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Method for preparing silver-enriched antibacterial film on pyrolytic carbon and TiN film for medical use

An antibacterial film, pyrolytic carbon technology, applied in the direction of ion implantation plating, coating, metal material coating process, etc., to achieve obvious antibacterial properties, uniform thickness and uniform distribution.

Inactive Publication Date: 2006-09-06
TIANJIN NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The method of preparing silver-rich antibacterial film on the surface of medical materials has not been reported so far

Method used

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  • Method for preparing silver-enriched antibacterial film on pyrolytic carbon and TiN film for medical use
  • Method for preparing silver-enriched antibacterial film on pyrolytic carbon and TiN film for medical use
  • Method for preparing silver-enriched antibacterial film on pyrolytic carbon and TiN film for medical use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Before injection, put the polished and cleaned pyrolytic carbon sample S11 on the rotating water-cooled sample stage (2) of the multifunctional ion beam assisted deposition equipment (such as figure 1 shown in middle 2); after the vacuum unit (1) is vacuumed, the background vacuum degree is higher than 1×10 -3 Pa is sufficient; the sputtering ion source (3) and the sputtering ion source (4) are sputtered and cleaned with a nitrogen ion beam with an energy of 1KeV for 5 minutes; the MEVVA source (8) is first used with a high energy of 70keV, and the implantation dose is 2× 10 14 / cm 2 silver ions, and then use relatively low energy 30keV, the dose is 3×10 14 / cm 2 The silver ions are injected into the surface of the pyrolytic carbon material; the rotating water-cooled target stage (7) is always circulated by the chiller with 10°C tap water to cool the rotating water-cooled target stage (7) and the sample stage (2), so that the pyrolysis The carbon temperature is main...

Embodiment 2

[0033] Example 2: Pyrolytic carbon material sample S12, after sputtering and cleaning for 5 minutes, the MEVVA source (8) uses high energy 70keV, and the injection dose is 2×10 15 / cm 2 Silver ions, and then use low energy 30keV, the dose is 3×10 15 / cm 2 The surface of the pyrolytic carbon material is implanted with silver ions, and the total dosage is 5×10 15 / cm 2uniform silver-rich layer. As shown in Table 2, the antibacterial rate to Staphylococcus aureus is tested by the direct contact method, and the antibacterial rate to Escherichia coli is as shown in Table 3, all reaching 100%, and all the other are the same as in Example 1.

Embodiment 3

[0034] Example 3: Pyrolytic carbon sample S13, after sputtering and cleaning for 5 minutes, the MEVVA source (8) uses high energy 70keV, and the injection dose is 2×10 16 / cm 2 silver ions, then use low energy 30keV, dose 3×10 16 / cm 2 The silver ions were implanted to form a total dose of 5×10 16 / cm 2 The uniform silver-rich layer, antibacterial rate also reaches 100%, all the other are with embodiment 2. like figure 2 It is the colony pictures of pyrolytic carbon non-silver injected sample S8 and the corresponding silver injected samples S12, S13 and S11. From this, it can be seen qualitatively that S11 has obvious antibacterial properties, and the antibacterial rates of S12 and S13 both reach 100%.

[0035] Sample serial number

[0036] Sample serial number

[0037] (2) Example of forming a uniform silver-rich antibacterial film on a TiN film on a stainless steel substrate

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Abstract

The invention relates the method for preparing rich silver antibiotic film used for medical pyrolytic carbon and TiN film. It solves the antibiosis question. The method comprises the following steps: on the pyrolytic carbon: a buffing and cleaning; b evacuating; c sputtering and cleaning for 5 minutes with 1keV nitrogen ion; d injecting silver ion: 70, 30keV energy, 2-8mA beam current, 2X1014 / cm2-3X1014 / cm2 dosage, and forming rich silver antibiotic film and antibiosis ratio being 100%; on TiN film: a buffing and cleaning; b evacuating; c sputtering and cleaning for 5 minutes with 1keV nitrogen ion; d sputtering Ti target with 3keV, 80mA Ar+ ion, 20-40keV, beam current: bombarding with 2-8mA high-energy N+ ion for 10-20 minutes; 50-350eV, beam current: bombarding with 10-30mA low-energy N+ ion for 60-180 minutes to deposit, N2 air pressure being 8X10 3Pa; e injecting silver ion: 30-80keV, beam current: 2-8mA, 1X1017 / cm2-5X1018 / cm2 dosage, forming rich silver antibiotic film and antibiosis ratio being 90%. The film has the advantages of good abradability, strong adhesive force and anti-corrosion, good cell compatibility and long antibiosis time-effect. The film can be used to prepare artificial heart valve and hard tissue alternate material which is implanted in human.

Description

technical field [0001] The invention relates to the surface modification and optimization of a medical material, in particular to a method for preparing an antibacterial film on the surface of a medical material for implanting into a human body. Background technique [0002] At present, when the medical materials used for implanting in the human body are in long-term (or temporary) contact with the human body, they must fully meet the characteristics of compatibility with the biological environment, antibacterial, non-toxic, etc., and this mainly depends on the interaction between the surface of the material and the biological environment . Therefore, controlling and improving the surface properties of medical materials is a key way to improve and promote the interaction between surfaces and organisms. Isotropic pyrolytic carbon, which has the characteristics of good mechanical properties, corrosion resistance and good biocompatibility, is the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C23C14/22C23C14/34C23C14/48C23C14/06
Inventor 赵杰唐慧琴郭希明刘谦祥
Owner TIANJIN NORMAL UNIVERSITY
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