The invention discloses a
tilmicosin sustained release enteric-coated
powder, a preparation method and application thereof. The
tilmicosin sustained release enteric-coated
powder comprises the following components by
mass percentage: 5-40% of
tilmicosin; 10-50% of a hydrophobic carrier; and 20-60% of an enteric material. Specifically, the hydrophobic carrier is one or more of
cholesterol, palmitin or
castor oil wax; the enteric material includes one or more of
cellulose acetate
phthalate, hydroxypropyl
methyl cellulose phthalate or polyacrylic resin II. According to the tilmicosin sustained release enteric-coated
powder provided by the invention, on the one hand, drugs are included in the hydrophobic carrier, and the
palatability of enteric-coated powder is improved; and on the other hand, the
acid resistance of the drugs is improved, so that drugs can be disintegrated and released after reaching the intestinal environment, the
plasma concentration in
livestock is relatively stable, the
cardiotoxicity of tilmicosin is greatly reduced, at the same time, the effective
plasma concentration maintenance time is significantly prolonged, the times of administration is reduced, and man power is saved.