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Medicinal composition for treating hyperuricemia

A technology of hyperuricemia and composition, applied in the field of pharmaceutical compositions for treating hyperuricemia, can solve problems such as human injury, liver function damage, etc., and achieve reduced damage, toxicity and side effects, high uric acid Level down fast effect

Inactive Publication Date: 2010-03-03
TIANJIN TAIPU PHARMA SCI & TECH DEV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

According to data, large doses of febuxostat can significantly damage liver function
[0005] (2) Drugs that promote uricosuric agents, such as probenecid, benzbromarone and sulfinpyrazone, etc., but they all have different degrees of side effects and toxicity, especially in the form of When used in large doses, it will cause harm to the human body

Method used

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  • Medicinal composition for treating hyperuricemia
  • Medicinal composition for treating hyperuricemia
  • Medicinal composition for treating hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Probenecid 1000g, febuxostat 10g, lactose 675g, microcrystalline cellulose 250g, mix well, add appropriate amount of 10% PEG6000 solution to granulate, dry, then add carboxymethyl starch sodium 83g, magnesium stearate 23.5g , mixed, compressed, film-coated.

Embodiment 2

[0057] Tablet preparation: mix probenecid 400g, febuxostat 20g, add lactose 1667g, pregelatinized starch 390g, hydroxypropyl cellulose 15g, croscarmellose sodium 63g, magnesium stearate 31.5g, mixed evenly, granulated with pure water, dried, compressed into tablets, and film-coated.

Embodiment 3

[0059] Preparation of tablets: mix probenecid 800g, febuxostat 20g, add lactose 300g, microcrystalline cellulose 110g, mix well, add appropriate amount of 10% PEG4000 solution to granulate, dry, then add carboxymethyl starch sodium 52g , 13.5g of magnesium stearate, mixed evenly, compressed into tablets, and film-coated.

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Abstract

The invention relates to a medicinal composition for treating hyperuricemia, which comprises Febuxostat or derivate thereof, probenecid and a pharmaceutically acceptable medicinal carrier, wherein theratio in weight portion of the Febuxostat or derivate thereof to the probenecid to the pharmaceutically acceptable medicinal carrier is 1:10-200:0.5-100. The medicinal composition can provide extremely beneficial effects of treating the hyperuricemia. Pharmacological tests prove that the medicinal composition has obviously synergistic action, can quickly reduce the concentration of purine trionein blood serum, remarkably improves effect of treating the hyperuricemia, greatly reduces medicament dosage of single component simultaneously, and effectively reduces toxic and side effect of medicament.

Description

technical field [0001] The present invention relates to the pharmaceutical composition that is used for treating hyperuricemia febuxostat and uricosuric agent treatment hyperuricemia, more specifically, the present invention relates to the combination of febuxostat or derivative thereof and probenecid A pharmaceutical composition for the treatment of conditions associated with hyperuricemia and gout. Background technique [0002] With the development of the economy and the improvement of people's living standards, changes in lifestyle and dietary structure, as well as many diseases lead to hyperuricemia (Hyperuricemia), its incidence rate is increasing year by year, and there is a trend of younger age. Like other metabolic diseases, the incidence of hyperuricemia has been on the rise in recent years, and it has increased the mortality rate of cardiovascular and cerebrovascular diseases. Hyperuricemia includes primary and secondary hyperuricemia. When hyperuricemia reaches ...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61K31/195A61P19/06
CPCA61K31/145A61K9/48A61K9/20A61K45/06A61K31/426A61P19/06A61K2300/00
Inventor 张殿镇谭明胜赵健朱红星
Owner TIANJIN TAIPU PHARMA SCI & TECH DEV
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