Polysaccharide gel formulation

A polysaccharide gel and preparation technology, applied in the field of polysaccharide gel preparation, can solve unsatisfied problems

Inactive Publication Date: 2011-01-19
ALLERGAN INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There remains an unmet need for polysaccharide formulati...

Method used

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  • Polysaccharide gel formulation
  • Polysaccharide gel formulation
  • Polysaccharide gel formulation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] Prepare HA filling gel according to the content disclosed in the present invention

[0057] 1-5 grams of polysaccharide filling ( 24HV, (Allergan Inc., Irvine, California)) supplemented with 10-200 mg Chondroitin Sulfate A (CSA-M w =5,000-120,000 Da) in 1000 μl of phosphate-buffered saline (PBS) solution (pH about 7). The mixture was mechanically homogenized.

Embodiment 2

[0059] Preparation of HA filled gels by prior art methods

[0060] 1-5 grams of polysaccharide filling ( 24HV) was mixed with 1000 μl of PBS to make the final HA concentration the same as in Example 1. The mixture was mechanically homogenized.

Embodiment 3

[0062] Preparation of another hyaluronic acid filling gel according to the disclosure of the present invention

[0063] 1-5 grams of HA-based polysaccharide filling ( 30) with supplementation with 1-20mg tannic acid (TA-M w =800-4,000Da) in 50 μl of PBS solution (pH about 7). The mixture was mechanically homogenized.

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Abstract

Described herein are polysaccharide gel formulations including at least one inhibitor of polysaccharide degradation and methods of making the same. The methods described herein involve the steps of providing at least one polysaccharide and incorporating at least one inhibitor of degradation into the polysaccharide. In some embodiments, the incorporating step comprises 1 ) mixing the at least one inhibitor with the at least one polysaccharide at a highly hydrated state thereby encapsulating the at least one inhibitor in a polysaccharide network, and 2) dehydrating the polysaccharide network thereby controlling release kinetics or final swell ratio. In another embodiment, the incorporating step comprises 1) encapsulating at least one inhibitor into a biocompatible or biodegradable vessel and 2) combining the polysaccharide and the vessel into a gel formulation. The polysaccharide gel formulations described herein can be used for a variety of cosmetic applications.

Description

[0001] inventor [0002] D. Stumpless, C.S. Mudd and A. Teisel [0003] Cross references to related patent applications [0004] This application claims priority based on US Provisional Patent Application 60 / 991,473, filed November 30, 2007, the entire disclosure of which is incorporated herein by reference. technical field [0005] Cosmetic and medical formulations for increasing the longevity of polysaccharide gels, as well as methods of making and using them are generally disclosed. Background technique [0006] Polysaccharides are relatively complex sugars. Polysaccharides are polymers composed of many monosaccharides linked together by glycosidic bonds. Thus, polysaccharides are large and often branched macromolecules. Polysaccharides, especially hyaluronic acid (HA), have been used in cosmetology and medicine. For example, such polymers have been used as fillers in soft tissue augmentation. [0007] HA resides in the extracellular space, where it functions as a s...

Claims

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Application Information

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IPC IPC(8): A61K8/60A61K8/73A61K8/04A61Q19/00A61Q19/08A61K9/10A61K31/738C08B37/00A61K9/00
CPCA61K8/731A61K31/728A61K47/42A61K31/721A61K47/38A61K2800/522A61K31/738C08B37/0072A61K47/36A61K8/60A61K8/492A61K8/735C08J2305/08A61K8/678A61K8/042A61K31/737A61Q19/08A61K31/717A61K47/183C08J3/075A61K8/736C08L2205/02A61K8/602C08L5/08C08K5/053A61K47/26A61K8/73A61K8/676A61K31/727A61K31/715A61L27/26A61L27/505
Inventor D·斯特姆普利斯C·S·马德A·泰泽尔
Owner ALLERGAN INC
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