14results about How to "Guaranteed release" patented technology

The application discloses a multifunctional injectable hydrogel and a preparation method and application thereof, and relates to the technical field of multifunctional hydrogel preparation and application. In the preparation, CMC-AGE and OD-SH are prepared respectively, and DSPE-se-se-PEG@AC NPs nanoparticles are prepared, then the multifunctional injectable hydrogel is prepared by forming a hydrogel through CMC-AGE and OD-SH and adding DSPE-se-se-PEG@AC NPs nanoparticles and / or beta nerve growth factor. The application also includes the multifunctional injectable hydrogel prepared by the above method and the application thereof. The application constructs an in-situ hydrogel delivery platform with good biocompatibility, is used for co-delivery of DSPE-se-se-PEG@AC NPs and NGF, is used in ischemic stroke treatment, and reshapes the pathological microenvironment of a cerebral infarction area, so that cerebral ischemic injury is reduced.

The utility model relates to a novel tobacco product field, concretely is a kind of heating cigarette tobacco core section structure, its characterized in that: including from inside to outside arrangement's cylindrical hollow support, tobacco sheet and cigarette paper composition, tobacco sheet is wound several rounds around cylindrical hollow support, forms a tobacco core with hollow, and cigarette paper is wrapped outside tobacco core.The utility model has the beneficial effect that:1, use hollow support to support the hole produced in the process of sheet rolling, prevent collapse in the process of cutting.2, support adopts large-area hollow design, while supporting the hole, maximum limit guarantees the release of smoke.3, support can be sprayed or impregnated essence spice, and different flavors are added to cigarette.

This application discloses a soluble microneedle composition of a GLP-1R agonist and its preparation method, belonging to the field of biomedical technology. It includes a needle body material and a base material. The needle body material contains a small molecule GLP-1R agonist, a penetration enhancer, and a soluble polymeric backbone material, and may further include pH adjusters, humectants, and stabilizers. The base material is composed of polylactic acid, polylactic acid-glycolic acid copolymer, cross-linked polyhyaluronic acid, cross-linked gelatin, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylpyrrolidone-vinyl acetate copolymer, N-(2-hydroxypropyl)methacrylamide polymer, or combinations thereof. Through injection, centrifugation, and drying, an integrated microneedle structure with mechanical strength and rapid dissolution is formed. It can pierce the stratum corneum of the skin to form microchannels and rapidly dissolve and release oxaliplatin subcutaneously, achieving transdermal delivery, effectively reducing gastrointestinal exposure and first-pass metabolism, and improving drug utilization and medication adherence.

A pneumatic landing gear retraction and extension system with mechanical sequence control and rapid unloading capability includes: a gas supply mechanism, an unloading valve, and a retraction and extension mechanism; the unloading valve has a left-position functional state and a right-position functional state; when the unloading valve is in the left-position functional state, the outlet of the unloading valve is connected to the inlet; when the unloading valve is in the right-position functional state, the outlet of the unloading valve is connected to the exhaust port; when the retraction and extension mechanism needs to be deployed, the unloading valve is in the left-position functional state; the gas supply mechanism supplies gas to the unloading valve, which enters the hatch retraction and extension mechanism and the positioning trigger valve of each retraction and extension mechanism; when the gas drives the hatch retraction and extension mechanism to deploy to the position, the positioning trigger valve switches to the conducting state, delivering gas to the landing gear retraction and extension mechanism to drive it to deploy to the position; when the retraction and extension mechanism is deployed to the position, the unloading valve is in the right-position functional state; the residual gas in the retraction and extension mechanism is discharged to the atmosphere through the exhaust port of the unloading valve, realizing rapid pneumatic unloading.

The application discloses a kind of functionalized magnetic beads, which are magnetic microspheres formed by wrapping magnetic beads with bifunctional nucleic acid, and can specifically bind mRNA.A fungal mRNA extraction kit composed of functionalized magnetic beads includes grinding material, lysing solution I, lysing solution II, magnetic bead binding solution, washing solution I, washing solution II and eluent.A mRNA extraction method includes sequentially adding grinding material, lysing solution I, lysing solution II, magnetic bead binding solution, washing solution I, washing solution II and eluent after sample pretreatment to obtain mRNA product.The application breaks through the traditional mRNA extraction method, obtains high-quality mRNA, and has the advantages of simple operation, safety, high sensitivity, good reproducibility and low cost.The mRNA obtained by the application can provide high-quality templates for RT-PCR detection, improve the specificity and sensitivity of detection, and has wide application prospects in the fields of clinical diagnosis of diseases, judicial identification, food safety detection, microbial detection and molecular biology.

The application discloses a semiconductor process equipment, and relates to the photovoltaic and semiconductor fields. The semiconductor process equipment comprises a bearing boat and a radio frequency isolation device. The bearing boat comprises a plurality of heating plates serving as radio frequency electrode plates or ground electrode plates respectively. The heating plates are provided with heating pieces. One end of the heating pieces is led out relative to the heating plates. The heating pieces comprise metal sleeves. The radio frequency isolation device comprises a first isolation component. The first isolation component comprises an isolation ring. The isolation ring is connected to the metal sleeves and is used for blocking radio frequency signals in the heating plates from being transmitted out through the metal sleeves. The application can solve the problems of radio frequency leakage and the like.

The utility model provides an auxiliary support for template processing, and relates to the technical field of template processing. According to the utility model, the auxiliary bracket assembly is arranged at the top of the bottom plate, the bracket is used for supporting a template or a workpiece, a plurality of insert cores and demolding insert cores are arranged on the bracket, the design of the insert cores and the demolding insert cores is mainly used for providing flexible adjusting and fixing functions, and the template or the workpiece is placed on the bracket; close combination of the template and the support is ensured through the insert cores, movement or deviation of the template in the machining process is prevented, the template can be conveniently separated from the support after machining is completed due to the arrangement of the demolding insert cores, the difficulty in manual demolding and the possible precision problem are avoided, and the machining efficiency is improved. The first demoulding insert core is used for preliminary loosening when the template is separated, and the second demoulding insert core and the third demoulding insert core provide a more accurate and stable demoulding function, so that demoulding is completed on the premise that the template is not damaged.

The invention belongs to the technical field of engine lubrication, and particularly relates to an assembly for replacing an engine oil filter element without shutdown of an engine, which comprises a filter element, an engine oil supply oil duct and an engine main oil duct, and is provided with an energy storage oil duct, a waste oil discharge oil duct and an exhaust oil duct. A reconfigurable oil way system is constructed, the reversing valves are all controlled by a filter PLC in a centralized mode according to signals of an engine ECU, and therefore the system can be automatically switched among the four modes of normal work, energy storage intervention, filter element replacement and system exhaust. Before the filter element is replaced, the energy storage oil way temporarily supplies oil to the main oil way of the engine through switching of the valve group, meanwhile, an old filter element oil way is isolated and emptied, pressure fluctuation of an engine oil way is reduced, it is guaranteed that the oil way of the main oil way is smooth, the filter element is replaced without shutdown of the engine, and the continuous operation capacity and maintenance efficiency of equipment are remarkably improved.

This invention relates to the field of biofertilizer technology, specifically disclosing a microalgae biofertilizer with soil remediation function and its preparation method. The preparation method includes: domesticating and culturing *Scenedesmus obliquus* liquid, *Cyanobacterium cyanobacteria* liquid, and *Monoflagellates* liquid with γ-aminobutyric acid-induced activation solution, and co-culturing them with *Bacillus polymyxa* and *Bacillus megaterium* to obtain a bioslurry; encapsulating the bioslurry with sodium alginate-carboxymethyl chitosan to obtain bioactive microspheres; impregnating corn straw with magnesium-iron salt precursors and pyrolyzing it under nitrogen to obtain modified biochar loaded with magnesium oxide and iron oxide, and compounding it with potassium humate to obtain a biochar suspension; and mixing the bioactive microspheres, biochar suspension, xanthan gum, zeolite, ammonium polyphosphate, potassium nitrate, zinc sulfate, potassium silicate, and deionized water evenly to obtain the microalgae biofertilizer with soil remediation function.

The application provides a kind of "antibacterial synergistic-mineralization regulation" bifunctional nanomaterial and its preparation method and application, belongs to the technical field of biomedical materials.The application first mixes sodium hydrogen phosphate solution and calcium chloride solution to obtain amorphous calcium phosphate suspension;Then amorphous calcium phosphate suspension and tannic acid solution are mixed to obtain ACP@TA suspension;Finally, ACP@TA suspension and hydroxypropyltrimethylammonium chloride chitosan solution are mixed to obtain bifunctional nanomaterial.Through the electrostatic adsorption of tannic acid and antibacterial layer hydroxypropyltrimethylammonium chloride chitosan to form a crosslinked shell, amorphous calcium phosphate is effectively wrapped, which can significantly delay the crystallization process of amorphous calcium phosphate, ensure long-term calcium and phosphorus ion release, and effectively exert antibacterial function, provide an ideal local microenvironment for the remineralization of dental hard tissue, and ultimately realize the biomimetic mineralization of dental enamel and the deep mineralization of dentin tubules.

The utility model discloses a mould with mobile phone screen lens shearing assembly, include: fixed mould unit and install on the core of movable mould unit, be provided with the cavity between fixed mould unit and the core, and the molten plastic liquid is injected into the cavity through the runner, and the lens workpiece is formed, the utility model discloses through the shearing in mould, completely solve the lens workpiece edge gate residual problem. Realize injection molding - shearing - demoulding integrated operation. Meanwhile, the shearing action is embedded in the injection molding cycle, and the single piece production rhythm is shortened by 4 seconds or more, and the yield is improved to 99.2%, and it is significantly adapted to the high -speed automatic production line. Compared with the prior art, not only avoids the yield loss of 8% to 12% and the efficiency bottleneck of offline shearing, but also reduces the comprehensive cost by 15% through in-situ treatment in the mould, ensures the optical performance of the lens and the reliability of the terminal product, and meets the stringent production demand of the intelligent mobile phone for the precision assembly.

The application provides an injection molding machine for plastic part production and relates to the technical field of automotive interiors, and comprises a U-shaped base, a mounting table fixedly arranged at the top of the U-shaped base, four groups of supporting columns fixedly arranged at the top of the mounting table, and a top injection cavity fixedly arranged at the top of the supporting column; an injection channel is fixedly arranged in the middle of the top injection cavity; a sliding valve disc is fixedly arranged at the bottom of the injection channel; a sliding valve core is slidingly arranged in the sliding valve disc; a sealing plate is fixedly arranged at the bottom of the sliding valve disc; and an injection head is fixedly arranged at the bottom of the sealing plate; the sliding valve core is arranged to provide a valve control structure capable of being automatically opened, a driving lifting lead screw is rotated to make a movable injection port contact the injection head to be in abutment and docking, then a compound mold continues to rise, the top surface of the compound mold contacts a spring rod to push the spring rod upward, the sliding valve core is no longer blocked from the injection head, injection is performed, and the problem that existing equipment lacks an automatically opened and closed valve is solved.

The invention relates to the technical field of industrial torches, in particular to a self-operated lifting variable-sectional-area discharging device which comprises a torch cylinder, a gas inlet pipeline is fixedly connected to the side wall of the torch cylinder, a gas outlet inner cavity is formed in the torch cylinder, a gas collecting plate is arranged in the gas outlet inner cavity, and the gas collecting plate is fixedly mounted at the gas outlet end of the gas outlet inner cavity; a gas outlet is formed in the middle of the gas collecting plate, unorganized combustible gas needing to be discharged can enter the gas outlet inner cavity of the torch barrel through the gas inlet pipeline, then can rise to pass through a bundle of the gas collecting plate to be discharged from the gas outlet, and then is blown to the lifting gas blocking plate located on the gas outlet. The impact force of gas exhausted from the gas outlet can be increased, then the lifting gas blocking plate can be pushed to ascend, when the lifting gas blocking plate ascends, the fan-shaped moving plate can slide into the fan-shaped sliding groove, the circulation area is increased, the use requirement is met, on the contrary, the fan-shaped moving plate can be shrunk, flexibility and convenience are achieved, and automatic adjustment can be achieved according to the gas flow.

This invention discloses a non-contact method for preserving pork using a composite essential oil emulsion combined with an electrostatic field and modified atmosphere packaging. The prepared composite essential oil nanoemulsion is packaged in polyethylene packaging, and the chilled pork is preserved using an electrostatic field synergistic with modified atmosphere packaging. A simple ultrasonic method is used to prepare a composite essential oil nanoemulsion composed of composite essential oils and Tween 80. This prepared emulsion and cooled, acid-removed pork are then placed in an O2 atmosphere. 2 CO 2 N 2 The product is stored in modified atmosphere packaging bags of polyethylene at 4±1℃. This invention can effectively control the increase in total bacterial count, volatile basic nitrogen, and pH of chilled pork during storage, better maintain the product's textural properties, color, and sensory quality, and extend the shelf life of chilled pork by 4-6 days.