14 results about "Nanoparticle Production" patented technology

The present invention relates to a quantum dot synthesis method for synthesizing chalcopyrite-based quantum dots, the quantum dot synthesis method comprising: a nanoparticle production step for reacting a group I element and a group VI element to produce nanoparticles; and a cation diffusion step for diffusing group III element cations into the nanoparticles by heat treatment. Accordingly, there is provided a method for synthesizing quantum dots having good light-emitting characteristics having uniform particle diameters but not having compositional inhomogeneity.

The present disclosure is directed towards improved systems and methods for large-scale production of nanoparticles used for delivery of therapeutic material. The apparatus can be used to manufacture a wide array of nanoparticles containing therapeutic material including, but not limited to, lipid nanoparticles and polymer nanoparticles. In certain embodiments, continuous flow operation and parallelization of microfluidic mixers contribute to increased nanoparticle production volume.

The invention relates to the technical field of progesterone sustained-release nanoparticle production, in particular to a progesterone sustained-release nanoparticle which comprises progesterone and further comprises solid lipid and liquid lipid according to the formula ratio of 1: 1.4: 1.2: 0.8. A preparation method of the progesterone sustained-release nanoparticle comprises raw material preparation of progesterone, solid lipid and liquid lipid and melt emulsification. The prepared progesterone lipid nanoparticles have high drug entrapment efficiency which can reach 77.48% at most, and have obvious drug sustained and controlled release performance, although the particle size of the nanoparticles is increased along with the increase of the content of liquid lipid-oleic acid in the lipid nanoparticles, the drug entrapment efficiency is improved, the in-vitro release of the drug is accelerated, and the progesterone lipid nanoparticles have good application prospects. According to the progesterone nanostructure lipid carrier, the drug content in the preparation process of the nanoparticles is improved, the drug encapsulation efficiency of the prepared progesterone nanostructure lipid carrier is reduced, but the drug loading capacity of the nanoparticles can be improved, and when the dosage reaches 20%, the drug loading capacity of the nanoparticles can reach 11.57%.

The present invention relates to automated nanoparticle synthesis systems and computer-implemented methods of monitoring and controlling a process of manufacturing lipid nanoparticles (LNPs) containing nucleic acid cargo. The present invention furthermore relates to a computer program product comprising computer-readable instructions, which, when loaded and executed on a computer system, causes the computer system to perform operations according to said methods.

Eco-Smart Biogenic Nanoparticle Production Device

Disclosed are a 3D micro-fluidic chip for producing a nano-biopharmaceutical, a method for preparing a product by using the chip, and a use of the product. Mixing channels of a 3D mixing unit include a first channel and a second channel, the first channel and the second channel among the mixing channels are located in the same plane, and any two adjacent mixing channels are located in different planes. In the 3D mixing unit, any two adjacent mixing channels are located in different planes, that is, the plurality of mixing channels form a 3D layout, so that when fluid in a mixing channel enters the next mixing channel, the fluid enters another space plane, and thus the probability that a turbulence component and a fluid component collide with each other is increased, the fluid mixing efficiency is improved, and the mixing effect is improved, thereby solving the problems in various applications such as low mixing efficiency and poor mixing effect of a lipid nanoparticle aqueous phase and an organic phase, thus accurately controlling the nanoparticle production, improving the drug embedding efficiency, and improving the drug delivery and treatment effects.

In some aspects, a method can include feeding an eLNP solution to a first inlet, the first inlet splitting into a first sub-inlet and a second sub-inlet, the first sub-inlet connected to a first side of a central region of a mixer, the second sub-inlet connected to a second side of the central region of the mixer, feeding an mRNA solution to a second inlet, the second inlet connected to a third side of the central region of the mixer, the third side orthogonal to the first side and the second side, mixing the eLNP and the mRNA in the central region to form encapsulated eLNP, and transferring the encapsulated eLNP out of the central region via an outlet, the outlet coupled to a fourth side of the central region, the fourth side opposite the third side.

The invention relates to the technical field of nano-material green manufacturing and waste water recycling, in particular to a PVP and acetic acid recycling method and system for nano-particle supercritical hydrothermal synthesis preparation, and the method comprises the following steps: carrying out continuous circulating filtration and concentration on waste liquid to obtain PVP concentrated liquid of membrane concentrated water and permeate liquid containing acetic acid; the PVP concentrated solution of the membrane concentrated water is used for producing nano-particles for reuse; the permeate containing acetic acid is concentrated, an acetic acid concentrated solution and permeate water are obtained, and the permeate water is also used for producing nano-particles for reuse; and reacting the acetic acid concentrated solution with a metal oxide to generate a metal salt solution which is recycled for producing nano-particles. By means of the method, the problems that in the prior art, energy consumption of treatment of waste water containing PVP and acetic acid is high and raw materials are wasted when the nanometer silver powder is prepared through a supercritical hydrothermal method can be effectively solved.

Provided is a metal phosphide nanoparticle production method with which it is possible to produce particles stably in terms of the shape and the size thereof by using, as raw materials, substances safe for the human body for both as a metal source and a phosphorus source. The present invention pertains to a metal phosphide nanoparticle production method comprising: mixing at least one metal source selected from the group consisting of prescribed compounds such as iron(II) chloride with a compound represented by general formula [1] X-Y-Z (in the formula, descriptions of symbols are omitted) in a solvent to obtain a metal complex of a metal constituting the metal source and a compound represented by general formula [1]; mixing a phosphorus compound (excluding sodium phosphide) with a surfactant while heating the same to obtain a first mixture; and heating a second mixture obtained by mixing the first mixture and the metal complex.

The present invention relates to an automated apparatus for producing nanoparticles, and a nanoparticle production method using same. Specifically, the present invention relates to the automated apparatus for producing nanoparticles, comprising: a microfluidic device; a mounting part for fastening the microfluidic device to the automated apparatus; an inlet part that supplies a fluid containing raw materials; a pneumatic pressure control part that provides pressure for fluid movement; and a recovery part that recovers the produced nanoparticles according to the condition thereof.

This disclosure relates to solvothermal synthesis-based method for nanoparticles production. In conventional methods, precursor loading is limited to below the solubility limit of the precursor and results in low throughput and low yield. The disclosed method increases metal precursor loading up to the solubility limit of the metal precursor solution. The method includes pouring the pH modifier dropwise into the metal precursor solution with vigorous stirring, resulting in formation of metal hydroxide solution. The concentration of metal precursor solution is maintained in range of 0.025 M to 2 M, pH in range of 9 to 12, and stirring speed of 800-1200 rpm. The metal hydroxide solution is heated and temperature of the reaction in the range of 25° C. to 400° C. is maintained with aging time in the range of 6 to 24 hours to obtain the nanoparticle slurry resulting production of high yield and high throughput nanoparticles.

The device 100 for producing nanoparticles includes a microplate 102 containing multiple fluid mixing units 104 arranged in an array. Each fluid mixing unit is configured to produce nanoparticles. The device is configured to enable high-throughput lipid nanoparticle testing and development and to generate a large number of novel or specific nanoparticle formulations.

The application discloses a kind of silane-based gold nanoparticles with high efficient photodynamic effect and its preparation method and application.The preparation method is specifically as follows: first, the aqueous phase chloroauric acid is transferred to toluene, and the chloroauric acid in toluene phase is stirred uniformly in methanol phase;The first ligand mercapto propyl trimethoxysilane is added and stirred;The second ligand mercapto polyethylene glycol is added and stirred;Sodium borohydride reducing agent is added and the reaction is continued;Deionized water is added for hydrolysis reaction;After purification, gold nanoparticles are obtained.The application enhances the photodynamic effect of gold nanoparticles by regulating the surface ligand and type of gold nanoparticles.The material has the advantages of fluorescence emission wavelength in near-infrared II region, high efficient photodynamic effect, good biocompatibility, strong targeting, high stability, etc.The gold nanoparticle production method is simple, low in cost and easy to industrialize, and has good application scenarios in the fields of tumor imaging and photodynamic therapy, etc.

This disclosure relates generally to production of stable and uniformly dispersed nanoparticles. Convention methods of nanoparticle production includes a two-step approach that utilizes additives or surface modifiers. The disclosed method avoids using any additives / surface modifiers owing to the environmental and economic implications. The method includes employing process conditions in a reaction to manipulate electrostatic double layer repulsive forces among nanoparticles to impart the dispersion stability of nanoparticles. The reaction includes pouring pH modifier dropwise into metal precursor solution with vigorous stirring forming metal hydroxide solution, while maintain ranges for concentration of metal precursor solution about 0.15M to 0.75 M, pH about 9 to 12, ionic conductivity about 50 to 200 mS / cm, stirring speed about 800 to 1200 rpm, aging time 6 to 24 hours. The metal hydroxide solution is heated with temperature maintained in range of 100 to 400° C. to obtain nanoparticle slurry comprising a stable suspension of the nanoparticles.