25 results about "Swelling ratio" patented technology

According to the injectable double-layer drug sustained-release hydrogel and the preparation method and application thereof, hydrogel swelling and degradation curve and mechanical property detection shows that extrusion secondary injury to optic nerves can be avoided due to the swelling ratio ratio of 14% of inner-layer hydrogel to 10% of outer-layer hydrogel; the hydrogel precursor solution prepared by the preparation method disclosed by the invention has proper mechanical strength and adhesive force so as to cope with an in-vivo environment, has good injectability, can control the gelling time within 2 minutes, perfectly conforms to a short time window of optic nerve decompression surgery, and has extremely high clinical practical value. The problems that the serious operation risk of cerebrospinal fluid leakage during optic nerve local administration and a traditional local administration carrier lacks in-situ stability and is prone to displacement are solved, the damaged microenvironment can be cooperatively regulated and controlled, and long-acting slow release of nerve regeneration is promoted; multiple functions such as operation safety, medicine long-acting slow release, biocompatibility and operation convenience are successfully integrated, and an unprecedented effective strategy is provided for solving the clinical problem of optic nerve injury.

The invention provides temperature-controlled hydrogel and a preparation method thereof, and belongs to the technical field of compositions of high-molecular compounds. The preparation method of the temperature control hydrogel comprises the following steps: preparing a polyglutamic acid-metacrylic acid ester copolymer, preparing composite chitosan, modifying fullerene with chitosan, and mixing. According to the temperature control hydrogel prepared by the invention, the swelling ratio of the temperature control hydrogel is 19.97-21.72 g / g, the swelling ratio of the hydrogel is high, the hydrophilicity of a hydrogel network is strong, the fullerene dispersity is good, and the biocompatibility is enhanced; the compression strength of the temperature control hydrogel ranges from 149.7 kPa to 152.3 kPa, the compression modulus ranges from 25.9 kPa to 28.6 kPa, the fracture deformation ranges from 70.5% to 73.1%, the mechanical performance of the temperature control hydrogel is excellent, and the critical solution temperature of the prepared hydrogel ranges from 31.12 DEG C to 31.35 DEG C.

This invention belongs to the field of biomaterials technology and discloses a two-component in-situ crosslinking agent, a biodegradable two-component hydrogel, and their applications. The two-component in-situ crosslinking agent disclosed in this invention has injectability and rapid gelation properties. The hydrogel formed after crosslinking has a low self-swelling rate, good elasticity, and is not easily crushed. It also has a suitable metal ion slow-release cycle and degradation cycle for preventing tissue adhesion or tissue repair. It is especially suitable for high-risk areas of postoperative adhesion such as the uterine cavity, abdominal cavity, and joints, and can also promote tissue regeneration.

The invention discloses a low-swelling-rate hydrogel material based on natural polysaccharide and a preparation method and application thereof, and belongs to the technical field of implantable medical devices. The low-swelling-rate hydrogel material is of a double-crosslinking network structure composed of a first crosslinking network and a second crosslinking network, the first crosslinking network is a covalent crosslinking network formed by zwitterionic monomers through free radical polymerization, and the second crosslinking network is a covalent crosslinking network formed by zwitterionic monomers through free radical polymerization. The second cross-linked network is a physical cross-linked network formed by coordination of alginate and metal ions. The low-swelling-rate hydrogel material provided by the invention has the characteristic of low swelling rate in normal saline, and can still reach compression stress and compression modulus equivalent to those of commercially available breast prostheses after balanced swelling in the normal saline.

The invention belongs to the technical field of anti-adhesion materials in biomedical engineering, and relates to an anti-adhesion membrane with coarse structure fibers and a preparation method of the anti-adhesion membrane. The method comprises the following steps: soaking an electrostatic spinning fiber membrane containing a high polymer material and a hydrophilic anti-adhesion component in a treating fluid containing the high polymer material and consisting of a poor solvent and a good solvent for a specific time, rinsing and drying to obtain the anti-adhesion membrane, the swelling ratio of the high polymer material in the treating fluid at 25 DEG C for 10 minutes is 1-10% due to the proportion of the inferior solvent to the benign solvent in the treating fluid. A stable integrated nano shish-kebab structure is formed on the surface of the prepared anti-adhesion membrane fiber, exogenous drugs are not needed, spreading of fibroblasts is limited by means of a physical topological structure, conversion of the fibroblasts to myofibroblasts is blocked, the anti-adhesion effect is good, and biocompatibility is good.

The application discloses an injectable double-layer drug sustained-release hydrogel and a preparation method and application thereof, and relates to the field of drug sustained-release hydrogels. The swelling and degradation curve and mechanical property detection of the hydrogel show that, when the swelling rate ratio of the inner layer hydrogel to the outer layer hydrogel is 14% to 10%, the secondary damage of the optic nerve caused by extrusion can be avoided; meanwhile, the hydrogel has suitable mechanical strength and adhesion to cope with the in-vivo environment. The hydrogel precursor solution has good injectability, and the gelation time can be controlled within 2 minutes, which perfectly matches the short time window of the optic nerve decompression surgery, and has high clinical practical value. The application solves the major surgical risk of cerebrospinal fluid leakage when the optic nerve is locally administered, and solves the problems of the traditional local drug carrier, such as lack of in-situ stability and easy displacement. The application can synergistically regulate the injury microenvironment and promote the long-acting sustained-release of nerve regeneration, successfully integrates multiple functions such as surgical safety, drug long-acting sustained-release, biocompatibility and operation convenience, and provides an unprecedented effective strategy for solving the clinical problem of the optic nerve injury.

Provided is an adhesion prevention film that sufficiently swells upon contact with moisture and is less prone to breaking. This adhesion prevention film contains a bioabsorbable polymer compound. The adhesion prevention film has a thickness of 10-500 µm, and a swelling ratio of 200-500 vol% after 15-minute immersion in phosphate buffer at pH 6.0. In the case where 1H-NMR measurement of the film is performed, using a sample solution prepared by adding the film and 1.2 mg of pyrazine to 1.1 mL of deuterated trifluoroacetic acid, with the resonance peak of pyrazine as a standard substance referenced to 9.45 ppm, when the integral value of the maximum resonance peak measured in the range of 9.4-9.5 ppm is defined as A and the integral value of the maximum resonance peak measured in the range of 5.0-5.2 ppm is defined as B, B / A is 0.10 or less.

The application provides a high-efficiency hemostatic dressing, a preparation method and application thereof. The hemostatic dressing is a crosslinked product containing hydroxypropyl chitosan and low molecular weight eucommia ulmoides gum. The hemostatic dressing has a high swelling rate, can better absorb water-soluble exudates, and is beneficial to rapid hemostasis. The hemostatic dressing has better mechanical strength, which indicates that the hemostatic dressing has excellent compression resistance and high-load impact resistance, so that appropriate eucommia ulmoides gum-based dressing can be selected according to specific application scenes and wound characteristics, so as to improve the treatment effect.

This invention provides a photothermal antibacterial hydrogel dressing for NIR-II, its preparation method, and its application. The preparation method involves mixing a 10%–15% PVA aqueous solution with an equal volume of other solutions, then mixing this mixture with CMCS and sodium tetraborate solution, stirring, and centrifuging to obtain the PBCM hydrogel. Each 1 ml of PVA solution corresponds to 40 mg of CMCS. The mass ratio of CMCS to sodium tetraborate solute is 10:1, and the solution concentration is greater than 0 μg / ml and less than or equal to 300 μg / ml. The hydrogel dressing prepared using this method exhibits mechanical strength, high swelling ratio (up to 798.45%), self-healing properties, and biocompatibility. Under low-power near-infrared II laser irradiation, it demonstrates a high antibacterial rate.

The invention discloses a carboxymethyl cellulose composite hydrogel dressing for promoting wound healing and a preparation method thereof, and belongs to the technical field of biological materials. According to the hydrogel dressing, oxidized carboxymethyl cellulose (OCMC), quaternized chitosan and polydopamine nanoparticles are cross-linked through Schiff base bonds and amido bonds to form a dual-network structure. The preparation method comprises the following steps: dissolving the OCMC in water to form a solution, adding the polydopamine nanoparticles to enable the final concentration to reach 7.5-30mg / mL, mixing with a quaternized chitosan solution, and standing for cross-linking. The hydrogel disclosed by the invention has the advantages of short gelation time (less than or equal to 30 seconds), strong tissue adhesion (the overlapping shear strength can reach 40kPa), excellent self-healing and injectable performance, high swelling ratio (greater than or equal to 400% within 1 hour) and broad-spectrum antibacterial activity, can effectively absorb percolate, reduce inflammation, accelerate collagen deposition and remarkably promote healing of infected wounds, and is particularly suitable for preparing irregular wound dressing.

The invention provides a tissue phase homogenizing agent and a preparation method and application thereof, and belongs to the technical field of biological tissue engineering, the homogenizing agent is composed of hydrophilic matrixes (glucose, polyglycerol, poloxamer F127 and polyvinyl alcohol), functional additives (mannose, N-acetylcysteine, sodium hyaluronate and polyethylene glycol) and ultrapure water, and the pH value is 7.0 + / -0.2. Hydrophilic groups and water molecules form a hydrogen bond network, a continuous hydration layer is constructed on a phase interface, phase domain fusion, refractive index homogenization and molecular ordering are achieved, the problem of biological tissue phase homogenization is solved, tissue light transmittance can be improved, the swelling ratio can be stabilized, and the hydrogel has cell proliferation promoting activity and is suitable for tissue transplantation operation and bioengineering tissue preservation.

The application discloses a kind of fast swelling, enzyme catalytic degradation hydrogel and its preparation method and application, in the present application based on by sucrose molecule connection multi-arm hydrophilic polymer crosslinked hydrogel, and the swelling rate is fast, and the swelling rate is high, and in the environment of sucrose enzyme degradation rate is fast, can be widely used for preparing in enzyme response biodegradable hydrogel carrier and promote weight loss product.

The invention discloses a method for testing the gel content of a cable insulation material, and relates to the field of material detection. The method comprises the following steps: crushing a sample to be detected, weighing, and recording as W1; after a solvent is added, heating treatment is carried out, and the heating temperature is 90-115 DEG C; the solvent comprises xylene and tetrachloroethane; taking out, drying, cooling, weighing, and recording as W2; and then calculating the gel content of the sample. According to the method, the solvent containing xylene and tetrachloroethane is adopted to extract the to-be-detected sample under a high-temperature condition, the non-uncrosslinked part of the cable insulation material is completely dissolved by using the xylene non-polar solvent, and the polar chain segment is effectively extracted by using the tetrachloroethane polar solvent, so that the affinity and the swelling rate of the solvent to the cable insulation material are improved; aiming at a cable insulation material grafted or copolymerized with polar groups, the accuracy of testing the gel content can be effectively improved.

The invention provides a preparation method of collagen-based microspheres and application of the collagen-based microspheres in preparation of a subcutaneous tissue filling material, and relates to the technical field of medical treatment and medical cosmetology. According to verification of a large number of experiments, the collagen-based microspheres are prepared through a two-step cross-linking method and adjustment of polarity of a solvent used in the second-step chemical cross-linking process; the mass swelling ratio and the effective crosslinking density of the collagen-based microspheres can be regulated and controlled; different from a traditional filling material which only depends on physical support, the collagen-based microspheres with specific mass swelling ratio and crosslinking density have good injectability and mechanical support performance and can realize subcutaneous cell recruitment and promote cell proliferation and extracellular matrix secretion, so that a long-acting and stable subcutaneous tissue filling effect is realized. In addition, the collagen-based microspheres have good biocompatibility and degradability, and conform to the idea of cell-free tissue engineering.

The application belongs to the technical field of hydrogel preparation, and relates to a high-strength low-friction swelling-resistant self-adhesive hydrogel material and a preparation method. The preparation method of the hydrogel comprises four steps of preparation of a precursor hydrogel containing a drag-reducing layer and a tough layer, preparation of a mineralization layer, pre-swelling, and preparation of an adhesive layer. The obtained hydrogel has a four-layer structure of the drag-reducing layer, the tough layer, the mineralization layer, and the adhesive layer. The preparation method is simple, and ideal effects are obtained through simple soaking and smearing. The obtained four-layer hydrogel has high strength, low friction, swelling resistance, self-adhesion, and excellent bone induction potential. The water content of the hydrogel is about 70%, the swelling rate is close to 0, the compressive strength can reach 78 MPa, the friction coefficient is as low as 0.024, the adhesion strength to the bone and the skin is as high as 123 kPa and 79 kPa, respectively. The performance of the hydrogel obtained by the application is better than the comprehensive level of the existing cartilage replacement hydrogel material, and has important significance for widening the application of the hydrogel in the field of artificial cartilage.

This application discloses an injectable wet-adhesive hydrogel, its preparation method, and its application, belonging to the field of biomedical materials technology. The hydrogel of this application is formed by in-situ covalent cross-linking of liquid component A and liquid component B. Liquid component A contains an aqueous solution of a four-arm polyethylene glycol succinimide ester compound; liquid component B contains an aqueous solution of serum albumin and an amino-containing biomedical polymer additive. Depending on the amino-containing biomedical polymer additive, the hydrogel has two composition schemes: one is a quaternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, polylysine, and sodium alginate; the other is a ternary structure of a four-arm polyethylene glycol succinimide ester compound, serum albumin, and a four-arm polyethylene glycol amine. This hydrogel possesses good injectability and low swelling rate, and can construct a multi-point covalent cross-linking mechanism combining chemical cross-linking and reversible physical cross-linking, significantly improving the wet adhesion performance and mechanical stability of the hydrogel, effectively achieving a long-term stable sealing effect during dynamic tissue activity in vivo.

The invention provides a preparation method of gelatin-based microspheres and an application of the gelatin-based microspheres in preparation of a subcutaneous tissue filling material, and relates to the technical field of medical treatment and medical cosmetology, the inventor finds through a large number of experimental exploration verifications that the physical properties of the gelatin-based microspheres can be regulated and controlled by adjusting the polarity strength of a solvent used in a chemical crosslinking process; different from a traditional filling material only depending on physical support, gelatin-based microspheres with specific swelling ratio and crosslinking density can promote cell recruitment, proliferation and extracellular matrix secretion subcutaneously, so that long-acting and stable subcutaneous tissue filling is realized, the treatment effect can be optimized by adjusting components, and the cell-free tissue engineering concept is met. In conclusion, the gelatin-based microspheres with the specific swelling ratio, crosslinking density and components have the potential obviously superior to that of existing products in the fields of aging resistance, wound repair, postoperative tissue filling and the like, and the gelatin-based microspheres have the basis of becoming a new generation of high-performance subcutaneous tissue filling materials.

This invention belongs to the field of biomaterials and discloses a protein-based hydrogel in-situ crosslinking agent. The in-situ crosslinking agent is characterized by being composed of a first precursor solution and a second precursor solution. The first precursor solution is prepared by dissolving thiolated polyethylene glycol (PEGSH) and protein in a buffer solution and adjusting the pH to 7.2 with NaOH. The second precursor solution is prepared by dissolving CuSO4 in deionized water. This protein-based hydrogel in-situ crosslinking agent possesses injectability, rapid gelation properties, and the hydrogel formed after crosslinking exhibits strong self-healing ability, low swelling ratio, good elasticity, and is not easily crushed. Furthermore, it can rapidly disintegrate under the action of a degelating agent.

The invention relates to the technical field of hydrogel, in particular to premixed mediated cross-linked two-component polyethylene glycol hydrogel and a preparation method thereof. Comprising a first reagent and a second reagent, the first reagent comprises a double-component solution, and the second reagent comprises a single-component solution; the first reagent and the second reagent contain polyethylene glycol derivatives, and the mass concentration of the polyethylene glycol derivatives in the first reagent is 1-20%. The curing speed can be effectively increased by premixing the mediated and cured gel, compared with the gel which is not premixed, the gel has longer degradation time and better mechanical property, and a system which cannot be normally cured into gel can be converted into curable gel. The hydrogel provided by the invention has the technical effects of low solid content, low swelling rate and mechanical enhancement.

The invention belongs to the technical field of biological materials. The preparation steps of the existing composite injectable gel are tedious, and the prepared composite injectable gel has the problems of poor injectability, low swelling rate, low mechanical strength, low drug loading rate, high cytotoxicity and the like. On the basis, the invention provides a method for preparing the composite injectable gel, and the method comprises the following steps: 1) dissolving hyaluronic acid and sodium chloride in an aqueous solution of NaOH or KOH; (2) adding a cross-linking agent 1, 4-butanediol diglycidyl ether or genipin, and mixing; 3) carrying out a cross-linking reaction; 4) purifying a reaction product; and 5) performing vacuum freeze-drying to obtain the final composite injectable gel. According to the method, the preparation process is simplified, and the prepared composite injectable gel has significantly improved injectability, swelling ratio, mechanical strength and drug loading rate, and lower cytotoxicity, and has good application prospects in the fields of drug delivery, tissue engineering, skin wound healing and repair, medical cosmetology and the like.

To provide: a compact obtainable through spontaneous bending caused by swelling with a solvent; a wearable terminal provided with the compact; a method for producing the compact; and a method for producing a cross-linked polymer.SOLUTION: A compact comprises a base and at least one bent portion connected to the base. Therein: the base and the bent portion are constituted of a first cross-linked polymer having a first mesh structure and a second mesh structure; and when thickness of the base before the solvent is impregnated is t1, thickness of the base after the solvent is impregnated is t2, thickness of the bent portion before the solvent is impregnated is ts1, and thickness of the bent portion after the solvent is impregnated is ts2, the compact has a swelling ratio (Q) expressed by the following formula (1) that is greater than 1 and up to 5. Q=(ts2 / ts1) / (t2 / t1) (1) (on condition that t1≥ts1).SELECTED DRAWING: Figure 1

The application discloses a temperature-sensitive sustained-release medical auxiliary material and a preparation method thereof, and belongs to the technical field of medical auxiliary materials.The temperature-sensitive sustained-release medical auxiliary material according to the application contains the following components in percentage by mass: 1-2% w / v of acrylamidated hydroxyethyl chitosan, 5-15% w / v of polyethylene glycol diacrylate, 1-6% w / v of N-methyl acrylate caprolactam, 0.05-2% w / v of an initiator, 0.01-0.5% w / v of a crosslinking agent, and the balance of a PBS solution; the acrylamidated hydroxyethyl chitosan is chitosan modified by hydroxy and modified by ethyl; the N-methyl acrylate caprolactam monomer provided by the application effectively improves the temperature sensitivity of the temperature-sensitive polymer auxiliary material; the acrylamidated hydroxyethyl chitosan can reduce the swelling ratio and slow down the drug release; the polyethylene glycol diacrylate can be a crosslinking monomer of the temperature-sensitive polymer auxiliary material, and can simultaneously introduce an ether bond to improve the biocompatibility; and the three components are combined to prepare a temperature-sensitive sustained-release medical auxiliary material which has a low drug release rate and responds to the human body temperature.

The present application belongs to the technical field of biomaterials. The existing preparation process of composite injectable gel is complicated, and the prepared composite injectable gel has the problems of poor injectability, low swelling rate, low mechanical strength, low drug loading rate and high cytotoxicity. Based on this, the present application provides a method for preparing a composite injectable gel, which comprises: 1) dissolving hyaluronic acid and sodium chloride in an aqueous solution of NaOH or KOH; 2) adding a crosslinking agent 1,4-butanediol diglycidyl ether or genipin and mixing; 3) performing crosslinking reaction; 4) purifying the reaction product; 5) vacuum freeze-drying to obtain the final composite injectable gel. The method simplifies the preparation process, and the prepared composite injectable gel has significantly improved injectability, swelling rate, mechanical strength, drug loading rate, and lower cytotoxicity, and has good application prospect in the fields of drug delivery, tissue engineering, skin wound healing repair, medical cosmetology and the like.

The application belongs to the cross technical field of polymer material forming and computer aided engineering, and discloses a silicone modified PA6 fiber preparation process parameter optimization method based on numerical simulation, and the preparation process parameters include the silicone mass fraction of the melt, the extrusion temperature and the inlet flow, and the specific process is as follows: firstly, the melt rheological parameter library, the geometric model grid model of the spinneret and the free extrusion section are established in sequence and the boundary conditions are set, then the control equation and the solution parameters are set, then the finite element fluid mechanics solver is coupled to solve the control equation and obtain the free surface topography, after the extrusion swell ratio B is calculated, at least one set of preparation process parameters with the extrusion swell ratio B less than or equal to the allowable extrusion swell ratio threshold β1 is screened out and is used as the preferred preparation process parameter. The application can realize the full digital prediction of the extrusion swell behavior without a large number of entity spinning tests, and provides a reliable basis for the PA6 spinning assembly structure parameter screening and process closed loop control.

The invention relates to the technical field of hydrogel, in particular to novel hydrogel capable of increasing the swelling rate based on AKBA and a preparation method and application of the novel hydrogel, and the novel hydrogel is prepared by mixing polyvinyl alcohol, chitosan quaternary ammonium salt, tannic acid and 11-carbonyl-beta-acetyl masticinic acid with deionized water and then conducting a repeated freezing and thawing method. According to the invention, the synergistic effect among AKBA, tannic acid (TA) and chitosan quaternary ammonium salt (QCS) is utilized, so that the swelling rate of the polyvinyl alcohol (PVA) hydrogel is increased under the condition of ensuring the mechanical properties and wound healing promotion capability of the hydrogel.