276 results about "Large animal" patented technology

The invention provides application of a Trim63 gene in preparation of a high muscle content and hypertrophic cardiomyopathy model cloned pig. Somatic cells of the Trim63 gene of a modified pig are utilized as nuclear transfer donor cells, oocytes are utilized as nuclear transfer recipient cells, and a cloned embryo is obtained through the somatic cell nuclear transfer technology. The cloned embryo is transferred into a pig uterus to gestate to obtain the Trim63 gene modified high muscle content and hypertrophic cardiomyopathy model cloned pig, artificial intervention methods, such as operation and so on for the cloned pig are not needed any more, and the efficiency of establishment of a disease model is improved. According to the high muscle content and hypertrophic cardiomyopathy model cloned pig, paired Cas9n targeting vectors are utilized for the first time to perform gene editing for large animals. The method is low in cost, sharply shortens the time for obtaining a homozygote pig and lays a foundation for gene function research and the disease model establishment for the large animals by utilizing the CRISPR/Cas9 technology.

A large animal, such as a cow, is brushed by a system that includes a brush mounted on a frame that is pivotally mounted on a structure such as a stall adjacent to the animal. A motor is connected to the brush to rotate the brush and is activated when the animal presses against the brush. A timer mechanism automatically de-activates the motor after a pre-set interval so another, separate, force must be applied to the brush to re-start the cycle. The brush is moved by the animal pressing against the brush to automatically accommodate different animal sizes.

An inhaler for the propellant-free nebulization of a medicament preparation produces a low speed aerosol. The inhaler is combined with an add-on device for intermediate storage of the aerosol produced. The inhaler has a tensioning device for the one-handed tensioning of a drive spring and release thereof. The inhaler is provided with a dispensing device for large animals.

A dental dog chew roll is cut from a flavored and colored hide piece. The hide pieced is rolled to form into a cylindrical body with two ends, with strips of the hide extending from the cylindrical body. Optionally, cuts are made in the body to provide more surface area. Preferably, the hide piece is made from a large animal hide that is cleaned, infused with flavor and dried.

An animal alerting device system and method for mounting in a vehicle produces a sound that stimulates an alertness response in large animals to reduce the likelihood that the animals will run into a roadway and cause an animal-vehicle crash. The sound produced by the device is a random sound pattern in an audible frequency range. The volume of the sound produced is automatically adjusted for vehicle speed. Different sound patterns may be produced automatically based on different geographical locations of the vehicle in which the device is mounted.

A drug delivery system is disclosed. The drug delivery system includes a recognitive polymeric hydrogel through which a drug is delivered by contacting biological tissue. The recognitive polymeric hydrogel is formed using a bio-template, which is a drug or is structurally similar to the drug, functionalized monomers, preferably having complexing sites, and cross-linking monomers, which are copolymerized using a suitable initiator. The complexing sites of the recognitive polymeric hydrogel that is formed mimic receptor sites of a target biological tissue, biological recognition, or biological mechanism of action. A system in accordance with some embodiments is a contact lens for delivering a drug through contact with an eye. In some embodiments, the drug is an anti-microbial, such as an anti-fungal agent for treatment of large animals. In some embodiments, a comfort molecule hyaluronic acid (HA) is delivered. In some embodiments, ketotifen fumarate (anti-histamine) and/or diclofenac sodium (anti-inflammatory) are delivered.

The invention discloses a biomass particle fuel. The biomass particle fuel comprises the following components in percentage by weight: 50 to 60 percent of plant straw, 2 to 5 percent of anthracite, 15 to 20 percent of coal slime, 2 to 5 percent of yellow mud, 2 to 5 percent of waste grease, 8 to 12 percent of food wastes, 8 to 12 percent of water and 10 to 15 percent of large animal manure. The fuel has the characteristics that: firstly, heat value is increased remarkably and unit heat value is up to 5,000 kilocalories; secondly, burning point is lowered greatly; thirdly, due to the addition of supporting materials such as the yellow mud and the like, air permeability is improved and heat utilization ratio is increased; fourthly, combustion time can be prolonged from 1.5 hours of a pure biomass fuel on average to over 3 hours; fifthly, a large number of food wastes are consumed, so that drainage oil and garbage pigs are reduced and prevented from being sold on the market; and sixthly, the pollution of the large animal manure on the environment is reduced.

An Electro Diagnostic Functional Assessment Unit (EFA-3) that is designed to wirelessly monitor muscle group activity and to provide treatment for humans and animals. The muscle groups include the body, fascial, cervical, thoracic, upper and lower extremities, lumbosacral, bladder, cardiac, and rectal. In large animals the muscle groups include torso, legs, neck and face. The EFA-3 simultaneously correlates the muscle activity EMG with cardiac activity, nerve activity, heart rate, blood flow and brain activity with range-of-motion, grip and pinch assessment and a functional assessment in humans. The EFA-3 is operated by proprietary software (78) which provides testing protocols by utilizing a set of wireless sensor(s) (14-40) that are interchangeable and rechargeable. The treatment includes ultrasound, heat, cold, massage and electrical stimulation.

A freestanding enclosure for temporarily retaining large animals has a frame including four upstanding corner posts with a plurality of vertical posts horizontally spaced between each upstanding corner post. A plurality of horizontal cross rails are vertically spaced and extend between each upstanding corner post and vertical post to form an area of retention. Connectors releasably secure the horizontal cross rails to the upstanding corner posts and vertical posts such that the enclosure can be easily assembled, disassembled, transported and stored. A plurality of panels block the openings formed in the frame. A door provides access with the area of retention.

The invention is a device, and a method of using the device, for securing an intermedullary (IM) orthopedic nail within a fractured long bone of a human or large animal. The nail is provided with a plurality of target apertures, a portion of which are located above and below the fracture point of the bone. The device further comprises a jig adapted to be securely affixed to the IM nail, the jig having proximal and distal target arms, each having a plurality of apertures adapted to align with the target apertures. When properly secured, the apertures of the jig align with the target apertures of the nail, and alignment devices are provided to accurately drill variable diameter holes through the bone cortex at the target apertures. A leading end of the slot finder is provided with a cross-sectional geometry substantially identical to the cross-sectional geometry of the target apertures, and enables the surgeon to be sure the slot finder is in the target aperture of the nail. The surgeon is assured that he has accurately located the target aperture because the rotational movement of the slot finder is limited to a maximum of about 20 degrees because of the securement of the leading end within the target aperture. The slot finder is further provided with a bearing surface that prevents further insertion of the slot finder within the target aperture, further providing the surgeon with assurance of the proper location of the slot finder. A unique screw secures the nail in place; the screw is provided with a larger, diameter threaded portion and a smaller diameter threaded portion. A further aspect of the invention is an apparatus for forcibly removing the nail from the bone.

The invention discloses a plastic-stone gecko cave device for preventing mosquitoes and flies in gardens, comprising plastic and stones, an enclosure, a cave opening, a passage, a lying cave and a spawning station. The device is characterized in that the lying cave is arranged at the upper part while the cave opening is arranged at the lower part of the device, which prevents the gecko cave from rain and wind; the cave opening, the passage and the lying cave in the enclosure are communicated with each other and take the shape of a seam which only allows gecko to resident and spawn while large animals such as cat and mouse and so on are prevented from invading. By adopting the idea, a bat cave device for preventing mosquitoes is designed. The invention has rational design, labor-saving maintenance and no energy consumption and no pollution and is applicable to be arranged in residential areas or interested places, and can make use of bat and gecko to prey mosquitoes and flies combined with artificial stocking technology to lead to propagation of bat and gecko, thereby establishing good residential or travel environments without mosquitoes or flies spreading diseases. The invention can also be applied in controlling harm to fruits and vegetables caused by the armyworm larvae.

The invention relates to model systems for allergic conditions, and in particular to in vivo model systems in a large animal. The model systems of the invention are especially useful for providing large numbers of activated or non-activated eosinophils, for the discovery and evaluation of novel anti-inflammatory drug targets and for providing a model for the in vivo study of asthma and the effects of allergy treatments. In a preferred embodiment the animal is a sheep. In one embodiment, repeated infusion of house dust mite allergen (HDM) into the mammary gland is used to induce a specific allergic response, which is characterised by the recruitment of inflammatory cells, particularly eosinophils, into the mammary lumen; these cells can be harvested from peripheral blood and mammary lavage (MAL). In a second embodiment, the mammal is immunised with soluble antigen, for example by repeated subcutaneous immunisation, and then subjected to a single challenge with the same antigen administered directly to the lung.

The invention relates to a method for improving water quality of a steep-slope river by drop-aeration. The invention comprises the following steps: driving wood piles at two sides of a river channel, backfilling a mixture of crushed stones and soil into a riverbed between a revetment and the piles, covering vegetation to form a plant platform, pouring a trapezoid concrete pier across the river channel to form a overflow weir, and stacking block stones on the overflow weir, wherein the block stones are divided into two sides; the side with higher block stones has small gaps, and the side with lower block stones has large gaps. The invention solves the defects that existing river treatment method results in the loss of deep pools and shoals in natural rivers; primary producers such as various phytoplankton and zooplankton can not reproduce; and benthic and large animals which eat them can not inhabit the river. The invention has low cost, and good permeability, can provide aquatic animals and plants with habitat space, can form a multi-flow changing zone, a multi-organism growing zone, and a multi-fish hideout, has good drop-aeration effect, and can reduce soil loss.

The invention provides a system for respiratory pharmacology test and a chamber device that enables respiratory pharmacology test on particular large animals under unanesthetized, unrestrained state, with easy acclimatization and reduced effect of stress, and a method for conducting safety pharmacology studies on the same large animal individual. The chamber device of the invention includes animal cage 10 and transparent chamber 20, which includes first and second compartments 21 and 22 separated by partition plate 23. The compartment 21 has a door and ventilation connection port 26, and the compartments 21 and 22 are provided with communication pipe 29 having opening 29a for introducing ambient air. The device of the invention has ventilation connection port 26 in a side face of the chamber 20, and communication pipe 29 for introducing air on the top face of the chamber 20, so that, with the cage 10 placed in the compartment 21, air flow through the compartment 21 is maintained constantly and allowed to communicate through the cage 10.

The present invention relates to a cushion device for supporting a large animal such as a cow, a horse, a buffalo, a sheep, a goat, a pig and so forth. The cushioning device includes a top and bottom surface interconnected by a ‘drop stitch’ structure and a chamber. Contained within the chamber of the cushioning device is a filling material. The filling material includes a gaseous compound, a liquid or a mixture of a gaseous compound and a liquid. Additionally, the present invention also relates to the methods of transporting and installing the cushioning device. The device is shipped to the installation site absent the filling material. During installation a controlled mixture of dual phase fluids such as water and inert gas are disposed into the cushioning device, creating a gelatinous and gaseous filling material.

A hyperbaric oxygen chamber for treatment of large animals such as horses is disclosed. The chamber is large enough for a horse to fit inside and comfortably move around. A specially designed davit door, though quite heavy, is easily manipulated and may be used to corral the horse during ingress or egress, and is serviceable using fluorocarbon lubricants. The door, sidewalls, and floor of the hyperbaric chamber are coated with a static dissipative polyurethane material suitable for oxygen environments and may protect the horse from injury and prevent sparks. The flooring is specially designed to allow the horse to eliminate during treatment, and may be cleaned easily and thoroughly without disassembly. The control mechanisms of the hyperbaric chamber include electro-pneumatic controls, for avoiding a fire hazard.

The invention provides an ultrasound monitoring and targeted controlled release system and belongs to the technical field of ultrasound molecular imaging. The ultrasound monitoring and targeted controlled release system can solve the problem that precise targeted controlled release of medicines or genes cannot be achieved through an existing ultrasound imaging device. The ultrasound monitoring and targeted controlled release system comprises an ultrasound monitoring unit for forming an image of a to-be-treated part, an ultrasound triggering unit for utilizing focusing ultrasound waves to trigger microbubbles of an ultrasound contrast agent where the medicines or the genes are loaded and an image analysis unit for analyzing the image collected by the ultrasound monitoring unit, wherein the ultrasound monitoring unit comprises an ultrasound monitoring probe for sending out the ultrasonic waves; and the ultrasound triggering unit comprises an ultrasound triggering probe for sending out focusing ultrasound waves. The center of the ultrasound triggering probe is provided with a hole path and the ultrasound monitoring probe is fixedly integrated in the hole path. The ultrasound monitoring and targeted controlled release system can be used for treatment and research of ultrasound molecular imaging of small animals and large animals.