The invention relates to equipment for carrying out spray freezing and drying on inert particles, comprising a fluidizing system, an atomizing system, a freezing system and a heat exchange system, wherein the heat exchange system is connected to the fluidizing system by virtue of a gas pipeline. The invention also relates to a method for carrying out spray freezing and drying on the inert particles, comprising the following steps of: (1) adding an inert particle group; (2) introducing a refrigerant; (3) introducing low-temperature low-humidity fluidizing gas; (4) freezing and spray coating; (5) freezing and drying; and (6) separating powder. The equipment and process for carrying out spray freezing and drying on inert particles in the invention couple processes such as fluidizing, cold spray coating, drying and separating, thus atomizing, freezing, drying and separating can be completed in one equipment, enclosed action and continuous operation are realized, no pollution is produced to the environment, dried feed liquid foods and medicines can be dried into powder finished products in one step, and no secondary processing is required; and besides, the structure is simple, the operation is convenient, and the manufacturing cost of equipment is reduced.