Oil-in-water type Pickering emulsion with stable ursolic acid and preparation method of oil-in-water type Pickering emulsion

Abstract

The present invention discloses an oil-in-water Pickering emulsion with stable ursolic acid and a preparation method of the oil-in-water type Pickering emulsion. The oil-in-water Pickering emulsion with the stable ursolic acid is prepared from the following raw materials in percentages by mass: 2-4% of ursolic acid, 2-8% of propylene glycol, 1-2% of phospholipid, 20-40% of functional grease, 0.04-0.2% of sucrose ester, 0.15-0.5% of tween 80, 0.5-1% of protein, 0.02-0.04% of a thickening agent and water. By constructing and utilizing the Pickering emulsion of the ursolic acid combined with a surfactant, multilayer microcapsule recombinant powder is prepared. The oil-in-water Pickering emulsion has characteristics of being green and safe, good in stability, high in compatibility, good in dispersibility, high in uniformity, excellent in instant solubility, etc.

Description

technical field

[0001] The invention belongs to the technical field of gel emulsification preparations, in particular to an ursolic acid-stabilized oil-in-water Pickering emulsion and a preparation method thereof. Background technique

[0002] Ursolic acid, also known as ursolic acid, has a wide range of pharmacological effects such as anti-hepatitis, anti-tumor, anti-inflammatory, anti-virus, lowering blood fat, anti-atherosclerosis and enhancing immunity, and has low toxicity and few adverse reactions. But because the solubility of ursolic acid in water is very small, the dissolution rate is slow, and the bioavailability is low, it belongs to the IV class drug (poor water solubility and poor absorption) in the biopharmaceutical classification system, so it is necessary to select a suitable dosage form to improve bioavailability Spend.

[0003] At present, invention patents such as ursolic acid freeze-dried powder preparation, ursolic acid sustained-release tablet, ursolic...

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