Gastroenteric tumor targeted magnetic adriamycin albumin nanoparticles manufactured through pressurization and vibration packing method

An albumin nanoparticle and tumor-targeting technology, which is applied in the field of gastrointestinal tumor-targeted magnetic doxorubicin albumin nanoparticles produced by the pressurized vibration encapsulation method, can solve the problems that anti-tumor drugs cannot be completely replaced

Inactive Publication Date: 2018-02-09
锡山区东港全宝机械经营部
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although molecularly targeted drugs have outstanding curative effects on the tumors they target, they are well tolerated and have mild toxicity, but it is generally believed that they cannot completely replace traditional cytotoxic antineoplastic drugs for a long time. More often, a combination of the two

Method used

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  • Gastroenteric tumor targeted magnetic adriamycin albumin nanoparticles manufactured through pressurization and vibration packing method

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Experimental program
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Embodiment Construction

[0016] 1. Preparation of Nanomagnetic Materials

[0017] Add a certain amount of concentrated hydrochloric acid to the magnetic powder Fe3O4, and stir thoroughly at room temperature for 30 min to completely dissolve it to form a brown-yellow transparent solution. Then add 18% NH4OH, stir while adding, and black precipitate can be seen, adjust the pH value to neutral, and let it stand for 72 h. Discard the supernatant and make a mud paste nano-magnetic substance. Take a certain amount of magnetic substance paste, weigh it, then dry it, weigh it again, and calculate the weight percentage concentration of the magnetic substance.

[0018] 2. Preparation of magnetic doxorubicin albumin nanoparticles

[0019] l ml 2 5% Add 20 mg of purified doxorubicin from the protein, then add magnetic substance paste equivalent to 72 mg of dry weight, and stir thoroughly. Add the stirred mixture to 30 ml cottonseed oil. Phacoemulsify lmin at 4 °C. Take 100ml of cottonseed oil and heat it at ...

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PUM

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Abstract

The invention relates to gastrointestinal tumor-targeted magnetic doxorubicin-albumin nanoparticles prepared by a compression-vibration wrapping method. The high polymer coating layer on the surface of magnetic doxorubicin albumin nanoparticles is uneven, and the surface of a single magnetic doxorubicin albumin nanoparticle is partially coated with a polymer coating layer, and some parts are not coated with a polymer polymer In the production process of the above magnetic doxorubicin albumin nanoparticles, the magnetic doxorubicin albumin nanoparticles powder is uniformly dispersed and laid on a flat, smooth surface with sufficient surface strength and surrounded by a circle. On the plane, another flat, smooth and hard enough circular surface is pressed on the magnetic doxorubicin albumin nanoparticle powder for pre-pressurization, the two circular planes have equal areas, and the upper surface is embedded in the lower surface circle; Then vibrate, pressurize to the required pressure while vibrating, and then drop the solution of high molecular polymer drop by drop around the magnetic doxorubicin albumin nanoparticle powder. .

Description

technical field [0001] The invention relates to gastrointestinal tumor-targeted magnetic doxorubicin albumin nanoparticles produced by a pressurized vibration encapsulation method. Background technique [0002] The use of molecularly targeted drugs in patients with gastrointestinal tumors can effectively prolong the survival of patients and control the condition of patients. Therefore, the degree of attention in clinical practice is constantly increasing. [0003] Molecular targeted drugs mainly target the key targets of pathophysiological occurrence and development of malignant tumors for therapeutic intervention, and some molecular targeted drugs have shown better efficacy in corresponding tumor treatments. Although molecularly targeted drugs have outstanding curative effects on the tumors they target, they are well tolerated and have mild toxicity, but it is generally believed that they cannot completely replace traditional cytotoxic antineoplastic drugs for a long time. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K41/00A61K47/42A61K47/34A61K31/704A61P35/00
CPCA61K9/5192A61K9/0009A61K9/5146A61K9/5169A61K31/704A61K41/00
Inventor 王全宝
Owner 锡山区东港全宝机械经营部
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