30results about How to "Guaranteed biocompatibility" patented technology

The PEEK medical composite catheter comprises an inner layer, a middle reinforcing layer and an outer layer which are sequentially arranged from inside to outside, and the inner layer, the middle reinforcing layer and the outer layer are all made of PEEK materials; the middle reinforcing layer is formed by weaving PEEK lines in a staggered mode, connecting gaps are formed between the PEEK lines, developing units are embedded in the connecting gaps, and the developing units are arranged according to a limited path and form a specified developing graph, so that the developing effect is greatly improved, and the safety of the catheter in the using process is guaranteed.

The invention discloses a method for preparing recombinant collagen antioxidant microspheres without a cross-linking agent. The method comprises the following steps: 1, dissolving recombinant collagen and chitosan in deionized water containing glacial acetic acid to serve as a water phase; petroleum ether containing a surfactant is used as an oil phase; 2, injecting the oil phase into the water phase, emulsifying and stirring through a homogenizer, and reducing the temperature of the system to obtain an emulsion; 3, a fixing agent, water and absolute ethyl alcohol are blended and precooled, and fixing liquid is obtained; 4, adding the stationary liquid into the emulsified liquid for curing, and washing the cured microspheres; and 5, transferring into a tannic acid aqueous solution to soak, then washing with deionized water, and freeze-drying to obtain the recombinant collagen microspheres with uniform size. The recombinant collagen microspheres prepared by the method have good dispersity and uniform and controllable size, avoid the toxicity problem of a cross-linking agent, can be applied to the fields of medical instruments, tissue engineering, drug delivery and the like as a filling agent, and have wide commercial application prospects.

The invention discloses a PEEK medical composite catheter containing a developing layer and a preparation method of the PEEK medical composite catheter. The PEEK medical composite catheter comprises an inner layer, a middle reinforcing layer and an outer layer which are sequentially arranged from inside to outside. The inner layer, the middle reinforcing layer and the outer layer are made of PEEK materials, the middle reinforcing layer is coated with a developing solution in a dip-coating mode, the developing solution is cured to form a developing layer, the developing solution is cured to form a developing layer, the catheter has a good developing effect, the developing layer is tightly connected with the middle reinforcing layer, the structure is more stable, and the service life of the catheter is prolonged. Compared with a traditional method that a developing ring is arranged on the catheter in a sleeving mode for developing, the situation that the developing ring is disengaged is avoided, and the whole developing ring has higher safety.

The invention belongs to the field of preparation of sedation maintaining agents, and particularly relates to a sedation maintaining agent administrated through oral mucosa and a preparation method of the sedation maintaining agent. Bamboo leaf polysaccharide and pigskin collagen peptide are heated and mixed with chlorogenic acid and butyl acetate under the catalytic action of lanthanum nitrate, and the obtained moisturizing adhesive has biocompatibility, can be stably adhered to oral mucosa and can promote salivary secretion of children; nanoparticles obtained through freeze spray drying are uniformly dispersed in a copolymer solution containing sodium salicylate and polyacrylate, and the obtained nervous system regulator can balance excitability of sympathetic nerves and parasympathetic nerves of children; the emotion relieving composition contains modified felwort powder obtained through esterification reaction, the modified felwort powder is mixed with a moisturizing adhesive and a nervous system regulator, and the prepared sedation maintaining medicament administrated through the oral mucosa protects oral health of children in the oral operation anesthesia process, is free of irritation, improves anxiety emotion and does not affect postoperative awakening.

The invention relates to a repetitive structural unit recombinant protein cpE2 and a preparation method and application thereof. The recombinant protein cpE2 of the repetitive structural unit has self-assembly performance and is formed by modifying an E2 subunit of a pyruvate dehydrogenase compound and dihydrofatty acid amide transacetylase. Specifically, the C end of the E2 protein is arranged at the N end through a connecting peptide by utilizing a circulating recombination principle, so that the recombinant protein cpE2 is constructed. The engineered cpE2 protein cage can be self-assembled into a cage-shaped structure, linking groups can be respectively brought into the protein cage through N-terminal or C-terminal modification of cpE2, the problem that a modifier or a drug is difficult to put into the protein cage by a traditional E2 protein is solved, meanwhile, the specific particle size of the cpE2 protein cage can be controlled through the length of a linking peptide, and the protein cage has a good application prospect. And efficient carrying of goods is achieved.

The invention relates to the technical field of biological materials, and discloses a chitosan fiber membrane and a preparation method and application thereof, and the preparation method comprises the following steps: (1) preparing a chitosan-containing fiber membrane through a spinning technology; (2) preparing a curing liquid: dissolving sodium hydroxide in an ethanol water solution with the volume concentration of 75% to prepare the curing liquid; and (3) carrying out curing treatment on the chitosan-containing fiber membrane: soaking the chitosan-containing fiber membrane in a curing liquid, then washing the chitosan-containing fiber membrane with water until the chitosan-containing fiber membrane is neutral, and drying the chitosan-containing fiber membrane at normal temperature to obtain the chitosan fiber membrane. By optimizing the curing process of the chitosan fiber membrane, a reagent with relatively strong toxicity does not need to be used in the curing process, and the curing liquid adopted in the curing process is also easy to clean and remove, so that the biocompatibility of the prepared chitosan fiber membrane can be ensured.

The invention discloses magnesium-based hydrogen-rich bone cement as well as a preparation method and application thereof. The magnesium-based hydrogen-rich bone cement is prepared by mixing and curing powder and curing liquid, the powder comprises the following components in parts by mass: 50-80 parts of structural powder, 10-15 parts of a bonding consumable, 5-10 parts of a healing accelerant and 15-40 parts of an auxiliary agent, the structural powder comprises reinforcing powder and compatible powder, the reinforcing powder comprises at least one of calcium silicate and calcium phosphate, and the compatible powder comprises at least one of magnesium silicate and magnesium phosphate; the healing accelerant comprises a biodegradable polymer and a magnesium-based material embedded in the biodegradable polymer; and after the powder and the curing liquid are mixed and cured, surface activation treatment is applied, and at least part of the bonded consumables are removed. The magnesium-based hydrogen-rich bone cement disclosed by the invention can be applied to preparation of bone defect repair materials, can relieve local tissue inflammatory response, and is high in oxidation resistance, long in oxidation resistance duration, few in organic residues on the ceramic surface of the bone cement and good in biocompatibility.

The invention discloses a directional osteogenesis induction skull patch based on an MXene dual-electrode plate and a pulsed direct-current electric field and a preparation method of the directional osteogenesis induction skull patch. The method specifically comprises the following steps: 1) performing intercalation on MXene by using a bacterial cellulose solution as an intercalation agent, and combining a layer-by-layer blade coating and laminating process to obtain a composite MXene electrode plate; (2) preparing a porous GelMA pre-solution loaded with bone marrow mesenchymal stem cells; 3) cutting the composite MXene electrode plate into a proper shape to obtain an upper-layer electrode plate and a lower-layer electrode plate, tiling the lower-layer electrode plate as a substrate, dispensing a cell-loaded porous GelMA pre-solution on the surface of the lower-layer electrode plate, covering the upper-layer electrode plate, and performing gelation by combining lateral UV curing to obtain a double-layer electrode plate composite gel material; and 4) carrying out in-vitro culture on the double-layer electrode plate composite gel material for several days, including electrical stimulation culture and non-electrical stimulation culture, and then stripping the upper electrode plate and the lower electrode plate to obtain the skull patch. According to the skull patch, in-vivo skull defect repair can be achieved, and a brand-new skull regeneration and repair strategy is created.

The invention provides a biological preparation for regulating placenta dysplasia, and belongs to the technical field of gynaecology and obstetrics. Core effective components of the biological preparation are lutjanus mixed polypeptide with the molecular weight ranging from 2 kDa to 10 kDa, and the lutjanus mixed polypeptide is prepared by combining lutjanus fish bones, fish scales and fish flesh according to the mass ratio of 5: 3: 2 through the steps of desalting treatment, ultrasonic-assisted degreasing, double-enzyme synergistic enzymolysis, double ultrafiltration purification and the like. Experimental results show that the lutjanus mixed polypeptide has a remarkable protection effect on a human trophoblast cell line HTR-8 / SVneo in a high-glucose environment, and can effectively promote cell proliferation and migration and reduce high-glucose-induced cell damage. Therefore, the biological preparation provides a novel effective intervention means for placenta dysplasia caused by gestational diabetes mellitus, and has a good application prospect.

The invention belongs to the technical field of micro-fluidic chip manufacturing, and discloses a method for preparing a micro-fluidic chip by using a focused laser etching method, the micro-fluidic chip and application. The method comprises the following steps: coating a photoresist on the surface of a substrate, forming a photoresist substrate through exposure polymerization, designing a scanning track of focused infrared laser according to a micro-channel pattern, performing micro-channel laser processing on the photoresist substrate to obtain a sample, and treating the surface of the sample through plasma to obtain a micro-channel sample. And bonding the photoresist and polydimethylsiloxane by using a coupling agent to obtain the micro-fluidic chip. According to the method, the technological process is simplified, the manufacturing cost is reduced, and meanwhile high precision is kept.

This invention belongs to the field of biomedical technology, specifically relating to a pharmaceutical composition formulation containing ertapenem and its preparation method. The ertapenem-containing pharmaceutical composition formulation comprises the following raw materials: 10-20 parts ertapenem, 40-60 parts choline-leucine ionic liquid, 30-50 parts polyethylene glycol-polylactic acid-glycolic acid copolymer, 2-5 parts gluconolactone, 2-3 parts antioxidant, 40-50 parts deionized water, 3-5 parts surfactant, and 20-30 parts mannitol. This invention utilizes choline-leucine ionic liquid to enhance the solubility and stability of the polyethylene glycol-polylactic acid-glycolic acid copolymer with ertapenem, forming uniform micelles to protect the drug from hydrolysis. Liquid nitrogen freezing technology is used to improve preparation efficiency and product quality, ensuring biocompatibility.

The invention discloses a high-toughness plastic for a medical needle tube and a preparation method of the high-toughness plastic, and belongs to the technical field of polymer composite materials. The product comprises the following components: polycaprolactone, maleic anhydride grafted polylactic acid, a chitosan modified hydroxypropyl methyl cellulose derived carbon dot bacteriostatic agent and the like. The preparation method comprises the steps of preparation of the carbon dot bacteriostatic agent, pretreatment of raw materials, preparation of the functionalized master batch, segmented temperature control twin-screw extrusion melt blending and the like. The composite carbon dot bacteriostatic agent is constructed by hydrothermal carbonization-two-step amidation grafting, and is matched with the functionalized master batch preparation and interface regulation and control technology, so that the problems that the bacteriostatic agent of the existing medical needle tube material is easy to migrate, poor in compatibility and insufficient in toughness are solved, the synergistic improvement of long-term bacteriostasis and high toughness is realized, the biocompatibility is guaranteed, and the medical needle tube material has a good application prospect. The device is suitable for intrusive medical instruments such as medical needle tubes.

The application provides a preparation method and application of a high-efficiency emergency antibacterial dressing and belongs to the technical field of biomedical materials. The high-efficiency emergency antibacterial dressing is prepared through a systematic process of alcohol-free wet spinning, secondary traction stretching, vacuum freeze drying, semi-dry state rapid carboxymethylation and needle punching / water jetting into cloth. The high-efficiency emergency antibacterial dressing has high mechanical strength and strong liquid absorption capacity, can absorb a large amount of wound exudate and keep the wound moist, and realizes the synergistic effect of multiple functions such as emergency, anti-adhesion, strong stability, antibiosis and repair promotion.

The invention relates to the technical field of pharmaceutical preparations. The invention provides a drug-loadable liposome and a preparation method thereof, and the preparation method comprises the following steps: (1) mixing lecithin, dipalmitoyl phosphatidylcholine, cholesterol and an organic solvent, and carrying out ultrasonic dissolution to obtain a phase A; (2) mixing polyoxyethylene sorbitan monostearate with a phosphate buffer solution to obtain a phase B; and (3) adding the phase A prepared in the step (1) into the phase B prepared in the step (2), stirring, evaporating, and filtering to obtain the product. The liposome prepared from the raw materials and the technical scheme is more stable in performance, better in drug loading stability and higher in drug entrapment capacity, and the drug release time can be prolonged.

The present invention relates to a liquid, positively charged, responsive self- assembling peptide, a liquid scaffold material formed from the self-assembling peptide, and applications of the liquid scaffold material.

The invention discloses a preparation method of a dual-action hip joint Zr-Nb alloy, the Zr-Nb alloy includes Nb 1.0-2.5%, Mo 0.3-1%, Ti 0.7-1.2%, Si 0.2-0.6%, Sn 1.0-2.0%, and the balance is Zr; the preparation method includes preparing a master alloy designed as follows, and the master alloys are all melted and cast into ingots under a vacuum protective atmosphere. The above-mentioned preparation method adopts the method of first preparing the master alloy, then subjecting the master alloy to vacuum melting, secondary feeding and other steps, making each component uniform and the temperature uniform, and finally subjecting the master alloy to solid solution, quenching, intermediate annealing and crystallization annealing, so as to realize multiple strengthening mechanisms such as solid solution strengthening, fine grain strengthening, and second phase strengthening, and generate a passive oxide on its surface, and improve its corrosion resistance and wear resistance on the basis of ensuring the biocompatibility of the alloy.

This invention belongs to the field of compositions of polymeric compounds for oral care products, specifically relating to a sustained-release system for oral care products, its preparation method, and its application. This invention discloses that when a cationic polymeric compound, sodium alginate, and ectoine are used in combination, a unique OraReliX™ sustained-release system can be formed on the tooth surface. The core working principle of this system is as follows: the cationic substance adheres to the negatively charged tooth surface through electrostatic adsorption, forming a cationic network; sodium alginate regulates the network density through polyelectrolyte complexation with this cationic network, while reversibly binding calcium ions; ectoine stabilizes the oral microenvironment and protects the sustained-release network structure. The synergistic effect of these three components significantly slows down the release rate of calcium ions, prolonging their effective retention time in the oral cavity.

The present invention provides a hydrogel and a preparation method and application thereof. The hydrogel is a hydrogel based on cross-linking of alginate and gelatin molecules, and has good biocompatibility; after further modifying alginate by maleimidation, the cross-linking of alginate and gelatin molecules can be made tighter and more stable, thereby further effectively improving the mechanical properties of the hydrogel under the premise of ensuring the biocompatibility of the hydrogel, so that the hydrogel of the present invention has both excellent biocompatibility and mechanical properties. The hydrogel has good application effects in wound dressings and coatings of implantable medical devices, and the preparation method of the hydrogel has simple operation procedures, high repeatability, and is easy to realize industrialization, so that the hydrogel has strong practicality and is conducive to the large-scale application of the hydrogel.

According to the polyvinyl alcohol and the preparation method thereof provided by the invention, the polyvinyl alcohol is prepared by taking 2-acrylamide-2-methylpropanesulfonic acid and dodecyl vinyl ether as reactive compound emulsifiers, and a hydrophilic sulfonic acid group and a soft-segment long-chain alkyl ether chain can be introduced into a polyvinyl alcohol molecular chain; on the basis of keeping the hydrophilicity, barrier property, biocompatibility and biodegradability of the polyvinyl alcohol, the flexibility and hydrolysis resistance of the polyvinyl alcohol are improved.

The invention discloses a grease-jasmonic acid methyl ester nano composite material, a preparation method thereof and an application of the grease-jasmonic acid methyl ester nano composite material in improving the freezing resistance of young pear fruits, and relates to the technical field of nano pesticides and young pear fruit freezing resistance. Comprising the following steps: 1, preparing an epoxy tea oil monomer from camellia oil; 2, dissolving an epoxy tea oil monomer and hydroxyethyl acrylate into ethanol, adding an initiator, and uniformly mixing to obtain a mixed solution; 3, carrying out freeze-thaw cycle, and carrying out polymerization reaction and purification in a nitrogen environment; and 4, adding jasmonic acid methyl ester, and then inducing self-assembly of the plant oil-based polymer to obtain the plant oil-based polymer. The method has the beneficial effects that the grease has good adhesion, and hydroxyl of hydroxyethyl ester and functional groups such as carboxyl on the surfaces of the young pears are bonded through hydrogen bonds, so that the adhesion of the nano-pesticide on the surfaces of the pears is improved, the rain wash resistance of methyl jasmonate on the surfaces of the young pears is improved, and the methyl jasmonate can be kept on the surfaces of the young pears for a long time; a large amount of hydroxyl also has an anti-freezing function, so that the anti-freezing capability of the young pears is greatly improved.

The invention provides a preparation method and application of a super-tensile and high-adhesiveness silver nanowire hydrogel, and the super-tensile and high-adhesiveness silver nanowire hydrogel is a conductive hydrogel. According to the silver nanowire hydrogel disclosed by the invention, acrylamide, silver nanowires, acrylic acid, polyvinylpyrrolidone and water are taken as main raw materials, and the silver nanowires are added into a hydrogel system, so that the toughness and the elasticity of the material are enhanced, and the conductivity of the hydrogel is improved. The finally prepared silver nanowire hydrogel has super-strong stretchability, extremely high adhesiveness, excellent conductivity and relatively low contact resistance. The hydrogel prepared by the invention can be used for a pressure sensor, and also can be attached to the skin to collect various physiological signals of a human body and monitor electrocardiosignals. In the aspect of pressure sensing, the hydrogel can accurately identify different numbers and letters, the accuracy rate reaches 93%, and various tiny motions of a human body can be identified; in the aspect of physiological signal acquisition, the stability is good, the precision is high, the impedance is low, materials are easy to obtain, and the operation is simple.

The invention relates to the field of high-entropy alloys, in particular to a 3D printing porous special-shaped high-entropy alloy component which comprises, by weight, 35%-55% of high-entropy alloy and 43%-65% of hydroxyl calcium phosphate. The 3D printing porous special-shaped high-entropy alloy component has the following beneficial effects that the high-entropy alloy has high hardness, good fatigue resistance and excellent corrosion resistance, and the high-entropy alloy is high in mechanical strength, high in mechanical strength and high in mechanical strength; after being combined with hydroxyapatite, the composite biological material can provide better mechanical support while keeping biocompatibility, is suitable for repairing hard tissues with large bearing capacity, and ensures good and uniform interface combination between hydroxyapatite and the high-entropy alloy by realizing the pore structure of the composite material; therefore, damage to human bodies caused by factors such as cracks and phase separation is avoided.

The utility model relates to the technical field of gluing production equipment, in particular to a gluing device for recombined collagen dressing paste production, which comprises a box body, a conveying roller is rotatably connected to an inner cavity of the box body, a bearing plate is welded to the inner cavity of the box body, a gluing roller is rotatably connected to one side opposite to the bearing plate, and the conveying roller is welded to the inner cavity of the box body. A material storage frame is welded to an inner cavity of the box body, through holes are formed in the surface of the box body, an adjusting mechanism is arranged on the surface of the box body and comprises a supporting plate, and the supporting plate is welded to the surface of the box body. Through cooperation of the conveying roller, the supporting plate, the driving motor, the rotating rod, the stirring blades and the transmission belt, the gluing device and an automatic production line of the conveying roller are integrated, full-automatic production from raw material conveying to gluing is achieved, the multiple sets of stirring blades are integrated, good quality can be kept in the using process, and the production efficiency is improved. The biocompatibility of the product is ensured, and the production efficiency is improved.

This invention discloses a method for preparing type III collagen peptides and their applications. The method for preparing type III collagen peptides effectively avoids the problem of easy degradation of small molecule peptides in microorganisms by expressing sequence monomers in tandem as highly stable macromolecular precursor proteins. Combined with cloning into expression vectors, high-yield expression is achieved. By combining specific enzymatic digestion methods with ultrafiltration and specific enzymatic digestion technology, the high uniformity of the final product sequence and a purity of over 95% are ensured. This method not only completely solves the pathogenic risks and batch instability of animal-derived extraction methods, but also overcomes the high cost and environmental pollution problems of chemical synthesis methods, realizing efficient, safe and controllable production of small molecule type III collagen peptides.

A method for preparing a regenerated silk fibroin conductive elastomer relates to an elastic hydrogel. The preparation method comprises the following steps: 1) preparing a regenerated silk fibroin solution; 2) adding a MXene dispersion to the regenerated silk fibroin solution and mixing evenly; 3) adding a crosslinking agent to the precursor solution mixed evenly in step 2); 4) pouring the mixed evenly solution into a mold to form a regenerated silk fibroin conductive elastomer hydrogel at room temperature. The silk fibroin elastomer is obtained by enzymatic crosslinking, and the reaction conditions for the preparation are mild. Thanks to the high conductivity, hydrophilicity and multifunctional groups of MXene, the obtained silk fibroin elastomer has excellent mechanical flexibility and elasticity, and can be used in flexible resistive pressure sensors; the compressibility is more advantageous than that of pure silk fibroin hydrogel.

The invention discloses a CeO2 nano-enzyme loaded SilMA hydrogel and application thereof in a 3D biological printing tissue engineering trachea, and belongs to the technical field of biology.The preparation method of the CeO2 nano-enzyme loaded SilMA hydrogel comprises the steps that 1, CeO2 nano-enzyme is prepared, specifically, cerous nitrate hexahydrate, dextran and deionized water are stirred to be uniform, ammonia water is added, water bath heating is conducted, and the CeO2 nano-enzyme is prepared; carrying out aging, centrifugation, washing, vacuum drying and calcination on the obtained CeO2 nano-enzyme precipitation slurry to obtain CeO2 nano-enzyme powder; step 2, mixing CeO2 nano-enzyme into a 20 w / v% SilMA solution, so as to obtain a CeO2 nano-enzyme loaded SilMA hydrogel; step 3, taking 20% w / v of SilMA as a water phase and a paraffin oil solution containing 5% w / v of Span 80 as an oil phase, mixing, stirring under water bath heating to obtain SilMA hydrogel microspheres, and freeze-drying to obtain a porous structure; the preparation method comprises the following steps: adding CeO2 nano-enzyme into deionized water containing the SilMA hydrogel microspheres, so as to obtain a SilMA hydrogel microsphere solution loaded with the CeO2 nano-enzyme;

The invention relates to a self-assembling peptide, a three-dimensional network material formed by the self-assembling peptide and application of the three-dimensional network material. The self-assembling peptide of the present invention comprises a hydrophilic domain comprising at least one beta-turn region capable of forming a beta-turn, and an RGD domain comprising an amino acid sequence of arginine (R)-glycine (G)-aspartic acid (D). The self-assembled peptide can be self-assembled to form a three-dimensional network material in a neutral solution without being started by any other exogenous components.

The present invention belongs to the technical field of microfluidic chip manufacturing, and discloses a method for preparing a microfluidic chip by using a focused laser etching method, a microfluidic chip and an application thereof. The method comprises the following steps: coating a photoresist on a substrate surface, forming a photoresist substrate by exposure polymerization, designing a scanning track of a focused infrared laser according to a microchannel pattern, performing microchannel laser processing on the photoresist substrate to obtain a sample, treating the sample surface by plasma, and bonding the photoresist with polydimethylsiloxane by a coupling agent to obtain a microfluidic chip. The method of the present invention simplifies the process flow, reduces the manufacturing cost, and maintains high precision at the same time.

This invention relates to a drug-loaded polypyrrole interdigitated microelectrode, its preparation method, and its application. The electrode comprises: a biocompatible metal substrate, an insulating layer disposed on the surface of the biocompatible metal substrate, a polypyrrole interdigitated microelectrode structure disposed on the insulating layer, and a bioactive drug loaded in the polypyrrole interdigitated microelectrode. In the preparation method, the insulating layer is first formed through pretreatment, and then the pyrrole monomer is rapidly and uniformly oxidized and polymerized to form a denser thin film using the high anodic potential of the interdigitated electrode. This invention can be applied to intelligent bone implants, enabling the simultaneous integration of therapeutic and diagnostic functions without compromising the mechanical properties of the implant, thereby significantly improving the success rate and long-term stability of the implant.

The invention discloses a preparation method of a double-acting hip joint Zr-Nb alloy. The Zr-Nb alloy comprises 1.0%-2.5% of Nb, 0.3%-1% of Mo, 0.7%-1.2% of Ti, 0.2%-0.6% of Si, 1.0%-2.0% of Sn and the balance Zr. The preparation method comprises the following steps: preparing an intermediate alloy designed as follows, and smelting and pouring the intermediate alloy into an ingot under a vacuum protective atmosphere. According to the preparation method, the intermediate alloy is prepared firstly, then the intermediate alloy is subjected to the steps of vacuum melting, secondary feeding and the like, all the components are made to be uniform, the temperature is made to be uniform, finally, solid solution strengthening, quenching, intermediate annealing and crystallization annealing are conducted, multiple strengthening mechanisms such as solid solution strengthening, fine grain strengthening and second phase strengthening are achieved, and blunt oxides are generated on the surface of the intermediate alloy; on the basis of ensuring the biocompatibility of the alloy, the corrosion resistance and the wear resistance of the alloy are improved.