432 results about "High sugar" patented technology

Various embodiments of freeze dryers and drying processes are disclosed that can be used to dry materials with low water content (no more than 20 wt % water) and / or high sugar content (at least 20 wt % sugar). Such materials include candy, confections, and the like. In one embodiment, a drying process includes drying the materials without freezing them. In another embodiment, a drying process includes warming the materials before drying them. In another embodiment, a drying process includes drying two batches of materials with low water content sequentially without defrosting the interior of freeze dryer.

The invention discloses a Pichia kluyveri yeast and its application. The Pichia kluyveri yeast is classified and named as Pichia kluyveri JLG30201, which has been deposited in the China Center for Type Culture Collection, with a deposit number of CCTCC NO: M 20242295 and a deposit date of October 22, 2024. The Pichia kluyveri JLG30201 has strong killer affinity and high sugar tolerance, unique aroma production, high production of extracellular superoxide dismutase (SOD), and low alcohol production; the strain is applied to the processing of fruit wine or edible plant enzymes, and has the effects of increasing ester and flavor, improving juice yield and product antioxidant activity.

The invention relates to the field of microbial fermentation, in particular to an ethyl carbamate-reducing Caribik Yarrowia spp. And application of the Caribik Yarrowia spp. The invention discloses Meyerozyma caribba P3, the enzyme activity of ethyl carbamate hydrolase of the Meyerozyma caribba P3 is high and can reach 980.40 U, and when the Meyerozyma caribba P3 is applied to yellow wine fermentation, 49.5% of yellow wine EC can be degraded. The yeast strain for degrading the ethyl carbamate in the fermented food has the advantages of being high in fermentation capacity, capable of tolerating low-acid, high-sugar and 12% alcohol environments and the like, and a valuable strain source is provided for degrading the ethyl carbamate in the fermented food through a microbiological method.

The invention belongs to the technical field of biological medicines, and particularly relates to an application of a Pucurbita pepo polypeptide Nacrein-LP20 in preparation of a medicine for promoting wound healing and a preparation method of the Pucurbita pepo polypeptide Nacrein-LP20. The amino acid sequence of the Hepu pearl polypeptide Nacrein-LP20 is as shown in SEQ ID NO: 1 (Sequence Identity Number 1). According to the present invention, the Pucurbita pepo active polypeptide Nacrein-LP20 has characteristics of strong DPPH free radical and hydroxyl free radical removing ability and excellent antioxidant activity, can significantly promote HaCaT cell proliferation in the high glucose environment, and can promote migration and repair of HaCaT cells in the high glucose environment; the traditional Chinese medicine composition has a remarkable healing promoting effect on full-cortical resection wound surfaces of normal rats and diabetic rats.

The invention relates to the technical field of artificial intelligence, and discloses a blood glucose management system based on artificial intelligence. According to the system, blood glucose monitoring is reminded through the blood glucose monitoring terminal, a blood glucose curve is drawn every week, abnormal blood glucose conditions are judged for reminding and alarming, the diet terminal is used for guiding low-sugar diet recommendation, high-sugar food intake is avoided, the mastering degree of a patient and family members for food classification is improved, and the exercise terminal determines the exercise time and exercise amount of the patient according to the blood glucose value. Parameters are input into an intelligent system, the system converts and selects a motion mode, time and intensity, a drug treatment terminal calculates the insulin injection amount of a patient every day and every meal according to the blood glucose level and food intake, the insulin dosage is adjusted according to the calculated numerical values, blood glucose fluctuation is reduced, and the treatment effect is improved. The education and self-management terminal guides a patient to improve the cognitive degree of diabetes and provides personalized propaganda and education guidance for the patient, and the complication reminding terminal controls the blood sugar of the patient within a normal range, guides a good lifestyle of the patient and guides behavior specifications.

The invention relates to the technical field of food processing machinery, in particular to a double-shaft stirring dough kneading device for high-oil and high-sugar dough, which comprises a stirring tank main body, a tank cover is arranged at the top of the stirring tank main body, and a main stirring shaft and an auxiliary stirring shaft which are positioned in an inner cavity of the stirring tank main body are respectively arranged on two sides of the lower surface of the tank cover; wave-shaped blades are evenly distributed on the outer side of the main stirring shaft, fan-shaped blades are evenly distributed on the outer side of the auxiliary stirring shaft, synchronous driving mechanisms corresponding to the main stirring shaft and the auxiliary stirring shaft are arranged on the upper surface of the tank cover, and a temperature control mechanism is arranged at the bottom of the stirring tank body. The double-shaft staggered reverse differential stirring device has the beneficial effects that through double-shaft staggered reverse differential stirring, a grease wrapping layer can be quickly and effectively broken, sugar oil is promoted to be uniformly dispersed and uniformly distributed and fully blended into dough, and then grease and sugar are fully blended into the dough, so that the dough is compact in structure, and the stirring and dough kneading effects are relatively good.

The invention relates to the technical field of food nutrition and health care and biological medicines, in particular to application of beta-1, 3 / alpha-1, 3-glucan in preparation of medicines for treating and / or preventing obesity and / or body weight super-severe illness and digestion-aiding health food. According to the experimental results, high-glucose and high-fat rats are continuously fed in the stomach for 8 weeks, and the food intake can be effectively reduced and the body weight can be reduced through preventive administration; the conclusion that beta-1, 3 / alpha-1, 3-glucan has the digestion-aiding health-care food function can be obtained according to the requirements of'health-care food function inspection and evaluation method (2023 edition) by combining the research results that beta-1, 3 / alpha-1, 3-glucan has the stimulation effect on small intestine peristalsis, promotes the growth of intestinal beneficial bacteria and regulates intestinal health in the existing research. The invention provides a new direction for preparing the medicine for treating and / or preventing obesity and / or body weight super-severe illness and health-care food beneficial to digestion.

The invention discloses a fruit and vegetable extract extraction method combined with ultrasonic enhancement, and particularly relates to the field of fruit and vegetable extract extraction.The fruit and vegetable extract extraction method comprises the steps that a composite micelle structure formed by saccharides and functional factors in fruit and vegetable raw materials is recognized as a structure obstacle before extraction, and a directional unbinding path is constructed according to the binding configuration and structural responsiveness of the structure obstacle; to generate a group of ultrasonically extracted target components; and constructing an ultrasonic cooperative transmission path with continuous penetrability and cavitation energy focusing capability by taking the sound response condition and the foam interference characteristic of the liquid phase environment in which the target component group is located as dynamic parameters. By constructing a multi-dimensional synergistic extraction process of a sugar-phenol deconstruction path, a cavitation energy penetration path and a migration enrichment feedback path, the problems of low functional component release efficiency and difficult purity control caused by superposition of a wrapping effect and an acoustic resistance barrier in a high-sugar system are solved.

The invention discloses a functional feed formula for improving endurance and reproductive performance of donkeys, and relates to the technical field of feed formulae, the functional feed formula comprises selection and pretreatment of raw medicinal materials, nutrient element proportioning, treatment of functional reinforcing materials and treatment after molding, the functional reinforcing materials comprise a functional formula A and a functional formula B, the method has the advantages that the mixed leaves are subjected to low-temperature freeze-drying treatment and then crushed into powder, bioactive components such as protein and flavonoids in the leaves are reserved, the leaves can be used as a high-quality plant protein source and a functional component source, carbon dioxide gas is introduced into the compound protein leaf powder for activation, and the compound protein leaf powder can be used as a high-quality plant protein source and a functional component source. The method has the advantages that bioactive components in the leaf powder can be activated, the bioavailability of the leaf powder can be increased, polysaccharide in the high-sugar Chinese velvet herb can be further decomposed into monosaccharide and oligosaccharide by saccharifying the high-sugar Chinese velvet herb, and the energy release speed can be increased.

The invention discloses a composition for assisting in reducing blood sugar and blood fat as well as a preparation method and application thereof, and relates to the technical field of functional compositions. The composition comprises highland barley powder and modified inulin, the preparation method of the highland barley powder comprises the following steps: soaking highland barley grains in a weakly alkaline aqueous solution, and sequentially carrying out first pulse microwave treatment, enzyme deactivation treatment and segmented baking treatment; the segmented baking treatment comprises first-stage baking treatment and second-stage intermittent infrared irradiation treatment; the temperature of the first-stage baking treatment is 40-60 DEG C; the temperature of the second-stage intermittent infrared irradiation treatment is 60-80 DEG C, and the emission wavelength is 2.5-4 microns; the preparation method of the modified inulin comprises the following steps: performing acidolysis treatment on inulin in a weakly acidic aqueous solution, and then drying. The highland barley powder and the modified inulin in the embodiment can synergistically improve glycometabolism and lipid metabolism, effectively reduce the body weight, blood sugar, blood fat and the like under high-glucose and / or high-fat diet, and protect and repair the pancreas islet function.

The invention discloses a non-invasive hyperglycemia detection method based on a multi-modal physiological signal, and the method comprises the steps: obtaining the multi-modal physiological signal of a person to be detected, the multi-modal physiological signal comprising a BVP signal, an HR signal and an EDA signal; extracting time domain features and frequency domain features of the BVP signal, the HR signal and the EDA signal through three-stage discrete wavelet transform, extracting DNN features of the BVP signal, the HR signal and the EDA signal through a preset CNN-LSTM network, and fusing the time domain features, the frequency domain features and the DNN features by using a deep neural network to obtain a mixed feature vector; and inputting the time domain features, the frequency domain features, the DNN features and the mixed feature vectors of the BVP signal, the HR signal and the EDA signal into a pre-trained integrated learning model, and predicting whether the to-be-detected person is in a high glucose state. The method has the advantages of noninvasiveness, high precision, real-time performance and individuation, is suitable for continuous monitoring and early screening of prediabetic people, and has good clinical prospects and practical application values.

This invention discloses a method for preparing a pH / glucose dual-responsive chronic wound dressing containing frankincense essential oil, comprising: (1) using 4-formaldehyde phenylboronic acid as a crosslinking agent to form Schiff base and borate ester bonds with carboxymethyl chitosan and two different molecular weight hyaluronic acids, respectively, to prepare a hydrogel capable of filling skin surface wounds and performing dual dynamic covalent crosslinking adhesion, and freeze-drying for later use; (2) preparing frankincense essential oil into microcapsules by emulsification coagulation method, and freeze-drying for later use; (3) mixing the hydrogel with the freeze-dried powder of frankincense essential oil microcapsules, adding deionized water or PBS and stirring to reconstitute to form a pH / glucose dual-responsive hybrid hydrogel dressing coated with frankincense essential oil microcapsules. The composite dressing prepared by this invention has anti-inflammatory, antioxidant, antibacterial, and healing-promoting effects, is quick and easy to prepare, and has the ability to respond to the acidic / high-glucose microenvironment of diabetic wounds, and has important practical application value.

The invention relates to the technical field of molecular biology, gene therapy and drug development, and provides application of TRIM44 as a target in preparation of a drug for treating non-alcoholic fatty liver. The medicine prevents, relieves and / or treats the non-alcoholic fatty liver disease by inhibiting the expression level of TRIM44. According to the application disclosed by the invention, the TRIM44 is taken as a target, and the non-alcoholic fatty liver is prevented, relieved and treated by reducing the expression level of the TRIM44. The TRIM44 inhibitor enables the liver weight and the proportion of the liver in the body weight of a patient to be remarkably reduced, lipid accumulation to be reduced, fat deposition and vacuolation degree of liver tissue to be reduced and liver texture to be improved under poor diet conditions of high fat, high sugar and the like, so that the non-alcoholic fatty liver is prevented, relieved and treated, and the health state of the patient is improved.

The invention discloses a cherry sugar transporter gene CpSWEET10 and application thereof, and belongs to the technical field of cherry gene engineering. A novel sugar transporter gene CpSWEET10 is obtained through cloning, the nucleotide sequence of the novel sugar transporter gene CpSWEET10 is shown as SEQ ID NO.1, and the coded amino acid sequence of the novel sugar transporter gene CpSWEET10 is shown as SEQ ID NO.2. The gene is highly expressed in cherry fruits, and the content of soluble solids and total sugar in mature fruits is remarkably positively correlated with the expression quantity of the soluble solids and the total sugar; through subcellular localization and sugar transport function defect type yeast mutant functional complementation experimental analysis, the protein coded by the CpSWEET10 gene is localized in a cytoplasmic membrane and has a sucrose transport function; the cherry sugar transporter gene CpSWEET10 disclosed by the invention can be applied to the improvement of the sugar degree character of the fruits, and a new gene resource is provided for molecular breeding for improving the high-sugar quality of the cherry fruits.

The invention relates to the technical field of biological pharmacy, in particular to application of a recombinant protein DEL-1 in preparation of a medicine for resisting pancreatic beta cell inflammation. The recombinant protein DEL-1 has a remarkable inhibition effect on pancreatic beta cell inflammatory response induced by high glucose and high fat. Experiments show that in an islet beta cell inflammation model constructed by combining high glucose with palmitic acid, DEL-1 can significantly reduce the expression level of inflammatory factors such as IL-1beta, IL-6, TNF-alpha and the like. The DEL-1 is proved to have a definite effect of resisting pancreatic beta cell inflammation.

The present invention discloses a low - serum medium and its application in the preparation of cultured meat from Larimichthys crocea cells, which is also applicable to other marine or freshwater fish, belonging to the field of bioengineering technology. The low - serum medium comprises a basal medium, fetal bovine serum accounting for 30 - 80 μL / mL, and exogenous additives. The exogenous additives include human serum albumin, ascorbic acid, basic fibroblast growth factor polypeptide, human holo - transferrin, lysophosphatidic acid, and human recombinant IGF - 1. Based on the DMEM / F12 medium, the low - serum medium provided by the present invention adds six substances that promote cell growth, reduces the dependence of satellite cells on fetal bovine serum, effectively reduces the usage amount of fetal bovine serum, and saves the culture cost. Compared with the general - type medium (DMEM high - glucose, adding 10% FBS), the low - serum medium provided by the present invention has an equivalent effect on the maintenance and proliferation ability of cell stem cells.

The invention discloses a construction method of a metabolism-related fatty liver cancer (MAFLD liver cancer) mouse model, and relates to the technical field of biology. The specific construction method comprises the following steps: feeding a 7-9-week-old mouse with a high-fat and high-sugar diet for 24 weeks, inducing the mouse to form fatty liver, and causing metabolic dysfunction; injecting carbon tetrachloride into the abdominal cavity of the mouse once a week while feeding the mouse with the high-fat and high-sugar diet, and inducing the liver of the mouse to form liver cancer continuously for 24 weeks, so as to construct the MAFLD liver cancer mouse. The mouse liver constructed by the method has metabolic dysfunction, fatty liver and liver cancer lesions, and has extremely high application value in research and development of drugs for researching MAFLD liver cancer pathogenesis and fatty liver related liver cancer in the future.

The invention provides a bismuth-based heterogeneous material for promoting healing of diabetic wounds and a preparation method and application thereof. The bismuth-based heterogeneous material comprises a bismuth-based porphyrin metal organic framework, and the surface of the bismuth-based porphyrin metal organic framework is modified with Au-Pt nanoparticles. According to the bismuth-based heterogeneous material disclosed by the invention, microenvironments of bacterial infection, high glucose, active oxygen damage, inflammatory disorder, pH rise and oxygen deficit of diabetic wounds are improved through multiple antibacterial effects and enzyme catalysis effects, so that the healing of the diabetic wounds is promoted.

The invention discloses a preparation method of a pH / glucose double-response chronic wound dressing containing frankincense essential oil, which comprises the following steps: (1) respectively forming Schiff base and boric acid ester bonds with carboxymethyl chitosan and two hyaluronic acids with different molecular weights by using 4-formylphenylboronic acid as a cross-linking agent; preparing adhesive hydrogel which can be used for skin surface wound surface filling and double-dynamic covalent cross-linking, and freeze-drying for later use; (2) preparing the frankincense essential oil into microcapsules by an emulsification and condensation method, and freeze-drying for later use; and (3) mixing the hydrogel with the freeze-dried powder of the frankincense essential oil microcapsules, adding deionized water or PBS, stirring and redissolving to form the pH / glucose double-response hybrid hydrogel dressing coated with the frankincense essential oil microcapsules. The composite dressing prepared by the invention has the effects of resisting inflammation, resisting oxidation, resisting bacteria and promoting healing, is quick and simple to prepare, has stimulation response capability on acid / high-glucose microenvironment of diabetic wound surfaces, and has important practical application value.

The invention relates to saccharomyces cerevisiae and application thereof in wine brewing. The saccharomyces cerevisiae strain is saccharomyces cerevisiae Y24 and is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on March 10, 2025, and the preservation number of the saccharomyces cerevisiae strain is CGMCC (China General Microbiological Culture Collection Center) NO. 33773. The saccharomyces cerevisiae strain is a saccharomyces cerevisiae strain. The saccharomyces cerevisiae Y24 strain can grow under the conditions that the alcoholic strength is 18% vol, the pH value is 2, the sugar content is 60% and the temperature is 4 DEG C, has good high-alcoholic strength, high-acid and high-sugar endurance capacity, and meets the low-temperature fermentation requirement of wine. Meanwhile, in wine fermented by the saccharomyces cerevisiae Y24 strain, the content of dry extracts capable of enriching wine bodies is higher, the content of aroma components is higher, and the content of undesirable component methanol is lower.

The invention discloses a low-temperature hot air drying preparation process of low-sugar preserved mangoes. The preparation process comprises the following steps: S1, pretreating mangoes; s2, blanching is conducted; s3, hardening and color protection; s4, rinsing is carried out; s5, performing sugaring; s6, sugar draining; s7, drying; and S8, cooling. The sensory score of the product prepared by the process is 86.96, and the product is golden in color, rich in fragrance and palatable in sour and sweet taste. The total sugar content is 35.88% and is obviously lower than that of the traditional high-sugar preserved fruit. And the water content is 21.78%. The hardness is 3216.35 + / -g, the cohesiveness is 0.88, the chewiness is 3155.35, the resilience is 0.56, and the texture property is good. The total bacterial colony number 1t; 10 CFU / g, and coliform bacteria are not detected.

The invention discloses an application of a Solyc02g060560 gene in regulation and control of sugar content and size of tomato fruits, wherein a CDS (Coding Sequence) sequence of the Solyc02g060560 gene is as shown in SEQ ID NO. 1. A tomato transcription factor mutant library is constructed through a CRISPR (clustered regularly interspaced short palindromic repeats) technology, and a mutant TOM6-126 with unknown functions at present in a C2H2 family is screened. Based on observation of the phenotype of the mutant, the inventor determines that the gene is related to the sugar content and the fruit size of tomato fruits. Compared with a wild type, the soluble solid content (brix) of tomato fruits of the mutant is increased, and the fruits become larger. It is indicated that the Solyc02g060560 gene plays an important role in negative regulation of tomato fruit growth and development and sugar content. According to the invention, a good gene genetic resource foundation is laid for the cultivation of a new variety of tomatoes with high sugar content.

The invention relates to saccharomyces cerevisiae and application thereof in wine brewing. The strain is Saccharomyces cerevisiae Y26, and is preserved in the general microbiological center of the China Committee for Culture Collection of Microorganisms on March 10, 2025, and the preservation number is CGMCC NO.33774. The invention further discloses a preparation method of the Saccharomyces cerevisiae strain. The saccharomyces cerevisiae Y26 strain can grow under the conditions that the alcoholic strength is 18% vol, the pH value is 2, the sugar content is 60% and the temperature is 4 DEG C, has good high-alcoholic strength, high-acid and high-sugar endurance capacity, and meets the low-temperature fermentation requirement of wine. Meanwhile, in wine fermented by the saccharomyces cerevisiae Y26 strain, the content of dry extracts capable of enriching wine bodies is higher, the content of aroma components is higher, and the content of undesirable component methanol is lower.

The invention discloses a molecular marker related to high-sugar feed utilization characters of siniperca chuatsi and application of the molecular marker. The molecular marker is located on a No.7 chromosome of siniperca chuatsi, and the molecular marker contains one SNP (Single Nucleotide Polymorphism) site slc25a11-1; the SNP site slc25a11-1 is located at the 1439370th basic group of the No.6 chromosome of siniperca chuatsi, and the polymorphic site is T / C. By implementing the molecular marker disclosed by the invention, the high-sugar feed utilization condition of siniperca chuatsi species can be remarkably improved, so that the feed cost is reduced, and the culture benefit is increased.

The invention provides a biological preparation for regulating placenta dysplasia, and belongs to the technical field of gynaecology and obstetrics. Core effective components of the biological preparation are lutjanus mixed polypeptide with the molecular weight ranging from 2 kDa to 10 kDa, and the lutjanus mixed polypeptide is prepared by combining lutjanus fish bones, fish scales and fish flesh according to the mass ratio of 5: 3: 2 through the steps of desalting treatment, ultrasonic-assisted degreasing, double-enzyme synergistic enzymolysis, double ultrafiltration purification and the like. Experimental results show that the lutjanus mixed polypeptide has a remarkable protection effect on a human trophoblast cell line HTR-8 / SVneo in a high-glucose environment, and can effectively promote cell proliferation and migration and reduce high-glucose-induced cell damage. Therefore, the biological preparation provides a novel effective intervention means for placenta dysplasia caused by gestational diabetes mellitus, and has a good application prospect.

The invention belongs to the technical field of assisted reproduction, and particularly relates to a glucose slow-release structure used in an embryo in-vitro culture solution, a preparation process and a use method. The glucose slow-release structure comprises at least one inner layer containing glucose and a biodegradable material outer layer wrapping the inner layer, and the biodegradable material outer layer comprises a matrix with a plurality of micropores and at least one sealing material layer used for sealing pores of the micropores. According to the invention, gradient release from low sugar in the cleavage stage to high sugar in the blastocyst stage is realized, midway liquid change or artificial sugar supplement is not needed, the operation is obviously simplified, and pollution and mechanical stress risks are reduced.

The invention belongs to the technical field of food processing, and particularly relates to a compound capable of improving illumination storage stability of phycocyanin and a preparation method of the compound. The compound is prepared from phycocyanin and zein through an anti-solvent precipitation method, the particle size range is 108-345 nm, the main secondary structure of the phycocyanin is reserved, and the specific blue hue and fluorescence characteristics of the phycocyanin can be maintained after continuous illumination storage at 25 DEG C for 28 days. The preparation method is simple, and the protein is composed of two natural proteins and is high in safety. On one hand, the problem that the phycocyanin easily loses the blue hue under illumination storage is solved, and on the other hand, the technical problem that the phycocyanin product can only be stored in a cold storage mode or applied to high-sugar food generally is solved.

The invention provides a single strain metabolism characteristic chromatogram database of oral key microorganisms in a high-glucose microenvironment and a construction method and application thereof, and belongs to the technical field of oral microbiology. The method comprises the following steps: simulating an intraoral high-glucose microenvironment in vitro; the method comprises the following steps: carrying out standardized single-strain culture on oral key microorganisms, carrying out whole-spectrum metabolism detection (non-targeted liquid chromatography-mass spectrometry (LC-MS) and non-targeted gas chromatography-mass spectrometry (GC-MS) on culture supernatant, and identifying and analyzing metabolism to construct a single-strain metabolism characteristic spectrum database of the oral key microorganisms in a high-glucose microenvironment. The database can be used for source attribution and cross validation of in-vivo metabolome results, and assists in screening key metabolites and key pathways related to high glucose. According to the method, the reliability of metabolite source judgment is improved, the directional influence of high glucose on the flora metabolism function is revealed, the method is standardized, and resources are platformized.

The invention relates to the technical field of food processing, and discloses novel agaric soft sweets and a production method thereof, and the novel agaric soft sweets are prepared from the following raw materials in parts by weight: 100-180 parts of agaric, 20-60 parts of gelatin, 50-90 parts of xylitol, 100-180 parts of natural fruit concentrated juice, 5 parts of citric acid, 3 parts of a licorice extract, 500 parts of water and 0.5 part of an antioxidant. The main component sugar content of traditional soft sweets is relatively high, but the xylitol is used for replacing part of sugar content, so that the overall calorie and sugar content of the soft sweets are reduced, the soft sweets are suitable for consumers needing to control sugar intake, the problem of excessive sugar intake is solved, the agaric is rich in polysaccharide substances, and the components can promote normal functions of an immune system. The black fungus is blended into the soft sweet product, so that the nutritional value of the soft sweet product is reserved, and a convenient immune health-care food can be provided.

The invention relates to genetic engineering combined lactobacillus salivarius and application of the genetic engineering combined lactobacillus salivarius. The strain is classified and named as combined lactobacillus salivarius CTMT2, and the preservation number of the strain is CCTCC (China Center for Type Culture Collection) M 2025547. After an NIAAA model is injected into the stomach of an alcoholic liver mouse, the acetaldehyde level of the liver of the mouse is obviously reduced, and the alcoholic fatty liver symptom of the mouse is obviously relieved; after long-term intragastric administration of a high-glucose and high-fat modeling mouse, the acetaldehyde level in excrement of the mouse can be obviously reduced, the progress of liver fibrosis is improved, and good application prospects are achieved.