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Medicinal composition for treating hyperuricemia

A hyperuricemia and composition technology, applied in the field of pharmaceutical compositions for the treatment of hyperuricemia, can solve problems such as human injury and liver function damage, reduce damage, reduce toxicity and side effects, and increase adaptability Effects on sex and tolerance

Inactive Publication Date: 2010-03-03
TIANJIN TAIPU PHARMA SCI & TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, some data have shown that large doses of febuxostat have significant damage to liver function
[0005] (2) Drugs that promote uricosuric agents, such as probenecid, benzbromarone and sulfinpyrazone, etc., but they all have different degrees of side effects and toxicity, especially in the form of When used in large doses, it will cause harm to the human body

Method used

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  • Medicinal composition for treating hyperuricemia
  • Medicinal composition for treating hyperuricemia
  • Medicinal composition for treating hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Preparation of tablets: 50g of benzbromarone, 20g of febuxostat, 43g of lactose, 16g of microcrystalline cellulose, mixed evenly, adding an appropriate amount of 10% PEG6000 solution to granulate, drying, then adding sodium carboxymethyl starch 5.3 g, 1.5g of magnesium stearate, mixed evenly, compressed into tablets, and film-coated.

Embodiment 2

[0062] Preparation of tablets: 80g benzbromarone, 20g febuxostat, 397g lactose, 93g pregelatinized starch, 15g hydroxypropyl cellulose, 29.8g croscarmellose sodium, stearic acid Magnesium 7.5g, mixed evenly, granulated with pure water, dried, compressed into tablets, coated with film.

Embodiment 3

[0064] Preparation of tablets: 40g of benzbromarone, 20g of febuxostat, 28.5g of lactose, 10.5g of microcrystalline cellulose, mix well, add an appropriate amount of 10% PEG4000 solution to granulate, dry, then add carboxymethyl starch Sodium 4.7g, magnesium stearate 1.2g, mixed evenly, compressed into tablets, coated with film.

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Abstract

The invention relates to a medicinal composition for treating hyperuricemia, which comprises Febuxostat or derivate thereof, benzbromarone and a pharmaceutically acceptable medicinal carrier, whereinthe ratio in weight portion of the Febuxostat or derivate thereof to the benzbromarone to the pharmaceutically acceptable medicinal carrier is 1:1-4:0.5-100. The medicinal composition can provide extremely beneficial effects of treating the hyperuricemia. Pharmacological tests prove that the medicinal composition has obviously synergistic action, can quickly reduce the concentration of purine trione in blood serum, remarkably improves effect of treating the hyperuricemia, greatly reduces medicament dosage of single component simultaneously, and effectively reduces toxic and side effect of medicament.

Description

technical field [0001] The present invention relates to the pharmaceutical composition that is used for treating hyperuricemia febuxostat and uricosuric agent treatment hyperuricemia, more specifically, the present invention relates to febuxostat or derivative thereof and benzbromarone A pharmaceutical composition for the treatment of disorders associated with hyperuricemia and gout. Background technique [0002] With the development of the economy and the improvement of people's living standards, changes in lifestyle and dietary structure, as well as many diseases lead to hyperuricemia (Hyperuricemia), its incidence rate is increasing year by year, and there is a trend of younger age. Like other metabolic diseases, the incidence of hyperuricemia has been on the rise in recent years, and it has increased the mortality rate of cardiovascular and cerebrovascular diseases. Hyperuricemia includes primary and secondary hyperuricemia. When hyperuricemia reaches a certain high va...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61K31/343A61P19/06
CPCA61K31/343A61K31/505A61K31/426A61P19/06A61K2300/00
Inventor 张殿镇谭明胜赵健朱红星
Owner TIANJIN TAIPU PHARMA SCI & TECH DEV
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