194results about How to "Address toxicity" patented technology

Pharmaceutical compositions for oral-transmucosally administering methadone. For oral transmucosal delivery, the compositions comprise an oral dissolution agent and methadone in a dosage formulation. The dissolution agent generally causes the formulation to break down or dissolve in the oral cavity. The formulation is buffered to a pH of at least 6 for substantial absorption of the methadone through the oral mucosal tissue from the dissolved dosage form.

The invention relates to drug-loading nano-micelles, and a preparation method and an application thereof. According to the to drug-loading nano-micelles, a polyethylene glycol derivative-polylysine-polyleucine amphiphilic triblock copolymer is adopted as a carrier, and self-assembly is carried out in a water solution, such that nano-micelles with a three-layer structure transferring gene and medicine are formed. With the hydrophobic effect between polyleucine, the copolymer forms a core of the micelles in water, such that a hydrophobic medicine docetaxel is entrapped. With polylysine, the nano-micelles are positively charged, such that negatively charged anti-apoptotic protein small interfering RNA can be bonded. Polyethylene glycol is used for protecting the stability of the nano-micelles loading the medicines and gene, and a cycle time of the nano-micelles in vivo is prolonged. The nano-micelles are used for loading both an anti-apoptotic protein small interfering RNA gene medicine and a docetaxel medicine, such that the gene treatment medicine and the chemotherapeutic medicine cooperates in treating cancer, and a synergetic effect of the two medicines can be developed. Therefore, a direction is provided for better treatment of breast cancer.

The invention discloses a method for preparing three-dimensional silk fibroin porous scaffold material, and relates to the field of biomaterial, in particular to the field of tissue engineering scaffolds. The method comprises: putting silk fibroin water solution with the volume concentration of 2-50wt% into a container, and adding sodium chloride into the silk fibroin water solution at 20-80 DEG C under continuous stirring, wherein the ratio between the mass (unit: gram) of sodium chloride granules and the volume (unit: ml) of silk fibroin solution is 1-20:1; after gelatinating, standing and precipitating the silk fibroin solution, taking out the precipitate to be continuously stirred and evenly mixed; then, putting the precipitate into a mould with the needed shape to be dried; finally, washing off the sodium chloride in the scaffold by distilled water, and obtaining the silk fibroin porous scaffold material having three-dimensional porous structure. No organic solvent is used in themethod, the method is simple and efficient, and the prepared silk fibroin porous scaffold has controllable porosity factor and pore size, highly communicated pore structure as well as degradability.

The invention relates to a curing agent, namely, 4, 4 (1)-diphenylmethane diisocyanate prepolymer and a preparation method thereof. The method comprises the steps that molten 4, 4(1)-MDI and an organic solvent are added into a reaction vessel, and stirred uniformly, the temperature is raised to 65 DEG C, polyhydric alcohol dehydrated through evacuation is added, to react for 2 to 4 hours at 60 to 100 DEG C, and then an MDI modifier is produced; when being stirred, the mixed liquor of trimethylol propane and the organic solvent is titrated into the reaction vessel for 1 to 4 hour(s), the titration temperature is 60 to 100 DEG C, heat preservation and reaction are performed for 1 to 3 hour(s), then the temperature is raised to 90 to 100 DEG C and the heat preservation and the reaction are performed again for 1 to 4 hour(s), the temperature is reduced, and the organic solvent is added for dilution to appropriate viscosity. The curing agent has the advantages that the application scope is broad, the molecular structure of the polyhydric alcohol can be adjusted according to the requirements of users to produce the prepolymer of polyurethane coating, adhesive, and the curing agent, the storage stability is good, the curing speed is quick, the toxicity is low, the price is low, products with high solid content can be obtained, etc.

A process for preparing trichlorosucrose-6-ester by solid-state phosgene chlorinating includes dissolving solid phosgene in inertial solvent, slowly dropping it in the solution of sucrose-6-ester in dimethyl formamide, stirring, heating while reaction, alkali solution neutralizing, distilling to remove solvent, dissolving in water, decoloring by activated carbon, extracting in organic solvent and crystallizing.

The invention relates to a protein self-assembled novel nanovaccine and a preparation method thereof. The protein self-assembled novel nanovaccine is prepared on the basis of antigen protein self-assembly; in the process of vaccine preparation, a molecular adjuvant is selectively introduced, the antigen content is higher than or equal to 85%, a high-efficiency immune effect can be triggered without needing assistance of an aluminum adjuvant, a Freund's adjuvant and the like, mercapto groups between protein molecules are exposed by virtue of physical regulation and control, and stable protein nanoparticles mainly based on disulfide bond crosslinking are formed through a mercapto/disulfide bond exchange reaction. The defects that the conventional nanovaccine needs to be introduced with an exogenous carrier or a cross-linking agent and the like are overcome, and the immune effect and the biosafety of the vaccine can be improved at the same time; the obtained vaccine granules are tidy in morphology, high in stability, flexible in regulation and control mode and good in repeatability, and can effectively stimulate dendritic cell maturation; the protein self-assembled novel nanovaccine has relatively strong generality and universality, is verified in a series of antigen proteins, and has a potential significant application value in the fields of novel vaccinating methods and biological pharmacy.

The invention relates to the field of synthetic production of cosmetics and aims to provide strippable water-based non-irritation nail polish. The strippable water-based non-irritation nail polish comprises deionized water, water-soluble modified polyurethane, chitosan, a wetting agent, a dispersing agent, an antifoaming agent, a rheological agent, water-soluble environment-friendly color paste and other additives. Water is used as a solvent, and no or only a small amount of absolute ethyl alcohol is added to be used as an additive, so that the nail polish has no paint smell of traditional oil-soluble nail polish or alcohol smell of alcohol-soluble nail polish and contains no alkali-associative thickener, and the whole nail polish system is neutral and causes no damage to the skin, nails and clothes.

The invention relates to a nano-fibrosis silk fibroin gel and a preparation method of the nano-fibrosis silk fibroin gel. Silk is degummed and then dissolved in salt-formic acid to obtain a silk fibroin solution; a silk fibroin-salt-formic acid solution is injected into a mould; the mould placed with the silk fibroin solution is immersed in an organic solvent or an aqueous solution, and stood for a certain time to form the silk fibroin gel. The preparation method disclosed by the invention is simple in preparation method, short in process, convenient to operate and easy for realization of batch production. The silk fibroin gel prepared by the invention has a natural bionic nanometer fibrillar structure, and is adjustable in mechanical properties and good in biocompatibility.

The invention belongs to the technical field of preparation of medicines and in particular relates to a preparation method of ceftiofur acid long-acting injection. The preparation method comprises the followings steps of: adding ceftiofur acid and 2-hydroxypropyl-beta-cyclodextrin in a molar ratio of 1:(1-2) to a ball mill for uniformly mixing; sufficiently grinding under the room temperature, and sufficiently uniformly and sieving to obtain a ceftiofur acid clathrate compound; dissolving sodium alginate in sterile water and adding poloxamer 407 and poloxamer 188, storing for 12-24 hours under the temperature condition of 4 DEG C, so that the poloxamer 407 and the poloxamer 188 are completely dissolved and sterilized under the temperature of 121 DEG C, carrying out ice-bath cooling to obtain a transparent solution; magnetically stirring under the temperature condition of 4 DEG C and the rotation speed condition of 150r/min; adding the ceftiofur acid clathrate compound in a weight ratio of the sodium alginate to the ceftiofur acid clathrate compound of (0.1-0.3):(5-10), so that the ceftiofur acid clathrate compound is sufficiently dispersed uniformly to obtain the ceftiofur acid long-acting injection. According to the preparation method of the ceftiofur acid long-acting injection, the preparation process is simple, the product intramuscular injection half-life period is long, the dissolution degree of the ceftiofur acid is high, the production and treatment cost is low, the cure rate is high and the environment is friendly.

The invention discloses a separating liquid of lymphocyte with Iodixanol density at 14.0-17.5%, which comprises the following steps: grinding the separated liquid of spleen; making single-cell suspension; centrifuging.

The invention discloses a multi-glycol epoxy derivative cross-linked sodium hyaluronate gel used for injection and a preparation method thereof. The multi-glycol epoxy derivative is preferably a compound with a single molecular weight, multiple ether bonds exist in the molecule, the compound is good in water solubility and can generate cross-linking reaction with polysaccharide more easily, and because the quantity of multi-glycol repeating units is easy to adjust and the length is relatively easy to control, the performance of sodium hyaluronate gel prepared as a cross-linking agent is relatively easy to regulate; and the cross-linked sodium hyaluronate gel is low in toxicity, less in residue, weak in extruding thrust, good in moulding property, good in enzyme resistance and long in retaining time in the body. The invention further discloses a mild cross-linking agent inactivation technology, unreacted epoxy group in the gel undergoes hydrolysis reaction in a carbonate buffer system with pH of 8-9, so as to effectively reduce the difficulty in impurity removal of cross-linked sodium hyaluronate gel and avoid the problem of toxicity of BDDE used in a cross-linking method of the prior art.

A preparation method of self-adhesive conductive hydrogel used as an electrode comprises the following steps: firstly, polyphenol, derivatives of polyphenol and a conductive polymer monomer are dissolved in an ethanol solvent, an oxidizing agent is added for oxidative polymerization, and conductive nanoparticles are prepared; a natural polymer is grafted with polyphenol and derivatives of polyphenol, the prepared polyphenol-doped conductive nanoparticles are added, and a polyphenol and derivative-natural polymer-conductive nanoparticle redox dynamic balance system is formed again; finally, monomer molecules and an initiator form an initiating system through a crosslinking agent and quinone-phenol in polyphenol and derivatives of polyphenol to be polymerized into gel. The conductive hydrogel prepared from the multiple redox doping system has good conductivity; natural polymer chains and synthesized polymer chains entangle each other, so that a gel matrix has good mechanical performance,besides, anionic groups in the natural polymer can perform ionic bonding on metal ions, the mechanical strength can be enhanced, and conductivity can be further enhanced.

The invention discloses a preparation method of amylose-coated I3<->-complexed silver-coated iron composite nanoparticles, which comprises the following steps: synthesizing silver-coated iron nanoparticles, coating amylose on the nanoparticles, and complexing the I3<-> into the amylose molecular spiral structure to finally form the composite magnetic silver nanoparticles. By designing and synthesizing the silver-coated iron composite nanoparticles, the invention solves the problem of targeted entry of silver; by coating the starch on the nano silver, the invention solves the problems of toxicity and stability in the nano silver; by complexing the iodine ions with the amylose, the invention solves the problem of introduction of iodine; under the magnetocaloric effect, the invention solves the problem of release of iodine complex ions; by using the specific fusion action of the iodine complex ions on the nano silver, the invention solves the problem of release of silver ions in the nano silver; and by generating the silver iodide, the invention solves the problem of removal of in-vivo silver ions. Meanwhile, the designed system can comprehensively utilize the thermotherapeutic benefit of magnetic particles as well as the broad spectrum and efficient sterilization characteristics of the silver.

The invention discloses a monomer containing a benzimide phenylacetylene structure. The monomer can enable self-crosslinking chemical reaction of a synthesized polymer under high temperature. The monomer containing a benzimide phenylacetylene structure and the structural units represented by I and II for synthesis of polyester can undergo random copolymerization to obtain high temperature self-crosslinked copolyester, and when the copolyester contains a PET structural unit, the characteristic viscosity number [eta] is 0.44-1.38dL/g, the vertical combustion UL-94 grade is from V-2 to V-0, the oxygen index LOI is 24.0-35.0%, and the cone calorimeter test peak heat release rate PHRR and the smoke release total amount are both lower than pure polyester. The invention also discloses a preparation method of the copolyester. The benzimide and phenylacetylene in the copolyester involved in the invention can generate synergistic cross-linking effect, so that the copolyester has very high flame-retardant and anti-dripping efficiency, and also the copolyester is endowed with excellent flame retardant, anti-dripping and smoke suppressing performance. The method provided by the invention is basically consistent with the synthesis method of conventional polyester, not only is mature in technology, and easy and convenient to operate, but also is easy to control and convenient for industrial production.

The invention relates to a nano composite soy protein plastic and a preparation method thereof. The nano composite soy protein plastic is prepared by the following steps: with soy isolate protein as a base material, dialdehyde polysaccharide with the aldehyde content of 5%-80% as a cross-linking agent, and amino nano clay as a nano filler, adding a plasticizer which is 10%-30% of dry weight of the soy isolate protein and a certain amount of deionized water; carrying out hot-pressing by using a hot press at 80-140 DEG C and 5-50MPa for 3-30 minutes. The nano composite soy protein plastic prepared by the method has relatively high water resistance, mechanical property and heat stability, is an environment-degradable high-strength protein plastic, and has a wide application prospect in the fields such as biological materials, foods and medicine packaging.

The invention discloses a preparation method of long raw bamboo fiber, which belongs to the technical field of vegetable fiber production, and solves the problems of low production efficiency, low yield and serious waste water pollution of the current preparation methods. The method comprises the following steps: bamboo wood slicing, high-temperature high-pressure treatment, tearing processing, enzyme processing, chemical treatment, drying, and carding processing. The obtained long raw bamboo fiber has the following characteristics that an average fiber length is 4-5 cm, fineness is no less than 100 Nm, and the yield is no less than 60%. In addition, the long raw bamboo fiber has the beneficial effects that high production efficiency (annual output of a production line is no less than 50,000 tons), waste water pollution is light, and fiber is soft.

The invention discloses a DC cell and a targeting immune cell population, and a preparation method and application thereof. The preparation method of DC cells includes the steps of: conducting first induced differentiation culture on mononuclear cells in order to obtain immature DC cells; transfecting the immature DC cells by using HSV-2 antigen mRNA, so as to obtain transfected immature DC cells; and conducting second induced differentiation culture on the transfected immature DC cells, so as to obtain mature DC cells, wherein the mononuclear cells are isolated from mononuclear cells of peripheral blood of a sample. The method can prepare DC cells safely and efficiently, has a low cost and high efficiency, and can effectively solve the problem of cytotoxicity. The method can be effectively used for immune cell treatment or stimulation of lymphocytes derived from a same patient to produce a targeting cell population containing a large amount of CTL cells, and then the cell population can be used for virus infection immunotherapy to reach better effect.

The invention discloses a preparation method of short natural bamboo fibers, pertaining to the technical field of production of plant fibers. The method comprises the following steps: slicing bamboo material, performing softening treatment, performing tearing operation, performing enzyme treatment, performing chemical treatment, performing operation with a disc mill, pre-dewatering the fibers, anddrying fibers. In order to resolve problems of an existing preparation method such as poor yield rate, heavy pollution and high cost, a spiral extruding and tearing machine replaces a conventional multi-roller grinding method. By putting biological treatment prior to chemical treatment, types of chemicals and biological enzyme are reduced. The disc mill and impinging stream drying operation replace steam drying, fiber splitting and multi-stage carding. The preparation method of short natural bamboo fibers has the following beneficial effects: high yield rate of short natural bamboo fibers, low cost and little pollution of a preparation process.

The invention provides water-borne wood paint, which comprises the following ingredients in percentage by weight: 10 to 20 parts of deionized water, 1 to 5 parts of propylene glycol, 1 to 3 parts of base association type thickening agents, 0.05 to 0.5 parts of dimethylethanolamine, 0.01 to 0.5 parts of non-silicone mineral oil system defoaming agents, 0.05 to 0.3 parts of water-borne carboxymethyl cellulose, 0.2 to 1.2 parts of ethanol, 60 to 80 parts of water-borne nanometer core-case crylic acid polymer dispersoid, 3 to 10 parts of water-borne fluorine-containing polyurethane nanometer dispersoid, 1 to 5 parts of alcohol ester twelve coalescing agents, 0.01 to 0.05 parts of fluorine flatting agents and 0.1 to 0.3 parts of anticorrosive and bacterium prevention agents. The water-borne wood paint has the advantages that the water-borne fluorine-containing polyurethane nanometer dispersoid is used as the core technology and is organically combined with water-borne auxiliaries such as the fluorine flatting agents, the problem that the wood surface cannot be easily moistened by the water-borne wood paint because the water surface tension is strong is solved, and the problems of poor paint film adhesion force, poor boiled water resistance and the like of the ordinary water-borne wood paint are solved. The invention also provides a preparation method of the water-borne wood paint at the same time.

The invention provides a polyolefin thermoplastic elastomer blended resin and a method for preparation the same. The resin is prepared through a melting and blending method and comprises the following compositions: (A) a segmented copolymer accounting for 60 to 80 percent of gross weight of which the middle part is an irregular copolymer chain segment of ethene and 1-butylene, and two ends are capped through styrene chain segments; (B) polypropylene resin accounting for 10 to 30 percent of gross weight; and (C) polyethylene resin accounting for 5 to 20 percent of gross weight. The blended resin has innocuity, does not need to add a plasticizer in processing, does not have dangers that a compound is precipitated out, pollutes medical liquid and enters human body, and can be used for manufacturing a vessel for storing human blood and blood compositions.

The invention relates to the technical field of thermoplastic elastomers, in particular to a halogen-free flame retardant thermoplastic elastomer and a preparation method thereof. The halogen-free flame retardant thermoplastic elastomer comprises, by weight, 75-110 parts of polyurethane elastomers, 12-30 parts of phosphorus based flame retardant, 5-35 parts of phosphorus-nitrogen containing flame retardant, 1-3 parts of inorganic salt flame retardant, 5-12 parts of plasticizer and 1.3-3 parts of lubricant. The halogen-free flame retardant thermoplastic elastomer solves the problem that an existing elastomer containing halogen flame retardant can generate toxic and corrosive gas, and the smoke formation quantity can be greatly controlled in the open fire burning process of the elastomer. According to the halogen-free flame retardant thermoplastic elastomer, the above raw materials are adopted, the weight ratio of all the raw materials is strictly controlled, the flame retardant effect is good, the flame retardant can reach the UL94-V0 level, fireproofing is good, and the smoke formation quantity is small; precipitation is low, dripping can be prevented, high electrical performance can be achieved, and the heat resistance is good. Moreover, the abrasion resistance is excellent, ozone resistance is extremely good, hardness is large, strength is high, elasticity is good, and comprehensive performance is excellent.

The invention discloses epoxidized soybean oil itaconate with the structural formula I shown in the specification and also discloses a preparation method of the epoxidized soybean oil itaconate and an application of the epoxidized soybean oil itaconate in a coating, further in an ultraviolet curing coating. Itaconic acid which has rich biological sources and is cheap and environment-friendly replaces acrylic acid, photocuring active double bonds are introduced into an epoxidized soybean oil molecule structure, and the toxicity problem caused by AESO residual acrylic acid is solved; besides, more polar carboxyl and ester bonds are introduced, the interaction of soybean oil based oligomers with other components in the coating and base materials can be increased, and the overall performance of the coating is improved. In the formula I shown in the specification, R1, R2, R3 and R4 are independently selected from a formula II shown in the specification, and n represents 0, 1, 2, 3 or 4.