108results about How to "Sufficient solubility" patented technology

An inhalable unit dose liquid formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of corticosteroid, such as budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus. The formulation is prepared by mixing SAE-CD, in solid or liquid (dissolved) form, with an inhalable suspension-based unit dose formulation.

An inhalable formulation containing SAE-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus.

Impure aromatic carboxylic acids such as are obtained by liquid phase oxidation of feed materials comprising aromatic compounds with substituent groups oxidizable to carboxylic acid groups, or comprising aromatic carboxylic acid and one or more aromatic carbonyl impurities that form hydrogenated species more soluble in aqueous solvents or with less color or color-forming tendencies than the aromatic carbonyl impurity, are purified to an aromatic carboxylic acid product with lower levels of impurities by a process comprising contacting an aqueous solution comprising the impure aromatic carboxylic acid with hydrogen at elevated temperature and pressure with an attrition-resistance, acid stable catalyst composition comprising at least one hydrogenation catalyst metal and a support comprising relatively high surface area silicon carbide.

The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering nucleic acid, DNA, RNA or siRNAs transdermally to an animal subject. The nanoparticles are composed of positively charged chitosan substrate and the nucleic acid encapsulated within the nanoparticles or electrostatically loaded on the exterior surface of the nanoparticles.

A process for improved safety and productivity when undertaking oil recovery from an underground reservoir by the toe-to-heel in situ combustion process employing a horizontal production well. Water, steam, and / or a non-oxidizing gas, which in the preferred embodiment substantially comprises carbon dioxide which acts as a gaseous solvent, is injected into the reservoir for improving recovery in an in situ combustion recovery process, via either an injection well, a horizontal well, or both.

The invention provides a non-fullerene solar energy cell acceptor material based on multiple condensed rings, a preparation method and an application thereof. A chemical structural formula of the acceptor material is shown in a specification, wherein X is selected from one of the following groups: Y is selected from one of the following groups: A is an acceptor unit having a pi-conjugated structure, and is respectively selected from the following groups. According to the non-fullerene solar energy cell acceptor material, the effective conjugation length is increased, at the same time, recombination performance is reduced, charge mobility is increased, good visible light near infrared area luminous absorption is guaranteed, electron mobility of the material is obviously increased, and the photoelectric conversion efficiency of an organic solar energy cell is greatly increased.

The invention discloses the nanoparticles composed of chitosan, poly-γ-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.

A polymerizable liquid crystal composition is provided that can exhibit a uniform homogeneous alignment by coating the composition on a supporting substrate having been subjected to an alignment treatment. The polymerizable liquid crystal composition contains a mixture of polymerizable compounds containing a compound selected from a group of compounds represented by the formula (1-1) as a component A and a compound selected from a group of compounds represented by the formula (2-1) as a component B as essential components, and optionally containing a compound selected from a group of compounds represented by the formulae (3-1) to (3-3) as a component C and / or a compound selected from a group of compounds represented by the formula (4-1) as a component D, and contains at least one nonionic surfactant as a component E. Examples of each of the components are shown below, in which T represents triptycen-1,4-diyl.

A transdermal patch comprising a backing 2 and an adhesive layer 3 laminated on the backing 2, wherein the adhesive layer 3 comprises a rosin-based resin and petroleum resin as a tackifier, the total compounding amount of the rosin-based resin and the petroleum resin is in a range of 15% by mass to 50% by mass, and compounding amount of the petroleum resin is ⅓ times by mass to 4 times by mass as that of the rosin-based resin.

A laser-welded article comprises: an integral construction of piled workpieces, that are welded by exothermic through irradiating laser and include thermoplastic resin, comprises of a laser-transmissible-absorptive molded workpiece including a thermoplastic resin and 0.001 to 0.3 weight % of colorant consisting of nigrosine which has an absorption coefficient: ε for a ray of 940 nm ranging form 4000 to 7000, that transmits laser partially and absorbs laser partially, and a laser-absorptive molded workpiece including a thermoplastic resin and 0.1 to 5 weight % of diverse colorant comprising of nigrosine and / or carbon black, that absorbs the laser.

The invention discloses the biodegradable nanoparticle for use in nanoparticle projectile bombardment as a carrier for administering proteins or peptides to an animal subject. The nanoparticles are composed of positively charged shell substrate, negatively charged core substrate with encapsulated bioactive agents of proteins or peptides.

The present disclosure provides an ophthalmic composition comprising 4-(3-amino-1-(isoquinolin-6-ylamino)-1-oxopropan-2-yl)benzyl 2,4-dimethylbenzoate or its pharmaceutically acceptable salts; about 0.01% weight / volume to about 1.0% weight / volume of a buffer; and about 0.01% weight / volume to about 10% weight / volume of a tonicity agent.

The invention provides an inverse emulsion synthesis method of polyacrylamide flocculent, which belongs to a macromolecular compound synthesis field. The invention utilizes the inverse emulsion method to synthesize the polyacrylamide flocculent. Firstly, the polymer emulsifier is prepared; then the water phase and oil phases are prepared, the polymer emulsifier is added into the oil phase, which is mixed and emulsified with the water phase; under the function of a polymerization initiator, the polyacrylamide flocculent emulsion is finally obtained through the chemical reaction. The mehtod of the invention utilizes the specialized polymer emulsifier to prepare the polyacrylamide flocculent emulsion, which has the advantages of a high concentration and a good stability.

A polymerizable liquid crystal composition is provided that has a wide range where a liquid crystal phase is exhibited, has excellent solubility in an organic solvent, and is facilitated in control of an alignment state. The use of the polymerizable liquid crystal composition provides a polymerizable liquid crystal composition that has good solubility in a solvent with high safety, such as PGMEA, and can control various alignment states. The polymerizable liquid crystal composition in one aspect contains a fluorenone derivative represented by the formula (1) and a compound having a bisphenol skeleton represented by the formula (2). In the formulae (1) and (2), W1 represents hydrogen, fluorine, chlorine, methyl or ethyl; X1 represents hydrogen, fluorine, methyl or trifluoromethyl; Z11 to Z14 are bonding groups; A1 represents a divalent cyclic group; Y1 represents alkylene having from 2 to 20 carbon atoms; A2 represents a divalent group having a bisphenol skeleton; X2 represents hydrogen, fluorine, methyl or trifluoromethyl; W2 represents hydrogen, halogen, alkyl or fluoroalkyl; Y2 independently represents a single bond, —CH═CH— or —(CH2)2—; and n2 independently represents an integer of from 2 to 15.

The invention discloses a composition of nanoparticles composed of positively charged chitosan, one negatively charged substrate, and optionally a zero-charge compound or at least one tumor necrosis factor inhibitor for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.

The invention discloses the nanoparticles composed of chitosan, poly-glutamic acid, and at least one bioactive agent characterized with a positive surface charge and their enhanced permeability for paracellular drug delivery.

A compound represented by the following formula (1) has sufficient solubility, a wide usable concentration range, and excellent haze-lowering performance. In the formula, L1 to L6 represent a single bond, —O—, —CO—, —COO—, etc; Sp1 to Sp4 represent a single bond or alkylene of 1 to 10 carbon atoms; A1 and A2 represent trivalent or tetravalent aromatic hydrocarbon or heterocyclic; T represents the following formulae, etc; Hb represent perfluoroalkyl of 2 to 30 carbon atoms; m and n are 2 or 3; and o and p are an integer of 0 or more.

The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.

A [1]benzothieno[3,2-b][1]benzothiophene compound expressed by General Formula (I): General Formula (I) where X and Y are each independently a hydrogen atom; a halogen atom; or a functional group having a straight or branched aliphatic alkyl group optionally having a halogen atom, a functional group having an alicyclic alkyl group optionally having a halogen atom, a functional group having a straight or branched aliphatic alkenyl group optionally having a halogen atom, a functional group having an alicyclic alkenyl group optionally having a halogen atom, a functional group having a carboxyl group, or a functional group having a thiol group, as a partial structure; and X and Y are the same or each independently different, provided that at least one of X and Y has a straight or branched aliphatic alkenyl group, an alicyclic alkenyl group, a carboxyl group or a thiol group, as a partial structure.

The present invention relates to a compound which is 6-amino-2-{[(1S)-1-methylbutyl]oxy}-9-[5-(1-piperidinyl)pentyl]-7,9-dihydro-8H-purin-8-one:in the form of a maleate salt, may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.

A method for removing iodine and iodide ions from heat transfer compositions which contain a hydrofluoroalkene, an iodocarbon, and iodine and iodide ions. Iodine and iodide ions from such heat transfer compositions by contacting the composition with a molecular sieve, ion exchange resin, clay or alumina, metal impregnated with a metal which is capable of reacting with iodine and iodide ions.

The present invention generally relates to polymeric membrane materials formed, at least in part, from monomeric material selected from 2,3,3,3-tetrafluoropropene (CF3CF═CH2, HFO-1234yf) or trans-1,3,3,3-tetrafluoropropene (CF3CH═CFH, HFO-1234ze), and to membrane preparations and uses thereof in water desalination, filtration, membrane distillation, pervaporation, and selective gas separation.

A method for removing iodine from heat transfer compositions which contain a hydrofluoroalkene, an iodocarbon, and iodine. Iodine from such heat transfer compositions by contacting the composition with activated carbon.

The invention discloses etimicin sulfate preparation and its preparing method which comprises, charging acids or alkali as pH conditioning agent so as to increase the dissolving degree of the etimicin, charging right amount of isoosmotic adjustment agent, thus resulting the action of quick sterilization.

The invention discloses a fabric leveling agent for an acid dye. The fabric leveling agent is prepared from the following materials by mass percent: 6 to 12 percent of styryl phenol polyoxyethylene ether ammonium sulfate, 3 to 8 percent of octadecylamine polyoxyethylene ether sodium laureth sulfate, 6 to 10 percent of peregal O, 2 to 6 percent of polyoxyethylene ether glycerol oleate, 5 to 10 percent of polyoxyethylene hydrogenated lanolin and the balance of deionized water. The fabric leveling agent is suitable for leveling acid and neutral dyes, good in leveling performance and stability, easy to dissolve at the normal temperature and convenient to use; and a leveling agent system is good in hard water resistant stability, good in affinity to dyes and wool fibers, favorable for dispersing and retarding the dye and capable of improving the utilization rate of the dye.