Inorganic material surface biological method

An inorganic material and biological technology, applied in metal material coating technology, ion implantation plating, coating, etc., can solve problems such as weak binding force, poor biochemical effect, and weakened biomolecular activity, and achieve strong binding force, The effect of uniform modification and accelerated healing

Inactive Publication Date: 2008-07-09
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After such modification, the activity of biomolecules may be weakened, and the binding force between the biocoating and the surface of the material is weak, and the biochemical effect is poor.

Method used

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  • Inorganic material surface biological method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1～8

[0023] These 8 embodiments are all coated with tantalum oxide film on the surface of inorganic materials, then generating hydroxyl groups on the tantalum oxide film, and finally covalently grafting albumin; all are carried out according to the following operation steps:

[0024] A. Sputtering coating, using the existing unbalanced magnetron sputtering technology to sputter on the surface of inorganic materials to form a tantalum oxide film.

[0025] The specific operation steps are as follows:

[0026] TaO thin films were prepared by unbalanced magnetron sputtering device. This embodiment adopts the existing unbalanced magnetron sputtering device, including: workbench (sample stage), four sputtering target stages, pulse or DC power supply, workpiece, changeover switch, gas cylinder, bias power supply and heating device .

[0027] Cleaning: First, install the metal tantalum target on the target stage of the unbalanced magnetron sputtering equipment, place the workpiece on the...

Embodiment 1-8

[0039] Examples 1-8, the more specific operation during covalent grafting is: first prepare the albumin solution with distilled water, and then add an appropriate amount of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide in sequence hydrochloride (EDC), N-hydroxysuccinimide (NHS) and 2-morpholineethanesulfonic acid (MES) to activate the albumin surface. Immerse the inorganic material treated in step B into the albumin solution and seal it, place it in a constant temperature water bath (can be shaken) for a fixed set time, and take it out. After the physical adsorption layer on the surface of the workpiece is removed by ultrasonic cleaning, it is dried and stored for use.

Embodiment 9-16

[0041] Embodiments 9-16 are the same as Embodiments 1-8 respectively, except that in step A, the target used for sputtering coating is titanium metal, so that a titanium oxide film is formed on the surface of the inorganic material.

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Abstract

A method of biolization to the surface of inorganic material includes the following steps: the surface is spattered to form a tantalum oxide or a titanium oxide thin film; and then the inorganic material is put in a plasma immersion ion implantation device; after vacuumization, hydrogen, water vapour or ammonia is fed in, with gas pressure 0.05 to 50 Pa; the radio frequency discharge power is 200 to 1200W; the range value of the loaded pulse high-voltage power is 1KV to 100KV, the frequency is 50 to 40000HZ, and the duty ratio is 3 percent to 80 percent; the heating temperature is 20 to 500 DEG C; the treatment time is 0.1 to 5 hours; finally, the inorganic material is put into 10 to 100mg/mL albumin or heparin solution to be soaked for 2 to 48 hours under 20 to 40 DEG C soaking temperature. The method does not damage the activity of the biomolecule and the protein; the prepared inorganic material with biolized surface has good anti-coagulability, is used for medical blood vessel scaffolds and artificial heart valves, and can greatly improve the product performance.

Description

technical field [0001] The invention relates to a biochemical method for the surface of materials, in particular to a biochemical method for the surface of inorganic materials. Background technique [0002] Biomedical materials used to manufacture artificial hearts, artificial valves, artificial lungs, vascular stents, and artificial blood vessels are called biomaterials that are in contact with blood. The activation of platelets and the aggregation and deformation of platelets can also selectively adsorb certain plasma proteins, thereby preventing the formation of thrombus. In recent years, great progress has been made in the biochemistry of polymer biomaterials, that is, anticoagulation research. The main method is to modify and modify the surface of polymer biomaterials with excellent performance. By changing the surface structure and morphology of materials , Hydrophilicity, chargeability, surface energy, etc., to guide the selective adsorption of biomolecules on the su...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/12A61L31/10A61L31/02A61L27/40A61L27/02A61L27/34A61L33/12C23C14/35C23C14/08
Inventor 冷永祥陈俊英黄楠陶涛
Owner SOUTHWEST JIAOTONG UNIV
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