Pharmaceutical composition for treating psychosis and preparation technology thereof

A composition and psychosis technology, applied in the field of medicine, to achieve the effects of short course of treatment, significant curative effect and high total effective rate

Inactive Publication Date: 2016-02-17
仁和堂药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its purpose is to solve the treatment of mental illness, overcome the side effects of western medici...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A pharmaceutical composition for treating psychosis, which is prepared from the following raw materials:

[0039] Clozapine 25kg, starch 28kg, dextrin 22kg, microcrystalline cellulose 2kg, 50% (volume ratio) ethanol 30kg, magnesium stearate 0.77kg.

[0040] Take the above raw materials, granulate according to the conventional method, and prepare 1,000,000 tablets.

Embodiment 2

[0042] A pharmaceutical composition for treating psychosis, which is prepared from the following raw materials:

[0043]Clozapine 18kg, starch 28kg, traditional Chinese medicine active ingredients 8kg, dextrin 22kg, microcrystalline cellulose 2kg, 50% (volume ratio) ethanol 30kg, magnesium stearate 0.77kg.

[0044] Take the above raw materials, granulate according to the conventional method, and prepare 1,000,000 tablets.

[0045] The active ingredient of the traditional Chinese medicine is prepared from the raw materials of the following weight:

[0046] 40 parts of tiankui, 40 parts of calamus, 40 parts of pseudophysalis, 35 parts of eucalyptus, 35 parts of frankincense,

[0047] 35 parts of Ligustrum lucidum, 35 parts of Herba huixincao, 30 parts of turmeric, 30 parts of Gastrodia elata, 30 parts of Rhodiola rosea,

[0048] 28 parts of inulae root, 28 parts of burdock seed, 28 parts of dandelion, 25 parts of Atractylodes macrocephala, 25 parts of astragalus,

[0049] 25 ...

Embodiment 3

[0059] Acute toxicity test: 60 mice, half male and half female, weighing 30-40 g, were used for acute toxicity test. The mice were randomly divided into two groups, i.e. the control group and Example 1 group, Example 2 group, 20 in each group, fasted for 12 hours before the experiment, and the administration group was given the preparation of Example 1 and Example 2 of the present invention respectively. The pharmaceutical composition was dissolved in water and administered intragastrically. The control group was given the same amount of normal saline, administered twice a day, with an interval of 6 hours between administrations. After administration, the mice were continuously observed for two weeks, and the toxic reactions and deaths of the mice were recorded. number. The experimental results showed that: compared with the control group, there was no significant difference in the mice after administration. The experiment was observed for two consecutive weeks, and the genera...

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Abstract

The invention relates to a pharmaceutical composition for treating a psychosis. The pharmaceutical composition for treating the psychosis is prepared from 25 kg of clozapine, 28 kg of starch, 22 kg of dextrin, 2 kg of microcrystalline cellulose, 30 kg of ethyl alcohol of 50% (volume ratio) and 0.77 kg of magnesium stearate, the raw materials are taken, granulation is conducted according to a conventional method, and one million tablets are prepared. The pharmaceutical composition is significant in curative effect, treatment of the symptoms and the causes is achieved, and wide application prospect is achieved.

Description

technical field [0001] The invention belongs to the technical field of medicine, in particular to Chinese and western medicine preparations for treating mental illness, in particular to the application of a pharmaceutical composition made of western medicine clozapine tablets and traditional Chinese medicine in treating mental illness. Background technique [0002] Mental illness refers to the general term for disorders in which the incidence of brain functional activities is disordered, resulting in varying degrees of impairment of mental activities such as cognition, emotion, behavior, and will. There are many pathogenic factors: congenital heredity, personality traits and physical factors, organic factors, social environmental factors, etc. Many mental patients have delusions, hallucinations, delusions, emotional disorders, erratic crying, talking to themselves, weird behavior, and decreased willpower. The vast majority of patients lack self-awareness, do not admit that...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K9/20A61K47/38A61P25/18A61K31/551
Inventor 林凡儒胡百忠付君叶杨川川薛颖
Owner 仁和堂药业有限公司
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