New bio-derived horn-fetal-bone material and application thereof

Abstract

The invention provides a new bio-derived horn-fetal-bone material, and belongs to the field of orthopedics transplanting materials. A preparing method of the new bio-derived horn-fetal-bone material includes the steps that a blood-stopping horn fetal bone of a mammalian artiodactyla bovidae animal is taken and stored for 22-26 mouths at the normal temperature after a membrane of the horn fetal bone is removed; the horn fetal bone stored at the normal temperature is degreased and subjected to protein removing and antigen extracting treatment to be processed into a shape required by bone coloboma or internal fixation, and the new bio-derived horn-fetal-bone material is obtained. The physicochemical properties and the biological properties of the new material are quite similar to the properties of a cancellous bone of the human body, and the new material has good histocompatibility, the good natural biological microenvironment, the good biomechanics microenvironment, the good blood-vessel fast-growing microenvironment and the good hole lumen microenvironment, has the advantages of being low in antigenicity, high in physical supportability, mechanical strength and toughness and the like, further has the advantages of being rich in source, low in cost, stable in property, easy to sterilize and suitable for storage and transportation, can serve as an ideal orthopedics direct transplantation or fixing material, and can be applied to orthopedics transplantation.

Description

technical field [0001] The invention relates to the field of orthopaedic implant materials, namely a new biologically derived keratinocyte material and its application. Background technique [0002] Bone grafts have been used for centuries to treat trauma, infection, and congenital bone defects and defects with good results. However, the large-scale clinical application of large pieces of load-bearing bone and long-segment bone defects has not been satisfactorily resolved. [0003] Autologous bone is currently a commonly used therapy, but the limited availability of donors limits its wide application and increases the suffering of patients. Allogeneic bone is antigenic, especially when the implant is large, because of the non-porous network structure, central ischemia, small new bone, disease transmission, immune rejection, and ethical issues, its application has also been affected. severe restrictions. In addition, although xenografts have abundant sources, good shape, l...

AI Technical Summary

Problems solved by technology

However, from the perspective of the particularity of the core elements of tissue-engineered bone, that is, scaffold materials, there are still many problems, and a single material cannot effectively solve the above-mentioned related problems: such as deproteinized bone matrix from biological sources, decalcified bone matrix, although porous and good inductivity, but low mechanical strength

The HA / TCP compound is made into a load-bearing bone scaffold, and its corresponding mechanical strength is significantly enhanced, and it is osteoinductive, which can achieve the highest compressive strength required by cancellous bone; however, the mechanical strength is poor, and large central ischemia can heal Slow process, lack of biological activity

[0011] All in all, in the current study of tissue engineering element material scaffolds, the available materials are divided into two categories: natural biologically derived materials and artificial synthetic materials, but so far none of them fully meets the requirements, and all of them have unsuitable strength, poor porosity, and degradation. Due to defects such as slow speed, difficult processing and shaping, poor surface properties of products, or shortage of sources, it is difficult to meet the technical problems of large-scale, long-segment load-bearing bone defect or supercritical bone defect repair

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