14 results about "Cyclopentanol" patented technology

The invention provides an anti-interference control method for the concentration of a main reactant in a continuous stirring reaction kettle process, belongs to the technical field of chemical process control, and solves the problem that in the chemical process of producing cyclopentanol by catalyzing electrophilic water with cyclopentadienoic acid, the concentration of the main reactant is not influenced. The technical problem that the concentration of a main reactant is difficult to track a set value without steady-state errors under the conditions of fluctuation of feeding concentration, uncertainty and external disturbance of the continuous stirring reaction kettle is solved. According to the technical scheme, the method comprises the steps of constructing a model pre-estimation compensator and an anti-interference control structure, designing a four-dimensional decision model, carrying out parameter collaborative optimization by adopting a multi-target genetic optimization algorithm, and carrying out optimal solution selection based on a TOPSIS method. Under the condition of feed concentration fluctuation, the dynamic response speed and the anti-interference capability of the system can be remarkably improved, and faster adjustment time, smaller overshoot and stronger robustness can be realized in linear and nonlinear models.

The application belongs to the technical field of fine chemical industry, and discloses a method for synthesizing cyclopentanol, which comprises the following steps: (1) taking cyclopentene and water as raw materials, adding a solubilizer, and mixing to obtain a reaction liquid; (2) continuously hydrating the reaction liquid in a fixed bed reactor filled with a cation exchange resin to obtain a reaction product; and (3) distilling and separating the reaction product to obtain cyclopentanol. The synthesis method has the advantages of simple process flow, environmental protection, low energy consumption, excellent product indexes, and long operation cycle of the catalyst. Polyethylene glycol-400 or polypropylene glycol-400 is used as a single solubilizer, and a specific macroporous strong acid cation exchange resin catalyst is used to realize the efficient and high-selectivity hydration reaction of cyclopentene.

The invention relates to the technical field of fine chemical engineering, in particular to a method for preparing cyclopentanol based on one-step synthesis of cyclopentene, which comprises the following steps: step 1) preparation of a modified strongly acidic cation exchange resin catalyst; (2) synthesizing by a one-step method; step 3) separation; and 4) purifying. In the step (2), under the inert atmosphere, the modified strong-acid cation exchange resin catalyst, cyclopentene, n-amyl alcohol and water are mixed and react; wherein the molar ratio of the cyclopentene to the water is (3-5): 1, the addition amount of the n-amyl alcohol is 1.0-2.0 times of the mass of the cyclopentene, and the n-amyl alcohol and the water form a cosolvent system. The method has the advantages that the process route is clean, efficient and pollution-free, the conversion per pass is high, the product is easy to separate, the low-temperature physical property of the product is good, the solvent and reactants in the whole reaction process can be repeatedly used, efficient and environment-friendly hydration preparation of cyclopentanol from cyclopentene can be realized, and the method has a good industrial application prospect.

The invention provides a nucleic acid protective agent and a preparation method and application thereof, the nucleic acid protective agent comprises a nucleic acid stabilizing main reagent, an RNA enzyme inhibitor and an antioxidant, the nucleic acid stabilizing main reagent comprises maltodextrin, xylitol and hydroxypropyl-beta-cyclodextrin; the RNA enzyme inhibitor comprises cyclopentanol and tetrahydrofurfuryl alcohol; the antioxidant comprises sodium thiosulfate, sodium pyrophosphate and ascorbic acid. According to the nucleic acid protective agent provided by the invention, free nucleic acid substances including DNA and RNA can be preserved for 2 weeks under the condition of 37 DEG C, preserved for 6 months under the condition of 2-8 DEG C and preserved for 15 months under the condition of-20 DEG C, and the degradation rate is less than 10%.

The invention discloses a method for preparing cyclopentanol by using furfural through a one-pot method, which comprises the following steps: by using isopropanol as a reaction solvent and Pt / H beta as a catalyst, reacting in a high-pressure reaction kettle at 180-190 DEG C in a hydrogen atmosphere of 4-4.5 MPa for 3-4 hours to prepare cyclopentanol by using furfural as a raw material through the one-pot method. The preparation process is simple, the raw materials are easy to obtain, the reaction time is short, the reaction process is environment-friendly and pollution-free, the catalytic system is relatively simple, the raw material conversion rate can reach 100%, and the highest cyclopentanol yield can reach 95.66%.

The invention provides a process for producing cyclopentanone from cyclopentene, and belongs to the technical field of cyclopentanone production.In the esterification reaction, acetic acid is used for removing metal ions to improve the activity stability of a sulfonic cation exchange resin catalyst; when the ester hydrogenation process is used, the cyclopentyl acetate is directly converted into cyclopentanol and absolute ethyl alcohol with high added value; the appropriate CuO-ZnO / Al2O3 high-activity dehydrogenation catalyst is selected, so that the reaction efficiency is obviously improved, the energy consumption is obviously reduced, the conversion per pass of the dehydrogenation reaction is 70% or above, and the selectivity of cyclopentanone is close to 100%. In short, the production method provided by the invention is high in catalyst activity, high in reaction conversion rate, short in reaction time, relatively easy in product refining and cyclopentanol recovery, obviously reduced in energy consumption and more suitable for industrial production.

The invention discloses a supported ternary transition metal catalyst as well as a preparation method and application thereof. The chemical formula of the supported ternary transition metal catalyst is Ni < x > W < 1-x > Py: D, and D is a carrier, 0 lt; x < lt >; 1. The supported ternary transition metal catalyst provided by the invention has high activity, excellent cyclopentanol selectivity and excellent stability, and shows 99.9% of activity in a cyclopentyl formate hydrogenation reaction, and the selectivity of cyclopentanol in a product can reach 96% or above. Through a long-time stability test, the catalyst shows good stability, and the service life is as long as 1200 hours. Moreover, the technical scheme provided by the invention is mild in reaction condition and high in environmental friendliness in the production process, so that the method can be widely applied to the cyclopentanol preparation process in industrial production, and has remarkable economic benefits and application prospects.

The invention relates to the technical field of organic synthesis, in particular to a method for preparing cyclopentanone through cyclopentanol dehydrogenation, which comprises the following steps: S1, raw material catalysis: taking cyclopentanol as a raw material, taking a modified copper-silicon catalyst as a fixed bed catalytic active component, and carrying out gas-phase dehydrogenation reaction in an integrated adiabatic bed reactor; s2, laying a bed layer; s3, regulating and controlling parameters; and S4, separating the product. Therefore, through combination of the modified copper-silicon catalyst, segmented temperature control and nitrogen dilution, the conversion per pass of cyclopentanol is greater than or equal to 83.52%, the selectivity of cyclopentanone is greater than or equal to 98%, and the by-product is less than or equal to 0.5%; a closed-loop control system achieves accurate control over temperature, pressure and flow, raw material circulation and activated carbon tail gas treatment are matched, no corrosion by-product is generated, equipment modularization is easy to maintain, and the system is suitable for industrial efficient and environment-friendly production.

The invention belongs to the field of catalysts, and particularly relates to a preparation method of a Co-MOF derivative catalyst and application of the Co-MOF derivative catalyst in catalytic hydrogenation of high-concentration furfural. The method comprises the following steps: preparing a Co-MOF material from cobalt nitrate hexahydrate, terephthalic acid and N, N-dimethylformamide, calcining the Co-MOF material in a reducing atmosphere to prepare a Co-C catalyst, and applying the catalyst to hydrogenation of 8-10wt% high-concentration furfural to prepare cyclopentanone and cyclopentanol. The catalyst is simple in preparation method, has a stable shell-core structure, has relatively strong magnetism, is convenient to separate and recover, and has high catalytic activity and recycling capability. Ethanol is used as a cosolvent, the solubility of furfural in water can be increased, side reactions are reduced to a certain extent, the catalytic hydrogenation reaction of high-concentration furfural in a water phase is achieved, the total mass yield of products is high, and the industrial development potential is achieved.

The present application relates to a pyrazole-substituted cyclopentanol ester derivative and use thereof, and in particular to a compound represented by formula (I), an isomer thereof, or a pharmaceutically acceptable salt thereof.

The invention provides a method for separating cyclopentene and cyclopentane in a C5 component and a preparation method of cyclopentanone, which comprises the following steps: firstly, under the action of a solid acid catalyst, enabling the cyclopentene in the C5 component to react with acetic acid to obtain cyclopentyl acetate, and by virtue of the characteristic that the boiling point difference between ester substances and alkane is relatively large, separating cyclopentene from cyclopentane in the C5 component to obtain cyclopentyl acetate; and separating the cyclopentane from the cyclopentyl acetate to achieve the separation of the cyclopentane and the cyclopentene. Furthermore, cyclopentyl acetate obtained through separation reacts with hydrogen under the action of a hydrogenation catalyst to produce cyclopentanol, cyclopentanol is oxidized under the action of the catalyst and an oxidizing agent to produce cyclopentanone, and unreacted cyclopentanol can be recycled. Through testing, the yield of cyclopentanol is greater than or equal to 90%, the yield of cyclopentanone is greater than or equal to 90%, and the purity of cyclopentane is greater than or equal to 95%.

The invention relates to the technical field of cyclopentanone production, in particular to a device for preparing cyclopentanone by hydrating and dehydrogenating cyclopentene, which comprises a hydration reaction unit, a solvent recovery unit, a cyclopentanol refining unit, a catalytic dehydrogenation unit and a cyclopentanone refining unit which are connected in sequence, the cyclopentanol refining unit comprises a heavy component removal tower, a water recovery tower, a phase separation tank and a cyclopentanol refining tower; wherein the de-heavy tower is connected to the solvent recovery unit; the split-phase tank is respectively connected to the heavy component removal tower, the water recovery tower and the cyclopentanol refining tower; and the cyclopentanol refining tower is connected to the catalytic dehydrogenation unit. Carrying out addition reaction on cyclopentene to generate cyclopentanol; carrying out oxidation reaction on the cyclopentanol to generate cyclopentanone; wherein the addition reaction catalyst is strongly acidic cation exchange resin modified by quaternary ammonium salt groups. According to the invention, the defects of a device for preparing cyclopentanone by hydrating and dehydrogenating cyclopentene in the aspects of reaction efficiency, separation effect and energy consumption are effectively overcome, and the purity and industrial production value of a cyclopentanone product are greatly improved.

This disclosure provides an application of a nickel-based polyimide catalyst in catalytic transfer hydrogenation. The application includes: adding a biomass derivative substrate, an alcohol hydrogen donor, and a water mixture as solvents to a reaction vessel; and, under an inert atmosphere without external hydrogen, converting the biomass derivative substrate into corresponding cyclopentanone and / or cyclopentanol products through a catalytic transfer hydrogenation reaction. The nickel-based polyimide catalyst comprises a polyimide microsphere support and a nickel metal active component supported on the polyimide microsphere support. This disclosure constructs a composite catalytic system with polyimide microspheres as the support and nickel metal as the active component, utilizing the unique proton enrichment function of the polyimide support to achieve efficient and highly selective hydrogenation conversion of furan aldehyde substrates using an alcohol hydrogen donor as the hydrogen source under a non-hydrogen inert atmosphere.

The invention discloses a preparation method of cyclopentanol, which comprises the following steps: in a closed reactor, reacting a mixture containing a catalyst, a solvent, an oxidizing agent and cyclopentane to obtain cyclopentanol, the catalyst is a zirconium-silicon hierarchical pore molecular sieve catalyst. The zirconium-silicon hierarchical pore molecular sieve catalyst provided by the invention is simple to prepare and has wide pore size distribution. Meanwhile, hydrogen peroxide is used as an oxidant, and the method is low in three-waste. Therefore, cyclopentanol can be prepared by green and efficient oxidation of cyclopentane, and the catalyst has excellent selectivity.