3 results about "Febuxostat" patented technology

This invention provides a method for preparing febuxostat. The route uses ethyl 2-(3-aldehyde-4-hydroxyphenyl)-4-methylthiazolium-5-carboxylate as the starting material, first alkylating the 4-hydroxyl group, then reducing the 3-aldehyde group to a cyano group, and finally hydrolyzing to generate febuxostat. This method is simple to operate, has mild reaction conditions, high yield, low cost, is environmentally friendly, and is suitable for large-scale industrial production of febuxostat.

The application belongs to the technical field of medicine detection, and particularly relates to a detection method of impurities in 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester. The method uses high performance liquid chromatography to detect related substances in 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester, and the content of each impurity is calculated by a principal component self-control method with a correction factor. Methodology verification shows that the detection method provided by the application is good in specificity, high in accuracy and sensitivity, and can be used for quality control of related substances in 2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid ethyl ester, so that the product quality can be effectively controlled, and the medication safety of febuxostat medicine is improved.

The application belongs to the technical field of drug use, and particularly relates to an application of febuxostat in preparation of an antifungal drug and an antifungal composition. The application expands the application range and indications of febuxostat, improves the selection range of the antifungal drug, improves the antifungal effect, and has an inhibiting effect on a ketoconazole-resistant strain.