The invention provides a preparation method for a trans 4-amino-cyclohexyl acetate derivative. The preparation method comprises the following steps that a formula (please see the description for the formula) is provided, wherein R is methyl or ethyl; a compound III is prepared from the raw materials of 4-amino
cyclohexanone II and is subjected to hydrogenation reduction, a compound I crude product is obtained, acid is added, and salt is formed; and a compound I is prepared by adding alkali. According to the preparation method, 4-amino
cyclohexanone not protected by amino is adopted as raw materials, witting reaction is conducted, and then through
catalytic hydrogenation, the trans crude product of the preparation method is obtained. The crude product can be subjected to salifying
crystallization so as to obtain the purer trans product, and the trans:syn ratio is 95-99.9:5-0.1. The product compound is high in purity and can be used for preparing
cariprazine. Operation is simple, the raw materials are easy to obtain, industrial production is suitable, and large application value is achieved.