The invention discloses a construction method and application of a central drowsiness
animal model, and belongs to the technical field of
biology. The central drowsiness
animal model contains a CAG-LSL-ATXN3 (Q77)
DNA (deoxyribonucleic acid) molecule and an Hcrt-IRES-CreERT2
DNA molecule, the
nucleotide sequence of the CAG-LSL-ATXN3 (Q77)
DNA molecule is shown as SEQ ID NO: 1, and the
nucleotide sequence of the Hcrt-IRES-CreERT2 DNA molecule is shown as SEQ ID NO: 2. The invention has the advantages that the
animal model provided by the invention can simulate the onset of human
narcolepsy 1, is beneficial to further research on the influence of orexin deficiency on brain functions and structures, and has good
genetic stability.