7 results about "Swelling ratio" patented technology

This invention belongs to the field of biomaterials technology and discloses a two-component in-situ crosslinking agent, a biodegradable two-component hydrogel, and their applications. The two-component in-situ crosslinking agent disclosed in this invention has injectability and rapid gelation properties. The hydrogel formed after crosslinking has a low self-swelling rate, good elasticity, and is not easily crushed. It also has a suitable metal ion slow-release cycle and degradation cycle for preventing tissue adhesion or tissue repair. It is especially suitable for high-risk areas of postoperative adhesion such as the uterine cavity, abdominal cavity, and joints, and can also promote tissue regeneration.

Provided is an adhesion prevention film that sufficiently swells upon contact with moisture and is less prone to breaking. This adhesion prevention film contains a bioabsorbable polymer compound. The adhesion prevention film has a thickness of 10-500 µm, and a swelling ratio of 200-500 vol% after 15-minute immersion in phosphate buffer at pH 6.0. In the case where 1H-NMR measurement of the film is performed, using a sample solution prepared by adding the film and 1.2 mg of pyrazine to 1.1 mL of deuterated trifluoroacetic acid, with the resonance peak of pyrazine as a standard substance referenced to 9.45 ppm, when the integral value of the maximum resonance peak measured in the range of 9.4-9.5 ppm is defined as A and the integral value of the maximum resonance peak measured in the range of 5.0-5.2 ppm is defined as B, B / A is 0.10 or less.

The application provides a high-efficiency hemostatic dressing, a preparation method and application thereof. The hemostatic dressing is a crosslinked product containing hydroxypropyl chitosan and low molecular weight eucommia ulmoides gum. The hemostatic dressing has a high swelling rate, can better absorb water-soluble exudates, and is beneficial to rapid hemostasis. The hemostatic dressing has better mechanical strength, which indicates that the hemostatic dressing has excellent compression resistance and high-load impact resistance, so that appropriate eucommia ulmoides gum-based dressing can be selected according to specific application scenes and wound characteristics, so as to improve the treatment effect.

This invention provides a photothermal antibacterial hydrogel dressing for NIR-II, its preparation method, and its application. The preparation method involves mixing a 10%–15% PVA aqueous solution with an equal volume of other solutions, then mixing this mixture with CMCS and sodium tetraborate solution, stirring, and centrifuging to obtain the PBCM hydrogel. Each 1 ml of PVA solution corresponds to 40 mg of CMCS. The mass ratio of CMCS to sodium tetraborate solute is 10:1, and the solution concentration is greater than 0 μg / ml and less than or equal to 300 μg / ml. The hydrogel dressing prepared using this method exhibits mechanical strength, high swelling ratio (up to 798.45%), self-healing properties, and biocompatibility. Under low-power near-infrared II laser irradiation, it demonstrates a high antibacterial rate.

This application discloses an injectable wet-adhesive hydrogel, its preparation method, and its application, belonging to the field of biomedical materials technology. The hydrogel of this application is formed by in-situ covalent cross-linking of liquid component A and liquid component B. Liquid component A contains an aqueous solution of a four-arm polyethylene glycol succinimide ester compound; liquid component B contains an aqueous solution of serum albumin and an amino-containing biomedical polymer additive. Depending on the amino-containing biomedical polymer additive, the hydrogel has two composition schemes: one is a quaternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, polylysine, and sodium alginate; the other is a ternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, and a four-arm polyethylene glycol amine. This hydrogel possesses good injectability and low swelling rate, and can construct a multi-point covalent cross-linking mechanism combining chemical cross-linking and reversible physical cross-linking, significantly improving the wet adhesion performance and mechanical stability of the hydrogel, effectively achieving a long-term stable sealing effect during dynamic tissue activity in vivo.

This invention belongs to the field of biomaterials and discloses a protein-based hydrogel in-situ crosslinking agent. The in-situ crosslinking agent is characterized by being composed of a first precursor solution and a second precursor solution. The first precursor solution is prepared by dissolving thiolated polyethylene glycol (PEGSH) and protein in a buffer solution and adjusting the pH to 7.2 with NaOH. The second precursor solution is prepared by dissolving CuSO4 in deionized water. This protein-based hydrogel in-situ crosslinking agent possesses injectability, rapid gelation properties, and the hydrogel formed after crosslinking exhibits strong self-healing ability, low swelling ratio, good elasticity, and is not easily crushed. Furthermore, it can rapidly disintegrate under the action of a degelating agent.

The present application belongs to the technical field of biomaterials. The existing preparation process of composite injectable gel is complicated, and the prepared composite injectable gel has the problems of poor injectability, low swelling rate, low mechanical strength, low drug loading rate and high cytotoxicity. Based on this, the present application provides a method for preparing a composite injectable gel, which comprises: 1) dissolving hyaluronic acid and sodium chloride in an aqueous solution of NaOH or KOH; 2) adding a crosslinking agent 1,4-butanediol diglycidyl ether or genipin and mixing; 3) performing crosslinking reaction; 4) purifying the reaction product; 5) vacuum freeze-drying to obtain the final composite injectable gel. The method simplifies the preparation process, and the prepared composite injectable gel has significantly improved injectability, swelling rate, mechanical strength, drug loading rate, and lower cytotoxicity, and has good application prospect in the fields of drug delivery, tissue engineering, skin wound healing repair, medical cosmetology and the like.