Method for preparing macromolecule resin type bilirubin sorbent

A polymer resin, bilirubin technology, applied in chemical instruments and methods, other chemical processes, etc., can solve the problems of insufficient access to BR, damage to human blood electrolyte balance, and small pores in activated carbon.

Inactive Publication Date: 2004-12-29
杭州科锐净化工程有限公司
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AI Technical Summary

Problems solved by technology

However, even with the continuous improvement of the coating technology of activated carbon, the effect of activated carbon adsorbents on removing BR is not very good, mainly because the inner pores of activated carbon itself are small and cannot sufficiently approach macromolecular substances such as BR.
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Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] The solution of the present invention is discussed in detail in the following examples.

[0016] Step 1. Select polystyrene-divinylbenzene with a crosslinking degree of 8-20% and a particle size of 80-120 mesh as the carrier of the polymer resin bilirubin adsorbent;

[0017] Step 2: Polymer polystyrene-divinylbenzene coating:

[0018] Mix a certain proportion of styrene, divinylbenzene, and hydroxyethyl methacrylate according to one of the following ratios of 1, 2, 3, 4, 5, and 6, add initiator, and add 100-500mL gelatin solution Disperse the system for suspension polymerization. Polymerize at 50~80℃ for 0.5~6 hours, cure at 60~70℃ for 24~48 hours, rinse the white beads with a large amount of deionized water for 5 times, then soak in acetone for 24 hours, and then use absolute alcohol and deionized water Rinse and dry to obtain coated polystyrene-divinylbenzene.

[0019] Plan number

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Styrene

(mL) ...

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PUM

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Abstract

The present invention features that the bilirubin adsorbent is synthesized by selecting well biocompatible polystyrene-divinylbenzene copolymer as carrier, PHEMA as coating agent, epichlorohydrin for activating the functional hydroxy radical of PHEMA, and glutaraldehyde as cross-linking agent for cross-linking functional cyclodextrin molecule. The bilirubin adsorbent has biocompatibility and adsorption capacity superior to active carbon and cationic resin adsorbing material, and has no adsorbent molecule falling resulting in immunological dysfunction. Animal experiment shows that the novel bilirubin adsorbent may be used to eliminate bilirubin from blood, blood plasma and albumin solution effectively.

Description

Technical field [0001] The invention belongs to the field of biological separation engineering, and relates to a new type of medical adsorbent, in particular to a bilirubin adsorbent for human hemoperfusion. Background technique: [0002] Bilirubin (BR) is a heme metabolite of senescent red blood cells. Bilirubin generally forms a water-soluble complex by binding to glucuronic acid in the human body. The content of bilirubin in normal human blood is generally 2-10mg / L. The metabolism of bilirubin is mainly completed in the liver. If liver metabolism is unregulated, bilirubin will accumulate in the blood. In severe cases, the concentration of bilirubin in plasma can be as high as 300-400mg / L. Excessive bilirubin becomes an endogenous toxin. Bile duct obstruction, acute and chronic icteric hepatitis, toxic hepatitis, and various hemolytic hepatitis can cause abnormal bilirubin metabolism in humans. Excessive free BR will deposit in tissues (especially in the brain), resulting in hi...

Claims

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Application Information

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IPC IPC(8): B01J20/26B01J20/30
Inventor 肖海军
Owner 杭州科锐净化工程有限公司
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