160 results about "High sugar" patented technology

This invention discloses a method for preparing a pH / glucose dual-responsive chronic wound dressing containing frankincense essential oil, comprising: (1) using 4-formaldehyde phenylboronic acid as a crosslinking agent to form Schiff base and borate ester bonds with carboxymethyl chitosan and two different molecular weight hyaluronic acids, respectively, to prepare a hydrogel capable of filling skin surface wounds and performing dual dynamic covalent crosslinking adhesion, and freeze-drying for later use; (2) preparing frankincense essential oil into microcapsules by emulsification coagulation method, and freeze-drying for later use; (3) mixing the hydrogel with the freeze-dried powder of frankincense essential oil microcapsules, adding deionized water or PBS and stirring to reconstitute to form a pH / glucose dual-responsive hybrid hydrogel dressing coated with frankincense essential oil microcapsules. The composite dressing prepared by this invention has anti-inflammatory, antioxidant, antibacterial, and healing-promoting effects, is quick and easy to prepare, and has the ability to respond to the acidic / high-glucose microenvironment of diabetic wounds, and has important practical application value.

The invention discloses a cherry sugar transporter gene CpSWEET10 and application thereof, and belongs to the technical field of cherry gene engineering. A novel sugar transporter gene CpSWEET10 is obtained through cloning, the nucleotide sequence of the novel sugar transporter gene CpSWEET10 is shown as SEQ ID NO.1, and the coded amino acid sequence of the novel sugar transporter gene CpSWEET10 is shown as SEQ ID NO.2. The gene is highly expressed in cherry fruits, and the content of soluble solids and total sugar in mature fruits is remarkably positively correlated with the expression quantity of the soluble solids and the total sugar; through subcellular localization and sugar transport function defect type yeast mutant functional complementation experimental analysis, the protein coded by the CpSWEET10 gene is localized in a cytoplasmic membrane and has a sucrose transport function; the cherry sugar transporter gene CpSWEET10 disclosed by the invention can be applied to the improvement of the sugar degree character of the fruits, and a new gene resource is provided for molecular breeding for improving the high-sugar quality of the cherry fruits.

The invention provides a single strain metabolism characteristic chromatogram database of oral key microorganisms in a high-glucose microenvironment and a construction method and application thereof, and belongs to the technical field of oral microbiology. The method comprises the following steps: simulating an intraoral high-glucose microenvironment in vitro; the method comprises the following steps: carrying out standardized single-strain culture on oral key microorganisms, carrying out whole-spectrum metabolism detection (non-targeted liquid chromatography-mass spectrometry (LC-MS) and non-targeted gas chromatography-mass spectrometry (GC-MS) on culture supernatant, and identifying and analyzing metabolism to construct a single-strain metabolism characteristic spectrum database of the oral key microorganisms in a high-glucose microenvironment. The database can be used for source attribution and cross validation of in-vivo metabolome results, and assists in screening key metabolites and key pathways related to high glucose. According to the method, the reliability of metabolite source judgment is improved, the directional influence of high glucose on the flora metabolism function is revealed, the method is standardized, and resources are platformized.

The invention discloses an application of isoquercitrin in preparation of a medicine for improving insulin resistance and diabetes-related liver diseases, and belongs to the technical field of medicines. According to the application, a high-glucose and high-fat diet and streptozotocin combined method is adopted to successfully construct a type 2 diabetes mouse model; experiments find that the isoquercitrin can effectively relieve the symptoms of weight loss and water intake increase of T2DM mice, significantly reduce the fasting blood-glucose level and improve abnormal glucose tolerance; the isoquercitrin can reduce the liver index of a T2DM mouse, relieve fatty degeneration of the liver and repair a liver cell structure; by activating a PI3K / AKT signal channel, the isoquercitrin up-regulates the expression levels of PI3K, p-AKT, p-GSK3 and GLUT4 and down-regulates the expressions of GSK3 and PEPCK at the same time, so that the insulin resistance of T2DM mice is effectively improved, the fatty degeneration of the liver is improved, and the isoquercitrin has a protection or repair effect on liver injury.

The invention provides a formula of low-sugar low-fat Fu tea ice cream containing partridge tea and a preparation process of the ice cream, and relates to the technical field of food processing. Comprising the following raw material components: 20-40 parts of a partridge tea extracting solution, 15-30 parts of a Fuzhuan tea extracting solution, 8-25 parts of a low-fat milk base material, 5-12 parts of a compound sweetening agent, 3-8 parts of dietary fibers and 2-5 parts of prebiotics. The preparation method has the advantages that the mallotus oblongifolius and the Fuzhuan tea extracting solution are in a specific proportion, the taste is improved through the synergistic effect of tea polyphenol, soft taste and rich flavor levels under the conditions of low sugar (less than or equal to 5%) and low fat (less than or equal to 5%) are achieved, low-temperature short-time sterilization and accurate congelation control are adopted in the process, heat-clearing and dampness-removing components of the mallotus oblongifolius and the bacteriostatic and lipid-lowering activity of golden flower of the Fuzhuan tea are effectively reserved, and the mallotus oblongifolius and the Fuzhuan tea are effectively preserved. The product has double health-care effects, solves the problems of high sugar and high fat, function deficiency and single flavor of the traditional tea-flavored ice cream, meets the requirement of healthy consumption, and has remarkable market value of country revitalizing and Hainan local tourism characteristic food.

The application belongs to the technical field of medicine, and relates to 3-benzylamino coumarin compounds and application thereof. Experimental results show that the compounds can significantly increase the survival rate of HUVEC cells in a high-sugar environment, and resist blood vessel injury caused by high sugar. The compounds can increase the release amount of NO in HUVEC cells damaged by high sugar, reduce the generation of malondialdehyde, and reduce the generation of tumor necrosis factor alpha.

The invention relates to the technical field of food processing, in particular to a natural spice seasoning and a preparation method thereof. The preparation method comprises the following steps: carrying out concentration treatment on natural spices under a vacuum condition to obtain concentrated spices; the concentrated spices are subjected to heating treatment, and the treated spices are obtained; and packaging and sealing the treated spices, and carrying out static pressure treatment to obtain the natural spice seasoning. In the whole preparation process, table salt, sugar, edible oil, preservatives, sweeteners or acidity regulators are not additionally added. The product completely depends on the components of the natural spices, so that the health risk caused by high salt, high sugar, high fat and chemical additives is fundamentally eliminated. The invention solves the problem of difficulty in long-term storage at normal temperature without adding seasonings through a pure physical process flow.

The invention belongs to the field of new application of medicines, and particularly relates to application of triptolide in preparation of medicines for treating diabetic vascular obstruction complications. Diabetes vascular obstruction is a common serious complication of diabetes and can cause various tissue injuries such as cardiovascular diseases, nephropathy and retinopathy. Experiments prove that the triptolide can remarkably improve the problems of blood vessel blockage, blood flow slowing, abnormal neovascularization and the like caused in a high-glucose environment, and meanwhile, the expression of blood glucose related indexes (such as Glucose and HbA1c) and inflammatory factors (such as TNF-alpha and IL-1beta) is reduced. In addition, triptolide can also protect pancreas from high glucose damage and improve functions of pancreatic beta cells. According to the invention, the clinical application range of the triptolide is expanded, and a new candidate substance is provided for drug treatment of diabetic vascular complications.

The application discloses a preparation method of yellow rice wine, the yellow rice wine and application. The preparation method of the yellow rice wine comprises the following steps: gelatinizing starch raw materials to prepare gelatinized starch; uniformly mixing the gelatinized starch, yellow rice wine starter, acidic protease, saccharomyces cerevisiae, yellow rice wine and water to prepare fermentation material, and performing fermentation; adding lactic acid bacteria at 72h-74h of fermentation, and continuing fermentation; and performing solid-liquid separation after the fermentation is completed, collecting clear liquid, decocting wine, aging, and preparing the yellow rice wine. The preparation method of the yellow rice wine breaks through the technical bottleneck that the metabolic time sequence of strains is uncontrollable in traditional mixed fermentation, optimizes the inoculation time of lactic acid bacteria, guarantees the acid production capacity of lactic acid bacteria under the condition of controlling alcohol metabolism, and obtains the yellow rice wine with the characteristics of high sugar, high acid and high ester, which can be used for seasoning.

The present application relates to the field of agricultural biotechnology, and particularly relates to a molecular marker capable of identifying allelic variations of a soluble acid invertase gene AcoInv-1 in pineapple fruits and application thereof. The molecular marker is amplified by using the following primers: forward primer 5-CTGCGAAATGAACTAGTCAACTC-3 and reverse primer 5-TAGAGAACCGTTCTTGG AATGG-3. The primers can identify allelic variations of the soluble acid invertase gene AcoInv-1 in pineapple fruits, i.e. AcoInv-1a and AcoInv-1b. It is found through research that the two allelic variations are extremely significantly related to the total sugar content of the pineapple fruits. It is proved through verification that the pineapple material of the AcoInv-1a type is related to high sugar content, and the pineapple material of the AcoInv-1a and AcoInv-1b types is related to low sugar content. The application of the molecular marker obtained by the present application in selecting pineapple varieties with high sugar content potential will help to accelerate the breeding selection cycle.

The invention relates to a chemoenzymatic synthesis method of a high-glucose-type homogeneity mucoprotein core structural domain. The method comprises the following steps: firstly, catalytically synthesizing a key alpha-linked glycosylated amino acid block Fmoc-GalNacalpha-Ser / Thr-OH at a low temperature (-20 DEG C to 0 DEG C); then assembling the building blocks on a repeated polypeptide skeleton rich in proline, serine and threonine at accurate intervals (3-5 amino acid residues) through a solid-phase peptide synthesis technology to form a'sugar chain growth scaffold '; then, a series of high-specificity glycosyl transferases are used for carrying out sequential and directional sugar chain enzymatic extension on the scaffold, and a uniform core structure (such as a core type 3) is constructed; and finally, performing high-efficiency purification by a three-step series method of size exclusion chromatography, ion exchange chromatography and lectin affinity chromatography. The technical bottleneck of inhomogeneity (lt, 70%) of glycoforms in a traditional method is overcome, the mucoprotein core fragment with glycoform homogeneity larger than or equal to 95% and bioactivity highly similar to that of natural mucoprotein can be prepared on a large scale, and the method has wide application prospects in the biomedical fields of mucous membrane protective agents, drug delivery carriers and the like.

The invention discloses a traditional Chinese medicine monomer composition derived from chrysanthemum plants and used for treating diabetic retinopathy as well as a preparation method and application of the traditional Chinese medicine monomer composition. The traditional Chinese medicine monomer composition prepared from the chrysanthemum plant as the raw material is high in safety, small in side effect and definite in component and is prepared according to a specific ratio, and pharmacodynamic experiments prove that compared with an ethanol extract, the traditional Chinese medicine monomer composition is more remarkable in curative effect on diabetic retinopathy, and the curative effect of the traditional Chinese medicine monomer composition on diabetic retinopathy is better than that of a traditional Chinese medicine composition on diabetic retinopathy. The composition can improve the pathological state of diabetic retinopathy from multiple targets and multiple ways, specifically can inhibit body mass increase caused by high glucose, reduce blood glucose level, improve retinal tissue structure damage, recover retinal tissue thickness, inhibit retinal cell apoptosis and inflammatory response, reduce the expression level of HIF-1alpha and VEGF protein in retinal tissue, and can be used for treating diabetic retinopathy. Scientific basis and technical support are provided for research and development of novel drugs for treating the diabetic retinopathy, and important clinical significance and market application prospects are achieved.

This invention discloses a remote real-time control system for ceramic membrane magnetic filtration based on the Internet of Things (IoT). The system comprises a sensing layer, an edge computing layer, a cloud control layer, a user interaction layer, and a modular access unit. The sensing layer, centered on a gradient field permanent magnet magnetic filtration module, integrates a Hall sensor array, an electromagnetic flowmeter, and a temperature sensor to collect key data such as magnetic saturation index, syrup flow rate, and liquid temperature in real time, achieving comprehensive perception of the ferromagnetic impurity capture status and raw material parameters. The gradient field permanent magnet magnetic filtration module is connected in series with the syrup delivery pipeline and includes a multi-stage detachable magnetic rod assembly, a Hall sensor array, a servo rotating sleeve, and a slag discharge channel. Compared to traditional iron removal equipment, this IoT-based remote real-time control system for ceramic membrane magnetic filtration is specifically designed for the characteristics of high-sugar, high-acid liquids. The gradient field magnetic circuit improves the capture efficiency, stably controlling the iron content below 0.3 ppm, effectively preventing product blackening, sedimentation, and a metallic taste.

The invention discloses a sugarcane high-sugar breeding method based on multi-modal data fusion, which comprises the following steps: constructing a sugarcane high-sugar parent germplasm resource library and a multi-modal phenotype database, constructing a sugarcane sugar content prediction model, performing phenotype screening and early prediction on filial generations, and collecting and planting sugarcane high-sugar parent materials with known sugar expression. The method comprises the following steps: establishing a core germplasm resource library, systematically measuring and recording multi-modal phenotypic data, including sugar traits and morphological growth traits, of each parent material in a plurality of key growth periods of sugarcane, and establishing a sugarcane sugar content prediction model by taking morphological growth traits data and physiological and biochemical traits data in different growth periods as characteristic variables; according to the method, pure phenotype data driving is completely based on directly measured phenotype data and environmental data, expensive genotyping or sequencing is not needed, the technical threshold and application cost are reduced, pure phenotype data driving is achieved, multi-modal data fusion is achieved, and prediction is accurate.

The invention relates to the technical field of biological medicines, in particular to a preparation containing mesenchymal stem cell-derived insulin-secreting cells and application of the preparation in preparation of blood sugar regulating products. The insulin-secreting cell is derived from mesenchymal stem cells, and the preparation method of the insulin-secreting cell adopts a four-stage directional induced differentiation strategy: in the first stage, all-trans retinoic acid, LDN-193189 and cyclopamine are combined, an endoderm program is started, non-target differentiation is specifically inhibited, and pedigree locking is realized; in the second stage and the third stage, a high-glucose environment and GLP-1 are utilized to promote the cells to differentiate into endocrine precursors and terminal insulin secreting cells; in the fourth stage, GLP-1, PTHrP and nicotinic acid are added for function strengthening, and the glucose responsiveness, maturity and stress resistance of the cells are synergistically improved. The method is accurate in differentiation path and economic in factor, and the obtained cells are high in insulin positive rate and mature in function. A preparation containing the cell can be used for preparing a medicine for treating diabetes mellitus.

This invention provides a method for simultaneously detecting 17 heat-processing hazards in 4 categories, comprising: adding n-hexane to the sample, mixing thoroughly, discarding the n-hexane phase, extracting acrylamide, 5-hydroxymethylfurfural, and free heterocyclic amines using dimethyl ketone and ultrasound-assisted extraction, collecting the supernatant, and purifying it; simultaneously transferring the precipitate to another tube, reducing it with sodium tetrahydroborate, hydrolyzing it with hydrochloric acid to release bound heterocyclic amines and late-stage glycosylation products, and performing UPLC-MS / MS analysis. This invention is the first to propose a two-step extraction method for simultaneously determining 17 heat-processing hazards in 4 categories within 7 minutes using UPLC-MS / MS. The accuracy, precision, detection limit, quantitation limit, and recovery rate of the method were verified, and all test indicators met the requirements. This method is applicable to the determination of heat-processing hazards in four types of food matrices: high starch, high protein, high fat, and high sugar.

The application provides a lactic acid bacteria with probiotic properties and application thereof, and the lactic acid bacteria is Lactobacillus plantarum (cc_Lp14) preserved in the China General Microbiological Culture Collection Center, with a preservation number of CGMCC No. 37211 and a preservation date of December 26, 2025. Lactiplantibacillus plantarum The lactic acid bacteria screened by the application can tolerate high-sugar and high-acid environment of fruit and vegetable juice, has strong oxidation resistance, and can significantly improve the content of total phenols and flavonoids when applied to fruit and vegetable juice fermentation, thus having significant application potential in the field of fruit and vegetable juice fermentation and providing important strain resources for development of a new generation of probiotic fermentation agents.

The invention discloses an application of spirulina (SP) in preparation of a product for treating diabetes-related diseases. According to the application disclosed by the invention, spirulina is found to be capable of alleviating oxidative stress in cells, promoting macrophages to be converted from a proinflammatory M1 type to an anti-inflammatory M2 type, remodeling redox balance and inhibiting an inflammatory microenvironment. More importantly, it is found that spirulina can lower the level of advanced glycation end products (AGEs) to inhibit the glycosylation process, and healing of diabetic wounds and bone defects is accelerated. In addition, the invention also finds that the spirulina can promote proliferation, migration and vascularization of vascular endothelial cells in a high-glucose and high-fat microenvironment, and further accelerate healing of bone defects. On the basis, the invention provides application of spirulina in preparation of products for treating diabetes-related diseases.

The invention relates to the technical field of food processing, in particular to a low-sugar refreshing milk beverage and a preparation method thereof. The pectin, the soybean polysaccharide and the citrus fiber / apple fiber are compounded to form a colloid system with a synergistic effect, so that the taste of the product is obviously changed, the beverage is refreshing, the defect that the traditional colloid system is thick in taste is overcome, the stability of the product is improved, and the quality stability of the product in the shelf life is ensured. Multiple sweeteners are adopted to form a low-sugar system, natural sweeteners are completely used, high-sugar and artificial sweeteners are avoided, the sugar content of the product is reduced, meanwhile, the sweet effect of the product is guaranteed, and the problem that consumers are sensitive to the high-sugar and artificial sweeteners is solved.

The invention discloses an edible and medicinal compound hippophae rhamnoides flavone concentrated plant beverage and a preparation method thereof, belongs to the technical field of plant beverages, and aims to solve the problems that an existing hippophae rhamnoides product is single in function, high in sugar and low in flavone content, and centrifugal equipment is easy to block, poor in sealing and difficult to maintain. The invention provides a beverage formula which comprises the following components in parts by weight: 11-15 parts of hippophae rhamnoides raw pulp, 2-4 parts of erythritol, 11-13 parts of edible and medicinal compound water extract concentrated solution and 0.001-0.003 part of stevioside. The preparation method provided by the invention comprises the following steps: performing low-temperature quick-freezing, fine grinding, high-efficiency centrifugation and high-pressure homogenization preparation on sea-buckthorn primary pulp, performing staged micro-boiling extraction on an edible and medicinal compound water extraction concentrated solution, and then mixing in proportion; a special centrifugal device in the preparation method is provided with a double-anti-blocking, double-sealing and closed-loop rigid frame, and the beverage is high in flavone content, low in sugar, safe, synergistic in function, efficient, stable and easy to maintain, can solve industrial pain points and has remarkable technical innovation and application value.

The application provides application of circ-0007527 as a target in screening of drugs for treating peritoneal dialysis related peritoneal fibrosis. The application also provides application of an inhibitor of circ-0007527 in preparation of a drug for treating peritoneal dialysis related peritoneal fibrosis. In a mouse peritoneal fibrosis model induced by high glucose peritoneal dialysis solution, circRNA expressed in peritoneal tissues is screened, and after bioinformatics analysis, it is found that the differential expression amount of circ-0007527 in the fibrotic peritoneal tissue is the highest, and the high expression of circ-0007527 in the fibrotic peritoneal tissue is verified by real-time fluorescent quantitative PCR. Further in-vitro cell experiments find that down-regulation of the expression of circ-0007527 can significantly inhibit peritoneal mesothelial cell phenotype transformation, proliferation and apoptosis, and thus reduce peritoneal injury and delay peritoneal fibrosis progression.

The invention provides application of nitraria tangutorum bobr extract in preparation of products for regulating glycolipid metabolism disorder, and relates to the technical field of plant extract application. The nitraria macrocarpa extract is a composition rich in alkaloid and flavonoid compounds, wherein the sum of the content of total alkaloid and the content of total flavonoids is not lower than 85% of the total weight of the extract. The extract is prepared through the processes of fresh fruit juicing, alcohol precipitation impurity removal and AB-8 macroporous resin gradient elution. Experiments show that the extract can significantly reduce fasting blood glucose of type 2 diabetes mice induced by high-fat and high-sugar diet combined with STZ, improve sugar tolerance and insulin resistance, and synchronously regulate the blood fat level, and shows an excellent glucose and lipid metabolism synergistic improvement effect. The extract disclosed by the invention provides a choice for developing a safe and effective glycolipid metabolism regulator.

The application belongs to the technical field of biology, and discloses a strain for efficiently fixing carbon dioxide and improving succinic acid conversion rate and a construction method thereof. The application discloses a genetically engineered bacterium, which is obtained by overexpressing carbonic anhydrase genes, phosphoenolpyruvate carboxylase genes and phosphoenolpyruvate carboxykinase genes in a succinic acid-producing strain. ‑ The carbonic anhydrase can enhance the conversion efficiency of CO2 to HCO3 , and the phosphoenolpyruvate carboxylase and the phosphoenolpyruvate carboxykinase can realize efficient fixation of C3 and CO2 into C4 intermediates. Experiments prove that the genetically engineered bacterium can effectively produce succinic acid by using glucose, and has a relatively high sugar acid conversion rate (up to 79.80%).

This invention discloses a magnesium alloy composite scaffold, its preparation method, and its application. The composite scaffold comprises a JDBM magnesium alloy scaffold with a highly interconnected porous structure and a composite hydrogel layer filling and encapsulating it. The hydrogel layer is formed by photocrosslinking and curing of methacrylamide-loaded glucose oxidase. This composite scaffold is a bio-battery-like therapeutic system. GOx catalyzes the biocatalytic oxidation of glucose to hydrogen peroxide, while magnesium alloy acts as an electroactive anode, together forming an adaptive electrochemical cascade reaction system. Through spontaneous oxidation dissolution and short-circuit electrochemical reactions, it rapidly removes hydrogen peroxide into water and oxygen while simultaneously promoting the oxidation of magnesium. 2+ Release. Therefore, this system not only transforms the harmful high-glucose microenvironment of diabetes into a microenvironment conducive to bone regeneration, but also achieves multiple synergistic effects of anti-inflammation, anti-oxidation, and bone promotion through the continuous supply of magnesium ions and the timely removal of H2O2, significantly promoting the repair and regeneration of bone defects under diabetic conditions.

A bee feeder designed to prevent bee drowning and minimize inter-hive fighting. The feeder comprises a long rectangular container, optimally 2 to 6 feet in length, with taller walls (4 to 10 inches) to contain a significant volume of bee syrup. Floating wooden dowels, approximately ¼ inch in diameter and slightly shorter than the width of the container, are placed side by side atop the syrup, creating a safe bee feeding surface. The dowels are light enough to float as bees land on them, enabling access to the syrup. High-sugar concentration syrup used in the feeder creates an osmotic preservation effect, protecting the dowels from decay. This invention provides an efficient and safe method for feeding large numbers of bees, with advantages over smaller or bucket-style feeders, particularly in terms of surface area and ease of use. It allows bees to feed without crowding and requires fewer refills.

The invention discloses a preparation method and application of a probiotic fermented black fungus extract and belongs to the technical field of biological medicine, and the probiotic fermented black fungus extract is prepared by fermenting black fungus through mixed bacteria of casei casei and lactobacillus plantarum. The extract can effectively improve oxidative damage of H9c2 myocardial cells induced by high glucose, and compared with an unfermented black fungus extract, the probiotic fermented black fungus extract shows better cell protection activity under the same concentration, the action mechanism is more comprehensive and systematic, and the probiotic fermented black fungus extract can be used as a probiotic fermented black fungus extract. A new natural medicine candidate and an effective solution are provided for preventing and treating diabetic cardiomyopathy.

The invention belongs to the technical field of food fermentation and functional drinks, and particularly relates to lactobacillus mucilaginosus and application thereof in preparation of fermented wolfberry juice for improving immunity. The lactobacillus mucus LFY21 strain is preserved in the China Center for Type Culture Collection on November 17, 2025, and the preservation number of the lactobacillus mucus LFY21 strain is CCTCC NO: M 20252569; the preservation address is Wuhan University. The strain grows vigorously in the Chinese wolfberry juice, the acid production capacity is weak in the Chinese wolfberry juice fermentation process, and the obtained Chinese wolfberry juice is high in saccharic acid content, good in flavor and palatability and high in free radical scavenging activity and total phenol content. In addition, animal experiments prove that the fermented Chinese wolfberry juice prepared from the strain can also generate the effect of effectively improving the immune function, and has the application potential as an immunopotentiator.

The invention relates to the technical field of biology, in particular to application of SAFit2 in preparation of a reagent for improving pancreas islet dysfunction. The invention discovers that SAFit2 has a remarkable improvement effect on insulin secretion dysfunction in a high-glucose and high-fat induced islet injury model. Experiments show that in a high glucose (33 mM) combined palmitic acid (500 [mu] M) injury model, the SAFit2 can significantly improve the insulin secretion function of the pancreas islet. Specifically, the SAFit2 is pretreated, the glucose stimulated insulin secretion (GSIS) index of the pancreas islet and the intracellular insulin content are remarkably increased, insulin secretion under high glucose stimulation is promoted, and the SAFit2 is proved to have the effect of promoting the insulin secretion function of the pancreas islet beta cells.

The application discloses a molecular marker related to a high-sugar feed utilization character of Procyprinus, and application thereof. The molecular marker is located on the 7th chromosome of the Procyprinus, and contains one SNP site slc25a11-1 on the molecular marker. The SNP site slc25a11-1 is located at the 1439370th base of the 6th chromosome of the Procyprinus, and the polymorphic site is T / C. The high-sugar feed utilization of the Procyprinus species can be obviously improved through the molecular marker, so that the feed cost is reduced and the breeding benefit is increased.

The invention discloses application of ISCA2 in preparation of drugs for preventing and treating peritoneal fibrosis and related products and methods, relates to the technical field of biological medicines, and is characterized in that the application of ISCA2 protein in preparation of drugs for preventing and / or treating peritoneal fibrosis is provided. The invention provides a brand new application of the ISCA2. Experiments prove that the expression of the ISCA2 protein in peritoneal tissues of mice is inhibited in a high-glucose environment, and the activity of the iron-sulfur cluster enzyme can be promoted by injecting the ISCA2 adeno-associated virus into the peritoneal cavity of the mice to over-express the ISCA2 protein, so that the peritoneal fibrosis condition is improved; based on experimental results, it can be known that the overexpressed ISCA2 can play a role in treating peritoneal fibrosis, and therefore the ISCA2 has a good application prospect in the field of preparation of related drugs.