32 results about "Chlorotoluene" patented technology

The invention discloses an o-chlorotoluene continuous chlorination reaction device and method, and relates to the technical field of chemical engineering, the o-chlorotoluene continuous chlorination reaction device comprises a reaction kettle, the top of the reaction kettle is fixedly provided with a power assembly, the o-chlorotoluene continuous chlorination reaction device further comprises a mixing assembly, the mixing assembly is arranged in the reaction kettle, and the mixing assembly comprises a fixed partition plate fixedly connected to the middle section in the reaction kettle; a methylbenzene input pipe and a chlorine input pipe are fixedly inserted into the top end of the reaction kettle, a rotating rod is fixedly connected to the power output end of the power assembly, a rotating sleeve is rotatably inserted into the top end of the reaction kettle, and a movable partition plate is fixedly connected to the bottom end of the rotating sleeve; a plurality of lowering holes are formed in the surfaces of the movable partition plate and the fixed partition plate, the rotating rod is inserted into the rotating sleeve, and the top end of the rotating sleeve is fixedly sleeved with an outer gear ring, so that the problems that in the period of time when prepared finished products are discharged, the production is stopped, the production interval is large, and the production efficiency is high are solved. And continuous chlorination reaction cannot be carried out.

The invention discloses a purification device for chlorotoluene production waste gas and a use method thereof, and relates to the field of purification devices.The purification device is characterized by comprising a waste gas collection unit, a pretreatment unit, an absorption unit, a catalytic combustion unit, a deep purification unit and a tail gas detection and emission unit which are sequentially communicated along a waste gas treatment path; the device has the advantages that a three-stage treatment process of the absorption unit, the catalytic combustion unit and the deep purification unit is adopted, insoluble VOCs are comprehensively covered, and it is ensured that the concentration of chlorotoluene in tail gas is reduced to 10 mg / m or below; liquid chlorotoluene is removed through a gas-liquid separator of the waste gas collecting unit, then dust is intercepted through a filtering assembly of the pretreatment unit, cooling is conducted through a cooling assembly, blockage and inactivation caused by the fact that impurities are attached to a catalyst are prevented, meanwhile, HCl is removed in advance through the absorption unit, and acid gas is prevented from corroding a combustion furnace.

The application belongs to the technical field of organic synthesis and particularly relates to a synthesis method of electronic-grade 2,3,4-trihydroxybenzophenone. The application comprises the following steps: catalytic reaction: taking water as a solvent, mixing water and a catalyst uniformly, adding pyrogallic acid, heating the system to 40-50 DEG C, continuously adding trichloromethylbenzene, performing insulation reaction, cooling the system to 10-15 DEG C after the reaction is completed, crystallizing and precipitating, and then filtering to obtain a crude wet product; purification treatment: removing impurities from the crude wet product to obtain the high-purity 2,3,4-trihydroxybenzophenone. The application does not need to react in an organic solvent system, is green and environmentally friendly, does not need nitrogen protection, has low production cost, and is suitable for industrialized processing and production, and the prepared 2,3,4-trihydroxybenzophenone has high purity and high yield.

The present disclosure relates to a process for the preparation of 4-chloro-5-(4-tolyl)-1H-imidazole-2-formonitrile. The methods of the present disclosure are performed under mild reaction conditions. Further, the method of the present disclosure is simple, cost effective and environmentally friendly, and provides 4-chloro-5-(4-tolyl)-1H-imidazole-2-formonitrile with relatively higher purity and higher yield.

The invention provides a preparation method of capicotib, which comprises the following steps: carrying out aromatic nucleophilic substitution (SNAr) on 4-aminopiperidine-4-carboxylic acid and 4-chloro-7-toluenesulfonyl-7H-pyrrole [2, 3-d] pyrimidine to obtain a compound as shown in a formula II, then esterifying under the action of trifluoroacetic anhydride to form a ring to form a compound as shown in a formula III, and carrying out cyclization on the compound as shown in the formula III to obtain the capicotib. The preparation method comprises the following steps: carrying out ring-opening reaction with (S)-3-amino-3-(4-chlorphenyl) propan-1-alcohol without separation under an alkali condition to obtain a compound as shown in a formula IV, and finally removing a toluenesulfonyl protecting group to obtain the carpatinib. The preparation method has the advantages of few reaction steps, mild conditions and short SNAr reaction time, the obtained intermediate compound is easy to purify, the purity and the total yield of the cappitatide can be improved, and the preparation method is suitable for industrial large-scale production.

The application belongs to the technical field of pharmaceutical chemistry synthesis, and particularly relates to a synthesis method of a fluorofelarana intermediate 2-methyl-4-acetylbenzoic acid. In the application, o-chlorotoluene and acetyl chloride are reacted under the action of anhydrous aluminum chloride to generate 4-chloro-3-methylacetophenone; the 4-chloro-3-methylacetophenone and acetonitrile are catalyzed by Ni to generate 4-acetyl-2-methylbenzonitrile; and then the 4-acetyl-2-methylbenzonitrile is hydrolyzed to generate 2-methyl-4-acetylbenzoic acid. The application has the beneficial effect that acetonitrile is used as a cyanogen to replace halogen, and a highly toxic cyanide is abandoned, so that the whole process is safer and more environmentally friendly, the production of three wastes is reduced, and the synthesis cost of 2-methyl-4-acetylbenzoic acid is greatly reduced.

The invention belongs to the technical field of organic synthesis, and particularly relates to a green synthesis method of electronic-grade 2, 3, 4-trihydroxy benzophenone. The method comprises the following steps: catalytic reaction: taking water as a solvent, uniformly mixing water and a catalyst, adding pyrogallic acid, heating the system to 40-50 DEG C, continuously adding trichlorotoluene, carrying out heat preservation reaction, cooling to 10-15 DEG C after the reaction is completed, crystallizing, separating out and filtering to obtain a crude wet product; and purification treatment: removing impurities from the crude wet product to obtain the high-purity 2, 3, 4-trihydroxy benzophenone. The method does not need reaction in an organic solvent system, is green and environment-friendly, does not need nitrogen protection and is low in production cost, and the prepared 2, 3, 4-trihydroxy benzophenone is high in purity and yield and suitable for industrial processing production.

The utility model discloses a dichlorotoluene production system which comprises an o-chlorotoluene rectifying tower, a 2, 6-dichlorotoluene rectifying tower and a 2, 3-dichlorotoluene rectifying tower which are connected in sequence, the o-chlorotoluene rectifying tower is provided with an o-chlorotoluene outlet and a first inlet for a crude product of a mixture to enter, the 2, 6-dichlorotoluene rectifying tower is provided with a 2, 6-dichlorotoluene outlet, and the 2, 3-dichlorotoluene rectifying tower is provided with a second inlet for a crude product of the mixture to enter. The 2, 3-dichlorotoluene rectifying tower is provided with a 2, 3-dichlorotoluene outlet; the tower top of the 2, 6-dichlorotoluene rectifying tower is provided with a second condenser, the tower kettle of the 2, 6-dichlorotoluene rectifying tower is provided with a second reboiler, the second condenser is provided with a refrigerant inlet and a refrigerant outlet, the second reboiler is provided with a thermal medium inlet and a thermal medium outlet, the thermal medium outlet of the second reboiler is connected with the refrigerant inlet of the second condenser, and the thermal medium outlet of the second reboiler is connected with the refrigerant outlet of the second condenser. And a refrigerant outlet of the second condenser is connected with a thermal medium inlet of the second reboiler. According to the dichlorotoluene production system disclosed by the embodiment of the utility model, the energy consumption of the 2, 6-dichlorotoluene rectifying tower can be greatly reduced, so that the energy consumption of the dichlorotoluene production system is reduced.

The application discloses a continuous separation method of o-chlorotoluene chlorination liquid and a catalyst, which adopts a continuous freezing treatment and filtration method, and first freezes the chlorination liquid to precipitate most of the catalyst, then removes the precipitated catalyst through filtration, and then circulates and evaporates the filtrate to a concentrated liquid, so that the content of the catalyst in the concentrated liquid is 5-10 wt%; after cooling, the concentrated liquid is mixed with the frozen chlorination liquid suspension to be filtered again. The application uses the continuous freezing and filtration method, uses the property that temperature significantly affects the solubility of the catalyst in the chlorination liquid, separates most of the catalyst from the chlorination liquid, removes the remaining catalyst which is not precipitated by freezing through evaporation of the filtrate, and realizes the continuous separation of the insoluble solid catalyst and the o-chlorotoluene chlorination liquid. The application not only avoids the defects that a large amount of waste water containing metal salts is generated in the process of removing the catalyst in the chlorination liquid through the traditional water washing and alkali washing methods, but also realizes the resource recycling of the catalyst.

The present application relates to the synthesis of pesticide compounds, in particular to a method for preparing a pyrasulfotole intermediate. The method comprises: (1) using p-chlorotoluene as a raw material, through nitration, chlorination, hydrolysis, or chlorination, hydrolysis, nitration, to obtain 3-nitro-4-chlorobenzaldehyde, (2) fluorination and reduction of 3-nitro-4-chlorobenzaldehyde to obtain 4-fluoro-3-amino benzaldehyde; (3) 4-fluoro-3-amino benzaldehyde is then contacted with chloroformate for reaction, and then chlorination to obtain compound IV; (4) compound IV is contacted with trifluorobutanamine ester under alkaline conditions for reaction to obtain compound I. The process for preparing compound I avoids using expensive raw material 2-chloro-4-fluorobenzoic acid, effectively reduces the cost of raw materials, reduces the three wastes generated in the process, and at the same time, the total yield of the reaction is high, and it is suitable for industrial mass production.

The present application relates to o-chlorotoluene preparation technical field, specifically to a kind of o-chlorotoluene rectification equipment and its using method, including feed tank, mixing tank and rectifying tank, the outside of feed tank is equipped with first temperature control box, the outside of mixing tank is equipped with second temperature control box, feed tank and mixing tank are connected by first conveying pipe between communication.The present application can be monitored by first temperature sensor and second temperature sensor respectively to the temperature in first temperature control box and second temperature control box, when temperature is higher or lower than set range, third water pump and first solenoid valve are opened by controller, so that cooling liquid in cooling water tank enters first temperature control box and is cooled or heating pipe is arranged in second temperature control box and is heated, without additional temperature control equipment, through reboiler and cooling water tank, energy is recycled, so that raw material is added in more suitable temperature, improve rectification effect, reduce cost.

The present disclosure relates to a process for the preparation of 4-chloro-5-(4-tolyl)-1H-imidazole-2-formonitrile. The methods of the present disclosure are performed under mild reaction conditions. Further, the method of the present disclosure is simple, cost effective and environmentally friendly, and provides 4-chloro-5-(4-tolyl)-1H-imidazole-2-formonitrile with relatively higher purity and higher yield.

The application discloses a 2,5-dichlorotoluene isomerization catalyst, wherein the carrier of the catalyst is a multi-stage pore hydrogen type molecular sieve, the active component is zirconium oxide, the cocatalyst is alkaline earth metal oxide, the total loading amount of the zirconium oxide and the alkaline earth metal oxide is 1-5 wt%, the molar ratio of zirconium and the alkaline earth metal is 10:0-0:10, and the multi-stage pore hydrogen type molecular sieve is obtained by modifying a hydrogen type molecular sieve with an organic acid. Through the organic acid dealumination modification, mesoporous channels can be effectively constructed in the molecular sieve crystal, the specific surface area, mesoporous pore size and pore volume of the molecular sieve are increased, the diffusion of macromolecules in the channels is greatly enhanced, and the carbon deposition inactivation of the catalyst is inhibited; the active component can provide more catalytic active sites, improve the catalytic activity of the catalyst, and the cocatalyst has a positive influence on the acidity, carbon deposition and other properties of the catalyst; the highest conversion rate of 2,5-dichlorotoluene reaches 59.14%, and the total selectivity of dichlorotoluene reaches 37.77%.

The utility model discloses a tail gas absorption device in trichlorotoluene production, which belongs to the technical field of trichlorotoluene production, and comprises an absorption tank, the left side surface of the absorption tank is fixedly connected with a fixed plate, the left side surface of the fixed plate is fixedly connected with a filter cartridge, the right side surface of the absorption tank is fixedly connected with a support plate, and the support plate is fixedly connected with the filter cartridge. A liquid storage box is fixedly installed on the upper surface of the supporting plate, a liquid pump is fixedly installed on the upper surface of the liquid storage box, the output end of the liquid pump fixedly communicates with a liquid discharging pipe, and the end, away from the liquid pump, of the liquid discharging pipe penetrates through the absorption tank and extends into the absorption tank; and the end, away from the infusion pump, of the liquid drainage pipe fixedly communicates with a liquid drainage spraying disc, and the upper surface of the absorption tank fixedly communicates with a communicating pipe. According to the tail gas absorption device in trichlorotoluene production, organic matters and the like in tail gas can be physically adsorbed, the purpose of removing pollutants is achieved, the tail gas can be efficiently absorbed and treated, and the subsequent treatment requirement of the tail gas can be met.

The invention relates to the technical field of chemical production, in particular to a synthesis process of o-chlorobenzyl chloride, which specifically comprises the following steps: compounding an azo initiator and benzoyl peroxide, adding a free radical catalyst, and dissolving with low-concentration o-chlorotoluene to prepare a catalyst system; the free radical stabilizer consumes high-concentration instant free radicals generated by the azo initiator in the initial stage, reaction out-of-control and temperature runaway are prevented, physical isolation of benzoyl peroxide is achieved through a paraffin wrapping technology, the segmented initiation effect is further improved, dominant starting of the azo initiator in the low-temperature stage is achieved, and the stability of the system is improved. And benzoyl peroxide in a high-temperature section is dominated and maintained, so that the reaction controllability is remarkably improved. A catalyst system and high-purity o-chlorotoluene are added into a photocatalysis tower type reaction device, a blue light lamp is adopted as a light source, and the temperature is increased by stages for chlorination reaction, so that the synthesis process of o-chlorobenzyl chloride, which is capable of realizing segmented controllable initiation, improving reaction selectivity, reducing energy consumption, reducing chlorine consumption and generating polychlorinated impurities, is realized.

The application discloses a chlorantraniliprole reaction mother liquor recovery method and recovery processing equipment, comprising the following steps: S1: K acid and K amine are dissolved in a solvent a; S2: an acid-binding agent b is added, and temperature is controlled to drop methylsulfonyl chloride for condensation reaction; S3: after the reaction is completed, water is added to cool and crystallize; S4: centrifugation is carried out to obtain chlorantraniliprole; S5: after alkalization, the reaction mother liquor is extracted to separate an organic phase; S6: the organic phase is distilled to obtain a distillate main product; and S7: the distillate main product is dehydrated through a molecular sieve. The application has the advantages that: in the chlorantraniliprole synthesis, the selected solvent a and the acid-binding agent b can make the reaction yield greater than 94%; meanwhile, the reaction solvent a can meet the requirements of the reaction, direct separation with water, and extraction and dissolution of the acid-binding agent b in water; in the mother liquor recycling, the selected solvent a and the acid-binding agent b meet the conditions of molecular sieve dehydration, and the recovery rate of the solvent a and the acid-binding agent b is more than 95%.

The invention discloses a system for producing o-(p-) chlorobenzyl chloride by'reacting first and then separating 'mixed o-(p-) chlorotoluene. The invention discloses a process for producing o (p) chlorobenzyl chloride from mixed o (p) chlorotoluene by'reaction-separation ', which comprises the following steps: carrying out side chain photochlorination reaction on the mixed o (p) chlorotoluene and chlorine in a photochlorination reactor, feeding the chlorination liquid into a deacidification tower for degassing operation, feeding the deacidified chlorination liquid into a chlorotoluene removal tower for rectifying to remove the mixed chlorotoluene, and feeding the deacidified chlorination liquid into a dechlorination tower for dechlorination; a tower kettle material enters an o-chlorobenzyl chloride refining tower, an o-chlorobenzyl chloride product is extracted after a tower top material of the o-chlorobenzyl chloride refining tower is condensed, a tower kettle material enters an o-chlorobenzyl chloride removal refining tower, a tower top material of the o-chlorobenzyl chloride removal refining tower is condensed and then returns to the o-chlorobenzyl chloride refining tower, and a tower kettle material enters a p-chlorobenzyl chloride refining tower; and condensing a material at the top of the p-chlorobenzyl chloride refining tower, and extracting a p-chlorobenzyl chloride product. According to the method, the separation difficulty is reduced, and the separation energy consumption is saved.

The invention relates to the technical field of chemical synthesis, and discloses a method for preparing o-chlorobenzyl bromide by using photofluid reaction equipment, o-chlorotoluene is used as a raw material, dibromohydantoin bromination reagent and blue light are used as initiators, free radical substitution reaction and post-treatment are carried out to prepare o-chlorobenzyl bromide, the method improves the conversion rate and selectivity of bromination reaction, and the method is suitable for industrial production. The preparation method has the advantages of short synthesis route, simple operation, high yield, capacity improvement, high recovery rate in the crystallization and purification process, yield of 90-93%, cheap and easily available raw materials, simple operation, environmental protection, low comprehensive cost, simplicity, continuous production and the like, and the process is suitable for large-scale production.

The invention relates to the technical field of chlorotoluene mixture separation, in particular to a process method for continuously removing hydrogen chloride acid gas in chlorotoluene mixed liquid. A continuous deacidification method for a chlorotoluene production process comprises the following steps: S1, feeding a raw material into a preheater for preheating to reduce the solubility of acid gas in liquid; s2, the preheated raw materials enter a separation tank, and mixed gas containing HCl and organic matter on the top is condensed through a condenser in sequence; s3, condensate flows back to a separation tank through a liquid flow groove 1, and uncondensed gas is sent to a liquid flow groove 2 for gas-liquid separation; s4, separated gas enters a vacuum pump, gas at a pump outlet is subjected to liquid separation through a liquid flow groove 3, HCl gas is sent to an acid making section, and liquid flows back to the separation tank; s5, conveying the liquid at the lower part of the separation tank to a subsequent separation section. According to the process, a continuous closed loop is constructed, the separation tank is taken as a core, and multi-stage condensation, multi-time gas-liquid separation and a vacuum environment are combined, so that efficient separation of acidic components and chlorotoluene is realized, useful components are recycled, raw material loss is reduced, and subsequent working section operation is guaranteed.

The invention discloses a high-pressure reaction tank for directional hydroxylation reaction of chlorotoluene, and relates to the technical field of chemical reaction equipment, the high-pressure reaction tank comprises a high-pressure reaction tank body, a tank cover, a directional catalysis assembly, a material uniform mixing assembly and a temperature and pressure control assembly; the directional catalysis assembly is suspended in the center in the tank through a detachable catalysis basket, and a fan-shaped filling cavity in the basket is filled with a supported catalyst containing directional group modification, so that directional selectivity of chlorotoluene hydroxylation is realized; the material uniform mixing assembly adopts a double-layer composite stirring paddle matched with an oxidant porous dispersion head to strengthen material mixing and oxidant dispersion; the temperature and pressure control assembly is linked with a PID controller through double temperature sensors and a pressure sensor, precise regulation and control of temperature, pressure and oxidant dripping rate are achieved, a liquid level sensor is linked with a feeding valve to achieve automatic control of feeding amount, and the problems that a traditional reaction tank is poor in directional selectivity, uneven in mixing, low in temperature and pressure control precision and the like are solved. The method is suitable for industrial oriented synthesis of chlorinated phenol.

The utility model relates to the technical field of an o-chlorobenzyl chloride reactor, in particular to an o-chlorobenzyl chloride continuous reactor which comprises a mixing tank for mixing a liquid reactant and a catalyst, a reaction tower which is communicated with the mixing tank through a pipeline and is used for providing a reaction place for the liquid reactant and a gas reactant, and a communicated heat exchanger of the reaction tower, the heat exchanger is communicated with the gas-liquid separation tank, the reaction tower is communicated with a receiving tank for receiving reaction products, a rotatable stirring paddle is arranged in the mixing tank, a flow guide pump is arranged on a pipeline between the mixing tank and the reaction tower, and reflux pipelines are arranged among the heat exchanger, the gas-liquid separation tank and the reaction tower. Therefore, chlorine and chlorotoluene can be heated, mixed and continuously fed and discharged, the conversion rate of reaction is improved, side reaction products are reduced, and the reaction yield is ensured.

The invention discloses a method for preparing p-chlorobenzaldehyde through selective oxidation of p-chlorotoluene, which comprises the following steps: in a stirring type reaction kettle, taking p-chlorotoluene or a mixture of p-chlorotoluene and p-chlorobenzaldehyde as a liquid-phase raw material, taking a variable-valence metal complex as a main catalyst, and taking chloride and / or iodide as a cocatalyst; introducing oxygen-containing gas to carry out oxidation reaction; the height-diameter ratio of the stirring type reaction kettle is (5-8): 1, and a stirring paddle and a porous sintering gas distributor are arranged in the stirring type reaction kettle; and the difference between the height-diameter ratio of the stirring type reaction kettle and the layer number of the stirring paddles is 2. By optimizing the reactor and the catalytic system, the reactant conversion rate and the p-chlorobenzaldehyde selectivity can be improved, the reaction temperature is greatly reduced, and the use of bromide is avoided.

The invention discloses a method for synthesizing o-chlorotoluene and parachlorotoluene through selective chlorination of toluene. The method comprises the following steps: adding tungstic acid and a tungstic acid active center phase distribution regulation and control aid into toluene, uniformly stirring, then adding a hydrochloric acid solution, dropwise adding hydrogen peroxide while stirring, and heating for reaction to obtain chlorotoluene. The tungstic acid active center phase distribution regulation auxiliary agent is an ion pair system formed by organic onium cations and strong acid stable anions; the organic onium cation is a quaternary phosphonium cation; and the strong acid stable anions are selected from hydrogen sulfate anions, phosphate anions or sulfonate anions. Tungstic acid is used as a catalyst, concentrated hydrochloric acid is used as a chlorine source, hydrogen peroxide is used as an oxidizing agent, and a tungstic acid active center phase distribution regulation auxiliary agent is used for realizing interphase dynamic exchange to carry out toluene chlorination reaction. According to the method, the conversion rate in the toluene chlorination reaction and the selectivity of chlorinated products can be improved, the waste hydrochloric acid can be applied in a green and efficient manner, the cost is effectively reduced, and the method is an important method beneficial to industrial production of chlorotoluene.

The utility model relates to a device for separating liquid containing methanol, water, hydrazine hydrate and toluene. The device comprises a first rectifying tower, a water washing tower, a second rectifying tower, an evaporator and a third rectifying tower, wherein the top of the first rectifying tower is connected with the bottom of the washing tower; the first rectifying tower kettle is connected into the second rectifying tower, the second rectifying tower kettle is connected with the evaporator, and an outlet of the evaporator is connected with an inlet of the third rectifying tower; a bottom discharge hole of the water washing tower is connected with an inlet of the first rectifying tower. The tops of the first rectifying tower, the second rectifying tower and the third rectifying tower are respectively provided with a condenser, a return tank and a delivery pump which are sequentially connected. The evaporator is used for reduced pressure evaporation, high-boiling-point impurities (o-chlorotoluene and other high-boiling-point impurities) in the mother liquor are discharged through residual liquid due to difficulty in vaporization, and hydrazine hydrate and the high-boiling-point impurities are separated from the evaporated and refined materials. The device has the characteristics of simplicity in operation, no introduction of a third component, high separation efficiency, good safety, equipment stability and the like.

The embodiment of the invention relates to a method for synthesizing 2-nitro-6-chlorotoluene, and belongs to the technical field of organic synthesis. According to the method, 2-nitrotoluene and chlorine are used as raw materials, a tubular reactor or a common reactor is used as reaction equipment, chlorination is carried out at 10-50 DEG C under the condition of 180-400 nm ultraviolet irradiation, a mixture of 2-nitro-4-chlorotoluene and 2-nitro-6-chlorotoluene is obtained, rectification separation and purification are carried out, and 2-nitro-6-chlorotoluene is obtained. The method has the advantages of cheap and easily available raw materials, simple reaction operation, simple post-treatment, greenness, environmental protection, small pollution generated in the production process, realization of continuous production, reuse of unreacted raw materials, and substantial reduction of the cost.

2-Arylindoles unique heterocyclic structure and recorded biological activity makes it has great application value in medicinal chemistry and pharmaceutical industry. Indole drugs are known to have antioxidant, antitumor, antifungal and antibacterial properties. Because of its wide application, many selective and high economic benefit of synthesis method has been introduced. Such as phenylhydrazine method, aniline method, o-aminoethyl benzene method, o-chlorotoluene method, etc., but these methods have their own shortcomings, such as two-step reaction leading to low yield, synthesis needs catalyst not easy to get, need transition metal catalysis, reaction temperature is far below 0 DEG C, not easy to scale production, etc. The purpose of the present application is to provide a kind of solution to the above problems, simple, economic and more widely applicable or suitable for scale production of 2-arylindole compound synthesis method. Here, we report a general method for the synthesis of indole from simple 2-fluorobenzene acetonitrile compound and various aryl Grignard reagent, which does not involve transition metal and the reaction condition is mild.

The invention belongs to the technical field of sewage treatment equipment, and particularly relates to o (p) chlorotoluene production sewage synchronous treatment equipment which comprises a support, and an extraction mechanism is mounted in the middle of the support. Light and heavy phase solutions can be mixed through operation of the extraction mechanism, the purpose of preliminarily and uniformly mixing the mixed solution is achieved, the extraction mechanism drives the separation mechanism to synchronously operate, the mixed solution is impacted and disturbed through the fixed inclined struts distributed in the separation mechanism in a staggered mode, and the mixed solution is further uniformly mixed; the extraction mechanism drives the stirring mechanism to rotate in an accelerated manner in the direction opposite to the operation direction of the extraction mechanism through the cooperation of the separation mechanism and the linkage mechanism, solution hedging can be locally formed, a mixed solution is uniformly mixed again, the mixing uniformity of a light-phase solution and a heavy-phase solution is remarkably improved, the contact time of the two phases is prolonged, and the extraction efficiency is improved. The problem of low extraction efficiency caused by poor mixing effect of existing equipment is effectively solved.

This invention belongs to the field of epoxy resin technology, specifically relating to an epoxy resin production process and apparatus for improving the recycling rate of stripping water. The epoxy resin production process for improving the recycling rate of stripping water includes the following steps: Epoxy resin reaction: In a stripping tower, the aqueous phase from vacuum distillation and the bubbling azeotropic aqueous phase are collected and then fed into a stripping water treatment vessel. Alkali dechlorination, toluene extraction, and epoxy resin purification: The resin solution from the reaction vessel in step a is fed into a purification vessel, and the toluene phase obtained in step d is added. After completion, the reaction solution is separated by stepwise settling to obtain toluene resin. Benzene removal yields the finished epoxy resin. The epoxy resin production process and apparatus for improving the recycling rate of stripping water provided by this invention are simple and easy to implement, require no significant addition of equipment, have low processing costs, and can effectively remove organic chlorine from stripping water, allowing it to be directly reused in production.

This invention discloses a chlorotoluene chlorination reactor based on photochlorination, comprising a reactor body with a lid, several ultraviolet lamps arranged in a ring array between the reactor body and a quartz protective cover, a chlorine gas inlet distribution assembly located at the bottom of the reactor body, and a vortex stirring assembly located inside the reactor body. In this invention, the ultraviolet light source is uniformly irradiated into the reactor body when the ultraviolet lamps pass through the reflector strip, causing the chlorotoluene material to undergo a photochlorination reaction. The vortex ring at the bottom of the reactor body creates a vortex effect on the chlorotoluene material, causing the chlorotoluene material to rotate in the vortex. The stirring blades create a shearing force, ensuring that the chlorotoluene material is fully mixed and participates in the photochlorination reaction. The arc-shaped stirring blades allow the chlorotoluene material to flow and stir from the center to the periphery in the reactor body, further ensuring that the chlorotoluene material has sufficient contact with the ultraviolet light source and improving the efficiency of the photochlorination reaction.

The application discloses a method for synthesizing meta-chlorotoluene through heterogeneous catalytic isomerization, and has the advantages of stable catalyst, easy recovery, green sustainability, high selectivity of the product meta-chlorotoluene and the like, and is a method for synthesizing meta-chlorotoluene with wide prospects. The method comprises the following steps: filling modified HZSM-5 molecular sieve into a fixed bed reaction constant temperature area and placing the fixed bed reaction constant temperature area in an inert atmosphere, feeding a mixture of raw material p-chlorotoluene and a diluent into the fixed bed reactor through a constant flow pump for preheating and vaporization, and then performing catalytic isomerization reaction in the fixed bed reaction constant temperature area, and collecting the product meta-chlorotoluene after condensation.