Patents
Literature
2 results about "Clozapine" patented technology
Efficacy Topic
Property
Owner
Technical Advancement
Application Domain
Technology Topic
Technology Field Word
Patent Country/Region
Patent Type
Patent Status
Application Year
Inventor
This medication is used to treat certain mental/mood disorders (schizophrenia, schizoaffective disorders). Clozapine is a psychiatric medication (anti-psychotic type) that works by helping to restore the balance of certain natural substances (neurotransmitters) in the brain. Clozapine decreases hallucinations and helps prevent suicide in people who are likely to try to harm themselves.
Agent for alleviating clozapine-induced sialorrhea
An object of the present invention to provide a clozapine-induced sialorrhea alleviator. The clozapine-induced sialorrhea alleviator of the present invention contains as an active ingredient dextromethorphan, a compound having an antagonistic action on an NMDA-type glutamate receptor, or a compound having an agonistic action on a sigma-1 receptor.
Owner:CHIBA UNIV
Use of clozapine and its combination with a chemotherapeutic agent for the preparation of a medicament for the treatment of triple negative breast cancer or breast cancer stem cells
This invention discloses the application of clozapine and its combination with chemotherapeutic drugs in the preparation of drugs for treating triple-negative breast cancer or breast cancer stem cells, belonging to the field of pharmaceutical technology. This invention experimentally verifies that clozapine can effectively inhibit the growth of breast cancer stem cells and has a strong growth-inhibiting effect on triple-negative breast cancer cell lines, but has no growth-inhibiting effect on other types of breast cancer cell lines and normal tissue cells, thus it can be used as a treatment drug for triple-negative breast cancer. Simultaneously, the combination of clozapine and chemotherapeutic drugs can significantly inhibit the growth of triple-negative breast cancer cells, and the inhibitory effect is significantly better than that of chemotherapeutic drugs alone. Clozapine alone and the combination of clozapine and chemotherapeutic drugs significantly inhibited the growth of triple-negative breast cancer tumors in mouse models, successfully solving the problem of drug resistance in triple-negative breast cancer caused by the inability of existing basic treatment drugs (chemotherapeutic drugs) to inhibit breast cancer stem cells.
Owner:DALIAN UNIV OF TECH