The application provides a method for separating and purifying medical Pb-212 from natural Th-232 and
daughter nuclides thereof, and belongs to the field of medical
isotope preparation. The method comprises the following steps: obtaining a Th-232 acid solution; providing a first
chromatographic column, performing one-dimensional lead enrichment on the Th-232 acid solution, and obtaining a Pb-212 crude liquid; providing a second
chromatographic column, performing two-dimensional refining separation on the Pb-212 crude liquid, and obtaining a Pb-212 purified liquid; providing a third
chromatographic column, performing three-dimensional concentration and salt conversion on the Pb-212 purified liquid, and obtaining high-purity and high-concentration Pb-212; the first chromatographic column is filled with coated resin as a
stationary phase, and the coated resin is a
polymer microsphere coated with a
crown ether compound; the second chromatographic column is filled with a cation exchange material as a
stationary phase; and the third chromatographic column is filled with a three-dimensional cation exchange resin or coated resin as a
stationary phase. The application discloses a method for separating Pb-212 from natural Th-232 and
daughter nuclides thereof, and ensures high purity and
recovery rate of the Pb-212, thereby meeting the demand of medical
radioactive drug application.