163 results about "Catalytic hydrolysis" patented technology

The invention discloses a phenanthridine-6-formaldehyde derivative and a preparation method and application thereof.The preparation method comprises the steps that 2, 4, 5, 6-tetra (9-carbazolyl)-isophthalonitrile serves as a photocatalyst, 1-azabicyclo [2.2. 2] octane serves as a hydrogen atom transfer catalyst, a biphenyl isocyanide compound, the photocatalyst, the hydrogen atom transfer catalyst and an alkali additive are jointly dissolved in 1, 3-dioxolane, the mixture is stirred to be uniform, and the phenanthridine-6-formaldehyde derivative is obtained. And carrying out free radical tandem cyclization and acid-catalyzed hydrolysis reaction to obtain the phenanthridine-6-formaldehyde derivative. The invention also provides a specific reaction equation. According to the developed synthesis method of the phenanthridine-6-formaldehyde derivative, the compound can be efficiently and conveniently prepared, the technical bottlenecks of harsh reaction conditions and tedious steps in a traditional process are successfully overcome, raw materials which are low in price and easy to obtain are adopted, operation is carried out under mild conditions, the synthesis method has the outstanding advantages of being high in yield, safe and simple to operate, environmentally friendly and the like, and the method is suitable for industrial production. Good industrial application potential is shown.

The invention belongs to the technical field of analytical chemistry and pesticide residue detection, and relates to a phosphate hydrolysis nano-enzyme sensing array-based p-nitrophenol pesticide identification and detection method, which comprises the following steps of: performing five groups of parallel data matrixes on each type of p-nitrophenol pesticide to distinguish single / five types of p-nitrophenol pesticides with different concentrations; establishing a discrimination model of different concentrations / types of pesticides by using the data matrix, and obtaining an HCA map and an LDA score map of the p-nitrophenol pesticides through hierarchical clustering analysis and linear discriminant analysis; after the absorbance value of the sample to be detected is measured, the sample to be detected can be identified and detected through comparison. According to the present invention, by using the inherent dynamic difference existing during the catalytic hydrolysis of different p-nitrophenol pesticides by CeO2, a plurality of reaction time points are selected to measure the absorbance change, the time-resolved sensing array fingerprint is constructed, and the type identification and the concentration quantification of a variety of p-nitrophenol pesticides and the mixture thereof are achieved by combining the pattern identification algorithm, such that the sensitivity is high, and the detection result is accurate. The measurable concentration range is 1-50 mu g / mL.

The invention discloses a composite fluorine removal agent and a preparation method thereof, and belongs to the technical field of water treatment. The preparation method of the composite fluorine removal agent comprises the following steps: dipping biomass charcoal in a lanthanum-containing solution, and calcining to obtain a La2O3 / charcoal carrier; the La2O3 / carbon carrier, nano-hydroxyapatite, MgO and magnetic Fe3O4 particles are mixed and then subjected to heat treatment, and a composite material is obtained; mixing the composite material, tetraethoxysilane and a solvent, dropwise adding ammonia water into the mixture for catalytic hydrolysis, and then annealing to obtain a SiO2-coated composite material; and mixing and granulating the SiO2 coated composite material and a binder, and then activating to obtain the composite fluorine removal agent. The method realizes the preparation of the composite fluorine removal agent which is wide in pH application range, can be recycled and can be suitable for efficient treatment of low-concentration fluorine wastewater.

The invention discloses a construction method and application of an electrochemical luminescence (ECL) biosensor based on a cell membrane hydrogel antifouling interface, and belongs to the technical fields of photo / electrochemical analysis, interface antifouling and biosensing. According to the invention, the cell membrane hydrogel is used as an efficient antifouling interface, so that non-specific adsorption of interfering proteins in a sample to be detected is hindered, and the service life of the biosensor is prolonged. Meanwhile, a luminophor copper nanosheet and a quencher MnO2 nanosheet are both introduced into the cell membrane hydrogel, in the presence of alkaline phosphatase (ALP), L-ascorbic acid-2-trisodium phosphate is catalyzed and hydrolyzed into ascorbic acid, and then MnO2 is reduced to recover ECL emission of the copper nanosheet. Therefore, the ECL signal of the biosensor is in a rising trend along with the rising of the ALP concentration. Based on this, the constructed ECL biosensor realizes sensitive detection of ALP, the linear range is 10 <-5 >-10 < 4 > U / L, and the detection limit is as low as 3.4 * 10 <-6 > U / L, which indicates that the ECL biosensor has potential application in clinical diagnosis.

The invention relates to a method for reducing the anaphylaxis of natural latex by multi-enzyme cascade catalysis of rubber protein. The invention relates to the technical field of catalysis of rubber protein hydrolysis, in particular to a method for reducing the anaphylaxis of natural latex by thoroughly hydrolyzing rubber protein through multi-enzyme cascade catalysis. The method for reducing the anaphylaxis of the natural latex by catalyzing the rubber protein through the synergistic effect of multiple enzymes from the perspective of industrial production comprises the following steps: adding an enzyme A and an enzyme B into the natural latex for reaction so as to reduce the anaphylaxis of the natural latex, the enzyme A is alkaline protease; and the B enzyme is at least one of aminopeptidase, carboxypeptidase B, carboxypeptidase A and carboxypeptidase Y. According to the method disclosed by the invention, the enzyme A-endopeptidase and the enzyme B-exopeptidase are subjected to multi-enzyme-stage combined treatment and concerted catalysis, so that the enzyme A-endopeptidase and the enzyme B-exopeptidase are completely hydrolyzed or are completely hydrolyzed into more amino acid substances and short-chain peptides (oligopeptides) as far as possible, and the amino acid substances and the short-chain peptides (oligopeptides) are retained in latex. Protein is highly hydrolyzed into amino acid with higher safety, so that the possibility of I-type anaphylactic reaction caused by protein allergens is greatly reduced or even eliminated.

The invention discloses a gamma-glutamyl transpeptidase catalytic hydrolysis induced charge upset polymer, which contains a gamma-glutamyl transpeptidase response element part and a fluorescent probe corresponding fragment part, the invention also discloses a preparation method of the polymer for turning charge by catalytic hydrolysis of gamma-glutamyltranspeptidase and an application method of the polymer in the field of tumor imaging. According to the present invention, the gamma-glutamyltranspeptidase catalytic hydrolysis electric charge overturning polymer is adopted as the response type tumor imaging probe, such that the electric charge can be converted from the negative or neutral state to the positive state so as to achieve the rapid uptake of the positively charged polymer by the tumor cells so as to achieve the rapid spraying imaging, and the probe response after the uptake is adopted so as to achieve the rapid spraying imaging; the imaging effect of the probe on the tumor is greatly improved, and the probe has important significance in solid tumor imaging for assisting a doctor in surgical resection.

The invention relates to the technical field of wastewater treatment, and discloses a modular electro-catalytic hydrolytic acidification reaction device and a wastewater treatment method. The modularized electro-catalysis hydrolytic acidification reaction device comprises a hydrolytic acidification area, an electro-catalysis area, a backflow system and a solar power supply system, the backflow system comprises a backflow pipe and a backflow channel, outlet water of the hydrolytic acidification area flows into the electro-catalysis area through the backflow pipe, and outlet water at the tail end of the electro-catalysis area flows into the hydrolytic acidification area through the backflow channel, the electro-catalysis area comprises a plurality of electro-catalysis modules which are electrically connected, each electro-catalysis module comprises an electrode assembly and an aeration device, each electro-catalysis module is divided into a micro-aerobic area and an anoxic area, and the micro-aerobic areas and the anoxic areas are alternately and continuously arranged. When the reaction device is used for treating wastewater, the function of synchronous nitrification and denitrification efficient nitrogen removal can be realized, the organic matter removal efficiency in the hydrolytic acidification stage is improved, and the biodegradability of sewage is enhanced.

The present application relates to a kind of anti-poisoning catalyst for blast furnace gas organic sulfur hydrolysis and its preparation method.Each component is as follows in percentage by weight: active component K2CO3 4-12%;Active component Cs2CO3 2-5%;Catalyst aid MoO3 3-8%;Catalyst aid La2O3 0.5-2%;Molding aid SiO2 1-5%;And composite metal oxide carrier Al2O3-TiO2 68-89.5%, the pore size of the composite metal oxide carrier Al2O3-TiO2 is three channel distribution.First, composite metal oxide carrier is prepared, and after being formed with silicon dioxide, active component and catalyst aid are impregnated to prepare catalyst.The catalyst prepared by the present application has excellent catalytic hydrolysis activity for organic sulfur in blast furnace gas, and has anti-sulfur, anti-chlorine and anti-oxygen poisoning performance and has persistent catalytic oxidation activity.

The invention relates to a catalytic hydrolysis method of waste epoxy resin, which comprises the following steps: putting the waste epoxy resin into a reaction kettle, adding ultrapure water, adding a small amount of sodium dodecyl diphenyl ether disulfonate surfactant and a boron trifluoride acetic acid catalyst, and carrying out hydrolysis reaction to realize catalytic degradation of the epoxy resin. Degradation products can be converted into epoxy monomers and anhydride monomers, so that cyclic utilization is realized. Compared with the prior art, the degradation method provided by the invention is not only green and safe, but also high in degradation efficiency, solves the problem that the waste epoxy resin cannot be recycled, saves resources, meets the green development requirement, and has practical engineering application value.

The present application relates to the field of treatment of biomass organic waste for efficient resource recovery, and in particular to a treatment method for biomass organic waste and a water-soluble organic fertilizer obtained therefrom. The treatment method for biomass organic waste includes crushing the biomass organic waste, adding a catalyst made from various metal compounds, heating the mixture to 140℃ to 160℃, and applying a pressure of 0.8 MPa to 1.4 MPa, followed by a catalytic hydrolysis reaction for 30 min to 60 min to obtain small molecule organic compounds; and adding mineral elements into the obtained small molecule organic compounds, and obtaining a water-soluble organic fertilizer through ultrasonic chelation. The method can efficiently, safely, and cost-effectively process biomass organic waste, and can also produce a water-soluble organic fertilizer that is beneficial for plant growth.

The invention discloses a method for catalyzing hydrolysis of hexafluorophosphate radicals by using a bifunctional solid acid material, the main active sites of the bifunctional solid acid material in the method are a Brnsted acid site formed by combining protonated sulfate radicals (HSO4 <->) with hydroxyl groups on the surface of TiO2 and a Ti < 4 + > (Lewis acid) site enhanced by induction of the Brnsted acid site, and in the catalytic hydrolysis process, the Brnsted acid site and the Ti4 < + > (Lewis acid) site can be used for catalyzing hydrolysis of the hexafluorophosphate radicals by using the bifunctional solid acid material. Ti4 < + > (Lewis acid site) generates strong adsorption and activation effects on PF6 <->, adjacent HSO4 <-> (Brnsted acid site) and PF6 <-> generate H.. F-P interaction, and the two sites apply a synergistic stretching effect on a P-F bond from different directions, so that a stable regular octahedron structure of PF6 <-> is greatly damaged, a reaction energy barrier of P-F bond breakage is remarkably reduced, efficient hydrolysis of PF6 <-> is realized, and the reaction time is shortened. The method has the advantages that the hydrolysis efficiency is high, the hydrothermal stability is good, extreme acid and alkali environments are not needed, the bifunctional catalyst is easy to regenerate and the like, and a brand new technical path and a solution are provided for harmless treatment of the hexafluorophosphoric acid-containing wastewater.

This invention proposes a method for synthesizing glyoxylic acid from methyl glycolate. Using methyl glycolate and oxygen / water as raw materials, glyoxylic acid is produced in a one-step process. This invention employs a novel catalyst based on ZSM-5 molecular sieve, modified with transition metals and organic bases, and finally extruded into strips. This catalyst can catalyze both oxidation and hydrolysis. This route is characterized by its simplicity, high reactivity, and high catalytic selectivity, making it a green route for glyoxylic acid synthesis.

The invention provides a transformer oil acetylene degassing-free detection method and system based on click chemistry, and relates to the technical field of gas detection analysis, a first product generated by a first click chemical reaction and a second product generated by a second click chemical reaction are used as catalysts to trigger a subsequent same cascade chemical amplification reaction, and the detection result is accurate. A single product molecule can catalytically hydrolyze a large number of acid-sensitive substrates, the conductivity of a mixed solution is obvious and can be measured and changed, accurate detection of acetylene with extremely low concentration is realized, and meanwhile, acetylene detection is calculated by utilizing a second click chemical reaction synchronously generated by an internal standard reagent and a triggering agent and independent of an acetylene concentration detection process, so that the accuracy of acetylene detection is improved. According to the method, the signal ratio is obtained by calculating the ratio of the first electric signal value to the second electric signal value instead of the single first electric signal value, interference factors are offset, online self-correction of acetylene detection is realized, and high consistency and accuracy of detection results under different times and different batches of reagents are ensured.

The present application belongs to the technical field of phosgene reaction tail gas treatment, and particularly relates to a phosgene tail gas alkali destruction device and method, which comprises the following steps: an operator passes the tail gas into a falling film absorber, the falling film absorber absorbs hydrochloric acid in the tail gas to obtain treated gas one; the treated gas one is passed into a catalytic hydrolysis box, a catalytic hydrolysis method is used to destroy phosgene in the treated gas one to obtain treated gas two; the treated gas two is passed into a multi-stage alkali destruction tower, 1% to 10% of a dilute alkali solution is sent into the top of the alkali destruction tower through a delivery pump, inorganic salt solution and treated gas three are generated through an acid-base reaction; the inorganic salt solution is sent to a high-salt wastewater treatment device for treatment, the treated gas three is sent to a burning device for treatment to remove unreacted carbon monoxide, organic matter and other combustible gases to obtain final gas which is discharged to the outside. The scheme solves the problem of waste caused by a large amount of generated high-salt wastewater.

A method for preparing a hydroxylamine aqueous solution by catalytic hydrolysis of cyclohexanone oxime belongs to the technical field of hydroxylamine aqueous solution preparation. Specifically, cyclohexanone oxime and deionized water are added to a hydrolysis kettle to completely dissolve the cyclohexanone oxime, and an appropriate amount of a bisphenol-based solid acid catalyst is added. The mixture is stirred, refluxed, and condensed to obtain a reaction solution containing hydroxylamine. An extractant is added to the reaction solution, and the organic phase in the reaction solution is separated to obtain cyclohexanone; the residual aqueous phase is centrifuged to obtain the product hydroxylamine aqueous solution and the bisphenol-based solid acid catalyst, respectively, and the catalyst is recovered and recycled. This method significantly improves the conversion rate of the catalytic hydrolysis of cyclohexanone oxime, has a simple process route, simple operation, mild reaction conditions, and low energy consumption, and is a green and environmentally friendly production process.

The invention discloses a gas decontamination and hydrolysis composite tank and a blast furnace gas fine desulfurization system, comprising a reaction tank body, wherein a gas inlet and a gas outlet are radially arranged on the reaction tank body, three mesh partitions are arranged inside the reaction tank body, the mesh partitions are arranged parallel to the center line of the reaction tank, and the gas flows radially along the tank body. The mesh partitions divide the interior of the reaction tank body into a gas distribution chamber, a decontamination chamber, a catalytic hydrolysis chamber and a gas collecting chamber. The gas inlet is arranged on the gas distribution chamber side of the reaction tank body, and the gas outlet is arranged on the gas collecting chamber side of the reaction tank body. A decontamination agent is placed in the decontamination chamber, and an organic catalytic converter is placed in the catalytic hydrolysis chamber. The gas enters the gas distribution chamber from the gas inlet, flows uniformly toward the decontamination chamber and the catalytic hydrolysis chamber, and is discharged through the outlet after merging in the gas collecting chamber. The gas has low resistance along the gas flow and low pressure loss, and can meet the requirements of removing harmful impurities in blast furnace flue gas and catalytically hydrolyzing organic sulfides.

The present application belongs to the technical field of fine chemical industry and water-based paint, and particularly relates to a use of adipic acid bis(1-butoxy-2-propyl) ester as a film-forming aid, a preparation method and a water-based paint composition. In view of the requirement of water-based paint for SVOC limit and the pain point that long open time and high paint film strength are difficult to be achieved simultaneously, constant azeotropic esterification is adopted to prepare non-SVOC odor-free target ester compounds. When the ester compounds are applied to water-based paint, the film-forming aid utilizes the specific large secondary methyl of the molecule to construct steric hindrance, effectively blocks the nucleophilic attack of hydroxyl ions, and solves the problem of alkaline catalytic hydrolysis of paint. The adipic acid bis(1-butoxy-2-propyl) ester has the following structure:

The invention relates to the technical field of compound synthesis, in particular to a method for directly reducing carboxylic acid into aldehyde. The preparation method comprises the following steps: mixing triphenylphosphine, dichloromethane, carboxylic acid and N-chlorosuccinimide, and reacting to obtain a reactant; mixing with pinacol borane and 4-dimethyl pyridine, and continuously reacting to obtain a continuous reactant; and separating and purifying to obtain aldehyde. The synthesis of the substrate carboxylic acid provided by the invention and the rapid deoxidation of the carboxylic acid are carried out to obtain an aldehyde product, especially the following compounds 2aa, 2ab, 2ae, 2bc, 2be, 2bf, 2bg, 2bh, 2bi, 2bj, 2bk and 2bl have catalytic hydrolysis effects on hypophosphamide; the compound 2bl has a particularly excellent effect on hydrolysis of hypophosphamide.

The invention relates to the technical field of plastics, in particular to a fiber-reinforced ABS plastic and a preparation method thereof. The fiber-reinforced ABS plastic is prepared from ABS resin, modified carbon fibers, an antioxidant and a lubricant through melt blending. Wherein the modified carbon fiber is obtained by synthesizing a compound A in a nitrogen atmosphere, performing catalytic hydrolysis on the compound A through sodium periodate and then uniformly coating the surface of the carbon fiber with the compound A. The modified carbon fiber has excellent interface compatibility with an ABS matrix, and the mechanical property and toughness of the composite material are improved. The finally prepared fiber-reinforced ABS plastic has excellent tensile strength, bending strength and impact toughness, is suitable for being applied to automobiles, electronics, electric appliances and the like with high structural and functional requirements, and has a wide industrial application prospect and a remarkable popularization value.

The application belongs to the technical field of barium compound preparation, and relates to a preparation method of nano barium sulfate. The method adopts an in-situ degradable dispersant based on a natural polysaccharide derivative, adsorbs on the surface of a barium sulfate crystal nucleus through a functional group in the reaction to inhibit agglomeration, adjusts the pH to 3.0-6.0 after the reaction is completed, and acid-catalytically hydrolyzes the dispersant into a water-soluble small molecule, so that a high-purity and high-dispersibility product can be obtained through simple water washing. The application introduces a natural polysaccharide derivative with a crystal face selective adsorption capacity and an acid-triggered degradation characteristic as an in-situ degradable dispersant, and constructs a new green preparation paradigm of nano barium sulfate with reaction-dispersion-self-cleaning integration. The method fundamentally eliminates the risk of organic impurity residue without sacrificing the dispersing performance, significantly improves the product purity and application safety, simultaneously simplifies the post-processing technology, reduces the energy consumption and wastewater treatment cost, and has both technical advancement and industrialization feasibility.

The invention discloses a method for asymmetrically synthesizing a ferruginactone II (ferruginactone II) of a cryptolepsis rusteri gather pheromone. The method comprises the following steps: by taking octyl-1-alkyne as a starting raw material, firstly, carrying out amide reaction on octyl-1-alkyne and Weinreb to prepare deca-3-alkyne-2-ketone; then, carrying out Corey-Bakshii-Shibata reduction and alkyne zipper reaction to synthesize (S)-decane-9-alkyne-2-alcohol, and carrying out a reaction on the (S)-decane-9-alkyne-2-alcohol and an alkyne zipper; then carrying out catalytic hydrogenation with NiAc2 / NaBH4 by utilizing a coupling reaction, so as to prepare (S, Z)-11-hydroxydodecane-3-olefine acid ethyl ester; and finally, carrying out catalytic hydrolysis by using lithium hydroxide, and carrying out an esterification reaction with Yamaguchi, so as to prepare the pyrethroid aggregation pheromone ferrulactone II (1). The method has the advantages of high total yield, simple synthetic route and the like.

The invention relates to the technical field of organic silicon materials, and discloses sulfydryl silicon resin, application thereof and an organic silicon pressure-sensitive adhesive, the sulfydryl silicon resin is obtained by catalyzing hydrolysis and polycondensation of an M-chain-link silane monomer, a T-chain-link silane monomer and a Q-chain-link silane monomer in an isopropanol aqueous solution of strong acid; the organic silicon pressure-sensitive adhesive is synthesized from sulfydryl silicon resin, double-end vinyl silicone oil and a free radical photoinitiator; the sulfydryl silicon resin is prepared from a silane end-capping reagent, sulfydryl silane, tetraethoxysilane and the like; a sulfydryl group is grafted to a silicon resin side chain to prepare the light-cured sulfydryl silicon resin, after light curing, the light-cured sulfydryl silicon resin can meet the application requirements of a light-cured organic silicon pressure-sensitive adhesive by utilizing a chemical reaction between sulfydryl and vinyl, and the problems of oxygen inhibition and the like existing in an acrylic acid light curing system are solved.

The invention relates to the field of biopesticides, in particular to a method for synthesizing sex pheromone of pinus tabulaeformis, which comprises the following steps: reacting 1-bromo-n-heptane (3) serving as an initial raw material with magnesium, and then reacting with (R)-epoxypropane (4) to obtain chiral alcohol 5; then reacting with paratoluensulfonyl chloride, and then reacting with dimethyl malonate to obtain malonate 7; carrying out sodium hydroxide catalytic hydrolysis and high-temperature decarboxylation to obtain an acid 8, and carrying out lithium aluminum hydride reduction and NBS bromination to obtain a chiral bromide 10; reacting with magnesium, and reacting with sulfonate 12 to obtain silyl ether 11; then carrying out TBAF deprotection to obtain chiral alcohol 13; and finally, reacting the chiral alcohol 13 with acetic acid to obtain acetic acid (2S, 3S, 7S)-3, 7-dimethyl-2-pentadecanol ester (1), and reacting the chiral alcohol 13 with propionic acid to obtain propionic acid (2S, 3S, 7S)-3, 7-dimethyl-2-pentadecanol ester (2). The method has the advantages of high total yield, low synthesis cost and the like.

The invention discloses a 3-ethyl-4-methyl-3-pyrrolin-2-one false template molecularly imprinted adsorption material for removing bilirubin as well as a preparation method and application of the 3-ethyl-4-methyl-3-pyrrolin-2-one false template molecularly imprinted adsorption material. 3-ethyl-4-methyl-3-pyrroline-2-ketone with a molecular structure similar to that of bilirubin is used as a false template molecule, 3-aminopropyltriethoxysilane is used as a functional monomer, tetraethoxysilane is used as a cross-linking agent, absolute ethyl alcohol is used as a solvent, and ultrapure water is used for catalytic hydrolysis to obtain the bilirubin fluorescent probe. A molecularly imprinted polymer adsorbent material is prepared and synthesized by using a sol-gel method; after the false template molecules in the adsorbent material are eluted, imprinted holes left in the material can specifically adsorb bilirubin molecules similar to the false template molecules in structure, so that the purpose of highly selectively adsorbing and removing the bilirubin molecules is achieved. The preparation method disclosed by the invention is simple and convenient to operate, low in cost and high in repeatability, and the 3-ethyl-4-methyl-3-pyrroline-2-one false template molecularly imprinted adsorption material has relatively high adsorption capacity, strong specificity and high biological safety.

The invention belongs to the crossing field of metal organic framework crystalline materials and chemical protection, and discloses a metal organic framework crystalline material containing an N-ethyl morpholine buffer system and a preparation method and application thereof. A carboxylic acid ligand containing an N-(2-aminoethyl) morpholine group and metal ions M < 4 + > ions (M = Zr, Hf, Ce and the like) or MO < 2 + > ions or metal clusters M6 (mu3-O) 4 (mu3-OH) 4 are assembled to prepare the crystalline porous metal organic framework material containing an N-ethylmorpholine (NEM) buffer system and having a specific topological structure (fcu, spn, csq, kgd and the like), and the crystalline porous metal organic framework material is called MOFs-NEM for short. The main representative materials comprise M-MOF-808-xNEM (M = Zr, Hf, Ce) (x = 1, 2, 3), M-UiO-66-NEM, M-UiO-67-NEM, M-UiO-68-xNEM (x = 1 and 2), M-BTB-xNEM (x = 1, 2 and 3), M-NU-1000-4NEM and the like. The MOFs-NEM meets the requirements of catalytic hydrolysis of organophosphorus ester on a high-accessibility catalytic active center and a buffer system, and realizes efficient catalytic hydrolysis of the organophosphorus ester nerve poison in a humidity environment.

This invention relates to the field of biomedical technology, specifically to the use of the N-terminal fragment of insulin-like growth factor binding protein-4 (IGF-4) in the clinical assessment of heart failure and coronary artery disease. The N-terminal fragment of IGF-4 is obtained by catalytic hydrolysis of IGF-4 by pregnancy-associated plasma protein A. Clinical assessment of heart failure includes diagnosing or assisting in the diagnosis of heart failure, or assessing or assisting in the prognostic risk of heart failure. Clinical assessment of coronary artery disease includes assessing or assisting in the prognostic risk of coronary artery disease. By detecting the content of the N-terminal fragment of IGF-4 in a sample, heart failure can be diagnosed or assisted in the diagnosis, and the prognosis of heart failure and coronary artery disease can be assessed or assisted in, demonstrating good clinical assessment efficacy.

This invention belongs to the field of pharmaceutical formulation technology and discloses a tenofovir prodrug tablet, its preparation method, and its application. The tablet is made from components comprising the following weight percentages: active pharmaceutical ingredient 2.0%-10.0%, non-hygroscopic backbone 60.0%-80.0%, mesoscopic buffer complex flow aid 2.0%-8.0%, in-situ water trap 3.0%-8.0%, and non-alkaline lubrication system 1.0%-3.0%. In this invention, the mesoscopic buffer complex flow aid is anchored around the active pharmaceutical ingredient to form a bound water buffer membrane with a uniform microenvironment pH. A solid-phase water activity gradient is formed between the in-situ water trap and this bound water buffer membrane. Driven by the chemical potential difference, free water in the system undergoes directional migration and is targeted and locked. This invention blocks the catalytic hydrolysis pathway of the active pharmaceutical ingredient under acidic and alkaline conditions, and simultaneously cuts off the hydrolysis mediator pathway caused by free water, thereby improving the chemical and physical stability of the tablet.

The invention belongs to the technical field of chemical synthesis, and discloses a method for synthesizing fatty diol from straight-chain fatty olefin through a one-pot method under catalysis of titanium silicalite molecular sieve loaded sulfate. Through metal sulfate modification, acid sites on the surface of the titanium silicalite molecular sieve are increased, so that the catalytic epoxidation function of tetra-coordinated titanium and the catalytic hydrolysis function of the acid sites have a synergistic effect, and olefin epoxidation-epoxide hydrolysis reactions are connected in series. According to the process, olefin can be almost completely converted, and the problem of raw material recovery does not need to be considered. The bifunctional catalyst is used for preparing 1, 2-pentanediol from 1-pentene through a one-pot method, the conversion rate of 1-pentene is larger than 98%, the yield of 1, 2-pentanediol is larger than 77%, intermediate separation and additional acid and alkali are not needed in the whole process, the equipment corrosion risk is reduced, the problems of environmental pollution and complex process of a traditional process are solved, and the catalyst can be recycled and reused for multiple times.

The invention discloses a method for preparing a Si (at) MOF composite hierarchical pore silicon-based negative electrode material based on a gel method, and belongs to the technical field of lithium ion battery negative electrode materials. The method specifically comprises the following steps: (1) pretreatment; (2) diatomite activation; (3) preparing an MOF precursor solution; (4) growing ZIF-8 in situ; (5) pre-dispersing; (6) catalytic hydrolysis; (7) cross-linking a polymer network; (8) aging and strengthening; (9) directional freezing; (10) gradient drying; (11) a pyrolysis procedure; (12) a zinc vapor recovery system; and (13) performing acid activation and chambering. According to the preparation method, high-valued utilization of the silicon waste is realized through bionic multilevel structure design and a green process, and a three-dimensional conductive network with macroscopic vertical pore channels, mesoscopic diatomite pores and a microcosmic ZIF-8 derived carbon cage confinement is synchronously constructed, so that the ion transmission efficiency, the structural stability and the electrochemical performance of the material are remarkably improved; meanwhile, hydrofluoric acid and other high-risk reagents are avoided, and environmental and safety risks are reduced.

The invention relates to the technical field of papermaking, and provides paper containing a composite reinforcing material and a preparation method of the paper. The preparation method comprises the following steps: S100, adding a silane precursor and an acid catalyst into a solvent, and adding silicon dioxide nanoparticles to obtain composite nano sol; s200, dispersing the paper pulp in water to form slurry, and adding a reinforcing agent and an inorganic filler into the slurry to obtain fiber slurry; s300, carrying out net forming, squeezing and preliminary drying treatment on the fiber pulp to obtain a paper base material; s400, coating the surface of the paper substrate with silane hydrolysate to form a silane bonding layer; and coating the composite nano sol on the surface of the silane bonding layer to obtain the paper. The silane precursor is catalyzed and hydrolyzed by acid to generate active silanol, the nano silicon dioxide sol is introduced, condensation of silanol, hydroxyl on the surface of the fiber and nano silicon dioxide is promoted through heat treatment, a composite reinforced layer is formed, and therefore the mechanical strength, surface smoothness, water resistance and printability of the paper are improved.