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Clozapine tablets for treating schizophrenia and preparation method thereof

A technology for schizophrenia and clozapine tablets is applied in the field of clozapine tablets for the treatment of schizophrenia and the preparation thereof, and achieves the effects of short course of treatment, significant curative effect and high total effective rate

Inactive Publication Date: 2016-07-20
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the treatment of mental illness, overcome the side effects of western medicine and the repeated withdrawal of medicine, and achieve the goal of treating both symptoms and root causes.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Clozapine tablets for the treatment of schizophrenia, which are prepared from the following raw materials:

[0038] Clozapine 25kg, starch 28kg, dextrin 22kg, microcrystalline cellulose 2kg, 50% (volume ratio) ethanol 30kg, magnesium stearate 0.77kg.

[0039] Take the above raw materials, granulate according to the conventional method, and prepare 1,000,000 tablets.

Embodiment 2

[0041] Clozapine tablets for the treatment of psychosis, which are prepared from the following raw materials:

[0042] Clozapine 10kg, starch 28kg, traditional Chinese medicine active ingredients 12kg, dextrin 22kg, microcrystalline cellulose 2kg, 50% (volume ratio) ethanol 30kg, magnesium stearate 0.77kg.

[0043] Take the above raw materials, granulate according to the conventional method, and prepare 1,000,000 tablets.

[0044]The active ingredient of the traditional Chinese medicine is prepared from the raw materials of the following weight:

[0045] Curculigo 35 parts, Dodder 35 parts, Morinda officinalis 35 parts, Rhubarb 30 parts, Aloe Vera 30 parts,

[0046] 30 parts of Dalbergia, 30 parts of Pistachio, 30 parts of Agarwood, 25 parts of Citrus aurantium, 25 parts of Peucedanum,

[0047] 25 parts of madder, 25 parts of windproof, 25 parts of aconite, 22 parts of salvia miltiorrhiza, 22 parts of tangerine peel,

[0048] 22 parts of white peony root, 20 parts of medlar...

Embodiment 3

[0057] Acute toxicity test: 60 mice, half male and half female, weighing 30-40 g, were used for acute toxicity test. The mice were randomly divided into two groups, i.e. the control group, the Example 1 group and the Example 2 group, 20 in each group, fasted for 12 hours before the experiment, and the administration groups were given the preparations of Example 1 and Example 2 of the present invention respectively. The pharmaceutical composition was dissolved in water and administered intragastrically. The control group was given the same amount of normal saline, administered twice a day, with an interval of 6 hours between administrations. After administration, the mice were continuously observed for two weeks, and the toxic reactions and deaths of the mice were recorded. number. The experimental results showed that: compared with the control group, there was no significant difference in the mice after administration. The experiment was observed for two consecutive weeks, and...

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Abstract

The invention relates to clozapine tablets for treating schizophrenia. The clozapine tablets are prepared from the following raw materials: 25 kilograms of clozapine, 28 kilograms of starch, 22 kilograms of dextrin, 2 kilograms of microcrystalline cellulose, 30 kilograms of ethanol of which the volume ratio is 50%, and 0.77 kilograms of magnesium stearate. The raw materials are taken and granulated according to the conventional method, and then one million tablets are prepared. The clozapine tablets disclosed by the invention are obvious in curative effect, and capable of treating both symptoms and root causes, and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to clozapine tablets for treating schizophrenia and a preparation method thereof. Background technique [0002] Mental illness refers to the general term for disorders in which the incidence of brain functional activities is disordered, resulting in varying degrees of impairment of mental activities such as cognition, emotion, behavior, and will. There are many pathogenic factors: congenital heredity, personality traits and physical factors, organic factors, social environmental factors, etc. Many mental patients have delusions, hallucinations, delusions, emotional disorders, erratic crying, talking to themselves, weird behavior, and decreased willpower. The vast majority of patients lack self-awareness, do not admit that they are sick, and do not actively seek help from doctors. Ordinary people also do not admit that they are sick, so lack of self-awareness and not ad...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/551A61K36/9066A61P25/18
CPCA61K9/2059A61K31/551A61K36/10A61K36/11A61K36/185A61K36/23A61K36/232A61K36/238A61K36/288A61K36/324A61K36/344A61K36/39A61K36/48A61K36/537A61K36/65A61K36/708A61K36/71A61K36/714A61K36/736A61K36/74A61K36/746A61K36/752A61K36/815A61K36/835A61K36/88A61K36/886A61K36/896A61K36/8964A61K36/9066A61K2236/331A61K2236/333A61K2236/39A61K2236/51
Inventor 林凡儒聂昌盛吴士平杨川川
Owner 仁和堂药业有限公司
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