Preparation method of amylose-coated I3<->-complexed silver-coated iron composite nanoparticles

Abstract

The invention discloses a preparation method of amylose-coated I3<->-complexed silver-coated iron composite nanoparticles, which comprises the following steps: synthesizing silver-coated iron nanoparticles, coating amylose on the nanoparticles, and complexing the I3<-> into the amylose molecular spiral structure to finally form the composite magnetic silver nanoparticles. By designing and synthesizing the silver-coated iron composite nanoparticles, the invention solves the problem of targeted entry of silver; by coating the starch on the nano silver, the invention solves the problems of toxicity and stability in the nano silver; by complexing the iodine ions with the amylose, the invention solves the problem of introduction of iodine; under the magnetocaloric effect, the invention solves the problem of release of iodine complex ions; by using the specific fusion action of the iodine complex ions on the nano silver, the invention solves the problem of release of silver ions in the nano silver; and by generating the silver iodide, the invention solves the problem of removal of in-vivo silver ions. Meanwhile, the designed system can comprehensively utilize the thermotherapeutic benefit of magnetic particles as well as the broad spectrum and efficient sterilization characteristics of the silver.

Description

technical field [0001] The invention relates to the field of nano silver technology, in particular to a kind of amylose coated and complexed I 3 - Preparation method of silver-coated iron composite nanoparticles. Background technique [0002] Nano-silver refers to silver clusters with a particle size between 1-100nm, formed by agglomerating several to dozens of silver atoms. Nano-silver is a non-drug-resistant, high-efficiency, broad-spectrum, and long-acting bactericidal material. It has been widely used in medical devices and external drugs, such as nano-silver fabrics, nano-silver burn and scald patches, nano-silver antibacterial dressings, nano-silver Silver catheters, nano-silver eye drops, nano-silver biomaterials, nano-silver bone cement, heart valves containing nano-silver, nano-silver women's surgical antibacterial devices (Ahimi), nano-silver invisible condoms, etc. [0003] However, due to the existence of nano silver: (1) toxicity problems. There are experime...

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Problems solved by technology

Some in vitro tests have also shown that nano-silver has certain cytotoxicity, and at the same dose, nano-sized silver particles and micron-sized silver particles with smaller particle sizes are more cytotoxic in vitro than micron-sized silver particles with larger particle sizes

(2) The problem of poor stability

(3) The problem of difficult excretion in the body

(4) The problem of poor targeting

[0006] Some researchers tried to use biological macromolecules (such as proteins, nucleic acids, starches and polysaccharides, etc.) to coat nano-silver to solve the toxicity and stability problems caused by its entry into the body, but the results showed that the sterilization and anti-inflammation of nano-silver after coating Significantly reduced action, leading to loss of its primary function

There is currently no feasible way to solve the targeting effect and final excretion of silver nanoparticles into the body

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