Clozapine tablet and preparation method thereof

A clozapine tablet and clozapine technology are applied in the field of clozapine tablet and its preparation, which can solve the problems of poor tablet core hardness, poor compressibility, splintering, etc. Safe, high similarity effects

Inactive Publication Date: 2018-10-09
南京双科医药开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of clozapine tablet and preparation method thereof, adopt existing conventional auxiliary material, by optimizing prescription and production process, to solve the problem that the prescription compressibility that proposes in the above-mentioned background technology is not good, tablet core hardness Not good, there are many problems of splitting during transportation

Method used

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  • Clozapine tablet and preparation method thereof
  • Clozapine tablet and preparation method thereof

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Embodiment 1

[0025] The invention provides a clozapine tablet and a preparation method thereof. The main ingredients and mass parts of the clozapine tablet are: 25 parts of clozapine, 61.2 parts of microcrystalline cellulose, 3.8 parts of lactose, povidone Appropriate amount, 0.5 parts of magnesium stearate, 1.4 parts of talcum powder, 0.4 parts of silicon dioxide;

[0026] Wherein, the preparation method of described clozapine tablet comprises the following steps:

[0027] Step 1: passing clozapine through a 100-mesh sieve for subsequent use;

[0028] Step 2: take by weighing clozapine, microcrystalline cellulose, lactose by the prescription amount in claim 1 and place in the wet mixing granulator together and mix evenly;

[0029] Step 3: Weigh an appropriate amount of povidone, dissolve it in water and prepare an aqueous solution with a concentration of less than 3%;

[0030] Step 4: Add an appropriate amount of starch binder to the mixed powder in the previous step to make a suitable ...

Embodiment 2

[0035] The invention provides a clozapine tablet and a preparation method thereof. The main ingredients and mass parts of the clozapine tablet are: 25 parts of clozapine, 61.2 parts of microcrystalline cellulose, 3.8 parts of lactose, povidone Appropriate amount, 0.5 parts of magnesium stearate, 1.4 parts of talcum powder, 0.4 parts of silicon dioxide;

[0036] Wherein, the preparation method of described clozapine tablet comprises the following steps:

[0037] Step 1: passing clozapine through a 100-mesh sieve for subsequent use;

[0038] Step 2: take by weighing clozapine, microcrystalline cellulose, lactose by the prescription amount in claim 1 and place in the wet mixing granulator together and mix evenly;

[0039] Step 3: Weigh an appropriate amount of povidone, add water to dissolve and prepare an aqueous solution with a concentration of 3% to 5%;

[0040] Step 4: Add an appropriate amount of starch binder to the mixed powder in the previous step to make a suitable sof...

Embodiment 3

[0044] The invention provides a clozapine tablet and a preparation method thereof. The main ingredients and mass parts of the clozapine tablet are: 25 parts of clozapine, 61.2 parts of microcrystalline cellulose, 3.8 parts of lactose, povidone Appropriate amount, 0.5 parts of magnesium stearate, 1.4 parts of talcum powder, 0.4 parts of silicon dioxide;

[0045] Wherein, the preparation method of described clozapine tablet comprises the following steps:

[0046] Step 1: passing clozapine through a 100-mesh sieve for subsequent use;

[0047] Step 2: take by weighing clozapine, microcrystalline cellulose, lactose by the prescription amount in claim 1 and place in the wet mixing granulator together and mix evenly;

[0048] Step 3: Weigh an appropriate amount of povidone, dissolve it in water and prepare an aqueous solution with a concentration greater than 5%;

[0049] Step 4: Add an appropriate amount of starch binder to the mixed powder in the previous step to make a suitable ...

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PUM

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Abstract

The invention discloses a clozapine tablet and a preparation method thereof. The clozapine tablet is prepared from the main material ingredients in mass fraction: 25 parts of clozapine, 61.2 parts ofmicrocrystalline cellulose, 3.8 parts of lactose, the defined amount of povidone, 0.5 part of magnesium stearate, 1.4 parts of talcum powder and 0.4 part of silicon dioxide. The preparation method ofthe clozapine tablet comprises the following specific operation steps: step 1, sieving the clozapine by a 100-mesh sieve for standby application; step 2, weighing the clozapine, the microcrystalline cellulose and the lactose according to a formula in the claim 1 and jointly putting into a wet mixing granulator to be mixed evenly; step 3, weighing the defined amount of the povidone and adding waterto dissolve the povidone to be prepared into a water solution; step 4, adding the defined amount of binding agent into mixed powder in the last step to be prepared into an appropriate flexible material. According to the clozapine tablet disclosed by the invention, existing general auxiliary materials are utilized, and the problems that an existing formula has poor compressibility, tablet core hardness is poor, and the tablet split phenomenon happens in a conveying process are solved by optimizing the formula and a production technology.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine production, in particular to a clozapine tablet and a preparation method thereof. Background technique [0002] Mental illness refers to the general term for disorders in which the incidence of brain functional activities is disordered, resulting in varying degrees of impairment of mental activities such as cognition, emotion, behavior, and will. There are many pathogenic factors: congenital heredity, personality traits and physical factors, organic factors, social environmental factors, etc. Many mental patients have delusions, hallucinations, delusions, emotional disorders, erratic crying, talking to themselves, weird behavior, and decreased willpower. The vast majority of patients lack self-awareness, do not admit that they are sick, and do not actively seek help from doctors. Ordinary people also do not admit that they are sick, so lack of self-awareness and not admitting that t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K47/36A61K47/32A61K47/38A61K31/551A61P25/18
CPCA61K9/2027A61K9/2054A61K9/2059A61K9/2095A61K31/551A61P25/18
Inventor 李磊
Owner 南京双科医药开发有限公司
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