14 results about "Swelling ratio" patented technology

The invention provides temperature-controlled hydrogel and a preparation method thereof, and belongs to the technical field of compositions of high-molecular compounds. The preparation method of the temperature control hydrogel comprises the following steps: preparing a polyglutamic acid-metacrylic acid ester copolymer, preparing composite chitosan, modifying fullerene with chitosan, and mixing. According to the temperature control hydrogel prepared by the invention, the swelling ratio of the temperature control hydrogel is 19.97-21.72 g / g, the swelling ratio of the hydrogel is high, the hydrophilicity of a hydrogel network is strong, the fullerene dispersity is good, and the biocompatibility is enhanced; the compression strength of the temperature control hydrogel ranges from 149.7 kPa to 152.3 kPa, the compression modulus ranges from 25.9 kPa to 28.6 kPa, the fracture deformation ranges from 70.5% to 73.1%, the mechanical performance of the temperature control hydrogel is excellent, and the critical solution temperature of the prepared hydrogel ranges from 31.12 DEG C to 31.35 DEG C.

This invention belongs to the field of biomaterials technology and discloses a two-component in-situ crosslinking agent, a biodegradable two-component hydrogel, and their applications. The two-component in-situ crosslinking agent disclosed in this invention has injectability and rapid gelation properties. The hydrogel formed after crosslinking has a low self-swelling rate, good elasticity, and is not easily crushed. It also has a suitable metal ion slow-release cycle and degradation cycle for preventing tissue adhesion or tissue repair. It is especially suitable for high-risk areas of postoperative adhesion such as the uterine cavity, abdominal cavity, and joints, and can also promote tissue regeneration.

The invention discloses a low-swelling-rate hydrogel material based on natural polysaccharide and a preparation method and application thereof, and belongs to the technical field of implantable medical devices. The low-swelling-rate hydrogel material is of a double-crosslinking network structure composed of a first crosslinking network and a second crosslinking network, the first crosslinking network is a covalent crosslinking network formed by zwitterionic monomers through free radical polymerization, and the second crosslinking network is a covalent crosslinking network formed by zwitterionic monomers through free radical polymerization. The second cross-linked network is a physical cross-linked network formed by coordination of alginate and metal ions. The low-swelling-rate hydrogel material provided by the invention has the characteristic of low swelling rate in normal saline, and can still reach compression stress and compression modulus equivalent to those of commercially available breast prostheses after balanced swelling in the normal saline.

The invention belongs to the technical field of anti-adhesion materials in biomedical engineering, and relates to an anti-adhesion membrane with coarse structure fibers and a preparation method of the anti-adhesion membrane. The method comprises the following steps: soaking an electrostatic spinning fiber membrane containing a high polymer material and a hydrophilic anti-adhesion component in a treating fluid containing the high polymer material and consisting of a poor solvent and a good solvent for a specific time, rinsing and drying to obtain the anti-adhesion membrane, the swelling ratio of the high polymer material in the treating fluid at 25 DEG C for 10 minutes is 1-10% due to the proportion of the inferior solvent to the benign solvent in the treating fluid. A stable integrated nano shish-kebab structure is formed on the surface of the prepared anti-adhesion membrane fiber, exogenous drugs are not needed, spreading of fibroblasts is limited by means of a physical topological structure, conversion of the fibroblasts to myofibroblasts is blocked, the anti-adhesion effect is good, and biocompatibility is good.

The application discloses an injectable double-layer drug sustained-release hydrogel and a preparation method and application thereof, and relates to the field of drug sustained-release hydrogels. The swelling and degradation curve and mechanical property detection of the hydrogel show that, when the swelling rate ratio of the inner layer hydrogel to the outer layer hydrogel is 14% to 10%, the secondary damage of the optic nerve caused by extrusion can be avoided; meanwhile, the hydrogel has suitable mechanical strength and adhesion to cope with the in-vivo environment. The hydrogel precursor solution has good injectability, and the gelation time can be controlled within 2 minutes, which perfectly matches the short time window of the optic nerve decompression surgery, and has high clinical practical value. The application solves the major surgical risk of cerebrospinal fluid leakage when the optic nerve is locally administered, and solves the problems of the traditional local drug carrier, such as lack of in-situ stability and easy displacement. The application can synergistically regulate the injury microenvironment and promote the long-acting sustained-release of nerve regeneration, successfully integrates multiple functions such as surgical safety, drug long-acting sustained-release, biocompatibility and operation convenience, and provides an unprecedented effective strategy for solving the clinical problem of the optic nerve injury.

Provided is an adhesion prevention film that sufficiently swells upon contact with moisture and is less prone to breaking. This adhesion prevention film contains a bioabsorbable polymer compound. The adhesion prevention film has a thickness of 10-500 µm, and a swelling ratio of 200-500 vol% after 15-minute immersion in phosphate buffer at pH 6.0. In the case where 1H-NMR measurement of the film is performed, using a sample solution prepared by adding the film and 1.2 mg of pyrazine to 1.1 mL of deuterated trifluoroacetic acid, with the resonance peak of pyrazine as a standard substance referenced to 9.45 ppm, when the integral value of the maximum resonance peak measured in the range of 9.4-9.5 ppm is defined as A and the integral value of the maximum resonance peak measured in the range of 5.0-5.2 ppm is defined as B, B / A is 0.10 or less.

The application provides a high-efficiency hemostatic dressing, a preparation method and application thereof. The hemostatic dressing is a crosslinked product containing hydroxypropyl chitosan and low molecular weight eucommia ulmoides gum. The hemostatic dressing has a high swelling rate, can better absorb water-soluble exudates, and is beneficial to rapid hemostasis. The hemostatic dressing has better mechanical strength, which indicates that the hemostatic dressing has excellent compression resistance and high-load impact resistance, so that appropriate eucommia ulmoides gum-based dressing can be selected according to specific application scenes and wound characteristics, so as to improve the treatment effect.

This invention provides a photothermal antibacterial hydrogel dressing for NIR-II, its preparation method, and its application. The preparation method involves mixing a 10%–15% PVA aqueous solution with an equal volume of other solutions, then mixing this mixture with CMCS and sodium tetraborate solution, stirring, and centrifuging to obtain the PBCM hydrogel. Each 1 ml of PVA solution corresponds to 40 mg of CMCS. The mass ratio of CMCS to sodium tetraborate solute is 10:1, and the solution concentration is greater than 0 μg / ml and less than or equal to 300 μg / ml. The hydrogel dressing prepared using this method exhibits mechanical strength, high swelling ratio (up to 798.45%), self-healing properties, and biocompatibility. Under low-power near-infrared II laser irradiation, it demonstrates a high antibacterial rate.

The application discloses a kind of fast swelling, enzyme catalytic degradation hydrogel and its preparation method and application, in the present application based on by sucrose molecule connection multi-arm hydrophilic polymer crosslinked hydrogel, and the swelling rate is fast, and the swelling rate is high, and in the environment of sucrose enzyme degradation rate is fast, can be widely used for preparing in enzyme response biodegradable hydrogel carrier and promote weight loss product.

The application belongs to the technical field of hydrogel preparation, and relates to a high-strength low-friction swelling-resistant self-adhesive hydrogel material and a preparation method. The preparation method of the hydrogel comprises four steps of preparation of a precursor hydrogel containing a drag-reducing layer and a tough layer, preparation of a mineralization layer, pre-swelling, and preparation of an adhesive layer. The obtained hydrogel has a four-layer structure of the drag-reducing layer, the tough layer, the mineralization layer, and the adhesive layer. The preparation method is simple, and ideal effects are obtained through simple soaking and smearing. The obtained four-layer hydrogel has high strength, low friction, swelling resistance, self-adhesion, and excellent bone induction potential. The water content of the hydrogel is about 70%, the swelling rate is close to 0, the compressive strength can reach 78 MPa, the friction coefficient is as low as 0.024, the adhesion strength to the bone and the skin is as high as 123 kPa and 79 kPa, respectively. The performance of the hydrogel obtained by the application is better than the comprehensive level of the existing cartilage replacement hydrogel material, and has important significance for widening the application of the hydrogel in the field of artificial cartilage.

This application discloses an injectable wet-adhesive hydrogel, its preparation method, and its application, belonging to the field of biomedical materials technology. The hydrogel of this application is formed by in-situ covalent cross-linking of liquid component A and liquid component B. Liquid component A contains an aqueous solution of a four-arm polyethylene glycol succinimide ester compound; liquid component B contains an aqueous solution of serum albumin and an amino-containing biomedical polymer additive. Depending on the amino-containing biomedical polymer additive, the hydrogel has two composition schemes: one is a quaternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, polylysine, and sodium alginate; the other is a ternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, and a four-arm polyethylene glycol amine. This hydrogel possesses good injectability and low swelling rate, and can construct a multi-point covalent cross-linking mechanism combining chemical cross-linking and reversible physical cross-linking, significantly improving the wet adhesion performance and mechanical stability of the hydrogel, effectively achieving a long-term stable sealing effect during dynamic tissue activity in vivo.

This invention belongs to the field of biomaterials and discloses a protein-based hydrogel in-situ crosslinking agent. The in-situ crosslinking agent is characterized by being composed of a first precursor solution and a second precursor solution. The first precursor solution is prepared by dissolving thiolated polyethylene glycol (PEGSH) and protein in a buffer solution and adjusting the pH to 7.2 with NaOH. The second precursor solution is prepared by dissolving CuSO4 in deionized water. This protein-based hydrogel in-situ crosslinking agent possesses injectability, rapid gelation properties, and the hydrogel formed after crosslinking exhibits strong self-healing ability, low swelling ratio, good elasticity, and is not easily crushed. Furthermore, it can rapidly disintegrate under the action of a degelating agent.

The present application belongs to the technical field of biomaterials. The existing preparation process of composite injectable gel is complicated, and the prepared composite injectable gel has the problems of poor injectability, low swelling rate, low mechanical strength, low drug loading rate and high cytotoxicity. Based on this, the present application provides a method for preparing a composite injectable gel, which comprises: 1) dissolving hyaluronic acid and sodium chloride in an aqueous solution of NaOH or KOH; 2) adding a crosslinking agent 1,4-butanediol diglycidyl ether or genipin and mixing; 3) performing crosslinking reaction; 4) purifying the reaction product; 5) vacuum freeze-drying to obtain the final composite injectable gel. The method simplifies the preparation process, and the prepared composite injectable gel has significantly improved injectability, swelling rate, mechanical strength, drug loading rate, and lower cytotoxicity, and has good application prospect in the fields of drug delivery, tissue engineering, skin wound healing repair, medical cosmetology and the like.

The invention relates to the technical field of hydrogel, in particular to novel hydrogel capable of increasing the swelling rate based on AKBA and a preparation method and application of the novel hydrogel, and the novel hydrogel is prepared by mixing polyvinyl alcohol, chitosan quaternary ammonium salt, tannic acid and 11-carbonyl-beta-acetyl masticinic acid with deionized water and then conducting a repeated freezing and thawing method. According to the invention, the synergistic effect among AKBA, tannic acid (TA) and chitosan quaternary ammonium salt (QCS) is utilized, so that the swelling rate of the polyvinyl alcohol (PVA) hydrogel is increased under the condition of ensuring the mechanical properties and wound healing promotion capability of the hydrogel.