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Etimicin sulfate preparation and its preparing method

A technology of etimicin sulfate and preparations, applied in anti-inflammatory agents, pharmaceutical formulas, non-central analgesics, etc., can solve problems such as easy pollution, achieve low production costs, increase new varieties, and expand the scope of clinical applications Effect

Inactive Publication Date: 2005-01-26
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since it needs to be dissolved in normal saline or glucose solution for injection every time it is used, it is easy to cause pollution

Method used

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  • Etimicin sulfate preparation and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] Take 100,000 units of etimicin sulfate to about 80ml of water for injection, dissolve it, add 5N acetic acid to adjust the pH of the solution, during the process of adding acetic acid, the pH will decrease with the amount added, and the pH will drop from 5.02 to 1.0 During the process, the medicinal solution remains colorless and clear, and no drug is precipitated. As can be seen from the above examples, the pH value of the medicinal solution is adjusted by acetic acid. When the pH of the medicinal solution is controlled within a certain range (pH1.0~5.02), the solubility of etimicin sulfate in aqueous solution has no effect, which can meet Target greater than 100,000 units / 100ml.

example 2

[0036] 10% lactic acid was selected as the pH regulator, and the same operation steps as in Example 1 were adopted, and there was also no drug precipitation phenomenon.

example 3

[0038] Select 1N hydrochloric acid as the pH regulator, the same operation steps as in Example 1, in the range of pH 1.0 to 5.02, it has no effect on the solubility of etimicin sulfate in water, and can meet the target of greater than 100,000 units / 100ml.

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PUM

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Abstract

The invention discloses etimicin sulfate preparation and its preparing method which comprises, charging acids or alkali as pH conditioning agent so as to increase the dissolving degree of the etimicin, charging right amount of isoosmotic adjustment agent, thus resulting the action of quick sterilization.

Description

technical field [0001] The invention belongs to pharmaceutical engineering, and relates to the drug composition and preparation technology of bactericides, in particular to the drug composition, preparation and preparation technology of etimicin sulfate. The mechanism of action of the drug is to inhibit the normal protein synthesis of sensitive bacteria, and it has good antibacterial effect on most Gram-positive bacteria and Gram-negative bacteria Background technique [0002] Etimicin sulfate is a class of new drugs developed in my country, also known as antibiotic 89-07, adamicin, semi-synthetic aminoglycoside antibiotics, and has the advantages of broad antibacterial spectrum and low toxicity. Suitable for sensitive Escherichia coli, Klebsiella pneumoniae, Serratia, Proteus mirabilis, Enterobacter, Acinetobacter, Proteus, Haemophilus influenzae, Pseudomonas aeruginosa and grape Various infections caused by cocci, etc. Its mechanism of action is to inhibit the normal pro...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/7036A61P11/00A61P13/00A61P17/02A61P29/00A61P31/00
Inventor 胡富强姚彤炜袁虹曾苏
Owner ZHEJIANG UNIV
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