Preparation process for glycyrrhizic acid-mediated hydroxycamptothecine albumin liver cancer targeting nanoparticle lyophilized powder
A technology of hydroxycamptothecin and targeting nanoparticles, which is applied in freeze-dried delivery, medical preparations containing active ingredients, powder delivery, etc., and can solve the problem that nanoparticles do not have active targeting and do not have active targeting , poor biocompatibility and other issues, to achieve the effect of low production cost, high drug loading and uniform distribution
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Examples
example 1
[0024] Dissolve 60 mg of glycyrrhizic acid-coupled albumin in 60 mL of water, dissolve 7.4 mg of hydroxycamptothecin in 2.4 mL of chloroform-absolute ethanol solution, ultrasonicate for 5 minutes, place the albumin aqueous solution under the rotor of a homogenizer, The homogenization speed is 5000rpm, dropwise add the organic phase dissolved in hydroxycamptothecin, homogenate for 1 minute after the dropwise addition, transfer the homogenized system to a homogenizer, and homogenize 7 times under 800bar pressure to obtain half Transparent system with light yellow opalescence. The organic phase is removed by rotary evaporation, and the obtained water dispersion is freeze-dried to obtain glycyrrhizic acid-coupled albumin-loaded hydroxycamptothecin nanoparticle freeze-dried powder. The average particle size of nanoparticles is less than 200nm, and the encapsulation efficiency and drug loading are 96.7% and 10.6%.
example 2
[0026] Dissolve 80 mg of glycyrrhizic acid-coupled albumin in 80 mL of water, dissolve 9.6 mg of hydroxycamptothecin in 3.2 mL of chloroform-absolute ethanol solution, ultrasonicate for 10 minutes, place the albumin aqueous solution under the rotor of a homogenizer, The homogenization speed is 5000rpm, dropwise add the organic phase dissolved in hydroxycamptothecin, homogenate for 1 minute after the dropwise addition, transfer the homogenized system to a homogenizer, and homogenize 7 times under 800bar pressure to obtain half Transparent system with light yellow opalescence. The organic phase is removed by rotary evaporation, and the obtained water dispersion is freeze-dried to obtain glycyrrhizic acid-coupled albumin-loaded hydroxycamptothecin nanoparticle freeze-dried powder. The average particle size of nanoparticles is less than 200nm, and the encapsulation efficiency and drug loading are 93.1% and 9.97%.
PUM
Property | Measurement | Unit |
---|---|---|
The average particle size | aaaaa | aaaaa |
The average particle size | aaaaa | aaaaa |
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com