2 results about "Albumin solution" patented technology

The application belongs to the technical field of biological medicine material preparation, and particularly relates to albumin nanoparticles loaded with ferroptosis related drugs and a preparation method thereof. The ferroptosis related drug composition comprises porphyrin drugs, unsaturated fatty acid drugs-cystamine and sulfosuccinimidyl oleate (SSO). The porphyrin drugs, the unsaturated fatty acid drugs-cystamine and the SSO are slowly added dropwise into an albumin solution under stirring, the drugs enter the hydrophobic cavities of the albumin, and uniform nanoparticles are spontaneously formed. The obtained nanoparticles are small in size and uniform, can efficiently deliver drugs through passive targeting mediated by the EPR effect and active targeting mediated by the Gp60-Caveola-SPARC pathway, improve stability, reduce accumulation at non-target sites and systemic toxicity, amplify the effect of ferroptosis after combination compared with the ferroptosis related drugs used alone, and thus produce a synergistic anti-tumor effect.

This invention discloses a method for preparing flower-shaped silver powder. The method includes: 1. Preparing a silver nitrate solution to obtain solution A; 2. Preparing equal volumes of ascorbic acid solution and soy albumin solution, and mixing them to obtain solution B; 3. At room temperature, simultaneously and symmetrically adding solution A and anhydrous ethanol to solution B to react, allowing the generated silver particles to settle, be washed, and dried to obtain flower-shaped silver powder; applying this flower-shaped silver powder to low-temperature silver paste and Raman-enhanced substrates. The preparation method of this invention effectively controls the morphology of the reduced product silver powder through the synergistic effect of soy albumin and ethanol, preparing flower-shaped silver powder with a multi-level nanostructure. This flower-shaped silver powder has good dispersibility and high activity, and the preparation process is simple, efficient, environmentally friendly, and easy to scale up for production, making it suitable for fields such as electronics, catalysis, and biomedicine.