The invention relates to a process for preparing sec-butyl acetate, with product separation and reclamation technology, which is characterized in that the reaction is processed in one catalysis distillation column composed of a column reactor, an exhausting section, a reaction section, a distillation section, and a column top reflux condenser, wherein the reaction section is filled with catalyst,acetic acid and mixture C4 or butene which are reversely contacted and reacted on the surface of catalyst, the non-reacted mixture C4 or butene is evaporated out from the top of the catalyst distillation column, the product mixture is fed into an azeotropic distillation column, added with an entrainer a which can form azeotropic material with sec-butyl acetate, the distillate at the top of the azeotropic distillation column is fed into a treating column, to be distilled to obtain sec-butyl acetate, and the fraction at the lower portion of the azeotropic distillation column, is fed into an acidconcentrating tower, added with an entrainer b which can form azeotropic material with the entrainer a, to process azeotropic distillation to be circulated and feedback to the reaction system. The invention has the advantages of simplified separation, low cost, low energy consumption, high material utilization and the like.