biomedicine application material for hard tissue repairing and replacing.