76 results about "Zedoary oil" patented technology

The invention relates to a Baofukang suppository with an expansion carrier, which is a vaginal suppository prepared by the following components in parts by weight: 60-100 parts of zedoary oil, 60-100 parts of borneol and matrix and 500-2,000 parts of expansion carrier; the surface of the expansion carrier is coated with a drug containing layer formed by at least a part of active ingredients and at least a part of matrix, and the expansion value of the expansion carrier is greater than 1.5. The Baofukang suppository has the benefits that the Baofukang suppository is convenient to use and long in effect time and takes effect fast; the pollution to clothes is avoided; an active drug can be uniformly distributed on a whole vaginal wall and uterine cervix, and permeated into a deep site of mucosa ruffles; surprisingly, the technological effects can still be realized under the conditions that even polyethylene glycol is not used and water is almost not used; the effective rate to mycotic vaginitis is 96.2%; and the effective rate to senile vaginitis is 96.6%.

The hydroxypropyl-beta-cyclodextrin inclusion of Rhizoma zedoariae oil consists of Rhizoma zedoariae oil and hydroxypropyl-beta-cyclodextrin in the ratio of 1 to 1-100. Rhizoma zedoariae oil dissolved in some organic solvent is added into water solution of hydroxypropyl-beta-cyclodextrin via stirring, and the mixture is freeze dried into water soluble inclusion. The included water solution is ultrafiltered, filtered in 0.22 micron porous film and freeze dried to prepare the freeze dried powder for injection. The present invention may be also used for oral taking and external application to result in antiviral and antibacterial effect.

An oil-in-water zedoary oil-fat emulsion for treating viral disease and cancer by injecting or oral taking is proportionally prepared from zedoary oil, soybean oil, lecithin, glycerin, oleic acid and the water for injection through high-speed stirring or ultrasonic oscillating, and high-pressure homogenizing. Its advantages are low by-effect and high curative effect.

The invention discloses an external spraying agent and / or eye drop of compound oil nano-emulsion as well as preparation method thereof. The pH value of the spraying agent and / or eye drop is 3-9. The spraying agent and / or eye drop comprise the following components according to the weight portion: 5-15 of compound oil, 0.5-2.0 of phospholipid, 0.5-3.0 of propanetriol, sodium hydroxide and medicinal water, wherein the compound oil comprises the following components: (1) zedoary turmeric oil and / or peppermint oil, and (2) soybean oil and / or castor oil. The mass ratio of the (1) and the (2) in the compound oil is 1:99-30:70. The spraying agent of the compound oil nano-emulsion, which is prepared by the invention, is used for antibiosis, inflammation diminishing and wound healing in the process of curing burn and scald. The eye drop of the compound oil nano-emulsion is used for curing eye strain, xerophthalmia and eye inflammation.

The invention relates to a method for extracting and purifying curdione from the oil of zedoary turmeric, a natural medicinal plant volatile oil. The purity of the curdione obtained by the method reaches 99.9%, and the curdione conforms to the requirement of the purity of a contrast product in the field of traditional Chinese medicine and provides a superior raw material for developing a subsequent product. The method comprises the following steps: mixing the oil of the zedoary turmeric and silica gel used for chromatography evenly, coating a silica gel column, taking petroleum ether and ethyl acetate which have different proportions as an eluent for gradient elution, collecting and merging eluant containing the component of the curdione, concentrating, refrigerating, standing, precipitating crystals and separating and purifying the crystals again by the same method to obtain recrystallized crystals so as to obtain the curdione. The method features simple operation and good repeatability.

The invention discloses a method for breeding the variety of zedoary, which is a traditional Chinese medicine. The method is carried out by combining a breeding method with the characteristics of vegetative propagation of the zedoary, and overcomes the defects that the prior zedoary is chaotic in germplasm, degraded in variety, low in yield and poor in quality, and has no excellent variety in cultivation. The method comprises the following concrete steps: a zedoary breeding target is determined first; an excellent individual plant is selected from wild or cultivated population materials; the selected excellent individual plant is subjected to indoor plant test after harvest; an elected individual plant is propagated into a strain; an elected excellent strain is propagated into a breed strain after indoor plant test; then an excellent breed strain and other seeds for production are subjected to variety comparative test; and the excellent breed strain is finally bred into a new excellent variety. The growth vigor and feature of plants, the weight of the individual zedoary plant and zedoary oil content are taken as election indices all the time in the whole breeding process.

The invention provides a zedoary oil injection. According to a preparation method, zedoary oil is used as an active ingredient, polyethylene glycol-12-hydroxy stearic acid ester (abbreviated as HS15) is used as a cosolvent, and a metal ion complexing agent, glucose and other pharmaceutic auxiliary materials are added properly and mixed with water for injection, thus obtaining the zedoary oil injection. According to the formula and the preparation process, the zedoary oil injection conforming to the standard of 'Chinese Pharmacopoeia' can be prepared; and the pharmaceutic auxiliary material HS15, of which the safety is higher than that of Twain 80, is adopted, so that the safety of the zedoary oil injection is improved greatly. The prepared zedoary oil injection is controllable in quality, good in stability, high in safety and simple in preparation process.

An antivirus medicine in the form of capsule is prepared from zedoary, oil as primary component, semisynthetic glycerine ester of fatty acid, polyethanediol and surfactant through proportioning, heating zedonary oil to 30-150 deg.c, sieving by 40-100 meshes, mixing with polyethanediol and surfactant, sirring for 30-60 min, and loading in capsule at 10-60 deg.C. Its advantages are high curative effect and no toxic by-effect.

The gas chromatographic method is used in measuring the zedoary oil and borneol content in suppository. The measurement method has powerful specialization, good separation effect, high linearity, high stability and high repeatability, and may be used in controlling the quality of the suppository effectively.

The present invention belongs to the field of medicine and medical equipment, relates to medicine eluted rack for preventing and treating re-stenosis inside rack, and is especially curcuma zedoary oil controlled releasing elution rack for preventing and treating re-stenosis inside coronary artery rack. The rack has curcuma zedoary oil as effective medicine component, rack of stainless steel, and composite polybutyl methylacrylate / nanometer silica material as controlled releasing coating. The rack of the present invention has the functions of inhibiting cell growth, inducing apoptosis, resisting inflammation, resisting thrombosis, inhibiting collagen synthesis and resisting proliferation for long time; has excellent tissue compatibility with coronary artery and excellent safety; and can prevent and treat the re-stenosis of the rack operation.

The invention discloses an establishment and evaluation method of a self microemulsion drug administration system public prescription system, which is suitable for multiple drugs. A puerarin, an indomethacin and an oil of zedoary turmeric are selected as the model drug. By adopting an orthogonal design, and multiple-index combined system of solution condition, emulsification speed, emulsification level, fluid level float oil layer and layered precipitation, the composite and dosage of the oil phrase, emulsifier and beeswax in the self microemulsion system are researched, selecting the best prescription composite and proportion. The invention has SMEDDS prescription design by adopting the method of multi-index combined evaluation, ensuring the evaluation index more overall, divided and quantized, with certain demonstration function for evaluating the quality of SMEDDS scientifically, objectively and roundly.

The invention discloses zedoary oil injection and a preparation method thereof. The zedoary oil injection mainly comprises the following components: (1) zedoary oil serving as an active component, (2) 15-hydroxystearic acid macrogol ester (also known as polyethylene glycol-12- hydroxystearic acid ester, and called HS-15 for short) serving as a solubilizing agent, (3) alcohol serving as a cosolvent, and (4) injection for water serving as a solvent. Compared with commercially available injection, the zedoary oil injection has the advantages that the product prepared by adopting a bran-new prescription and technology is in line with the pharmacopoeia criterion for the zedoary oil injection and the safety of clinical medication of the product is also greatly improved.

The invention relates to a preparation process of zedoary oil submicron emulsion; by using parameters such as average particle diameter, particle size distribution, potential and the like as indexes, the preparation process determines a formula containing 2.0 g of zedoary oil, 2.0 g of soybean oil, 1.2 g of refined yolk phospholipid, 0.04 g of oleic acid, 0.8 g of poloxamer 188, and 100 mL of injection water. The preparation process comprises the following steps: weighing zedoary oil, soybean oil for injection, refined yolk phospholipid, and oleic acid in a beaker according to the proportions in the formula, stirring and well mixing in a water bath at 60 DEG C, preparing a clarified stable oil phase to keep in reserve at 60 DEG C; weighing poloxamer 188 according to the proportion in the formula, heating, stirring to uniformly disperse to obtain a water phase to keep in reserve at 60 DEG C; then dropwisely adding the oil phase into the water phase, putting into a high-shear dispersion emulsifying machine, mixing to prepare crude emulsion, adding injection water to reach a whole amount; homogenizing the crude emulsion by a two-step high-pressure homogenizer, adjusting the pH to 7.5-8.0, filling into ampoules, and sealing. The product is autoclaved. The product is basically stable after stored at room temperature for 6 months.

The invention relates to a Curcuma zedoary oil extract, a preparation method thereof, a detection method thereof, and a purpose thereof, and concretely relates to a CO2 supercritical extraction method for preparing the Curcuma zedoary oil extract. The Curcuma zedoary oil provided by the invention has the advantages of stable and controllable quality, no irritation, no Curzerene containing, extraction completeness of effective components, and simple preparation. The invention provides the purpose of the Curcuma zedoary oil in the preparation of anticancer medicines.

The invention discloses a product for preventing cervical cancer and treating human papillomavirus (HPV) infection, cervical erosion and other vagina inflammations and a preparation method. According to the invention, zedoary oil for preventing cervical cancer and soy isoflavone for supplementing female estrogen are prepared into gel to prevent and treat female gynecological inflammation. The gel comprises the following components by mass concentration: 0.1-5% of tea tree oil, 1-6% of Carbomer, 0.3-3% of soy isoflavone, 1-10% of zedoary oil, 0.001-0.1% of a carrot extracted liquid, 0.1-0.3% of Kathon, and the balance water. The product provided by the invention is a disinfection product, contains zedoary oil, soy isoflavone, tea tree oil, carrot extracted liquid, and the slow release component Carbomer, and can slowly release effective ingredients and play a lasting role.

The zedoary extractive is prepared with zedoary oil as material and through chromatography with silica gel column, and contains curdione 30-60 wt%, elemenone 15-40 wt%, neo-curdione 1-15 wt%, curcumenol1-20 wt% and no instable benzofuran derivative. The zedoary extractive has high effect, less side effect and high stability, and may be mixed with different medicine carrier to prepare various medicine preparations, such as capsule and injection, for treating viral diseases, cardiac and cerebral vascular diseases and tumor.

Extraction of zedoary alcohol is carried out by vacuum split-flowing for zedoary oil, flowing out solid-liquid mixture at some vacuum degree and temperature, collecting the fraction, re-crystallizing for the filtered solid from organic solvent or mixed solvent, and obtaining colorless needle crystal zedoary alcohol. Its advantages include simple process, higher recovery rate and purity.

The invention relates to a production method of a zedoary turmeric oil microcapsule. The produced zedoary turmeric oil microcapsule comprises the following main components: 35% to 40% of starch sodium octenylsuccinate, 5% to 30% of zedoary turmeric oil, 10% to 20% of mannitol, 5% to 15% of glucose, 15% to 35% of maltodextrin, 0.5% to 1.5% of sodium tripolyphosphate, 1% to 2% of sodium ascorbate, 0.04% to 0.08% of vitamin E, 0.1% to 0.15% of magnesium ascorbyl palmitate and 0.4% to 0.8% of tricalcium phosphate. The production method has the advantages that all raw materials for preparing the zedoary turmeric oil microcapsule conform to the application range of GB2760, i.e., the raw materials are safe and reliable and can be obtained widely; the microcapsule embedding rate reaches more than 99.5%, so that the microcapsule can be directly taken orally and can also be served as the raw material for preparing capsules, suppositories and gels; and the oxidation stability of the microcapsule product is superior to that of the same-type product in the market, i.e., the microcapsule product can be stored for two years at the temperature of 37+ / -2 DEG C. Therefore, the production technology can be used for producing the microcapsule which is high in medicinal value, simple to store, convenient and safe to use and low in cost.

An emulsified injection of zedoary for treating viral disease, tumor and thrombus is proportionally prepared from the volatile zedoary oil, plant oil for injection, emulsifier and isotonic regulator through mixing.

The emulsified injection is prepared with zedoary oil, middle chain oil for injection, long chain oil for injection, emulsifier, isoosmotic regulator, antioxidant, pH regulator and water for injection. The preparation process include adding emulsifier into the middle chain oil and the long chain oil, heating and stirring to dissolve emulsifier, adding zedoary oil, heating and stirring to dissolve and mix, and adding tocopherol via stirring to obtain oil phase; adding isoosmotic regulator into water for injection, and heating and stirring to dissolve to obtain water phase; mixing the oil phase and the water phase, emulsifying, regulating pH value and adding water for injection to required amount. The preparation has great medicine carrying amount, no toxic side effect, stable property, convenient use and fast and simple preparation, and is suitable for mass production.

The invention discloses a healthcare honey pine needle tea powder and a processing method thereof. The tea powder is composed of the following raw materials in parts by weight: 20 to 40 parts of rice wine, 20 to 30 parts of pine needle, 10 to 20 parts of milk powder, 20 to 30 parts of longan pulp, 6 to 10 parts of yak meat, 80 to 100 parts of honey, 10 to 15 parts of haw jam, 2 to 3 parts of pipewort, 1 to 2 parts of fructus viticis, 1 to 3 parts of epimedium, 2 to 3 parts of rabdosia rubescens, 2 to 3 parts of broad bean flower, 2 to 3 parts of pomegranate leaf, 0.1 to 0.2 part of tea polyphenol, 0.1 to 0.2 part of zedoary oil, and 6 to 10 parts of nutrition additive. The prepared healthcare honey pine needle tea powder comprises a pine needle component, so the tea powder has a unique pine needle aroma and the functions of softening the blood vessels, increasing the elasticity of blood vessels, and preventing cardio cerebrovascular diseases. Moreover, yak meat is added to enrich the nutrients and strengthen the immunity, cooperates with other components to generate a synergetic effect, can improve the disease resistant property, and is benefit for human health.

The invention discloses a process for extracting curcumenol by a molecular distillation method. The process comprises the following steps of: adding zedoary oil into a feeding unit; firstly carrying out normal-temperature degassing under vacuum degree, and then opening condensed water and an oil-bath heater; after the temperature is stable, starting scraping-film stirring; then dripping the zedoary oil into a distiller; after the dripping is finished, collecting direct condensation fractions, external condensation fractions, unevaporated residual parts and degassed light components and losing; after the unevaporated residual parts are placed for one day, precipitating a great amount of crystals, using petroleum ether to carry out milliliter pulping, filtering, and drying to obtain white crystal; using alcohol with the mass concentration being 95% to recrystallize the crystal, and obtaining the curcumenol crystal with the gas chromatography GC being larger than 99%. The process disclosed by the invention has the advantages that according to the molecular distillation principle, the zedoary oil is treated by molecular distillation, the liquid part is condensed into liquid on an internal condenser by short-process distillation, then the discharged material is discharged, the zedoary oil can be rapidly separated from the curcumenol, and by combination with the recrystallizing technology, the curcumenol with high purity can be obtained.

The spray for treating burns, scalds and chronic ulcer has PEG-aFGF decorated chemically with polyethylene glycol as acid fibroblast growth factor as main medicinal component. The spray contains mainly PEG-aFGF decorated chemically with polyethylene glycol as acid fibroblast growth factor 1-100 microgram, hot zedoary oil 1-100 mg, protecting agent 0.001-0.05 mg, preservative 0.001-0.01 mg, stabilizer 0.0001-0.001 mg and corrective 0.01-0.2 mg in each milliliter, and the rest is physiological saline or water for injection. The spray has high stability, long biological half time, high safety and other features.

The invention discloses a medical 'zedoary oil' and a manufacturing method for its micro capsule, the zedoary oil is acquired by confecting the beta-elemene, zedoary alcohol, curdione according to a fixed proportion, compared with natural zedoay oil, its effective ingredients content are high, and in virtue of the cooperation among the three, thus it has higher functions for resisting tumor, bacteria, and virusl; the producing method for mciro capsule is: because of increasing the even process, and through controlling the inner circulation in the even process, the particle size of the capsule is controllable between 50nm and 500nm, it can acquire the micro capsule with the uniform particle size, its irregularity is not more than plus and minus 5 nm.

The invention discloses a compound common andrographis herb injection for treating high fever of pigs and a preparation method thereof. The invention aims to provide the compound common andrographis herb injection and the preparation method thereof, wherein the compound common andrographis herb injection can treat the high fever caused by pig bacteria and virus composite infection, has quick treatment response, can treat both principal and secondary aspects of diseases, reduces taking frequency and is convenient to take; and the preparation method has a simple process and is easy to implement. Each 100L of injection comprises 3 to 7 kg of common andrographis herb extractum, 0.5 to 1.5kg of zedoary oil, 1 to 6kg of gentamycin sulfate, 1.5 to 4.5kg of ofloxacin, 8 to 30kg of analgin, 0.05kg of ammonium chloride bethanechol, 0.2kg of anhydrous sodium bisulfite, 0.01kg of EDTA-2Na, 1kg of Tween-80, 0.5kg of hydrochloric acid, and the balance of water for injection. The injection has the effect in many aspects at the same time by the reasonable proportion of a plurality of medicaments, has quick response to treat the high fever caused by the pig bacteria and the virus composite infection, is directly applied without diagnosis and can achieve the treatment effect of a plurality of medicaments when used at one time.

The invention belongs to the technical field of medicine, and relates to a preparation method for a zedoary turmeric lactone enantiomer having anti-tumor activity. The structure of the zedoary turmeric lactone enantiomer is represented by a structure (I). The preparation method comprises: adopting new curdione separated from zedoary turmeric oil as a substrate, carrying out a three-step chemical reaction to carry out isomerization on chiral carbon on site 4 to obtain a curdione enantiomer, and carrying out acid catalysis. The test results show that the prepared enantiomer has good anti-tumor activity.

The invention relates to a medicament for treating periodic psychosis. The medicament is prepared by the following method of: decocting 8 to 12 parts of red paeony root and 7.5 to 10.5 parts of raw rhubarb twice, and concentrating filtrate to form extract; crushing 0.5 to 1.5 parts of raw rhubarb, mixing the crushed rhubarb and the extract, and crushing the mixture into fine powder of 80 to 120 meshes; mixing the fine powder, thinner and adhesive uniformly; uniformly spraying 0.02 to 0.03ml of zedoary oil on the granules, and mixing the granules uniformly; and adding a lubricating agent into the granules, and pressing the granules into tablets. The invention also provides a preparation method and application of the medicament for treating the periodic psychosis. The medicament has the advantages that: the compatibility of the whole formula accords with the principle of 'monarch, ministers, assistants and guides'; and proved by years of clinical trials, the medicament has accurate curative effect on the periodic psychosis and a few medicament gouts, has no obvious adverse reaction, is favorable for scale production, and is a safe and effective medicament for treating the periodic psychosis.

The invention provides a clove peculiar smell purifying agent. The clove peculiar smell purifying agent comprises the following components: chitosan, cyclodextrin, clove basil oil, zedoary turmeric oil, nano zinc oxide, nano titanium dioxide, nanometer silica, a surfactant and purified water. The clove peculiar smell purifying agent can effectively remove peculiar smell and can effectively relievediscomfort of respiratory systems of people in a peculiar smell environment. The invention further provides a production process of the decorative wood-based panel without peculiar smell, the key position of peculiar smell generation of the decorative wood-based panel is researched and found, the decorative wood-based panel without peculiar smell acts on the key position of peculiar smell generation in a targeted mode, and the peculiar smell problem of the decorative wood-based panel is well solved.

The invention discloses vagina-shrinking antibacterial essence. The essence is composed of the following components in parts by weight of 35 parts of saffron crocus, 15 parts of fructus cnidii, 13 parts of radix angelicae sinensis, 10 parts of purple perilla, 10 parts of borneol, 8 parts of zedoary turmeric oil, 5 parts of radix sophorae flavescentis and 4 parts of propolis. The essence is simplein preparation process, has a relatively strong sterilization effect on staphylococcus aureus, escherichia coli and candida albicans, has the health-care effects of cleaning, moistening and shrinkingthe vagina, and has the characteristics of being fresh, pleasant, mild, comfortable, safe and convenient.