5 results about "Nanoparticle Production" patented technology

The present invention relates to a quantum dot synthesis method for synthesizing chalcopyrite-based quantum dots, the quantum dot synthesis method comprising: a nanoparticle production step for reacting a group I element and a group VI element to produce nanoparticles; and a cation diffusion step for diffusing group III element cations into the nanoparticles by heat treatment. Accordingly, there is provided a method for synthesizing quantum dots having good light-emitting characteristics having uniform particle diameters but not having compositional inhomogeneity.

In some aspects, a method can include feeding an eLNP solution to a first inlet, the first inlet splitting into a first sub-inlet and a second sub-inlet, the first sub-inlet connected to a first side of a central region of a mixer, the second sub-inlet connected to a second side of the central region of the mixer, feeding an mRNA solution to a second inlet, the second inlet connected to a third side of the central region of the mixer, the third side orthogonal to the first side and the second side, mixing the eLNP and the mRNA in the central region to form encapsulated eLNP, and transferring the encapsulated eLNP out of the central region via an outlet, the outlet coupled to a fourth side of the central region, the fourth side opposite the third side.

The device 100 for producing nanoparticles includes a microplate 102 containing multiple fluid mixing units 104 arranged in an array. Each fluid mixing unit is configured to produce nanoparticles. The device is configured to enable high-throughput lipid nanoparticle testing and development and to generate a large number of novel or specific nanoparticle formulations.

The application discloses a kind of silane-based gold nanoparticles with high efficient photodynamic effect and its preparation method and application.The preparation method is specifically as follows: first, the aqueous phase chloroauric acid is transferred to toluene, and the chloroauric acid in toluene phase is stirred uniformly in methanol phase;The first ligand mercapto propyl trimethoxysilane is added and stirred;The second ligand mercapto polyethylene glycol is added and stirred;Sodium borohydride reducing agent is added and the reaction is continued;Deionized water is added for hydrolysis reaction;After purification, gold nanoparticles are obtained.The application enhances the photodynamic effect of gold nanoparticles by regulating the surface ligand and type of gold nanoparticles.The material has the advantages of fluorescence emission wavelength in near-infrared II region, high efficient photodynamic effect, good biocompatibility, strong targeting, high stability, etc.The gold nanoparticle production method is simple, low in cost and easy to industrialize, and has good application scenarios in the fields of tumor imaging and photodynamic therapy, etc.

This disclosure relates generally to production of stable and uniformly dispersed nanoparticles. Convention methods of nanoparticle production includes a two-step approach that utilizes additives or surface modifiers. The disclosed method avoids using any additives / surface modifiers owing to the environmental and economic implications. The method includes employing process conditions in a reaction to manipulate electrostatic double layer repulsive forces among nanoparticles to impart the dispersion stability of nanoparticles. The reaction includes pouring pH modifier dropwise into metal precursor solution with vigorous stirring forming metal hydroxide solution, while maintain ranges for concentration of metal precursor solution about 0.15M to 0.75 M, pH about 9 to 12, ionic conductivity about 50 to 200 mS / cm, stirring speed about 800 to 1200 rpm, aging time 6 to 24 hours. The metal hydroxide solution is heated with temperature maintained in range of 100 to 400° C. to obtain nanoparticle slurry comprising a stable suspension of the nanoparticles.