The invention provides a method for comprehensively recycling manganese, lead, silver and selenium from manganese anode slime. The method comprises the steps that firstly, the manganese anode slime, lead sulfide concentrate and ball milling liquid are mixed and subjected to wet-type ball milling; secondly, leaching of valuable metals such as manganese and selenium is conducted, leachate is reserved, and leached residues serve as lead smelting raw materials for recycling lead and silver; thirdly, a calcium-magnesium removing agent is added for impurity removing; and fourthly, a neutralizer, namely, ammonium hydroxide, and ammonium sulfate are added, a cleaning agent, namely, sodium dimethyl dithiocarbamate is dropwise added, and after stewing is conducted, activated carbon is added for adsorption, filter pressing is conducted, an electrolyzing additive is dropwise added into filtrate, and electrolytic manganese metal is prepared through electrolyzation. The method is small in investment, simple in technology, low in cost and capable of effectively increasing the comprehensive recovery rate.