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Preparation method of OLETF rat fasting blood-glucose elevation model

A rat fasting blood glucose and model technology, which is applied in the field of zoological medical models, can solve the problems of OLETF rats, such as long modeling time and long feeding time, so as to shorten the time to develop diabetes, reduce test costs, and accelerate modeling effect

Inactive Publication Date: 2010-02-03
天津市公安医院
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Problems solved by technology

[0013] The present invention aims to solve the problems of long modeling time and long feeding time of OLETF rats, and provides a preparation method of an OLETF rat fasting blood sugar elevation model that accelerates modeling

Method used

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  • Preparation method of OLETF rat fasting blood-glucose elevation model
  • Preparation method of OLETF rat fasting blood-glucose elevation model
  • Preparation method of OLETF rat fasting blood-glucose elevation model

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Embodiment Construction

[0018] 1. Basis

[0019] According to the pathological changes of the pancreas, the disease course of OLETF rats can be divided into three stages.

[0020] Early stage: 6-20 weeks, the structure and function of the pancreas are basically normal at this stage.

[0021] Pancreatic hyperplasia period: 20-40 weeks, at this stage, fibrosis occurs in the islets, and the fibrosis gradually increases. As islets are divided or completely replaced by fibrous tissue, islet hyperplasia begins at this stage.

[0022] Late stage: After 40 weeks, the replacement of islets by connective tissue is more serious.

[0023] Therefore, this method decided to give the rats a high-fat diet at 8 weeks.

[0024] 1. Feeding time

[0025] The present invention feeds OLETF rats with a kind of high-fat feedstuff since 8 weeks,

[0026] 2. Feed

[0027] Described high-fat feed adopts 600g standard feed, 100g egg yolk powder, 120g lard, 120g sugar-free whole milk powder, 40g sucrose, 20ml water are mix...

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Abstract

The invention discloses a preparation method of an OLETF rat fasting blood-glucose elevation model, belonging to animal zoological medicinal models and feeds specially used for specifically animals. In the invention, an OLETF rat is feed by high-fat feed in 6-8 weeks, and the high-fat feed comprises the following raw materials in percentage by weight: 60-65 percent of standard feed, 10-12 percentof yolk powder, 10-12 percent of lard, 8-12 percent of sugar-free full-cream powder, 2-14 percent of cane sugar and 1-2 percent of water. The OLETF rat fed by the feed can simulate the morbidity process of human type II diabetes more and is good for the research of the type II diabetes; and the invention also shortens the time the OLETF rat develops into the diabetes, accelerates the molding, saves the experimental period and reduces the experimental cost.

Description

technical field [0001] The invention relates to a zoological medical model, or a feed specially used for a specific animal, in particular to a preparation method of an OLETF rat fasting blood glucose elevation model. Background technique [0002] Animal models of diabetes are mainly divided into three categories: spontaneous genetic animal models, experimental animal models, and transgenic animal models. [0003] 1. Spontaneous type 2 diabetes animal model: Spontaneous diabetes refers to DM that occurs naturally in animals without any conscious artificial treatment. OLETF rat is one of them, but its natural course is longer. [0004] 2. Experimental type 2 diabetes animal model: [0005] (1) Special dietary induction, namely high-fat diet. [0006] (2) Streptozocin (STZ) induction. [0007] (3) STZ / alloxan plus diet-induced diabetes model (STZ and diet induced diabetes): A small amount of STZ was given to experimental animals to destroy part of the islet β-cell function,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A01K67/027A23K1/18A23K1/16
Inventor 田凤石雒荣赵紫琴姚瑞栋郑喜兰
Owner 天津市公安医院
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