161results about How to "Expand the scope of clinical application" patented technology

The invention discloses a lanthanide rare earth coordinated cellulose medical material and a preparation method thereof. The medical material is prepared by oxidizing primary hydroxyl of cellulose into carboxyl and then coordinating with lanthanide rare earth metal ions, namely performing sol-gel self-assembling reaction to rare earth metal hydrate and cellulose the primary hydroxyl of which is selectively oxidized into carboxyl. The preparation method is simple in preparation technology and good in controllability. The material not only has excellent moisture absorption and preservation properties and breathability, and better biocompatibility and excellent degradability of cellulose materials, but also has antibacterial property of the rare earth complex, can be used for antibacterial and bacteriostasis wound dressing due to broad-spectrum antibacterial property, and can also be used for detection tracing, special marking and optical display of biomolecules; the lanthanide rare earth coordinated cellulose medical material can be prepared into powder, gel, thin films, sponge or other porous materials, thus expanding the clinical application range; and the lanthanide rare earth coordinated cellulose medical material can be doped or grafted with macromolecular compounds so as to enhance the antibacterial and bacteriostasis properties and promote therapeutic effect on wound recovery.

The invention discloses a preparation method of a quick absorption saturation gelation seaweed hemostatic dressing. The method includes the steps of: soaking, rinsing and drying on calcium fiber textile or non-woven products containing alginate, and the carrying out cutting, packaging and sterilizing to obtain the quick absorption saturation gelation hemostatic dressing. The invention also discloses the application of the quick absorption saturation gelation seaweed hemostatic dressing prepared by the above method. The invention is applicable to rapid absorption and removal of a large amount of surgical diffusate in surgical operation process, so as to realize the effects of rapid hemostasis and operation wound clean; the hemostatic dressing is used for burn, scald and other acute and chronic wounds, can cover the wound and prevent moisture loss in body fluids, provide a positive moist environment for wound healing, prevent the wound from effusion and erosion, isolate bacterial infection, and play the effects of stopping bleeding, relieving pain, promoting wound healing, and reducing scar.

The present invention provides a bone marrow stem cell protection solution, which is mainly prepared by dissolving a hypoxic protection agent, heparin sodium and an aminoglycoside antibiotic in a DMEM/F12 culture medium aqueous solution, wherein per mL of the DMEM/F12 culture medium aqueous solution can respectively dissolve 5-10 mg of the hypoxic protection agent, 0.01-0.05 U of the heparin sodium and 50-200 U of the aminoglycoside antibiotic, and the concentration of the DMEM/F12 culture medium aqueous solution is 30-40 mg/ml. According to the present invention, the bone marrow stem cell protection solution has advantages of stable performance, safety and no toxicity, can effectively protect bone marrow stem cells, can make bone marrow stem cells be preserved for a long time and can maintain the cell activity in vitro, can maintain the original multidirectional differentiation ability, and can expand the clinical application of bone marrow stem cells, wherein the bone marrow stem cells can be transported to most domestic cities and neighboring countries by using the existing transportation tools.

The invention relates to the field of pharmaceutical preparations and particularly relates to a slow-release micropill preparation containing enrofloxacin and a preparation method of the preparation. The slow-release micropill provided by the invention is formed by coating an enrofloxacin micropill; the enrofloxacin micropill comprises enrofloxacin and auxiliary material and is formed through extruding and rounding; the auxiliary material is any one or more of microcrystalline cellulose, starch, cane sugar, artificial gum, lactose and sodium carboxymethyl starch; according to weight percent, the auxiliary material in the micropill accounts for 70% to 95%; and coating is made of high-molecular enteric material, film forming material, opaquer and the like. The slow-release micropill preparation has the characteristics of slow release and high bioavailability, can be used for treating bacteria and mycoplasma infection of livestocks, and has better curative effect on chronic respiratory diseases, colibacillosis and salmonellosis, and the frequency of medicine taking can be reduced; and in addition, the slow-release micropill provided by the invention has the advantages that the stability of medicine is improved, and peculiar bitter of enrofloxacin can be covered completely, so that feeding intake of the animals is not influenced, and the recovery rate is improved.

The invention discloses etimicin sulfate preparation and its preparing method which comprises, charging acids or alkali as pH conditioning agent so as to increase the dissolving degree of the etimicin, charging right amount of isoosmotic adjustment agent, thus resulting the action of quick sterilization.

Disclosed is the use of paeonol in preparing medicament for the prevention or treatment of fatty liver, and also the use of medicinal combination preparation of paeonol with medicinal carrying agent in preparing medicaments for the prevention and treatment of fatty liver disease, the dose forms of the medicament include soft capsules, drop pills, pills, powders, tablets, capsules, granules, injections, fluid infusions, freeze-dried powders for injection, suppositories, film agents, tiny capsules, tincture, syrup, oral liquids and other pharmaceutically acceptable dose forms.

The invention discloses the technical field of medical devices, and particularly relates to a classical prescription medicine intelligent dialectical treatment system based on big data. The system isbased on a modern mobile information platform to complete the collection of information of 'seeing, smelling, asking and pulse-taking. The overall guidance of the system is 'eight-class syndrome differentiation'. The dialectical method of 'six-meridian syndrome differentiation' in 'Treatise on Febrile Diseases' is used. The traditional Chinese medicine theory is combined, and when dialectic is carried out, disease differentiation is carried out on a patient. Mutual reference of diseases and intelligent diagnosis of traditional Chinese medicine are realized. Finally, guidance classic prescription medicine is provided. The modern research results and clinical experience of classic prescription medicine are fully absorbed. The clinical application scope of classic prescription medicine is effectively expanded. Due to the fact that the system has less hardware and is simple and portable, the system can be widely accepted by the general public, and can effectively popularize and promote traditional Chinese medicine.

This invention discloses a disperse tablet for cardiovascular disease therapy and its preparing method. Firstly dry raw materials separately and pass them through 100 orders screen; then adopting equivalent incensement method, mix D with micro-crystal cellulose, gelatinized starch, hydropropyl cellulose, acepaten and crosslinked polyketone, execute it to soft material by 2% hydropropyl methylcellulose, pass the soft material through20 orders screen to produce grains, dry the grains in bake oven at 60deg C, treat the grains, add micronized powder silica gel and stearate, mix, tablet and package is ok. This invention has the characteristics of disintegration rapid, absorption quick, biology availability high, adverse affects few and taking convenient. It has efficacies of promoting Qi and blood, and activate collaterals to relieve pain, it can be used to cure thorax paralysis, heartache and intermittent pulse caused by qi stagnation and blood silt, and coronary disease, arrhythmia with above symptoms. It is especially available to old people and patients difficult to swallow solid.

The invention discloses a compressive sensing computer tomography image reconstruction method based on a p-norm, and particularly to a CT image algebraic reconstruction method which performs image total variation Lp norm minimizing on incomplete projection data. The method mainly comprises the steps of (1) acquiring a CT system imaging parameter and scanning system projection data; (2) initializing the projection data, performing discrete processing and filtering noise-reduction processing on the projection data by means of a wavelet transformation base, solving a projection matrix through weighting and performing assignment x(0)=0 on an initial image x; and (3) performing algebraic reconstruction on the projection data, performing total variation Lp norm minimizing adjustment on the image after iteration each time by means of a gradient decent algorithm, and determining whether a convergence condition is satisfied. If the convergence condition is satisfied, the reconstructed image is stored and output; and otherwise, continuing iteration in a manner that the adjusted image which is iterated this time as an interaction initial value.

The invention aims to provide a high-strength and high-corrosion-resistance biomedical Mg-Ga alloy and a preparation method thereof. The alloy comprises the following chemical components of, by weight, 4.5%-10.0% of Ga and the balance Mg element and other inevitable impurities. By adding a proper amount of the Ga element is added into a pure magnesium matrix, alloy grains can be refined, and the mechanical strength and the corrosion resistance of the alloy are improved. In addition, a Zn element can be added, the Mg-Zn-Ga phase can be separated from the alloy by adjusting a heat treatment system, so that the alloy is further strengthened. The alloy is excellent in biocompatibility, has the biological functions of promoting bones and the like, and is a multifunctional biomedical degradablemagnesium alloy material with excellent comprehensive performance, and has an important application value in the medical fields such as orthopedic implants.

The invention provides an application of a dihydromyricetin composition in preparation of medicines for inhibiting adriamycin cardiotoxicity. The composition is composed of dihydromyricetin and adriamycin; as shown by in vivo and in vitro experimental studies, the dihydromyricetin can inhibit cell apoptosis activated by the adriamycin and dependent to mitochondrial membrane potential so as to reduce lethality caused by adriamycin cardiotoxicity, and the composition provided by the invention has excellent protection effect on cardiotoxicity induced by adriamycin. The composition provided by the invention can be used for preventing and alleviating the cardiotoxicity educed by adriamycin and has clinical practicability.

The invention relates to a composite slow-release agent, wherein it contains indomethacin, aminoglucose salt, slow-release material and other findings, while their ratios are 5-45%, 20-80%, 1-75%, and the left is findings. Its preparation comprises that mixing indomethacin and/or aminoglucose salt, and slow-release material and/or packs, then adding other findings, using general slow-release technique to obtain one or several skeleton or mould-contoro slow-release agent. The invention can be made into particle, oral, tablet or capsule. The invention can keep stable blood drug density in 8-36h, reduce side effect.

A water soluble of Penxiluowei contains the Penxiluowei or its salt, solubilizer, cosolvent and pH regulator. It can be used to prepare injection, eye drops and nose drops for treating the diseases caused by herpes simple virus, herpes zoster virus and hepatitis B virus.

The invention discloses a nano hybrid silk fibroin hydrogel and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The nano hybrid silk fibroin hydrogel is prepared by pre-blending a regenerated silk fibroin aqueous solution and nano hydroxyapatite and performing ultrasonic treatment. According to the preparation method of the nano hybrid silkfibroin hydrogel, the ultrasonic condition and the mixing ratio of the two materials are changed, the gelation time is controlled, and rapid gelation is realized, so that use of a potentially toxic chemical crosslinking agent is avoided, and activity of cells or biological factors can be well maintained. The nano hybrid silk fibroin hydrogel provided by the invention has controllable gel performance, controllable mechanical performance, good cell compatibility and good bone induction capability, can load stem cells for repairing bone defect, and is expected to be used for embedding active factors for synergistic treatment.

The invention which belongs to medical instrument techmology field involving a preparation method of hemostasis tiedan that can absorb fibrous protein.This method is that adding the roboflavin,fibrinogen and thrombin freeze dry powder according to certain proportion into the mortar,then add anhydrous ethanol to the mortar and stirring into uniform distribution suspension,then put the uniform distribution into the flat chassis to make the surface of adhesive olynthus contact,at last,the adhesive olynhus which adhesion of mixed dry powder particle is vacuumized and drying disinfected.The hemostasis tiedan that mentioned in this invention is good at the body biocompatibility and can be degradated in vivo thoroughly.This hemostasis tiedan which is combined with the biochemical hemostasis and mechanical hemostasis can not only rein up capillary permeability blood,also can rein up the arterioles and vein hemorrhage,so that expanding the range of the clinical application greatly and this hemostasis tiedan can be used to hemostasis of visceral operation and large body surface trauma.Also,this hemostasis tiedan increase the function of drug release and partial administration by adding antibiotics and anticancer drug in the glue olynthus.

The invention belongs to the technical field of biomedical technologies, and discloses a growth hormone controlled-release coating and a preparation method thereof. The coating comprises three layersof structures which are an outermost layer superhydrophobic coating, a middle layer silk fibroin peptide coating and an innermost layer growth hormone controlled-release microballoon sphere. The invention aims at providing a preparation method of an oral administration dosage form. The three layers of structures with different ingredients are targetedly arranged to serve as the coating of growth hormone according to the structure and reaction rules of human digestive tracts, an advanced electrostatic spraying technology is adopted for making the coating, the number of times of administration of a patient is reduced, the growth hormone medicine clinical application range is increased, and the coating has the wide market prospect.

The invention discloses a cannabidiol self-nanoemulsion buccal membrane preparation as well as a preparation method and application thereof. The bioadhesive membrane comprises a backing membrane and a bioadhesive membrane layer adhered to the backing membrane, wherein the bioadhesive film layer is formed by dispersing cannabidiol in a self-nanoemulsion system, adsorbing the cannabidiol by a solid carrier and then dispersing the cannabidiol in a film-forming polymer, and the self-nanoemulsion system comprises an oil phase, a surfactant and a cosurfactant. According to the cannabidiol self-nanoemulsion buccal membrane preparation disclosed by the invention, the cannabidiol is in a supersaturated dissolved state in an oil phase, the solubility of the cannabidiol in a system is improved, nano-scale liquid drops formed by the self-nanoemulsion promote permeation and absorption of the cannabidiol in buccal mucosa, the taking effect time of a medicine is shortened, and the bioavailability of the medicine is improved. The cannabidiol self-nanoemulsion buccal membrane preparation disclosed by the invention can be applied to the aspects of resisting epilepsy, easing pain, treating mental diseases (such as schizophrenia, division affective disorder and delusional disorder), resisting anxiety, resisting depression and the like.