58results about How to "Excipients are easy to get" patented technology

The invention discloses a production method of artificial isaria cicadae miq. The production method has the advantages that the technical parameters, cultivation medium conditions and the like of the method are obtained after years of optimization, each parameter, cultivation medium proportion and production conditions are quite scientific and precise, and tests show that high-quality artificial isaria cicadae miq can be obtained by the method; the method is short in cultivation time, the cultivation medium is rice, wheat or mixture of wheat and yeast, the auxiliary materials are easy to get and low in cost, and massive industrial production can be performed; the artificial isaria cicadae miq produced by the method can be used as food, healthcare product, and medicine, or as the auxiliary materials of foods, healthcare products and medicines.

The invention discloses a Febuxostat tablet. The Febuxostat tablet comprises a tablet core and a coating, wherein the tablet core comprises the following components in weight percentage: 5-30 percent of Febuxostat, 15-60 percent of filler, 1-20 percent of disintegrating agent, 0.1-5 percent of surface active agent, 0.1-8 percent of lubricant and a right amount of adhesive. According to the Febuxostat tablet, trough adopting the powerful disintegrating agent within a reasonable proportional region, and meanwhile, through jointly using the surface active agent, the poorly water-soluble drug Febuxostat dissolves out, and further, the dissolvability of the Febuxostat is increased, and the bioavailability of the Febuxostat is improved. Moreover, the Febuxostat tablet is simple in preparation method, controllable in quality and high in stability.

The invention provides an oral ciclosporin A sustained-release agent. The sustained-release agent comprises the following components in part by mass: 1 part of ciclosporin A, 2.5 to 7.5 parts of polyvidone-K30, 0.15 to 4.82 parts of hydroxypropyl methyl cellulose 4000cPa.s, 0.1 to 3.94 parts of microcrystalline cellulose, 0 to 2.57 parts of hydroxypropyl methyl cellulose 15000cPa.s and 0.1 to 1.0part of phospholipid. By combining a solid dispersing technology and a sustained-release hydrophilic gel matrix technology and based on the 'double release' principle of fast release first and slow release second, the method prepares the insoluble medicament of ciclosporin A sustained-release agent; and the method has the obvious advantages that the solubility of ciclosporin A is improved, and the oral agent can quickly play the effect first and then smoothly and slowly release drug. The ciclosporin A sustained-release tablets reduce the lowered blood concentration peak-valley phenomenon and lower the drug-taking frequency. The invention also discloses a method for preparing the oral ciclosporin A sustained-release agent.

The invention discloses a high-dissolubility children's calcium carbonate D3 granule. The high-dissolubility children's calcium carbonate D3 granule comprises, by weight, 12,000-14,000 parts of calcium carbonate, 0.03-0.1 part of vitamin D3, 1,800-2,100 parts of glucose, 2,300-3,100 parts of maltodextrin, 150-300 parts of sodium citrate and 95-108 parts of polyvinylpyrrolidone K30. The invention further discloses a preparation method of the high-dissolubility children's calcium carbonate D3 granule. The high-dissolubility children's calcium carbonate D3 granule and the preparation method thereof have the advantages that since granularity of fine powder and dosage of raw and minor ingredients and a preparation technology are controlled effectively, granule uniformity is improved, and the high-dissolubility children's calcium carbonate D3 granule is higher in dissolubility, vitamin D3 content and administration compliance and beneficial to calcium absorption of human bodies; the preparation method is simple, convenient, feasible and suitable for large-scale production.

A spray of diversine hydrochloride is prepared from the tuduranine hydrochloride, percutaneous promoter and solvent. Its advantages are high percutaneous effect and curative effect, quick absorption, and low toxic by-effect.

The invention relates to Chinese medicinal external washing powder and effervescent tablets for treating lumbago and a preparation method thereof. The formula of the external washing powder is prepared from 3,750 grams of epimedium herb, 6,250 grams of bark of eucommia, 3,750 grams of prepared common monkshood daughter root, 3,125 grams of Morinda officinalis and 3, 125 grams of malaytea scurfpea fruit. The Chinese medicines in the formula are weighed by weight and ground into 200-mesh powder respectively, the different kinds of powder are mixed uniformly, the mixture is packaged according to a ratio of 20 grams per bag, and thus the external washing powder is obtained. The formula of the effervescent tablets comprises 690 grams of epimedium herb, 1,110 grams of bark of eucommia, 690 grams of prepared common monkshood daughter root, 520 grams of Morinda officinalis and 520 grams of malaytea scurfpea fruit, which service as raw material medicines, and 650 grams of citric acid, 780 grams of sodium bicarbonate, 1,105 grams of starch, 260 grams of sodium carboxymethyl starch, 195 grams of hydroxy propyl cellulose, and 195 grams of polyethylene glycol 6000. The preparation method of the effervescent tablets comprises: (1) preparing paste powder; (2) dividing the paste powder into two parts, adding 650 grams of citric acid into one part, granulating, drying, finishing grains, adding 780 grams of sodium bicarbonate powder into the other part, uniformly mixing, granulating, drying and finishing grains; and (3) adding 195 grams of hydroxy propyl cellulose and 195 grams of polyethylene glycol into the particles, uniformly mixing and tabletting.

The invention relates to formulas and preparation methods of traditional Chinese medicine external washing powder and effervescent tablets. The formula of the external washing powder comprises 3750g of heaven ailanthus fruit, 6250g of radix et rhizome rhei, 3750g of clematis chinensis osbeck, 3125g of bletilla striata, and 3125g of glauber salt. The preparation method of the external washing powder comprises the steps that: the medicine materials are weighed according to the formula; the medicine materials are respectively crushed and grinded into powders with particle sizes of 200 meshes; the powders are well-mixed; and the mixed powder is packed according to a specification of 20g/pack, such that the external washing powder is prepared. The formula of the external washing effervescent tablets comprises raw medicine materials and auxiliary materials. The raw medicine materials comprise 690g of heaven ailanthus fruit, 1110g of radix et rhizome rhei, 690g of clematis chinensis osbeck, 520g of bletilla striata, and 520g of glauber salt. The auxiliary materials comprise 650g of citric acid, 780g of sodium bicarbonate, 1105g of starch, 260g of sodium carboxymethyl starch, 195g of hydroxypropyl cellulose, and 6000195g of polyethylene glycol. The preparation method of the external washing effervescent tablets comprises steps that: (1) an extract powder is prepared; (2) the extract powder is divided into two portions; 650g of citric acid is added to one portion of the extract powder, and the mixture is well-mixed, granulated, dried, and shaped; 780g of sodium bicarbonate is added to the other portion of the extract powder, and the mixture is well-mixed, granulated, dried, and shaped; (3) 195g of hydroxypropyl cellulose, and 6000195g of polyethylene glycol are added to the granules obtained from step (2); the mixture is well-mixed, and is pressed into tablets.

The invention provides a wood-imitating skirting board capable of heating and a manufacturing method thereof, and belongs to the technical field of decorative accessories. The wood-imitating skirtingboard is composed of six layers of structures, the outermost layer is an abrasion-resistant layer made of a transparent aluminum oxide film, the second layer is a decorative layer with a PVC film being drawn with design and color patterns such as wood grains or stone patterns, the third layer is a skeleton layer formed by an aluminum-magnesium alloy forming board with the thickness being 0.4-0.7 mm, the fourth layer is a heating layer manufactured through a low-temperature radiation electric heating film, the fifth layer is a heat preservation layer manufactured through a polyurethane foam board with the thickness being 10-15 mm, and the sixth layer is a reflective layer undertaken by an aluminum foil film. The manufacturing method comprises the steps that during manufacturing, the decorative layer is pasted on one face of the skeleton layer first; then the abrasion-resistant layer is hot pressed on the decorative layer; then after the skeleton layer is formed by using special equipment, and the heating layer is pasted and the heat preservation layer is sprayed on the other face of the skeleton layer in sequence; after sizing of the heat preservation layer is achieved, the reflective layer is pasted, thereafter, the skirting board is cut, and a power line is connected; and finally, a convex male connector and a concave female connector are correspondingly machined on the two side edges of the skirting board, and a plurality of small holes are evenly drilled in the concave female connector of the skirting board at intervals in a sleeving mode.

The invention discloses an ivermectin controlled-release capsule and a preparation method and application thereof. The ivermectin controlled-release capsule comprises, by mass, 0.1-1% of ivermectin raw material, 20-60% of water-soluble carrier and 30-70% of enteric-soluble wrapping material, the water-soluble carrier is one or multiple of hydroxypropyl-beta-cyclodextrin, methyl-beta-cyclodextrin,HPMC, PVP, PEG, poloxamer 188, mannitol, D-alpha-tocopherol PEG 1000 succinate, cholate/phospholipid mixed micelle, polyethylenediamine dendritic polymer, phospholipid or cholesterol, and the enteric-soluble wrapping material is one or multiple of hydroxypropyl methyl cellulose phthalic acid, acrylic resin II, acrylic III, cellulose acetate phthalate, polyethylene diacetate phthalate or hydroxypropyl methyl cellulose acetate succinate. The ivermectin controlled-release capsule has the advantage of outstanding acid resistance, enables drug to reach intestinal tracts to be disintegrated and released, remarkably improves bioavailability and has remarkable treatment effect.

The invention discloses a stably isoosmotic freeze-drying preparation, which takes a recombinant desmoteplase alpha1vampire bat plasminogen activator or mutant thereof as an active ingredient. The stably isoosmotic freeze-drying preparation comprises the desmoteplase alpha1 or the mutant thereof and a freeze-drying protective agent. The freeze-drying preparation of the invention can be re-prepared into a solution preparation by using a proper diluent so as to be used in clinic.

An aerosol for treating viral colod, upper respiratory tract infection, infantile viral pneumania, ulcer is digestive tract, viral hepatitis A, etc is prepared from zedoary oil, solubilizer, flavouring and solvent.

The invention relates to formulas and preparation methods of Chinese medicinal washing powder and effervescent tablets for treating osteoporosis. The formula of the washing powder comprises 3750g of twotooth achyranthes root, 6250g of teasel root, 3750g of bark of eucommia, 3125g of curcuma aromatica and 3125g of drynaria rhizome. The preparation method of the washing powder comprises the following steps of: weighing the traditional Chinese medicine raw materials according to the formula, respectively smashing the traditional Chinese medicine raw materials into 200 meshes, stirring to be uniform, and packaging according to the specification of 20g/bag. The formula of the effervescent tablets comprises the following traditional Chinese medicine raw materials: 690g of twotooth achyranthes root, 1110g of teasel root, 690g of bark of eucommia, 520g of curcuma aromatica and 520g of drynaria rhizome; and the formula also comprises the following auxiliary materials: 650g of citric acid, 780g of sodium hydrogen carbonate, 1105g of starch, 260g of carboxy methyl starch sodium, 195g of hydroxy propyl cellulose and 195g of polyglycol 6000. The preparation method of the effervescent tablets comprises the following steps of: (1) preparing extract powder; (2) dividing the fine extract powder into two parts, adding 650g of critic acid into one part of the fine extract powder and mixing, granulating, drying and pelletizing; adding 780g of sodium hydrogen carbonate powder into the other part of the fine extract powder and mixing, granulating, drying and pelletizing; and (3) adding 195g of hydroxy propyl cellulose and 195g of polyglycol 6000 into the granules, mixing, and pressing into 1000 tablets.

The invention relates to a formula of external washing powder and effervescent tablet for treating varicose veins of lower extremities and a preparation method thereof. The formula of its external washing medicinal powder: Sophora flavescens 3750g, Fangfeng 6250g, white fresh skin 3750g, Kochia scoparia 3125g, alum 3125g. The preparation method of the external washing medicinal powder: take the above-mentioned medicines, crush and grind them into 200 meshes respectively, fully stir them evenly, pack according to 20g/bag, and obtain the external washing medicinal powder. The formula of its effervescent tablet for external washing: 690g of raw materials Sophora flavescens, 1110g of Fangfeng, 690g of white fresh skin, 520g of Kochia scoparia; excipients 650g of citric acid, 780g of sodium bicarbonate, 1105g of starch, 260g of sodium carboxymethyl starch, hydroxypropyl Base cellulose 195g, polyethylene glycol 6000195g. The preparation method of its effervescent tablet: (1) prepare extract powder; (2) divide above-mentioned extract powder fine powder into two parts, add 650g fine powder of citric acid to mix in one part, granulate, dry, granulate; Add 780g of sodium bicarbonate as fine powder, mix evenly, granulate, dry, and granulate; (3) add 195g of hydroxypropyl cellulose and 6000-195g of polyethylene glycol to the above granules, mix evenly, and press into tablets.

A cyclosporine A sustained-release pellet preparation is obtained by bland pellets coated by two layers of coatings. A quick release coating solution is obtained by dissolving one part of cyclosporine A, 0.67-3 parts of polyvinylpyrrolidone K30, 0.67-3 part of poloxamer188, 0.1-1 part of polyethylene glycol and 0.18-1 part of superfine silica powder into an ethanol solution; and a sustained-release coating solution is formed by dissolving one part of ethyecellulose, 0-0.2 parts of phthalic acid diethyl ester, 0.1-0.3 parts of polyethylene glycol and 0.12-1 part of superfine silica powder into ethyl alcohol. The blank pellet serves as a pellet core, quick release coating and sustained-release coating technologies are combined, indissolvable drug cyclosporine A sustained-release pellets are prepared according to the double drug release principle of first quick release and then sustained release, and the aim that a sustained release preparation first rapidly effects and then steadily release the drug when being taken orally. The preparation method is also disclosed.

The invention discloses an (R)-Lansoprazole time-selection pulse controlled-release pellet preparation and a preparation method thereof.The basic structure of the preparation comprises a blank pellet core, a medicine layer, a swelling layer and an enteric controlled release layer from inside to outside.The swelling layer contains swelling materials and a binding agent, and the enteric controlled release layer contains enteric materials and sustained-release materials.Compared with routine technologies, the release rate of the pellets, prepared through the preparation method, in a 0.1 mol/L hydrochloric acid solution is smaller than 10% of labeled amount within two hours of tolerance, certain time lag is presented at the upper end of the small intestine, and then quick pulse controlled-release is conducted.Adopted adjuvant is easy to get, the production technology is simple and controllable, and the preparation is suitable for industrial production.