72 results about "Large animal" patented technology

The invention discloses a field miniature PVC litter decomposition experiment ring which comprises a miniature ring structure, observation opening structures are oppositely formed in the outer surface of the miniature ring structure, a nylon net structure with the pore diameter of 5 mm is glued in an inner cavity of one observation opening structure, a nylon net structure with the pore diameter of 50 microns is glued in the other observation opening structure, and the inner cavity of the other observation opening structure is glued with a nylon net structure with the pore diameter of 50 microns. The top of the outer ring of the miniature ring structure is sleeved with a disassembly and assembly ring, and a cover net structure which is in a stretched state and has the aperture of 50 micrometers is glued to the top of the disassembly and assembly ring. Firstly, the influence of microenvironment interference and physical limitation in the litter decomposition process is solved, and the situation that the decomposition rate deviates from a true value due to litter compaction and rainfall erosion in the environment is avoided; secondly, the problem that a litter mesh bag method changes the feeding preference of soil animals is solved, it is ensured that the decomposition behavior is consistent with the natural state, and finally, due to the fact that the decomposition process is protected by the miniature environment, the influence of human factors and large animals is avoided.

A far-infrared camera mounted in a vehicle generates an image frame. When an image of a large animal is identified in the image frame, a pixel intensity of the large animal image is determined. An estimated distance to the large animal from the far-infrared camera based on the pixel intensity is determined. When the animal is classified as a tracked animal, and future trajectories of the tracked animal and the vehicle intersect, a component in the vehicle is actuated.

The utility model discloses a double-cylinder ironing and hair removing all-in-one machine, the double-cylinder ironing and hair removing all-in-one machine comprises a bin body, a soaking pool, an automatic fishing assembly and a spraying assembly, the spraying assembly is arranged on the side wall of the bin body, and the spraying assembly is connected with a rolling hair removing assembly; in order to solve the problems that in the prior art, when ordinary unhairing equipment is used for unhairing animals, manual soaking treatment is needed, large animals are difficult to carry, and manpower is consumed in operation, the automatic fishing assembly is designed, and through arrangement of the automatic fishing assembly, the large animals can be conveniently fished; according to the animal depilation device, animals can be fully soaked in hot water and then automatically fished and conveyed to the rolling depilation assembly for rolling depilation, a spraying assembly is further arranged, hot water can be automatically sprayed in the depilation process through the spraying assembly, and therefore the situation that in the rolling process, animal epidermis and hair are rapidly cooled, and the depilation efficiency is improved is effectively avoided. Therefore, the problem of difficulty in fully plucking hair is solved.

The application provides a dam surface animal intelligent identification and tracking method, a large number of thermal imaging pictures of animals possibly intruding into a dam range in different postures are collected in advance by using an infrared thermal imaging camera, a deep learning algorithm is used to train thermal imaging samples labeled with animal positions, and automatic detection of animal regions in the thermal imaging pictures is realized; then, intelligent classification of animal body types is realized based on a color step gradient algorithm of the infrared thermal imaging pictures; for large animals, an animal type identification algorithm is constructed by taking body posture characteristics and body surface temperature distribution as characteristic parameters; for small animals, a deep learning model is constructed by taking walking track characteristics and walking speed as characteristic parameters, and intelligent identification of target animal types is realized. The application is highly consistent with the living habits of wild animals, can accurately identify animal types, action tracks and cave positions on the dam at night, and reduces the possibility of dam collapse caused by cave leakage channels.

The application discloses a kind of big animal approach avoidance behavior detection method and system, it is related to animal behavior detection technical field, including, 5 or more than 5 standard unit cage is connected in series or parallel to form combined transparent cage, according to the detection paradigm of pre-set, install grid partition, entity partition or entity partition with loose-leaf small door between adjacent unit cage;Using the overhead camera and side video recorder installed in unit cage top synchronously collects the behavior video of big animal in the combined transparent cage;After big animal is introduced into the combined transparent cage and is trained, by changing the state of partition and introducing external stimulant, trigger the approach or avoidance behavior of big animal, and use the behavior video to carry out index analysis.The application solves the problem that the existing detection device is rigid due to structure, which leads to rigid experimental paradigm and difficulty in comprehensive evaluation of complex approach avoidance behavior of animals.In addition, the prior art relies on manual observation and recording, and the analysis efficiency is low and subjective, and high-throughput automatic extraction of animal instantaneous action and fine behavior index cannot be realized.

The utility model relates to the technical field of blood sampling devices for large animals, and discloses a sterile blood sampling device for large animals, which comprises a blood sampling needle, a blood sampling main pipe and a plurality of blood sampling branch pipes which are communicated in sequence, a peristaltic pump is arranged on the blood sampling main pipe, the blood sampling main pipe is communicated with a plurality of blood sampling branch pipes through a three-way pipe or a four-way pipe, the tail end of each blood sampling branch pipe is respectively connected with a blood sampling bottle, and a stop valve is arranged on each blood sampling branch pipe. According to the scheme, the peristaltic pump and the blood sampling branch pipes are combined, so that the blood sampling amount of a large animal in the end is ensured, meanwhile, the continuity of collecting blood for different project purposes is effectively improved, and the situation that the whole blood sampling amount is affected by blood coagulation and pipe blockage possibly caused by the fact that blood sampling bottles need to be switched and blood sampling is suspended in the midway is avoided.

A large animal modeling device for blunt wound research belongs to the technical field of medical experiment auxiliary tools and comprises a base, a first electric turntable and a second electric turntable. A large animal model; the lifting mechanism comprises a fixed rod, a movable rod and an air cylinder, the fixed rod is installed on the first electric rotating disc, a guide hole is formed in the fixed rod, the movable rod is in sliding contact with the inner wall of the guide hole, and the air cylinder is used for controlling the movable rod to move up and down; each blunt mechanism comprises a first transverse plate, a sliding block and a blunt device, the first transverse plate is fixedly connected with the movable rod, the sliding block is connected with the first transverse plate through a flexible part, and the blunt device is fixedly connected with the sliding block; the swinging mechanism comprises a rack, a swinging frame, a first motor, a fixing box and a locking assembly, the swinging frame is rotationally connected with the rack, the first motor controls the swinging frame to rotate, the fixing box is installed on the swinging frame, a sliding groove is formed in the top of the fixing box, and the locking assembly is used for locking the sliding block in the sliding groove.

The animal husbandry oral cavity dilator comprises a distraction frame, a fixing strip is installed at the bottom of the distraction frame, movable cavities are formed in the positions, close to the two ends, of the interior of the fixing strip respectively, and a supporting piece is installed on one side of the distraction frame. The animal oral cavity can be outwards supported to different degrees through the supporting piece, the supporting piece can be locked and fixed through the lock catch piece, the situation that the supporting piece is closed due to occlusion of a large animal is prevented, and the situation that arms and fingers of medical staff or medical equipment are damaged due to closing of the animal oral cavity can also be prevented; the problems that in the treatment process, the livestock is uncomfortable and prone to biting, medical staff or medical equipment is damaged, the oral cavity of the animal is blocked easily by expanding equipment, and it is inconvenient for an operator to conduct treatment operation on the livestock through the oral cavity of the animal are solved.

A controllable vascular ring constrictor for large animals comprises an elastic hoop, an inflation air bag ring and an inflation air pipe, the elastic hoop comprises an upper hoop and a lower hoop, an outer ring of the inflation air bag ring is fixed to the upper hoop, a central hole of the inflation air bag ring forms a coronary artery compression area, and the inflation air pipe is fixed to the lower hoop. The side, facing the lower hoop, of the inflatable air bag ring is provided with a notch communicated with the coronary artery compression area to form a passageway, after the upper hoop and the lower hoop are opened, the coronary artery can enter the coronary artery compression area through the passageway, the size of the coronary artery compression area is reduced along with inflation of the inflatable air bag ring, and controllable compression of the coronary artery in the coronary artery compression area is achieved. When the inflatable air bag ring is in an uninflated state, the coronary artery compression area is larger than the outer diameter of the coronary artery, the device is fixed to the set position of a coronary artery system through the elastic hoop, meanwhile, the inflatable air bag ring and the pressure sensor are matched, controllability of blood vessel ring contraction and blood flow blocking is achieved, and therefore an acute and chronic myocardial ischemia model can be built according to needs.

To protect a camera and an animal so that the camera is not damaged and the animal is not injured when photographing the large-sized animal such as a bear by remote control.SOLUTION: The camera storage stand 1 includes a storage case 10 for covering and storing a camera 13, an installation stand 11 for installing the camera 13, and a leg part 12 for fixing the installation stand 11. The storage case 10 is formed in a transparent dome shape, the installation base 11 is formed in a disk shape, and the leg portion 12 is formed in a cylindrical shape. The camera 13 and the installation base 11 are fixed by coupling an attachment member 20a provided in the camera 13 and an attachment member 20b provided in the installation base 11. The storage case 10 and the installation base 11 are fixed by fixing members 14a, 14b, 14c, and 14d. The installation base 11 and the leg portion 12 are fixed to each other by coupling an attachment member 20c provided in the installation base 11 and an attachment member 20d provided in the leg portion 12.SELECTED DRAWING: Figure 1

The utility model relates to mouse killing device technical field, and disclose a kind of outdoor mouse killing bait station, including fixed base plate, the fixed base plate top is fixedly arranged with mousetrap, the lower end of mousetrap is cylindrical structure, its upper end is hemispherical structure, mousetrap upper end is equipped with trap mouth, the both sides of mousetrap rotatably installed with guide ladder, the center of fixed base plate is equipped with bait installation groove, bait installation groove inside screw thread is equipped with bait placing tray. Through the four fixing holes of fixed base plate, fixed peg is used to pass through fixed hole, and the anti-pulling barb of fixed peg bottom end is inserted into soil, so as to guarantee the stability of the bait station, avoid multiple mice or larger animals to overturn the bait station, detachable guide ladder and bait placing tray, convenient for user to disassemble and preserve the bait station, at the same time, it is also convenient to wash or take and place bait, improve the use convenience of the bait station.

The invention provides an adenovirus vector delivery method based on ultrasonic guidance and application, and relates to the technical field of biology. Comprising the following steps: designing siRNA and shRNA and synthesizing a target adenovirus vector; preparing a polypeptide hydrogel solution, and mixing an adenovirus vector with the polypeptide hydrogel solution to obtain a mixed solution; the mixed solution is delivered to a target receptor delivery point by using an ultrasonic system and a multi-point injection mode, the mixed solution prepared by coating an adenovirus vector with polypeptide hydrogel is delivered through ultrasonic positioning, the effect of locally, continuously and slowly releasing viruses in an animal body can be achieved, and the problems that the adenovirus in the animal body is easy to remove, and the toxic and side effects are caused are solved. The defect of non-specific tissue transfection caused by difficulty in multi-time administration and easiness in exudation from tissues is overcome; meanwhile, the action time of the adenovirus can be prolonged. In addition, the invention further provides application of the method in a large animal model, and various negative effects on animals caused by a traditional operation exposure method are avoided.

1. The name of the design product: solar energy livestock GPS locator. 2. The use of the design product: the design product is used for positioning the location and counting the number of large animals. 3. The design points of the design product: the shape of the product. 4. The picture or photo that best indicates the design points: perspective view 1.

A large animal lifting and moving apparatus includes a frame having a front end and a rear end, the frame, a drive shaft rotatably coupled to the frame, a drive motor coupled to the frame and operatively coupled to the drive shaft; the drive motor selectively powered by a power source, and one or more roller chains coupled to the drive shaft. The frame is structured to support a large animal between the front end and the rear end and structured to be moved during operation of the large animal lifting and moving apparatus. When the drive motor is powered by the power source, the drive motor drives the drive shaft and the roller chains coupled to the drive shaft.

The invention relates to the technical field of animal husbandry blood collection, and discloses a large animal blood collection and defibering integrated device which comprises a base frame, a sheep conveying assembly, a blood collection fixing assembly and an animal whole blood defibering assembly. According to the large animal blood sampling and defibering integrated equipment, the equipment integrates three core assemblies of sheep transportation, blood sampling fixing and blood plasma defibering, animals or blood sampling bags do not need to be manually transported, and the problem of operation fault caused by independent operation of traditional equipment is thoroughly solved, namely, after blood sampling, the blood sampling bags can be directly fixed to the animal whole blood defibering assembly; blood pollution and activity loss in the transfer process are avoided, and the overall operation duration is shortened compared with a traditional sub-equipment mode; meanwhile, the electric hoist sheep lifting mechanism replaces multi-person lifting, animal transfer can be completed by a single person, and the labor cost is reduced; the blood sampling fixing assembly is of a detachable sleeve structure, the size is reduced after disassembly, and the requirements for large-scale operation and portable storage are met.

The invention belongs to the technical field of preparation of vaccine immunologic adjuvants, and discloses a surface-modified aluminum hydroxide nanoparticle adjuvant as well as preparation and application thereof. The aluminum hydroxide-based adjuvant is a next-generation aluminum hydroxide-based adjuvant at an optimal level specially optimized for veterinary vaccines. The formula of the adjuvant solves the limitation of the traditional aluminum hydroxide adjuvant, including poor cellular immune induction and variable efficacy in large animals. The adjuvant promotes balanced Th1 / Th2 immune response, reduces local injection site reaction, and improves the shelf life of the vaccine. The preparation method comprises ultrasonic homogenization and co-precipitation under pH control, vaccine compositions containing the adjuvant, and uses of the adjuvant in prevention of infectious diseases in animal husbandry, companion animals and poultry. Experimental data show that in bovine respiratory disease and avian influenza models, compared with traditional adjuvants, the immunogenicity is excellent, the antibody titer is increased by 3 times, and CD8 + T cell response is enhanced.

The invention relates to the technical field of large animal blood sampling auxiliary instruments, and discloses a turnover type blood sampling device special for sheep blood sampling, which comprises a bottom plate, a supporting mechanism, a turnover frame, a head placing frame, a locking mechanism, a driving mechanism, a steering connecting mechanism, a binding rope and a tightening mechanism. According to the turnover type blood sampling device special for sheep blood sampling, by arranging the turnover frame, the driving mechanism and the steering connecting mechanism, the manual operation intensity is remarkably reduced; in the blood sampling process, a user only needs to fix a sheep on the overturning frame through a binding rope, the steering connecting mechanism is driven to rotate through the driving mechanism and human assistance of a single person, and therefore the overturning frame is driven to automatically reset to the supporting mechanism, and it is not needed that multiple persons lift the sheep or depend on expensive hoisting equipment.

An animal restraint device for inhalation drug administration comprises: a support frame consisting of multiple support legs and support plates at the top of the support legs; an animal restraint box mounted on the support plates for accommodating and restraining experimental animals; a head cover with a side opening closable to one side of the animal restraint box along its length; and a tray movably mounted on the support legs and located below the animal restraint box, the tray having sliding through holes corresponding to the support legs, the tray being slidably connected to the support legs through the sliding through holes; a support hole communicating with the sliding through hole and a fixing member disposed within the support hole on the side of the tray; a predetermined gap exists between the sliding through hole of the tray and the support leg to allow adjustment of the tray's horizontal angle by adjusting only the height of one side of the tray. This device can reduce pressure on the lungs and abdomen of large animals, improving the accuracy and stability of inhalation drug administration data for large animals.

The utility model relates to the field of animal transport equipment, in particular to a living animal transport vehicle, at least two placement frames are arranged in a transport cabin of the living animal transport vehicle at intervals, each placement frame comprises at least one placement plate, and the placement plates are arranged in the horizontal direction and divide the interior of the transport cabin into a plurality of placement layers in the vertical direction; the mounting position of the placement plate on the placement frame is adjustable in the vertical direction; for animals which are small in size and suitable for being caged, the height of the placement layers can be reduced, animal cages can be placed on the placement frames as many as possible, and the placement frames are arranged at intervals, so that workers can walk and assemble and disassemble the animal cages conveniently; for animals which are large in size and not suitable for being caged, the placement frame in the transportation cabin can be detached, so that the animals are loaded in the transportation cabin, the placement frame is adjusted according to factors such as the size habits of the animals, the number of the animals capable of being loaded in the transportation cabin can be increased as much as possible, the transportation efficiency is improved, and the cost is reduced.

The utility model provides a large animal behavioristics observation cage, and relates to the technical field of animal behavioristics research, the top and the back of a movable cage are correspondingly provided with a top plate and a back plate made of transparent glass plates, other surfaces of the movable cage are formed by stainless steel woven meshes, one side of the movable cage is provided with a side separation net, and the opposite side of the movable cage is provided with an animal inlet; the animal inlet is closed through an openable door, a tray is installed at the bottom of the movable cage in an openable mode, a separation net is arranged in the middle of the front face of the movable cage, the movable cage is divided into two halves through the separation net, the separation net can be freely pulled and opened from the front face of the movable cage, and a push net is arranged in the movable cage close to one side of the animal inlet. The push rod is freely separated from or close to the front surface of the movable cage. On the premise that the number of glass faces is as large as possible and shooting of the camera is not affected, it is guaranteed that an enough large space is provided for an animal to move and stretch, natural actions such as climbing, jumping and circle turning can be shown, and operation of experimenters can be simplified.

The disclosure relates to a sorting system for automatically selecting animals to be treated during a treatment period. A first aspect is a sorting system automatically selecting animals to be treated during a treatment period. The sorting system includes an automatic sort gate and a control arrangement receiving, via a user interface, user input indicative of sorting criteria applicable to animal properties and a maximum number of the animals allowed to be present simultaneously in the sorting area. The control arrangement is further configured to monitor a number of animals that enter and exit the sorting area. The control arrangement is finally configured to adjust one or more parameter values of the one or more sorting criteria, based on the monitored number of animals that enter and exit the sorting area. The disclosure also relates to a corresponding method and to a computer program for performing the method.

The invention belongs to the technical field of animal models, and particularly provides a construction method of a tetrazolehydroxylamine salt induced mouse cirrhosis with splenomegaly model, which comprises the following steps: S1, selecting an experimental mouse; s2, preparing a sodium carboxymethyl cellulose solution with the mass percent of 1%; s3, preparing a tetrazole hydroxylamine salt solution with the mass concentration of 12mg / mL-48mg / mL by using a sodium carboxymethyl cellulose solution with the mass percent of 1%; and S4, feeding the tetrazole hydroxylamine salt solution obtained in the step S3 to the laboratory mouse according to the dosage and the administration time, so as to obtain the liver cirrhosis with splenomegaly model. The problems that an existing liver cirrhosis with splenomegaly animal model is complex in preparation operation, long in modeling time, large in animal trauma or poor in tolerance and high in death rate are solved, the simple and convenient operation mode is lower in modeling cost, short in modeling time, free of animal trauma, good in tolerance, free of death rate and good in repeatability, the modeling success rate reaches 100%, and the method is suitable for industrial production. And the model is stable and good in continuity.

The utility model discloses biological monitoring and tracking equipment for environmental ecology, relates to the technical field of monitoring equipment, and solves the technical problem that the existing technical scheme cannot track and monitor in a large range, the biological monitoring and tracking equipment comprises a main base, four traction towers are fixedly mounted on the main base, and the traction towers are arranged on the main base. The four traction towers are arranged on the base, a steel cable traction structure is arranged on the four traction towers, traction steel cables are arranged on the steel cable traction structure, and hoisting frames are connected among the traction steel cables. Wide and complex-terrain areas such as valleys, large animal botanical gardens and river valleys can be covered, and wide-area monitoring and biological tracking of the ecological environment are achieved; the position of the monitoring camera can be flexibly adjusted, the technical bottleneck that traditional fixed monitoring equipment is limited by terrains and distances and the monitoring range is limited is broken through, and the flexibility and effectiveness of ecological monitoring are greatly improved.

The invention relates to a modular wild animal transport case suitable for different species, and belongs to the technical field of auxiliary animal transport equipment, the modular wild animal transport case mainly comprises a plurality of sub-bins which can be detachably assembled, and the sub-bins can be combined into terrestrial bins and aquatic bins to realize partitioned transport of land and water species. The first terrestrial bin is matched with large animals, the bin bottom is a steel fence, and the second terrestrial bin drives a sliding body through a lead screw to drive an isolation plate to move horizontally and can be flexibly divided into spaces of different sizes to be matched with small animals of different sizes. And a sewage discharge bin is arranged below each terrestrial bin, so that sewage isolation and collection are realized. The bin doors are oppositely arranged to avoid animal disturbance, the air inlet channel guarantees air circulation in the bin, the lead screw is provided with scales and can be clamped and fixed, and the isolation plate is detachable and is provided with a positioning structure. The device can flexibly meet the transportation requirements of animals of different species and different body types, the transportation efficiency and the animal comfort degree are improved, cleaning is convenient, fixing is reliable, the structure is modularized, independent installation and use are achieved, and practicability is high.

The utility model relates to a urine collecting device. The urine collection device comprises a first rod piece, a stimulation element, a second rod piece and a collection mechanism. The stimulation element is arranged on the first rod piece and used for stimulating the animal to urinate. The second rod piece is detachably arranged on the first rod piece. The collecting mechanism is arranged on the second rod piece and used for collecting urine of animals. According to the urine collecting device, the urination desire of a large animal can be increased, the urination speed of the large animal is higher, the waiting time is shortened, the urine of the large animal can be collected through the collecting mechanism, and the urine collecting device is more convenient to carry and use.

The utility model relates to the technical field of animal husbandry and veterinary, in particular to a large animal binding structure for animal husbandry and veterinary, which comprises a bottom plate, four corners of the lower end of the bottom plate are fixedly connected with working legs, the middle of the upper end of the bottom plate is fixedly connected with a placing table, and the right end of the placing table is fixedly connected with a slope table. The lower end face of the slope table is flush with the lower end faces of the four working legs, a control keyboard is fixedly connected to the front portion of the right end of the bottom plate, and rectangular grooves are formed in the front end and the rear end of the bottom plate. According to the large animal binding structure for the animal husbandry veterinarian, through cooperation of the bottom plate, the containing table, the slope table, the control keyboard, the four-limb binding structure, the neck binding structure and the like, the large animal binding structure can effectively adapt to large animals with different body types and habits, it is guaranteed that the veterinarian smoothly carries out medical operation, and meanwhile the working efficiency is improved. The comfort and the safety of the animal during constraint are improved, and the stress response and the injury of the animal are reduced.

The invention discloses an aortic valve regurgitation modeling device with controllable regurgitation degree for large animals, which comprises a sheathing canal, a catheter is inserted in the sheathing canal, the head of the catheter is rotatably connected with at least one valve cutting knife, the valve cutting knife is connected with a sliding button through a traction guide wire in the catheter, and the sliding button is used for driving the valve cutting knife to open and close. The sliding button is arranged at the tail of the catheter. After the cutting knife reaches the position of the aortic valve, the aortic valve can be rapidly and simply cut and damaged. And the design of different numbers of blades correspondingly establishes active valve regurgitation models with different regurgitation degrees. The aortic valve of a large animal is destroyed by using modeling instruments with different numbers of blades, active valve regurgitation models with different regurgitation degrees can be stably established, and the process is simple and rapid.

The utility model provides a spine holder for two-photon recording, comprising: a first support comprising a first clamping arm arranged along a first direction, a first extension plate arranged along the first direction and connected with the first clamping arm, and a first connecting plate arranged along a second direction, the first connecting plate being connected with the first extension plate; the second support comprises a second clamping arm arranged in the first direction, a second extending plate arranged in the first direction and connected with the second clamping arm and a second connecting plate arranged in the second direction, and the second connecting plate can be connected with the first connecting plate in a sliding mode in the second direction; and the lead screw is arranged in the second direction and connected with the first extending plate and the second extending plate, and the lead screw and the clamping space are located on the two opposite sides of the first connecting plate and the second connecting plate in the first direction correspondingly. The spine clamp holder is high in structural strength and structural stability, and not only can adapt to spine structures of small animals, but also can adapt to spine structures of large animals.

The invention discloses a special X-ray cone-beam computed tomography system for animals with a double-image system, and relates to the technical field of cone-beam computed tomography. Comprising an internal rotary supporting structure, a detachable bed board, a large animal imaging module, a small animal imaging module and a control module. The large animal imaging module and the small animal imaging module are coaxially installed on the rotating rack and share the same electrical system and imaging control logic. Through the design of a dual-module coaxial rotation imaging structure, high and low power imaging modules adapted to animals with different body types and a detachable low-attenuation bed board, the comprehensive improvement of the animal imaging system in resolution, application range and imaging stability is realized.

The utility model relates to a combined type large animal negative pressure protection inhalation exposure restraint device, and relates to the technical field of inhalation exposure animal restraint devices, the combined type large animal negative pressure protection inhalation exposure restraint device comprises a mask, a negative pressure head cover box and a fixing vehicle, the mask comprises an airflow channel and a cover body communicated with the airflow channel, and the cover body is provided with an extraction opening in a communicated mode; an elastic fixing sleeve with a neck opening is arranged on the side, away from the airflow channel, of the cover body. The negative pressure hood box is used for containing a mask and comprises a box body and a flexible neck sleeve communicated with the box body, and a negative pressure extraction opening is formed in the box body; the fixing vehicle comprises a vehicle frame, an abdomen supporting platform and a leg supporting platform, the abdomen supporting platform and the leg supporting platform are sequentially arranged in the vehicle frame from top to bottom, the negative pressure head cover box is hinged to one end of the top of the vehicle frame, leg holes for legs of the experimental animal to penetrate through are formed in the abdomen supporting platform, and binding holes for binding and fixing four limbs of the experimental animal are formed in the leg supporting platform. By arranging the fixing device capable of stably fixing the large animal, the requirement of the large animal inhalation exposure experiment is met.