The invention relates to a sturgeon healthy high-density culture method. The method comprises the steps of (a) pond conditions; (b) preparation before stocking; (c) fish frying feeding; (f) daily management, and the sturgeon bait fed in the step (c) is prepared from the following components, by weight, of 10-20 parts of maltodextrin, 20-30 parts of fish meal, 30-50 parts of earthworm powder, 8-12 parts of baker's yeast autolysis powder, 5-10 parts of rice bran polypeptide, 0.5-1 part of decavitamin and 10-25 parts of immunopotentiator; the immunopotentiator is prepared from the traditional Chinese medicine raw materials, by weight, of 6-10 parts of andrographis paniculata, 6-10 parts of Forsythia suspensa, 6-10 parts of root of Chinese thorowax, 6-10 parts of folium artemisiae argyi, 6-10 parts of Codonopsis pilosula, 6-10 parts of Astragalus mongholicus, 6-10 parts of Lonicera japonica, 6-10 parts of Lycium barbarum, 6-10 parts of indigowoad root and 6-10 parts of Houttuynia cordata. According to the method, the sturgeon survival rate is high, the weight gain rate is high, the selected bait quality is high, and the bait coefficient is low.