The invention provides a disease-resistant perch culture method. The method comprises the following steps of S1, selecting a quiet and safe environment to build a pond, wherein the area of the pond is8-12 mu, the water depth is 2-3 m, and the water surface every 1.2-1.5 mu is provided with an aerator; S2, drying the pond, dredging and conducting solarization on the pond, and disinfecting with 70-80 kg / mu of quicklime 14-16 days before seedling releasing; S3, desalinating fry; S4, daily feeding, wherein the fry is fed, the environment inside the culture pond is checked, water in the culture pond is changed every other week, high-density perch culture brings a lot of residual bait and excrement at the bottom of the pond, the decomposition concentration of harmful substances is high, the oxygen in the water is consumed in large quantities, which is more serious in hot weather, and counts as an important cause of fish diseases, components such as plant ash, chlorite, zeolite powder and the like are added to improve the decomposition efficiency of the residual bait and the excrement, the consumption of the oxygen in the water is reduced, the outbreak of the fish diseases is avoided, the water quality is purified, the oxygen content of the water is increased, and the yield per unit area of perch and the net weight of individuals are improved.