17 results about "Cardiovascular implant" patented technology

The invention relates to a real-time wear test device for a cardiovascular implant mitral valve / tricuspid valve, which comprises a plurality of test mechanisms, and each test mechanism comprises a first compliance adjusting module, a second compliance adjusting module, a liquid flowing pipeline and a driving module, a valve carrier module and a return pipe are connected between the second compliance adjusting module and the first compliance adjusting module; one end of the liquid flowing pipeline is communicated with the first compliance adjusting module, and the other end is connected with the driving module; test liquid sequentially flows through the liquid flowing pipeline, the first compliance adjusting module, the backflow pipe, the second compliance adjusting module and the valve carrier module and flows back into the first compliance adjusting module and the liquid flowing pipeline so as to perform circulating reciprocating motion. According to the invention, a test environment highly similar to human physiological conditions can be simulated, so that the credibility and the accuracy of test results of the mitral valve and the tricuspid valve are ensured, and a real and reliable basis is provided for evaluating the service life of the mitral valve and the tricuspid valve.

A cardiovascular implant device includes an annular body, one or more anchoring members, and a flow directing component. The annular body includes a central flow tube extending from an inflow end to an outflow end and a flow path extending through the central flow tube. The one or more anchoring members extending outward from the annular body and are configured to secure the cardiovascular implant device to a tissue wall. The flow directing component is positioned to align a flow of blood out of the cardiovascular implant device with a natural flow pattern of blood in a right atrium so that the flow of blood out of the cardiovascular implant device joins with the natural flow pattern of blood in the right atrium.

The invention relates to an intravascular stent for regulating neutrophil phenotype and a preparation method of the intravascular stent, and belongs to the technical field of cardiovascular implant materials. Specifically, a polymer coating for loading a neutrophil chemotactic active substance and a neutrophil phenotype regulation substance is formed on the outer wall of the intravascular stent. The coating can induce neutrophile granulocytes collected due to intimal mechanical injury caused by intravascular stent implantation to infiltrate into a focus and convert to N2 phenotype. Then, the neutrophil exerts an upstream immune regulation effect, induces the macrophages to be converted from a pro-inflammatory M1 type to a repair-promoting M2 type, further secretes repair-promoting related factors, improves an immune microenvironment related to endangium tissue regeneration and repair, realizes stent surface endothelialization, and finally realizes endangium tissue regeneration and repair.

The invention discloses an in-situ conversion anticorrosive coating material as well as a preparation method and application thereof, and relates to the technical field of cardiovascular implant materials. The functional coating in the in-situ conversion anticorrosive coating material provided by the invention contains the degradable polymer with the closed inner hole structure, the metal ion chelating agent is loaded in the closed inner hole of the degradable polymer, and the coating is in a polymer state in the material implantation process, so that the compliance requirement in the implantation process can be met; and in the service stage, the polymer coating absorbs water and is degraded, the inner holes are sealed, and the chelating agent in the inner holes restrains metal ions and hydroxyl ions released in the degradation process of the stent, so that the coating is converted into an inorganic coating with a corrosion protection effect in situ. Therefore, the in-situ conversion anti-corrosion coating material provided by the invention has the advantages of both an inorganic coating and an organic coating, and the corrosion rate of the degradable metal intravascular stent is effectively reduced.

The invention relates to a cardiovascular implant device for directing flow. A cardiovascular implant device includes an annular body, one or more anchoring members, and a diversion assembly. The annular body includes a central flow tube extending from an inflow end to an outflow end and a flow path extending through the central flow tube. The one or more anchoring members extend outwardly from the annular body and are configured to secure the cardiovascular implant device to a tissue wall. The diversion assembly is positioned to align blood flow out of the cardiovascular implant device with a natural flow pattern of blood in the right atrium such that the blood flow out of the cardiovascular implant device is combined with the natural flow pattern of blood in the right atrium.

The cardiovascular implant device includes an annular body, one or more anchor members, and a flow directing component. The annular body includes a central flow tube extending from an inflow end to an outflow end and a flow path extending through the central flow tube. The one or more anchor members extend outward from the annular body and are configured to secure the cardiovascular implant device to a tissue wall. The flow directing component is positioned to align blood flow from the cardiovascular implant device with a natural flow pattern of blood in the right atrium, such that blood flow from the cardiovascular implant device merges with the natural flow pattern of blood in the right atrium.

1. The name of the design product: buffer paste. 2. The use of the design product: used as a paste attached to the part of the human body implanted with cardiovascular implant electronic devices for buffering protection. 3. The design points of the design product: in shape. 4. The picture or photo that best indicates the design points: perspective drawing.

The cardiovascular implant device includes an expandable annular frame and a flow regulator. The expandable annular frame is formed from a plurality of struts and is configured to conform to the internal shape of a blood vessel or chamber of the heart when expanded within the blood vessel or chamber of the heart. The flow regulator is connected to the plurality of struts of the expandable annular frame. The flow regulator is arranged to alter the hemodynamic characteristics of the blood flow that is derived from or through the expandable annular frame and flows therethrough.

The present invention discloses a preparation method of a self-responsive coating for the whole process regulation and control tissue reaction of a cardiovascular implant interventional device, wherein 4-carboxylphenylboronic acid, carbodiimide and N-hydroxysuccinimide are dissolved in dimethyl sulfoxide at a molar ratio of 1:1.5:1.2, gelatin is added after sufficient reaction, deionized water is dialyzed, freeze-dried, and the product is dissolved in PBS to obtain a phenylboronic acid gelatin solution, which is then dropped into a mixed solution of polyphenol and dimethyl sulfoxide and fully reacted, and PBS is dialyzed to obtain a nanoparticle solution; the cardiovascular implant interventional device is immersed in an alkaline aqueous solution of dopamine to react, and after taking out and cleaning, it is sequentially immersed in a polycationic electrolyte solution, a nanoparticle solution, an antiplatelet drug, and an oxidized polysaccharide solution to react, and the reaction cycle is repeated multiple times. The coating prepared by the present invention can carry out whole process regulation and control, and the modified cardiovascular implant interventional device shows ideal endothelial regeneration and low intimal hyperplasia, thereby improving its function and long-term service rate.

Apparatus for compressing a cardiovascular implant, optionally a prosthetic heart valve, to a small size for transcatheter implantation. The apparatus having a funnel with an interior surface defining a tapered channel configured for compressing the implant in response to longitudinal translation of the implant within the channel, the channel having an axis extending from an entrance to an exit, and at least one longitudinal cantilevered element configured for insertion into the channel via the entrance for supporting the implant from within during compression. The cantilever element having a tip biased towards a position spaced from the axis of the channel. The tip being deflectable towards the channel axis to accommodate tapering of the channel. The cantilever element biases the implant outwardly against the interior surface of the funnel as the implant translates longitudinally within the channel, to prevent inward kinking during compression of an implant having a noncircular profile.

The invention relates to the technical field of cardiovascular implant abrasion tests, in particular to a cardiovascular implant real-time abrasion test device which comprises a shell and a controller, an opening and closing door is arranged on the shell, an upper piston box, a liquid storage box and a lower piston box are arranged in the shell, a mounting plate is arranged on the upper piston box, and a simulated heart is arranged in the upper piston box. A monitoring assembly is arranged on the upper piston box, and the liquid storage box communicates with the interior of the lower piston box. A driving part is arranged on the liquid storage tank, a cam is arranged on an output shaft of the driving part, a swing rod is arranged on the cam, a swing frame is arranged on the swing rod, and a transmission assembly is arranged in the swing frame; a limiting assembly and an adjusting assembly are arranged in the shell, the limiting assembly is located below the monitoring assembly, and the adjusting assembly is located on one side of the limiting assembly; a simulation assembly is arranged in the shell and located on one side of the monitoring assembly. According to the invention, the swing frequency of the transmission rod is adjusted through the adjusting assembly, and the wear conditions of cardiovascular implants under different heart rates can be simulated.

The invention relates to the technical field of biomedical materials, and particularly discloses a laser surface treatment method and application of a magnesium alloy wire. The invention discloses a laser surface treatment method of a magnesium alloy wire. The surface of the magnesium alloy wire is treated by adopting a laser surface treatment technology with the following process parameters: the scanning speed is 5-15 mm / s, the wavelength is 1050-1080 nm, the pulse width is 1 * 10 <-9 >-3 * 10 <-9 > s, the power is 5-8 W, the frequency is 18000-22,000 Hz, the light spot size is 1 / e2, the diameter is 150-175 microns, and the pulse energy density is 2.0-3.0 J / cm < 2 >. According to the scheme, in-situ tissue reconstruction is carried out through a laser surface treatment method, so that the corrosion resistance of the magnesium alloy is greatly enhanced, the reliability of the magnesium alloy wire in a cardiovascular implant is improved, the service life of the magnesium alloy wire in the cardiovascular implant is prolonged, meanwhile, the green manufacturing requirement is met, and the defects of a traditional method in the degradation control aspect are overcome.

The present application relates to a kind of real-time wear test device for cardiovascular implant bicuspid valve / tricuspid valve, including multiple test mechanisms, test mechanism includes first compliance adjustment module, second compliance adjustment module, liquid flow pipeline and drive module, second compliance adjustment module is connected with valve carrier module and reflux pipe between first compliance adjustment module;Liquid flow pipeline one end is communicated with first compliance adjustment module, the other end is connected with drive module;Test liquid sequentially flows through liquid flow pipeline, first compliance adjustment module, reflux pipe, second compliance adjustment module and valve carrier module, and reflux to first compliance adjustment module and liquid flow pipeline, to carry out cyclic reciprocating motion.The present application can simulate the test environment of highly approximate human physiological condition, to ensure the reliability and accuracy of bicuspid valve and tricuspid valve test result, provide real and reliable basis for evaluating the service life of bicuspid valve and tricuspid valve.

1. The name of the design product: buffer clothes. 2. The use of the design product: used as a buffer protection clothes for the part of the human body implanted with cardiovascular implant electronic devices. 3. The design points of the design product: in shape. 4. The picture or photo that best shows the design points: combined state perspective view. 5. The design product is a thin product, and other views are omitted.

A cardiovascular implant device includes an annular body, one or more anchoring members, and a diversion assembly. The annular body includes a central flow tube extending from an inflow end to an outflow end and a flow path extending through the central flow tube. The one or more anchoring members extend outwardly from the annular body and are configured to secure the cardiovascular implant device to a tissue wall. The diversion assembly is positioned to align blood flow out of the cardiovascular implant device with a natural flow pattern of blood in the right atrium such that the blood flow out of the cardiovascular implant device is combined with the natural flow pattern of blood in the right atrium.

This invention relates to a recombinant hirudin fusion protein with collagen affinity, its preparation method, and its applications. The fusion protein is a recombinant hirudin fusion protein incorporating a collagen-binding domain (CBD). The fusion protein of this invention possesses affinity for type I and type III collagen, and can inhibit thrombin activity to exert an anticoagulant effect. Furthermore, it can bind well to collagen-based composite materials, making it suitable for use in cardiovascular implants such as heart valves, cardiac occluders, dialysis membranes, oxygenation membranes, artificial blood vessels, and vascular stents, as well as in extracorporeal circulation and blood purification devices, enhancing anticoagulant and antithrombotic effects.