36 results about "Cardiovascular implant" patented technology

The invention provides a valve fatigue-life testing device. The valve fatigue-life testing device comprises a body at least, wherein the body is composed of an upper channel and a lower channel which is communicated with the upper channel, one side of the bottom of the body is provided with an opening, a linear motor is arranged on one side of the top of the body, a liquid container which is communicated with the body is arranged on the other side of the top of the body, and a cover is arranged at the top of the liquid container. A damper is arranged at one end of the lower channel and under the linear motor, and a temperature sensor is arranged at the other end of the lower channel. The upper channel of the body further comprises a valve fixer provided with a through hole, wherein the valve fixer is horizontally placed inside the upper channel of the body and arranged below the liquid container. A shaft of the linear motor is connected with a piston provided with a rolling membrane, and the piston is arranged inside the body in a stretching mode. The linear motor of the valve fatigue-life testing device enables loads to be directly applied to test liquid in a waveform mode under current control and to be transmitted to a test valve or other test pieces according to the Pascal law, and high-frequency oscillation signals in the test liquid are filtered through the liquid container. All test indexes can meet relevant national standards for artificial cardiac valves which are cardiovascular implants, and the final testing result is accurate and reliable.

Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

A delivery catheter for implanting a self-expanding implant such as a cardiovascular implant. An outer catheter shaft is formed as an implant capsule for encasing the implant during delivery. A flexible distal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is attached, directly proximally of the implant, in a fixed position to a first, inner catheter shaft, and / or a flexible proximal support element having a substantially truncated cone-shaped portion, which tapers in the proximal direction, is inserted at the proximal end of the implant capsule into the second, outer catheter shaft in a fixed position.

The invention discloses an artificial polymer aorta valve, belongs to the technical field of medical instruments, and particularly belongs to angiocarpy implantation materials. The artificial polymer aorta valve comprises three valve leaflets and a valve ring. The valve leaflets are fixed to the valve ring, and the valve ring is sutured to the human aortic root in a valve replacement operation. The valve leaflets have the function of controlling blood to move in one direction under the drive of differential pressure. According to the diameter of the aorta valve ring of a patient, the artificial polymer aorta valve of the proper size is selected. The artificial polymer aorta valve has the advantages that the artificial polymer aorta valve is suitable for replacing the human aorta valve; stress borne by the free edges of the valve leaflets, the coaptation area, the connecting positions of the valve leaflets and the aortic root and the middles of the valve leaflets is increased in sequence; the middles of the valve leaflets are thinnest and bear the largest deformation, and therefore the performance of the materials can be achieved fully; the service life of the valve is prolonged in the high circulating bending force bearing environment; the artificial valve is designed according to the anatomical structure of the human aorta valve, and the blood flows through the valve in the excellent hemodynamic environment.

The invention provides a preparation method of a medical implant material surface function atom doped molecular sieve layer and belongs to the technical field of preparation of the molecular sieve layer having high biological activity. New-generation medical implant alloy materials (a bone repair material, a dental implant material and a cardiovascular implant material) having low elasticity modulus and high biocompatibility are used as a substrate, a Silicalite-1 type molecular sieve layer doped with different function atoms grows on the surface of the substrate by means of a co-synthesis method, and accordingly the biological activity, corrosion resistance and bone growing induction capacity of a composite material is improved. The preparation method is suitable for various low-elasticity-modulus medical implant materials, has the advantages of being moderate in preparation conditions, simple in process, low in cost and the like, can be applied to implant materials of any shapes and surface roughness and shows the potential of further development of novel hard-tissue implant materials.

The invention discloses a hydrogel coating with a long-term antibacterial function and a preparation method thereof. The method comprises the following steps that 1, pre-treatment is conducted on a base material; 2, at room temperature, the base material subjected to pre-treatment is placed in a polycation electrolyte solution and a mixed solution of a polyphenol compound and an antibacterial medicine in sequence, and after reaction is carried out in a polyanion electrolyte solution for 5-20 min, washing is conducted for 3-5 times; 3, operation of step 2 is repeated for 5-20 times to obtain the hydrogel coating. The method is simple and convenient to operate and cheap in raw material, and the prepared hydrogel coating has good biocompatibility and excellent antibacterial performance; the hydrogel coating has good medicine loading capacity and stable medicine releasing performance, and can be used for preparing and modifying cardiovascular implant endovascular devices, orthopedics filling materials and antibacterial wound dressings.

The invention discloses a method for mediating albumin to form a protein layer on the surface of a material, a biological material and an application thereof, and relates to the technical field of biological materials. The method for mediating albumin to form a protein layer on the surface of the material comprises: standing the material to be loaded in an alkaline solution to obtain an alkali-activated material; immobilizing dendrimers on the surface of the alkali-activated material, and then immersing the modified material in Standing reaction in the albumin solution; preferably, the dendritic macromolecule is polyamidoamine type dendritic macromolecule PAMAM; more preferably, the molecular weight of PAMAM is 6000-10000. The biomaterial forms a PAMAM layer and an albumin layer on the surface of the material to be loaded, and then mediates the albumin to form a protein layer. The biomaterial is used to prepare a cardiovascular implant material, which can reduce the adhesion of platelets to play an anticoagulant effect and improve the biocompatibility of the material.

The invention discloses a nickel-titanium alloy containing a biologically-active coating. A preparation method for the alloy comprises the following steps: polishing the surface of the nickel-titanium alloy so as to allow the surface of the nickel-titanium alloy to be shining; then soaking the alloy in a Tris-dopamine hydrochloride solution with a concentration of 1 to 3 mg / mL for 12 to 36 h so as to allow a polydopamine film to be formed on the surface; preparing a chitosan solution with a concentration of 1 to 10 mg / mL with 0.1 to 0.5% (v / v) acetic acid as a solvent, preparing a gelatin solution with a concentration of 1 to 10 mg / mL and an endothelial cell growth factor solution with a concentration of 100 to 500 ng / mL by using a phosphate buffer solution, soaking the treated nickel-titanium alloy in the gelatin solution for 12 to 36 h and then carrying out self-assembling of chitosan-gelatin-endothelial cell growth factor-gelatin layer by layer, wherein soaking in each solution lasts for 5 to 20 min and there are 4 to 10 cycles of layer-by-layer self-assembling; and finally, carrying out blow-drying with nitrogen. The coating can effectively promote adhesion and growth of endothelial cells on the surface of the nickel-titanium alloy, so demands of rapid endothelialization of the nickel-titanium alloy as a cardiovascular implant material are met, the problems of induction of thrombi and generation of coagulation on the surface of the nickel-titanium alloy are overcome, and the clinical application scope of the nickel-titanium alloy is broadened.

The invention belongs to the technical field of biomedicine and relates to a cardiovascular implant and a preparation method thereof, in particular to a cardiovascular implant capable of regulating immune response in situ to promote intima regeneration and a preparation method thereof. The cardiovascular implant includes a cardiovascular implant body, and the cardiovascular implant body is modified with CD133 aptamers and slow-release nanoparticles. Modified the CD133 aptamer and slow-release nanoparticles containing axon-guiding molecule-1 onto the body of the cardiovascular implant to regulate the immune response in situ and promote intima regeneration, effectively overcome thrombus formation, and promote long-term patency of blood vessels . Especially for patients with clinical inflammatory basic lesions, the present invention provides a cardiovascular implant that is easy and quick to prepare, has wide applicability, can regulate excessive inflammatory reactions in situ, promote intimal regeneration and maintain long-term function, and has the advantages of Good application prospects.

The present invention provides a method and system for automatic detection and evaluation of an OCT-based cardiovascular implant stent, the method comprising the following steps: acquiring a coronary artery OCT image to be detected; Perform preprocessing; perform sliding window traversal on the preprocessed image; perform feature extraction on the sliding window image; judge whether the feature value of the extracted sliding window image is greater than the feature threshold corresponding to the classifier model; detect where the bracket is located in the sliding window image The area and the center of the stent; detect the inner wall contour of the coronary artery in the preprocessed image; calculate the shortest distance between the center of the stent and the inner wall contour of the coronary artery to obtain the adhering situation or coverage of the stent; the adhering situation of the stent or coverage is displayed. The method and system proposed by the invention are not affected by noise such as blood artifacts, can work in a complex imaging environment, have high detection accuracy of the stent, and have good robustness.