The invention discloses a radix isatidis planting method, which comprises the following steps of selecting a clay block which is good in drainage, fertile and loose for planting and applying a base fertilizer; carrying out seeding, thinning and final singling, applying a compound fertilizer and spraying a foliage fertilizer, wherein the base fertilizer is prepared from bryozoatum, akadama, rice bran, duck manure and a nitrogen-phosphorus-potassium compound fertilizer, and the compound fertilizer is prepared from urea, plant ashes, kaolin, basic zinc sulfate and a rhizobium inoculant; the foliage fertilizer is prepared from zinc sulfate, borax, ammonium molybdate, ammonium molybdate, fulvic acid, naphthylacetic acid and rapin ficusin; spraying a pest and disease prevention agent with 450fold water once every two months, wherein the pest and disease prevention agent is prepared from tubatoxin, cinnamon, onion and ramie; and harvesting folium isatidis and collecting roots in November. According to the radix isatidis planting method, the yield of radix isatidis can be greatly improved, pests and diseases of the radix isatidis are greatly reduced and the growth environment of the radix isatidis is purified; and the folium isatidis is good in palatability and high in input-output ratio and suitable for massive popularization and the nutrient value is improved.