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Curcumin colon-targeted medicine preparation and preparation method thereof

A colon-targeting and pharmaceutical preparation technology, which is applied in drug combination, drug delivery, pharmaceutical formulation, etc., can solve the problems of low drug stability, incomplete drug release, and small drug loading, so as to reduce the volume of the preparation and effectively Facilitate dissolution and absorption, improve solubility and stability

Active Publication Date: 2016-03-23
石家庄市度智医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The purpose of the present invention is to provide a curcumin colon-targeted pharmaceutical preparation and a preparation method thereof to solve the problems of the existing curcumin dosage forms such as small drug loading, low drug stability, poor targeting, and incomplete drug release, so that clinical Colon cancer treatment and prevention offer more drug options

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Embodiment 1 curcumin-beta-cyclodextrin inclusion compound preparation

[0048] Get 300g beta-cyclodextrin and be dissolved in the aqueous ethanol solution of 1000g (mass percentage concentration is 50%); Place in constant temperature magnetic stirrer, keep temperature 40 ℃, add the dehydrated alcohol solution that 600g contains curcumin (curcumin 100g, without 500 g of water and ethanol), stirring while adding, and after 2 hours of inclusion, put the suspension containing the inclusion compound in the refrigerator for 24 hours, then suction filter, wash the solid with absolute ethanol, and reduce the inclusion compound at 40 ° C. Press and dry to obtain yellow curcumin-β-cyclodextrin inclusion compound powder.

Embodiment 2

[0049] The preparation of embodiment 2 curcumin-hydroxypropyl β-cyclodextrin inclusion compound

[0050] Dissolve 300g of hydroxypropyl β-cyclodextrin in 1000mL of water, place it in a constant temperature magnetic stirrer, add 1100g of curcumin-containing acetone solution (100g of curcumin, 1000g of acetone) while stirring at 40°C, stir for 2h, and use Filter through a 0.45 μm microporous membrane, and spray-dry the filtrate to obtain a yellow loose powder of curcumin-hydroxypropyl β-cyclodextrin inclusion compound.

Embodiment 3

[0051] The preparation of embodiment 3 curcumin-alpha-cyclodextrin inclusion compound

[0052] Dissolve 200g of α-cyclodextrin in 1500mL of water, place it in a constant temperature magnetic stirrer, add 900g of curcumin-containing propylene glycol solution (100g of curcumin, 800g of propylene glycol) while stirring at 40°C, stir for 2h, and use 0.45μm Filter through a microporous membrane, and freeze-dry the filtrate for 24 hours to obtain curcumin-α-cyclodextrin inclusion complex yellow loose freeze-dried powder.

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Abstract

The invention discloses a curcumin colon-targeted medicine preparation which comprises a curcumin cyclodextrin inclusion compound, a natural polysaccharide colon-targeted material and an enteric coating material according to a specific ratio. Meanwhile, the invention further discloses a preparation method of the preparation. The preparation method includes the steps that curcumin and cyclodextrin are prepared into the curcumin cyclodextrin inclusion compound according to a proportion; the curcumin cyclodextrin inclusion compound and the natural polysaccharide colon-targeted material are subjected to cross-linking and solidification according to a proportion and are filtered, washed and filtered, and curcumin colon-targeted micelles are obtained; the curcumin colon-targeted micelles are coated with the solution of the enteric coating material, and the curcumin colon-targeted medicine preparation is obtained. The curcumin colon-targeted medicine preparation is developed and prepared through the special method, the defect that curcumin is low in water solubility and poor in stability is overcome, the medicine can be released on colons in a positioning mode, the aim of colon targeting is achieved, and the preparation is simple in technology and easy to use and popularize.

Description

technical field [0001] The invention relates to a traditional Chinese medicinal preparation and a preparation method thereof, in particular to a curcumin colon-targeting medicinal preparation and a preparation method thereof. Background technique [0002] Colon cancer is one of the main malignant tumors of human beings. Since the 1970s, with the progress of our society, the improvement of living conditions and the gradual westernization of people's lifestyles, the incidence of colon cancer in my country has risen rapidly, and it has become the most common cancer in China. It is one of the five common malignant tumors and seriously endangers human health. Inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are also related to the occurrence of colon cancer, and both are considered to be precancerous lesions of colon cancer. [0003] Oral colon-targeted drug delivery system is a class of pharmaceutical preparations that deliver drugs to the colon for loc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/50A61K47/48A61K47/36A61K47/40A61K47/32A61K47/38A61K47/44A61K31/12A61P35/00
CPCA61K9/0002A61K9/5015A61K9/5026A61K9/5036A61K9/5042A61K31/12
Inventor 曹德英杜青向柏方瑜敦洁宁党云洁王静齐晓丹
Owner 石家庄市度智医药科技有限公司
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