Bionic alginate composite antimicrobial dressing and preparation method thereof

A technology of compounding antibacterial and alginic acid, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problems of difference and poor long-term release effect, achieve simple and controllable process, good product transformation feasibility, and improve liquid absorption performance effect

Active Publication Date: 2014-07-09
山东颐诺生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Most of the current existing patents and products use materials such as alginic acid / chitosan / activated carbon to prepare antibacterial dressings containing silver ions by spraying or soaking. The process is simple and effective, but the long-term release effect is not good
Patents CN102406957, CN1935268A, CN102505461A, CN10450222A, etc. also disclose methods for preparing alginic acid-based antibacterial dressings in various ways, but there are certain differences with the methods of the patent of the present invention

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation steps of a kind of bionic alginic acid-based composite antibacterial dressing of the present invention are as follows:

[0023] The alginic acid component is composed of sodium alginate and calcium alginate; the chitosan component is carboxymethyl chitosan; and the silver ion component is silver nitrate. Among them, the molecular weights of sodium alginate, calcium alginate and carboxymethyl chitosan are 80,000, 30,000, and 200,000 Daltons, respectively.

[0024] Weigh 9g of alginic acid component (mass ratio of sodium alginate: calcium alginate is 8:1), 0.9g of carboxymethyl chitosan, 0.1g of silver nitrate, mix the above three powders, add deionized water 300ml, stirred at room temperature for 3 hours and fully mixed, so that the silver ions were fully chelated on the polysaccharide molecular chain; the resulting mixed hydrogel was placed at -20°C and repeatedly frozen and thawed for 3 times; finally freeze-dried to obtain a biomimetic alginic acid-bas...

Embodiment 2

[0026] The preparation steps of a kind of bionic alginic acid-based composite antibacterial dressing of the present invention are as follows:

[0027] The alginic acid component is composed of potassium alginate and calcium alginate; the chitosan component is carboxymethyl chitin; the silver ion component is nano silver. Among them, the molecular weights of potassium alginate, calcium alginate and carboxymethyl chitin are 100,000, 20,000, and 150,000 Daltons, respectively.

[0028] Weigh 8g of alginic acid component (mass ratio of potassium alginate: calcium alginate is 5:1), 1.5g of carboxymethyl chitin, 0.5g of silver nitrate, mix the above three powders, add 300ml of deionized water , stirred at room temperature for 2 hours and fully mixed, so that the silver ions were fully chelated on the polysaccharide molecular chain; the resulting mixed hydrogel was placed at -20°C and repeatedly frozen and thawed twice; finally, it was freeze-dried to obtain a bionic alginate-based co...

Embodiment 3

[0030] The preparation steps of a kind of bionic alginic acid-based composite antibacterial dressing of the present invention are as follows:

[0031] The alginic acid component is composed of sodium alginate and calcium alginate; the chitosan component is hydroxypropyl chitosan; and the silver ion component is sulfadiazine silver. Among them, the molecular weights of sodium alginate, calcium alginate and hydroxypropyl chitosan are 80,000, 30,000, and 100,000 Daltons, respectively.

[0032] Weigh 7.5g of alginic acid component (mass ratio of sodium alginate: calcium alginate is 5:1), 1.5g of hydroxypropyl chitosan, 1.0g of silver nitrate, mix the above three powders, add deionized 300ml of water, stirred at room temperature for 4 hours and fully mixed, so that the silver ions were fully chelated on the polysaccharide molecular chain; the resulting mixed hydrogel was placed at -20°C and repeatedly frozen and thawed 4 times; finally freeze-dried to obtain a biomimetic alginic ac...

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Abstract

The invention belongs to the field of biomedical materials, and particularly relates to bionic alginate composite antimicrobial dressing and a preparation method thereof. The bionic alginate composite antimicrobial dressing is prepared from the following raw materials: alginate components, chitosan components and silver ion components. The method is characterized by comprising the following steps: adding deionized water to agitate a solvent after mixing the raw materials, so as to obtain mixed water gel; repeatedly thawing, freezing and drying the mixed water gel to obtain a product, wherein the product comprises the following raw materials by weight percent: 60-90% of alginate components, 9.8-39% of chitosan components and 0.2-1% of silver ion components. The process system disclosed by the invention is controllable in temperature and condition, the problems of residues such as a toxic cross-linking agent or an assistant and the like do not exist, the safety risk of clinical application is greatly reduced, and the bionic alginate composite antimicrobial dressing has good product transformation feasibility.

Description

(1) Technical field [0001] The invention belongs to the field of biomedical materials, in particular to a bionic alginate-based composite antibacterial dressing and a preparation method thereof. (2) Background technology [0002] With the improvement of people's requirements for medical effects, infection control and accelerated healing have become more and more important factors related to the quality of prognosis of various surgical clinical operations. Especially in special environmental injuries such as battlefield wounds or large wounds, deep trauma first aid, rapid hemostasis, effective anti-inflammatory and promotion of healing can provide a strong guarantee for saving lives. In 2003, the market value of wound care and disposal products in the United States reached 4.76 billion US dollars, mainly including biological skin and dressings, alginate wet wound healing products, wound control products such as adhesive bandages, and wound sealing products such as sealant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/28A61L15/44C08J9/28
Inventor 位晓娟顾其胜奚廷斐王庆生
Owner 山东颐诺生物科技有限公司
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