Intelligent molecular blotting affinity membrane for chiral resolution and its preparation method

A technology of chiral resolution and molecular imprinting, which is applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve problems such as hindering the application of solid membranes and weakening resolution capabilities, and achieves industrial production and high processing efficiency. Quantity, the effect of simple separation process

Inactive Publication Date: 2006-06-21
李连超
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  • Summary
  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Usually one isomer can be more selectively adsorbed on the chiral selector, while the other isomer is more free in the polymer membrane. There are several preparations as follows: (1) immobilize chiral selectors, such as cyclodextrin and its derivatives, on the porous base membrane by grafting or staining (see: Kreig HM, Breytenbach J C, Keizer K, Chiralresolution by β -cyclodextrin polymer-impregnated ceramic membranes, Journal of Membrane Science, 2000, 164, 177-185), bovine serum albumin (BSA), apoenzyme and DNA, etc.; (2) Mix and dissolve cyclodextrin and other chiral selectors Using the membrane-making solution to make a non-porous polymer membrane (see Long Deyuan, Huang Tianbao, β-cyclodextrin polymer membrane for separation of amino acid enantiomers, Chemical Journal of Chinese Universities, 1999, 20: 884-886.) : (3) U

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0027] Example 1

[0028] The smart molecular imprinting chiral resolution affinity membrane in this example uses a polyvinylidene fluoride porous membrane as the base membrane, and the base membrane is formed by thermal polymerization to contain polyisopropylacrylamide chains and template molecular imprinting chiral resolution. The preparation method of the affinity membrane includes the following process steps:

[0029] 1 Treatment of base film

[0030] Wash the base film with an ethanol solution with a volume concentration of 60% and dry it to a constant weight. The drying temperature is 50°C. The dried base film is placed in a base film bottle, and the base film bottle is replaced with high-purity nitrogen. Repeat 3 times to form a high-purity nitrogen atmosphere in the base film bottle;

[0031] 2 Preparation and treatment of monomer solution

[0032] Monomer solution preparation: pass the refined methyl acrylate, acrylic acid, acrylamide, isopropyl acrylamide and other monom...

Example Embodiment

[0041] Example 2:

[0042] The smart molecular imprinting chiral resolution affinity membrane in this embodiment uses a polyvinylidene fluoride porous membrane as the base membrane, and polymerization is initiated on the pores of the base membrane or on the surface of the membrane to obtain the smart molecular imprinting chiral resolution affinity membrane. And membrane, its preparation process steps are as follows:

[0043] 1 Treatment of base film

[0044] Wash the base film with an ethanol solution with a volume concentration of 60% and dry it to a constant weight. The drying temperature is 50°C. The dried base film is placed in a base film bottle, and the base film bottle is replaced with high-purity nitrogen. Repeat 3 times to form a high-purity nitrogen atmosphere in the base film bottle;

[0045] 2 Preparation and treatment of monomer solution

[0046] Monomer solution preparation: pass the refined methyl acrylate, acrylic acid, acrylamide, isopropyl acrylamide and other mo...

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Abstract

The present invention is chiral resolving affinity membrane for resolving, concentrating and separating chiral molecules and its preparation process. The present invention prepares temperature sensitive intelligent chiral resolving affinity membrane with porous inorganic or organic membrane as base membrane, and through heating polymerization or UV initiated polymerization of acrylate, acrylic acid, acrylamine, diacrylamine, isopropyl acrylamine, initiator and template molecule solution inside the pores and on the surface of the base membrane, and subsequent washing off the template molecule via altering the temperature. The preparation process includes the steps of: base membrane treatment, compounding monomer solution, polymerization and eliminating template. The intelligent chiral resolving affinity membrane has simple separation process, high chiral resolving capacity, high treating amount and no selectivity.

Description

1. Technical field [0001] The invention belongs to the field of membrane separation technology for splitting chiral molecules, and in particular relates to the preparation of an intelligent molecule imprinted chiral splitting affinity membrane. 2. Background technology [0002] Separation membrane is a high-efficiency and energy-saving separation material with broad application prospects. Membrane chiral separation is a new research hotspot that has been vigorously developed at home and abroad in recent years. Membrane-based chiral separation technology has both resolution and large-scale processing capabilities, and will play an important role in the separation of chiral molecules such as medicine, spices, biochemical reagents, and food additives. [0003] Membrane separation Membrane technology to split chiral molecules mainly includes liquid membrane method, solid membrane method and membrane reactor method. Due to the disadvantages of poor stability of chiral liquid me...

Claims

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Application Information

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IPC IPC(8): B01D71/40
Inventor 李连超邓玉林王保国张治
Owner 李连超
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