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Extraction and separation method of cannabidiol

A technology of cannabidiol and separation method, which is applied in chemical instruments and methods, preparation of organic compounds, organic chemistry, etc., and can solve problems such as high cost, low extraction efficiency, and large loss

Active Publication Date: 2018-07-24
FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Solvent extraction is the most commonly used method for extracting polyphenols in plants. Common cannabidiol extraction is obtained by alcohol extraction, water precipitation, and separation and purification by macroporous resin silica gel column chromatography; the existing cannabis extraction process is the target Chromatography begins when the content of the crude extract is very low, resulting in continuous loss of components, large loss, low extraction efficiency, and high cost, which is not conducive to popularization and application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: The extraction and separation method steps of this cannabidiol are as follows:

[0023] (1) Using cannabis branches and leaves as raw materials, after crushing, use ethanol solution with a mass concentration of 60% to heat reflux and extract twice , refluxing and extracting for 2 hours each time, combining the extracts, concentrating under reduced pressure to recover ethanol, and obtaining concentrated liquid extracts for ethanol extraction;

[0024] (2) Add water twice the volume of the liquid extract to the ethanol extraction concentrated liquid extract in step (1), mix well, add ammonia solution to adjust the pH value to 11, then reflux extraction twice, combine and filter the extract, and discard the filter residue , the filtrate was adjusted to pH 7 with dilute hydrochloric acid (mass concentration 5%), and then an equal volume of chloroform-petroleum ether solution (volume ratio 1:1) was added to the filtrate to extract 3 times, and the cannabidiol w...

Embodiment 2

[0029] Embodiment 2: The extraction and separation method steps of this cannabidiol are as follows:

[0030] (1) Using cannabis branches and leaves as raw materials, after crushing, use ethanol solution with a mass concentration of 70% for heat reflux extraction for 3 times, add ethanol solution with 7 times the mass of raw materials for the first extraction, and add 5 times the mass of raw materials for the second and third extractions Ethanol solution, reflux for extraction for 1.5 hours each time, combine the extracts, concentrate under reduced pressure to recover ethanol, and obtain concentrated liquid extract for ethanol extraction;

[0031] (2) Add water three times the volume of the liquid extract to the ethanol extraction concentrated liquid extract in step (1), mix well, add NaOH solution to adjust the pH value to 12, then reflux extraction twice, combine and filter the extract, and discard the filter residue , the filtrate was adjusted to pH 7 with dilute hydrochlori...

Embodiment 3

[0036] Embodiment 3: The extraction and separation method steps of this cannabidiol are as follows:

[0037] (1) Using cannabis branches and leaves as raw materials, after crushing, heat reflux extraction with ethanol solution with a mass concentration of 65% for 3 times, adding ethanol solution with 8 times the mass of raw materials for the first extraction, and adding 6 times the mass of raw materials for the second and third extractions Ethanol solution, reflux extraction for 2.5 hours each time, combined extracts, concentrated under reduced pressure to recover ethanol, to obtain ethanol extraction concentrated liquid extract;

[0038] (2) Add water twice the volume of the liquid extract to the ethanol extraction concentrated liquid extract in step (1), mix well, add triethylamine solution to adjust the pH value to 11, then reflux extraction for 3 times, combine and filter the extract, Discard the filter residue, adjust the pH of the filtrate to 7 with dilute hydrochloric a...

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PUM

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Abstract

The invention discloses an extraction and separation method of cannabidiol. According to the method disclosed by the invention, the water solubility of the cannabidiol is enhanced through adopting analkaline solution and the cannabidiol is extracted and enriched by utilizing an organic solvent; then the cannabidiol is purified and enriched through a polyamide resin column, neutral aluminum oxideand a bonded silica gel column; then the cannabidiol is crystallized to obtain high-purity cannabidiol. The method disclosed by the invention is easy to operate, strong in practicability and suitablefor industrial popularization and application.

Description

technical field [0001] The invention relates to a method for extracting and separating cannabidiol, which belongs to the field of extracting phytochemical components. Background technique [0002] marijuana( Cannabis sativa ) is an ancient cultivated plant with medicinal development value. Cannabidiol (CBD) is the main chemical component in plant cannabis and a non-addictive component in cannabis. It has anti-spasmodic, anti-anxiety, Anti-inflammatory, anti-oxidation, anti-rheumatic, anti-tumor and other pharmacological effects; the application of CBD in the medical field is mainly based on its protective effect on the nervous system; CBD exerts pain relief and Anti-inflammatory effect, and the effect is stronger than that of aspirin, which is well known and widely used; GABA neurotransmitter in the human brain has a calming effect and inhibits the excitability of the brain center. CBD can help control the consumption of GABA neurotransmitter and inhibit the brain. Excitem...

Claims

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Application Information

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IPC IPC(8): C07C37/70C07C37/72C07C37/82C07C39/23
CPCC07C37/685C07C37/70C07C37/72C07C37/82C07C39/23
Inventor 王昆华徐玉高运辉王华伟俞珏华
Owner FIRST AFFILIATED HOSPITAL OF KUNMING MEDICAL UNIV
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