462 results about "Artificial heart" patented technology

Implantable prosthetic valve systems and methods for implanting them are provided. Magnets are employed within one or more components of the valve systems to facilitate anchoring of the prosthetic valve at a target implant site, delivery of the prosthetic valve to the target implant site or both.

An apparatus for replacing a cardiac valve includes a first ring assembly and a second ring assembly. The first ring assembly includes a first magnetic member. The second ring assembly includes a second magnetic member and is magnetically attachable to the first magnetic member to sealingly attach the first and second ring assemblies together. A prosthetic cardiac valve is secured within the second ring assembly. A method for replacing a cardiac valve is also described.

A prosthetic valve for replacing a cardiac valve includes an expandable support member and at least two valve leaflets made of a first layer of biological material selected from peritoneal tissue, pleural tissue or pericardial tissue. A second layer of biological material is attached to the support member. The second layer is also made from peritoneal tissue, pleural tissue or pericardial tissue. The second layer includes a radially inwardly facing surface that defines a conduit for directing blood flow. The valve leaflets extend across the conduit to permit unidirectional flow of blood through the conduit. Methods for making and implanting the prosthetic valve are also provided.

The present invention relates generally to decellularized extracellular matrix of conditioned body tissues. The decellularized extracellular matrix contains a biological material, preferably vascular endothelial growth factor (VEGF), produced by the conditioned body tissue that is in an amount different than the amount of the biological material that the body tissue would produce absent the conditioning. The invention also relates to methods of making and methods of using said decellularized extracellular matrix. Specifically, the invention relates to treating defective, diseased, damaged or ischemic cells, tissues or organs in a subject by administering, injecting or implanting the decellularized extracellular matrix of the invention into a subject in need thereof. The invention is further directed to a tissue regeneration scaffold for implantation into a subject inflicted with a disease or condition that requires tissue or organ repair, regeneration and / or strengthening. Additionally, the invention is directed to a medical device, preferably a stent or an artificial heart, having a surface coated or covered with the decellularized extracellular matrix of the invention or having a component comprising the decellularized extracellular matrix of the invention for implantation into a subject, preferably a human. Methods for making the tissue regeneration scaffold and methods for manufacturing a coated or covered medical device having a component comprising decellularized extracellular matrix of conditioned body tissues are also provided.

An artificial heart valve and weaving method thereof are disclosed. The valve stent includes a tubular stent (10), valve leaflets (33), sealing membranes (351, 354), x-ray opaque markers (311, 312) and flexible connecting loops (41). The middle segment (15) of the net stent (10) is tubular or drum-shaped, or provided with radial protrusion structures (153), or provided with outer annular structures (155), or provided with outer free tongues (156), or provided with radial protrusion structures (153) and outer free tongues (156). The stent can be made by up and down interweaving the same one elastic metal wire, and also can be made by up and down interweaving different elastic metal wires. Moreover, the structure, shape and function of the valve stent are optimized; in radical compression, the valve can be transported to the right place with the help of interventional device; after expansion, fitted with figure of the vascular wall in the radical and axial direction, the artificial heart valve stent will not produce paravalvular leak; even more after implanting, the valve has a normal effect on prevent the slippage of artificial valve, which is caused by the blood reflux through the closed valve.

The present invention provides a human engineered power and control system for artificial hearts or assist devices configured for ease of use, ruggedness, and high reliability. Battery powered systems of the prior art have required multiple cables and connectors that are subject to failure due to damage or wear. In the present invention, direct connection of the batteries to the control system eliminates multiple cables and connectors used with previous designs. A novel method of connecting batteries to the control system and exchanging batteries without interruption of power is provided in a compact user friendly configuration. The control system may provide periodic reductions in assist device flow to permit the natural ventricle to eject blood through the natural outflow valve, open the valve leaflets to prevent them from adhering together, and achieve sufficient washout to prevent thrombosis. Using either software based control or software independent electronic circuitry, the flow pumped by the artificial heart is reduced for a long enough period of time to permit at least a few beats of the natural heart to generate sufficient pressure to open the outflow valve. In a control system embodiment in which the patient manually adjusts the pump speed to incremental settings for rest and exercise conditions, a pulsatile flow mode is disclosed which provides approximately the same flow at a given incremental setting as the pump produces when running in a constant speed mode at the same setting. As the patient learns which speed setting is best for daily activities, the patient may use the same setting with either a pulsatile or constant pump speed mode.

An artificial heart valve comprising a tubular base body having sinuse(s) of Valsalva and valve cusp(s) provided inside the base body, characterized in that the base body and the valve cusps comprise a bioabsorbable polymer material.

The invention is directed to compositions comprising decellularized bone marrow extracellular matrix and uses thereof. Methods for repairing or regenerating defective, diseased, damaged or ischemic tissues or organs in a subject, preferably a human, using the decellularized bone marrow extracellular matrix of the invention are also provided. The invention is further directed to a medical device, preferably a stent or an artificial heart, and biocompatible materials, preferably a tissue regeneration scaffold, comprising decellularized bone marrow extracellular matrix for implantation into a subject.

A prosthetic stented heart valve which includes a compressible and expandable stent structure having first and second opposite ends, an expanded outer periphery, and a compressed outer periphery that is at least slightly smaller than the expanded outer periphery when subjected to an external radial force. The valve further includes a valve segment comprising a dual-layer sheet formed into a generally tubular shape having at least one longitudinally extending seam, and a plurality of leaflets formed by attachment of an outer layer of the dual-layer sheet to an inner layer of the dual-layer sheet in a leaflet defining pattern. The valve segment is at least partially positioned within the stent structure. The valve may further include at least one opening in the outer layer of the dual-layer sheet that is spaced from both the first and second ends of the stent structure.

The invention relates to an artificial heart support valve, wherein it comprises tubular mesh support, valve blade, sealing film, impermeable x-ray mark, and flexible coiple ring; the middle part of mesh support is round or cylinder, or arranged with radial protrusion, or arranged with outer annular structure, or arranged with outer free tone, or arranged with radial protrusion and outer free tone. The invention can radial compress to transmit into accurate position via medium device, to be expanded, while the expanded valve will meet the shape of valve, without leakage. The invention can avoid being pushed when the blood refluxes and it is closed.

In an artificial heart valve for the replacement of an aortic or a mitral valve, including an annular body, which is provided at its outer circumference with means for mounting the artificial valve in place by surgical procedures and which defines in its interior a blood flow passage in which valve flap elements are pivotally supported so as to open or close the blood flow passage depending on their pivot positions, the annular body includes circumferentially spaced projections extending into the flow passage and being provided at their inner ends with pivot joints on which the valve flap elements are pivotally supported.

At least one aspect is directed to a totally artificial heart, and at least another aspect is directed to a method of controlling blood flow in a patient. The totally artificial heart may include a first rotary pump having an input to receive blood and an output to provide blood to a patient's lungs, a second rotary pump having an input to receive blood and an output to provide blood to the patient's body, a first sensor associated with the first rotary pump, a second sensor associated with the second rotary pump, and a control system coupled to the first sensor, the second sensor, the first rotary pump and the second rotary pump and configured to control characteristics of the first rotary pump and the second rotary pump based on signals received from at least one of the first sensor and the second sensor such that an average flow of blood through the second rotary pump is greater than an average flow of blood through the first rotary pump

This invention relates to rotary pumps adapted, but not exclusively, for use as artificial hearts or ventricular assist devices and, in particular, discloses in preferred forms a seal-less shaft-less pump featuring open or closed (shrouded) impeller blades with the edges of the blades used as hydrodynamic thrust bearings and with electromagnetic torque provided by the interaction between magnets embedded in the blades and a rotating current pattern generated in coils fixed relative to the pump housing.

A blood pump system for an artificial heart including: a control unit for controlling a blood pump, the control unit including a first alarm generating part for generating a first alarm signal according to the state of the blood pump, and a speaker for outputting an audible sound upon receiving the first alarm signal when the blood pump is in an abnormal state; a supervisory section configured to supervise the state of the control unit; a determining section configured to determine whether the control unit is in an abnormal state or not, based on output signal from the supervisory section; and a second alarm generating part for generating a second alarm signal according to the state of the control unit, based on the result of determination by the determining section.

Provided is an artificial heart control device for controlling a blood pump which assists flow of blood in a heart, the artificial heart control device including: a timing detection part which is configured to detect reference timing within a cardiac cycle of the heart; and a blood pump control part which is configured to control a rotational speed of the blood pump, wherein the blood pump control part controls, with reference to the reference timing detected by the timing detection part, the rotational speed of the blood pump such that the rotational speed becomes a rotational speed corresponding to a predetermined control pattern. According to the present invention, it is possible to provide an artificial heart control device, an artificial heart system and an artificial heart control method which can provide a load control optimum for the recovery of functions of a patient's own heart.

Devices and methods can be used for artificial cardiac pacing and / or resynchronization. For example, this document provides improved electrodes for stimulating and sensing electrical activity of the heart, and provides pacing and resynchronization systems incorporating such electrodes. While the devices and methods provided herein are described primarily in the context of pacing, it should be understood that resynchronization can additionally or alternatively be performed in an analogous manner, and that the scope of this disclosure includes such subject matter.

The present disclosure describes devices, systems, and methods for loading, delivering, positioning, and deploying an artificial heart valve device at the mitral annulus. A delivery system includes a delivery member coupled to a handle assembly and extending distally from the handle assembly. The valve device is attached at the distal end of the delivery member, and is constrained within a valve cover of an outer sheath. A delivery catheter is configured to advance the valve relative to the outer sheath, and a suture catheter includes sutures / tethers which maintain proximal tension on the valve prior to deployment.

The invention is directed to compositions comprising decellularized bone marrow extracellular matrix and uses thereof. Methods for repairing or regenerating defective, diseased, damaged or ischemic tissues or organs in a subject, preferably a human, using the decellularized bone marrow extracellular matrix of the invention are also provided. The invention is further directed to a medical device, preferably a stent or an artificial heart, and biocompatible materials, preferably a tissue regeneration scaffold, comprising decellularized bone marrow extracellular matrix for implantation into a subject.

An artificial heart pump system is concerned where the load of a processor in a controller used for a blood pump system is reduced and the performance of the hardware is maintained or guarantied, and the artificial heart pump system is provided independently with a controlling processor for controlling an operation status of a blood pump so as to perform in a preset condition and with an observing processor for controlling a display unit displaying an operation status and an operation condition of the blood pump. In addition, a memory device is mounted in an outside-the-body type battery pack included in the artificial heart pump system; data such as pump data, event log or the like is stored therein; and data are collected and managed automatically by a battery charger when charging the battery charger for a daily performance. Further, a user interface unit of an artificial heart pump is proposed where a user can confirm displayed contents of the controller without exposing the controller externally.

The invention relates to a magnetic suspension artificial heart pump, comprising a frame, a motor, a magnetic bearing and a blood pump blade wheel, wherein, the blood pump blade wheel, a motor rotor and a magnetic bearing rotary magnetic ring form a combined rotor to be mounted in a blood separating sheath with blood inlet and outlet, a motor stator, a fixed magnetic ring of the magnetic bearing and a radial displacement sensor combine a combined stator to be arranged at an outer ring of the blood separating sheath to be fixed with the frame. The invention realizes magnetic suspension on the rotor, with reliable operation, and uses blood separating sheath to avoid polluting blood from heart pump most. The invention has compact structure, small volume, better integration, long service life, and better transplant property.

A method of biolization to the surface of inorganic material includes the following steps: the surface is spattered to form a tantalum oxide or a titanium oxide thin film; and then the inorganic material is put in a plasma immersion ion implantation device; after vacuumization, hydrogen, water vapour or ammonia is fed in, with gas pressure 0.05 to 50 Pa; the radio frequency discharge power is 200 to 1200W; the range value of the loaded pulse high-voltage power is 1KV to 100KV, the frequency is 50 to 40000HZ, and the duty ratio is 3 percent to 80 percent; the heating temperature is 20 to 500 DEG C; the treatment time is 0.1 to 5 hours; finally, the inorganic material is put into 10 to 100mg / mL albumin or heparin solution to be soaked for 2 to 48 hours under 20 to 40 DEG C soaking temperature. The method does not damage the activity of the biomolecule and the protein; the prepared inorganic material with biolized surface has good anti-coagulability, is used for medical blood vessel scaffolds and artificial heart valves, and can greatly improve the product performance.

A wholly implantable non-natural heart for humans is a double pump configuration provided with two auricles and two ventricles. Both the said auricles and ventricles are driven by solenoid actuators interacting with high energy magnets; the auricles and ventricles which are hollow chambers are provided with one-way valves in the usual manner, for the purpose of effectively and rhythmically moving blood to and from the said chambers; power generation for driving said solenoid actuators, as well as an electronic control unit is accomplished by a power generating module which could be a simple battery, a miniature spring-driven generator, a mems generator or a redundant self-sustaining generator or a combination of all of the above; the self-sustaining generator has been proposed and designed to power this present artificial heart and will be presented in a separate patent application in the near future as a follow up to this present one; the aforementioned electronic control unit is preferably configured to amplify the signals from the power generating unit as well as utilizing input / output signals from temperature and pressure sensors embedded in the heart to vary contractile force and frequency of beats, based on bodily requirements, thereby mimicking some functions of the natural heart; the electronic unit is also preferably provided with a translator chip that converts signals from the cardiac / vargus trunks (sympathetic and parasympathetic nerves) via electrodes into clear electric currents for varying actuator outputs; the heart would be implanted in the normal position in the chest, atop the diaphragm, while the electronic control unit and the power generation module would preferably be implanted behind the breastbone and lower abdomen respectively; all components of the present invention are amenable to current mass production techniques and miniaturization for the purpose of fitting into individuals of various sizes; as is clearly shown in FIG. 1, this present invention is an integral three-tiered configuration constituted of pumping unit I, the power generating unit II and the controller III. Also, as aforementioned, additional signals from the embedded temperature and pressure sensors, as well as nerve connecting electrodes are used to manipulate instantaneous outputs. The said electrodes are in the form of cuffs and are to be implanted on the vargus nerves (sympathetic and parasympathetic); Texas Instruments (TI) manufactures reliable operational and instrumentation amplifiers which can detect condition, and amplify nerve signals. The VCO in the controller uses the signals to manipulate instantaneous outputs of the actuating solenoids.

An auxiliary artificial heart pump drive device for driving an auxiliary artificial heart pump includes first and second pump control parts which are arranged in duplexed configuration. Each pump control part controls the auxiliary artificial heart pump by outputting a drive signal to the auxiliary artificial heart pump. Each pump control part has a means which, when a failure is detected in the pump control part, electrically cuts off a path through which the drive signal is outputted to the auxiliary artificial heart pump. According to the present invention, it is possible to provide an auxiliary artificial heart pump drive device and an auxiliary artificial heart system which exhibit high availability even when a serious failure occurs by any chance without duplexing a pump device.

The present invention provides a total artificial heart system for auto-regulating flow and pressure balance. In one embodiment the system comprises an atrial reservoir comprising inlets and outlets connectable to a mammalian cardiovascular system and at least first and second continuous pumps connected to the atrial reservoir. In further embodiments, the system comprises an atrial reservoir comprising at least two atrial chambers, and a means for transmitting fluid pressure between the atrial chambers. The means for transmitting fluid pressure include, but are not limited to a diaphragm, an interatrial window, a flexible membrane, a valve, a filter, or combinations thereof. In another embodiment, the means for transmitting fluid pressure comprises an implantable diaphragm comprising an outer rim attachable to biological tissue and a membrane anchored at its periphery by said outer rim.

A mitral annuloplasty ring that has a saddle shape with an upward bow in both an anterior segment and a posterior portion, with the upward bow being more pronounced in the anterior segment. The ring defines a closed ring body with a rounded isosceles triangular shape and the anterior segment along a long side. The posterior portion bulges outward to create a minor-major axis dimension ratio of between about 3.3:4 to 4:4. An inner ring body is made of a generally rigid material such as titanium that will substantially resist distortion when subjected to the stress imparted thereon after implantation in the mitral valve annulus of an operating human heart. The outward and upward posterior bow of the annuloplasty ring corrects for pathologies associated with mitral valve prolapse, as seen with Barlow's syndrome for instance, in which the leaflets tend to be elongated or floppy. The anterior segment has an enhanced upward bow to conform to systolic mitral annulus shapes, and the upward posterior bow is somewhat lower, for example between 1-2 mm lower, to help reduce the chance of suture pull-out, or dehiscence.